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Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?

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Neural Regeneration research 2015年第1期10卷 7-9页

作者： Suk Yu Yau Ang Li Aimin Xu Kwok-fai So State Key Laboratory of Brain and Cognitive sciences Li Ka Shing Faculty of MedicineThe University of Hong Kong Division of Medical sciences University of Victoria BCCanada department of Anatomy The University of Hong Kong department of Medicine The University of Hong Kong department of Pharmacology and Pharmacy The University of Hong Kong research Centre of Heart BrainHormone and Healthy AgeingThe University of Hong Kong State Key Laboratory of Pharmaceutical Biotechnology Li Ka Shing Faculty of MedicineThe University of Hong Kong department of Ophthalmology The University of Hong Kong Guangdong-hong kong-macao Institute of CNS Regeneration Jinan University Guangdong Key Laboratory of Brain Function and Diseases Jinan University

Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recog- nized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neuro- genesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counter- acting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents.

关键词： hippocampus adult neurogenesis physical exercise voluntary wheel running depression neural progenitor cell adipocyte adiponectin adiponectin receptor AMP-activated protein kinase

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High genetic diversity and strong differentiation in dramatically fluctuating populations of Zostera japonica(Zosteraceae):implication for conservation

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Journal of Plant Ecology 2018年第5期11卷 789-797页

作者： Kai Jiang Po-Keung Eric Tsang Na-Na Xu Xiao-Yong Chen School of Ecological and Environmental sciences Shanghai Key Lab of Urban Ecological Processes and Eco-RestorationEast China Normal UniversityShanghai 200241China Shanghai Chenshan Plant science research center Chinese Academy of SciencesChenshan Botanical GardenShanghai 201602China department of science and Environmental Studies The Education University of Hong KongHong KongChina School of Fishery Zhejiang Ocean UniversityZhoushan 326022China

Aims Seagrasses provide a variety of ecosystem goods and services,but they are subjected to frequently anthropogenic *** this study,we genotyped samples collected from Zostera japonica mead-ows with dramatic fluctuations in the area in order to understand the distribution of genetic variation within and among *** We collected samples from eight extant populations along coastal areas of southern *** polymorphic microsatellites were adopted to genotype the *** of genetic diversity and differentiation were calculated with general *** Findings High levels of genetic diversity were found in the studied populations,suggesting that the effective population size has not decreased signifi-cantly,which was supported by no signs of recent *** genetic diversity reflects an important role of sexual seedling recruit-ment in *** *** found a significant relationship between genetic differentiation and the shortest sea surface distance of populations,suggesting that ocean currents play a critical role in shap-ing the genetic structure of *** *** soft-ware analysis clustered the eight populations into two groups:western and eastern populations separated by the Qiongzhou Strait/Leizhou Peninsula,hinting that there was very limited gene flow through the narrow strait in this marine *** populations had high contribu-tion diversity and,thus,high priority for in situ conservation.

关键词： Seagrass Zostera japonica Genetic diversity Genetic differentiation Microsatellites

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Structural plasticity-based hydrogel optical Willshaw model for one-shot on-the-fly edge learning

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InfoMat 2023年第4期5卷 48-59页

作者： Dingchen Wang Dingyao Liu Yinan Lin Anran Yuan Woyu Zhang Yaping Zhao Shaocong Wang Xi Chen Hegan Chen Yi Zhang Yang Jiang Shuhui Shi Kam Chi Loong Jia Chen Songrui Wei Qing Wang hongyu Yu Renjing Xu Dashan Shang Han Zhang Shiming Zhang Zhongrui Wang department of Electrical and Electronic Engineering The University of Hong KongHong Kongthe People's Republic of China ACCESS-AI Chip center for Emerging Smart Systems InnoHK CentersHong Kong Science ParkHong Kongthe People's Republic of China School of Computer science and Engineering Faculty of Innovation EngineeringMacao University of Science and TechnologyMacaothe People's Republic of China Key Laboratory of Microelectronics Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijingthe People's Republic of China Collaborative Innovation center for Optoelectronic science Technology International Collaborative Laboratory of 2D Materials for OptoelectronicsScience and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsShenzhen UniversityShenzhenthe People's Republic of China School of Microelectronics Southern University of Science and TechnologyShenzhenthe People's Republic of China Microelectronics Thrust Function Hub of the Hong Kong University of Science and Technology(Guangzhou)Guagndongthe People's Republic of China

Autonomous one-shot on-the-fly learning copes with the high privacy,small dataset,and in-stream data at the *** such learning on digital hardware suffers from the well-known von-Neumann and scaling *** optical neural networks featuring large parallelism,low latency,and high efficiency offer a promising ***,ex-situ training of conventional optical networks,where optical path configuration and deep learning model optimization are separated,incurs hardware,energy and time overheads,and defeats the advantages in edge ***,we introduced a bio-inspired material-algorithm co-design to construct a hydrogel-based optical Willshaw model(HOWM),manifesting Hebbian-rule-based structural plasticity for simultaneous optical path configuration and deep learning model optimization thanks to the underlying opto-chemical *** first employed the HOWM as an all optical in-sensor AI processor for one-shot pattern classification,association and *** then leveraged HOWM to function as a ternary content addressable memory(TCAM)of an optical memory augmented neural network(MANN)for one-shot learning the Omniglot *** HOWM empowered one-shot on-the-fly edge learning leads to 1000boost of energy efficiency and 10boost of speed,which paves the way for the next-generation autonomous,efficient,and affordable smart edge systems.

关键词： associative memory hydrogel one-shot learning optical neural network structural plasticity Willshaw model

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Boron nitride nanofibers enhanced composite PEO-based solid-state polymer electrolytes for lithium metal batteries

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Chinese Chemical Letters 2024年第6期35卷 216-221页

作者： Qianqian Song Yunting Zhang Jianli Liang Si Liu Jian Zhu Xingbin Yan School of Materials science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China College of Physics and Materials science Tianjin Normal UniversityTianjin 300387China department of Chemistry&center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongHong Kong 999077China Guangdong-hong kong-macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology School of Physics and Optoelectronic EngineeringFoshan UniversityFoshan 528225China

Polyethylene oxide(PEO)-based solid-state polymer electrolytes(SPEs)are limited by their poor cyclic stability and inferior ionic conductivity for applicating in high-safety,long-cycling and high-energy-density lithium metal ***,porous boron nitride nanofibers(BNNFs)are filled into PEO-based SPE,which significantly suppresses Li dendrites growth and enhances the electrochemical performance of Li metal *** with high porosity have more active sites to connect with PEO,which can effectively reduce the crystallinity of the PEO matrix and enhance its ionic ***,owing to the hardness and good stability of BNNFs,BNNFs/PEO/Li TFSI electrolyte exhibits a wider electrochemical window,better mechanical property and higher thermal stability compared with PEO/Li TFSI ***,the Li symmetric cell composed of 1%BNNFs/PEO/Li TFSI performs good cyclic stability(>1800 h),and the Li||1%BNNFs/PEO/Li TFSI||LFP full battery shows obviously improved performances in charge-discharge polarization voltage,discharge specific capacity,rate performance and cyclic stability than the Li||PEO/Li TFSI||LFP battery.

关键词： Solid-state polymer electrolyte Boron nitride nanofibers Lithium metal battery Ionic conductivity Li dendrite

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Targeted protein degradation in cancers:Orthodox PROTACs and beyond

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The Innovation 2023年第3期4卷 5-19页

作者： Jin Li Xinxin Chen Aiping Lu Chao Liang department of Biology School of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China Institute of Integrated Bioinfomedicine and Translational science(IBTS) School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 999077China State Key Laboratory of Proteomics National Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 100850China Guangdong–hong kong–macao Joint Lab on Chinese Medicine and Immune Disease research Guangzhou 510006China

Targeted protein degradation(TPD)is emerging as a strategy to overcome the limitations of traditional small-molecule ***-targeting chimera(PROTAC)technology can be used to target proteins by hijacking the ubiquitin-proteasome ***,PROTAC aims to target the“undruggable”majority of proteins in the human *** constant exploration and optimization of PROTACs and the exploitation of other TPD strategies over two decades,TPD has expanded from theoretical studies to clinical strategies,with practical applications in oncological,immunological,and other *** this review,we introduce the mechanisms,features,and molecular targets of orthodox PROTACs and summarize the PROTAC drugs under study as cancer therapeutics in clinical *** also discuss PROTAC derivatives and other TPD strategies,such as lysosome-targeting chimeras,autophagy-targeting chimeras,and molecular glue ***,the studies summarized herein support the full potential of TPD in the biomedical industry.

关键词： overcome summarized herein

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“On Water”Effect for Green Click Reaction:Spontaneous Polymerization of Activated Alkyne with“Inert”Aromatic Amine in Aqueous Media

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CCS Chemistry 2023年第2期5卷 385-396页

作者： Xinyue Liu Chen Zhang Lianrui Hu Jinghan Wang Kai Li Hai-Tao Feng Jacky WYLam Benzhao He Ben Zhong Tang department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionGuangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 HKUST-Shenzhen research Institute Shenzhen 518057 department of Biomedical Engineering SUSTech Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen 518055 AIE research center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013 center for Advanced Materials research Beijing Normal University at ZhuhaiZhuhai 519085 School of science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen 518172

Organic reactions in water have attracted great attention due to their advantages such as unique reaction performance and environmental *** reactions as well as polymerizations in aqueous media have been extensively investigated,and so far,there has been a massive amount of reporting about polymerizations in ***,reports about click polymerization in water have been ***,click polymerization of activated alkyne and aromatic amine in aqueous media is ***“on water”effect facilitates polymerization in aqueous media better than in organic solvents,and its mechanism is deciphered through experimental data and theoretical *** participates in the reaction and reduces the energy barrier to some ***,polymerization makes it possible for aromatic amine with low reactivity to be *** using this strategy,polymers with high molecular weights can be obtained in high yields(up to 95.4%).They show good thermal stability and high *** can be *** polymers with tetraphenylethylene moieties show aggregation-induced emission and can be used as materials for generating photopatterns and visualizing agents for specific staining of lysosome in living cells.

关键词： “on water”effect click polymerization aromatic amine photodegradation specific lysosome-staining

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Elevated meteorin-like protein from high-intensity interval training improves heartfunctionviaAMPK/HDAC4pathway

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Genes & Diseases 2024年第6期11卷 409-424页

作者： Yongshun Wang Jie Yuan Huadong Liu Jie Chen Jieru Zou Xiaoyi Zeng Lei Du Xin Sun Zhengyuan Xia Qingshan Geng Yin Cai Jingjin Liu department of Cardiology Shenzhen People's Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China Shenzhen Clinical research center for Geriatrics Shenzhen People's HospitalShenzhenGuangdong 518020China department of Anesthesiology Affiliated Hospital of Guangdong Medical UniversityZhanjiangGuangdong 524001China Faculty of Chinese Medicine State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyTaipaMacao 999078China department of Health Technology and Informatics The Hong Kong Polytechnic UniversityKowloonHong Kong 999077China

High-intensity interval training(HIlT)has been found to be more effective in relieving heart failure(HF)symptoms,than moderate-intensity continuous aerobic training(MICT).Additionally,higher meteorin-like protein(Metrnl)levels are seen after HIIT versus *** investigated whether Metrnl contributed to post-HF cardiac functional improve-ments,and the signaling pathways involved.50 HF patients underwent MICT,and another 50,HllT,which was followed by cardiac function and serum Metrnl *** was also measured in both blood and skeletal muscle samples of mice with transverse aortic constriction-induced HF after undergoing ***,shRNA-containing adenovectors were injected into mice,yielding five groups:control,HF,HF+HIIT+scrambled shRNA,HF+HIIT+shMetrnl,and HF+Metrnl(HF+exogenous Metrnl).Mass spectrometry identified specific signaling pathways associated with increased Metrnl,which was confirmed with biochemical *** metabolism and mitochondrial functioning were evaluated in cardiomyocytes from the five *** HF patients and mice had higher circulating Metrnl levels *** activated AMPK in cardiomyocytes,subsequently increasing histone deacetylase 4(HDAC4)phosphorylation,leading to its cytosolic sequestration and inactivation via binding with chaperone protein ***4 inactivation removed its repression on glucose transporter type 4,which,along with increased mitochondrial complex I-V expression,yielded improved aerobic glucose respiration and alleviation of mitochondrial *** these changes ultimately result in improved post-HF cardiac *** increased skeletal muscle Metrnl production,which then operated on HF hearts to alleviate their functional defects,via increasing aerobic glucose metabolism through AMPK-HDAC4 signaling.

关键词： AMPK GLUT4 HDAC4 Heart failure High intensity interval training

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Photodegradation-Induced Turn-On Luminescence of Tetraphenylethylene-Based Trithiocarbonate Polymers

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Chinese Journal of Chemistry 2021年第10期39卷 2837-2842页

作者： Hanchen Shen Wenjie Wu Shunjie Liu Jing Zhang Jacky WYLam Ben Zhong Tang department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute of Advanced StudyThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina department of Laboratory Medicine Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China HKUST Shenzhen research Institute No.9 Yuexing 1 st RDSouth Area Hi-tech ParkNanshanShenzhenGuangdong518057 China center for Aggregation-induced Emission SCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhouGuangdong510640 China HKUST AIE Institute Guangzhou Development DistrictHuangpuGuangzhouGuangdong510530 China Guangdong-hong kong-macao Joint laboratory of Optoelectronic and Magnetic Functional Materials The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Main observation and conclusion Fluorescent intelligent materials have attracted wide attention because of their great potential *** major hurdle for the development and application of fluorescent intelligent materials is the aggregation-caused quenching effect in the solid ***,tetraphenylethylene-based trithiocarbonate polymers with satisfactory molecular weights(Mw up to 24900)were synthesized through a one-pot polymerization route under mild *** polymers were non-emissive due to the quenching effect of the trithiocarbonate ***,upon UV irradiation,the polymers degraded and strong emission from the tetraphenylethylene unit was *** a unique property endows them with great potential applications,such as photopatterning,anti-counterfeit labels,and UV detection.

关键词： Photochemistry Trithiocarbonate polymers Luminescence Polymerization Aggregation-induced emission

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Towards net zero carbon buildings:Accounting the building embodied carbon and life cycle-based policy design for Greater Bay Area,China

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Geoscience Frontiers 2024年第3期15卷 284-297页

作者： Hanwei Liang Xin Bian Liang Dong Collaborative Innovation center on Forecast and Evaluation of Meteorological Disasters/research center of Urban Sustainable Development/School of Geographical sciences Nanjing University of Information Science&Technology(NUIST)Nanjing 210044China department of Architecture and Civil Engineering Chalmers University of TechnologySE-41296 GothenburgSweden Shenzhen research Institute(SRI) City University of Hong KongShenzhenChina department of Public and International Affairs(PIA) City University of Hong Kong999077Hong Kong Special Administrative Region School of Energy and Environment(SEE) City University of Hong Kong999077Hong Kong Special Administrative RegionChina Centre for Public Affairs and Law City University of Hong Kong999077Hong Kong Special Administrative RegionChina

Carbon mitigation of buildings is critical to promote a net-zero *** international society has vigorously promoted“Net Zero Carbon Buildings”across the globe,and accounting for building carbon emissions is critical to support this *** carbon,which represents carbon emissions from the entire lifecycle of the buildings,is fundamental for realizing the idea of zero ***,only limited studies have been conducted so far that take into account the city *** paper aimed to act as a first try to account for the embodied carbon emissions in buildings in 2020 for the Guangdong-hong kong macao Greater Bay Area in China(GBA).We integrated remote sensing techniques such as night-time light data(NLT)and building material flows analysis to calculate and spatialize the newly generated building material stocks(MS).Based on the MS data,we further applied life cycle assessment(LCA)to assess the embodied carbon in the *** results highlighted that over 163 million tons of embodied carbon in buildings of GBA are expected to be generated,from 497 million tons of newly generated building MS in *** embodied carbon in each life cycle stage is valuable for further lifecyclebased policy designs for:(i)supporting the updating of the green building certification system with consideration of the embodied carbon;(ii)promoting the green building material application and certification;and(iii)reducing the embodied carbon intensity from compact urban planning policy,such as the urban agglomeration policies in *** goal of this paper was to shed a light on reducing carbon emissions from the perspective of the entire lifecycle and promote the development of net zero carbon buildings in China and Asia-Pacific.

关键词： Net zero carbon building Embodied carbon Life cycle assessment Life cycle-based policies Greater Bay area

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Organic near-infrared photodetectors with photoconductivityenhanced performance

Aggregate

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Aggregate 2023年第5期4卷 120-127页

作者： Siwei Zhang Zhenlong Li Jingzhou Li Bingzhe Wang Fang Chen Xubiao Li Shunjie Liu Jacky W.Y.Lam Guichuan Xing Jiangyu Li Zheng Zhao Feiyu Kang Guodan Wei Ben Zhong Tang department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Guangdong-Hong Kong-Macro Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsThe Hong Kong University of Science and TechnologyKowloonHong KongChina Tsinghua-Berkeley Shenzhen Institute Institute of Materials ScienceTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhenChina Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhouChina Institute of Applied Physics and Materials Engineering University of MacaoAvenida da UniversidadeTaipaMacaoChina department of Materials science and Engineering Southern University of Science and TechnologyShenzhenChina Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchunChina School of science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenChina center for Aggregation-Induced Emission South China University of TechnologyGuangzhouChina

Organic near-infrared(NIR)photodetectors with essential applications in medical diagnostics,night vision,remote sensing,and optical communications have attracted intensive research *** with most conventional inorganic counterparts,organic semiconductors usually have higher absorption coefficients,and their thin active layer could be sufficient to absorb most incident light for effective ***,due to the relatively poor charge mobility of organic materials,it remains challenging to inhibit the photogenerated exciton recombination and effectively extract carriers to their respective ***,this challenge was addressed by increasing matrix conductivities of a ternary active layer(D–A–D structure NIR absorber[2TT-oC6B]:poly(N,N′-bis-4-butylphenyl-N,N′-bisphenyl)benzidin[PolyTPD]:[6,6]-phenyl-C61-butyric acid methyl ester[PCBM]=1:1:1)upon in situ incident light illumination,significantly accelerating charge transport through percolated interpenetrating *** greatly enhanced photoconductivity under illumination is intrinsically related to the unique donor–acceptor molecular structures of PolyTPD and 2TT-oC6B,whereas stable intermolecular interaction has been verified by systematic molecular dynamics *** addition,an ultrafast charge transfer time of 0.56 ps from the NIR aggregation-induced luminogens of 2TT-oC6B absorber to PolyTPD and PCBM measured by femtosecond transient absorption spectroscopy is beneficial for effective exciton *** solution-processed organic NIR photodetector exhibits a fast response time of 83μs and a linear dynamic range value of 111 dB under illumination of 830 ***,our work has opened up a pioneering window to enhance photoconductivity through in situ photoirradiation and benefit NIR photodetectors as well as other optoelectronic devices.

关键词： AIEgens organic NIR photodetectors photoconductivity

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