检索结果-南通市图书馆

Variation of Serum Monocyte Chemoattractant Protein-1 in Patients with Diabetes and Metabolic Syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Huazhong University of science and Technology(Medical sciences) 2011年第3期31卷 312-316页

作者：黎慧清邓秀玲李贞琼罗长青刘建社王玉梅 department of Endocrinology Union HospitalTongji Medical CollegeHuazhong University of Sci-ence and Technology department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Sci-ence and Technology

This study investigated the variation of serum monocyte chemoattractant protein-1（MCP-1） in patients with both diabetes mellitus（DM） and metabolic syndrome（MS）.Based on the International Diabetes Federation（IDF） diagnostic criteria,93 patients enrolled in this study were divided into four groups：normal control（NC）,simple DM,simple MS,and DM plus MS（DM-MS） *** main measures included height,weight,waist circumference（WC）,hip circumference,blood pressure,fasting blood glucose,insulin resistance index（HOMA-IR）,serum triglyceride（TG）,HDL-ch,LDL-ch,and *** results showed that the serum levels of MCP-1 in the DM-MS group were significantly increased as compared with those in the DM and MS groups（P0.05）,and the increase in the MCP-1 level in the DM group was much higher than in the MS group（P0.05）.The DM-MS group had the highest HOMA-IR levels,followed by MS,DM and NC groups（P0.05）.Correlation tests showed that the association of MCP-1 with age,HDL-ch,or LDL-ch was insignificant,whereas that of MCP-1 with body mass index（BMI）,waist hip rate（WHR）,WC,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,TG,and HOMA-IR was significantly *** was concluded that circulating MCP-1 was substantially increased in patients with both DM and MS as compared with that in the patients with DM or MS alone,and the central obese state may contribute to a more vicious proinflammatory condition and insulin resistance in patients with diabetes.

关键词： monocyte chemoattractant protein-1 diabetes metabolic syndrome

PEO-b-P4VP/Yttrium Hydroxide Hybrid Nanotubes as Supporter for Catalyst Gold Nanoparticles

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2012年第3期25卷 352-358,374页

作者： Qian Yang Dao-yong Chen The State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Sci-ence Fudan University Shanghai 200433 China

吸附(乙烯氧化物) poly， -b-poly(4-vinylpyridine)(PEO-b-P4VP) 微粒与稠密的 P4VP 内部层和包围 YNT 的拉长的 PEO 外部层导致了到钇氢氧化物 nanotubes (YNT ) 的表面上混合 nanotubes。稠密的 P4VP 层被 crosslinking 进一步作为 c... 详细信息

吸附(乙烯氧化物) poly， -b-poly(4-vinylpyridine)(PEO-b-P4VP) 微粒与稠密的 P4VP 内部层和包围 YNT 的拉长的 PEO 外部层导致了到钇氢氧化物 nanotubes (YNT ) 的表面上混合 nanotubes。稠密的 P4VP 层被 crosslinking 进一步作为 crosslinker 用 1,4-dibromobutane 稳定。然后， crosslinked 混血儿 nanotubes (CHNT ) 作为一个新奇 nano 支持者被使用在 crosslinked P4VP 层以内装载催化剂金牌 nanoparticles (GNP ) 。结果的 GNPs/CHNTs (在 CHNT 上装载的 GNT ) 被使用催化 p-nitrophenol 的减小反应。结果显示这个新奇 nano 支持者在暂停，在装载 GNP (0.87 mmol/g ) 的高能力，装载 GNP (12.9 mol1min1 ) 的高催化的活动，和 GNTs/CHNTs 的好可重用性有象好 dispersity 那样的优点。

关键词：纳米催化剂碳纳米管纳米金混合氢氧国民生产总值乙烯基吡啶载体

A performance-based hybrid deep learning model for predicting TBM advance rate using Attention-ResNet-LSTM

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 65-80页

作者： Sihao Yu Zixin Zhang Shuaifeng Wang Xin Huang Qinghua Lei department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghaiChina Key Laboratory of Geotechnical and Underground Engineering Ministry of EducationTongji UniversityShanghaiChina department of Earth sciences ETH ZürichZürichSwitzerland department of Earth sciences Uppsala UniversityUppsalaSweden

The technology of tunnel boring machine(TBM)has been widely applied for underground construction worldwide;however,how to ensure the TBM tunneling process safe and efficient remains a major *** rate is a key parameter of TBM operation and reflects the TBM-ground interaction,for which a reliable prediction helps optimize the TBM ***,we develop a hybrid neural network model,called Attention-ResNet-LSTM,for accurate prediction of the TBM advance rate.A database including geological properties and TBM operational parameters from the Yangtze River Natural Gas Pipeline Project is used to train and test this deep learning *** evolutionary polynomial regression method is adopted to aid the selection of input *** results of numerical exper-iments show that our Attention-ResNet-LSTM model outperforms other commonly-used intelligent models with a lower root mean square error and a lower mean absolute percentage ***,parametric analyses are conducted to explore the effects of the sequence length of historical data and the model architecture on the prediction accuracy.A correlation analysis between the input and output parameters is also implemented to provide guidance for adjusting relevant TBM operational *** performance of our hybrid intelligent model is demonstrated in a case study of TBM tunneling through a complex ground with variable ***,data collected from the Baimang River Tunnel Project in Shenzhen of China are used to further test the generalization of our *** results indicate that,compared to the conventional ResNet-LSTM model,our model has a better predictive capability for scenarios with unknown datasets due to its self-adaptive characteristic.

关键词： Tunnel boring machine(TBM) Advance rate Deep learning Attention-ResNet-LSTM Evolutionary polynomial regression

Resistive field generation in intense proton beam interaction with solid targets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2024年第1期9卷 35-43页

作者： W.Q.Wang J.J.Honrubia Y.Yin X.H.Yang F.Q.Shao department of Physics National University of Defense TechnologyHunanChina ETSI Aeronáutica y del Espacio Universidad Politécnica de MadridMadridSpain department of Nuclear science and Technology National University of Defense TechnologyHunanChina

The Brown-Preston-Singleton(BPS)stopping power model is added to our previously developed hybrid code to model ion beam-plasma *** simulations show that both resistive field and ion scattering effects are important for proton beam transport in a solid target,in which they compete with each *** the target is not completely ionized,the self-generated resistive field effect dominates over the ion scattering ***,when the target is completely ionized,this situation is ***,it is found that Ohmic heating is important for higher current densities and materials with high *** energy fraction deposited as Ohmic heating can be as high as 20%-30%.Typical ion divergences with half-angles of about 5°-10°will modify the proton energy deposition substantially and should be taken into account.

关键词： interaction beam intense

Association between Promoter Polymorphisms of Interleukin-4 Gene and Allergic Rhinitis Risk: a Meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Huazhong University of science and Technology(Medical sciences) 2014年第3期34卷 306-313页

作者：李志鹏尹丽丽王慧刘立思 department of Otorhinolaryngology-Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong University of Sci-ence and Technology

Summary： The relationship of interleukin-4 （IL-4） C-33T and C-590T （C-589T） gene polymorphisms with allergic rhinitis was analyzed. Data about the case control studies of IL-4 gene promoter polymorphisms [C-33T and C-590T （C-589T）] and their association with allergic diseases and correlation between serum IL-4 levels and allergic rhinitis were retrieved. The Stata 12.0 statistical soitvcare was applied to analyze the correlation between IL-4 gene polymorphisms and allergic rhinitis. The meta-analysis result of TT/CC genotype of -590 （-589） polymorphism showed a significant association with allergic diseases [OR=1.93, 95% CI （1.61 2.31）, P=0.00]. Meta-analysis of the TT＋TC versus CC genotype of IL-4 C-33/T polymorphism revealed significant associations with allergic diseases [OR=3.23, 95% CI （1.13-9.25）, P=0.03]. Meanwhile, there was a significant correlation between serum IL-4 levels and allergic rhinitis [OR=2.52, 95% CI-（1.80-3.23）, P=0.00]. IL-4 gene -590 TT genotype may increase the risk of allergic rhinitis and the T allele mutation of -33 might be correlated with aller- gic rhinitis.

关键词： interleukin-4 polymorphisms allergic rhinitis meta-analysis

Novel insights on acetylcholinesterase inhibition by Convolvulus pluricaulis,scopolamine and their combination in zebrafish

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2022年第1期12卷 56-70页

作者： Kalyani Bindu Karunakaran Anand Thiyagaraj Kirankumar Santhakumar Supercomputer Education and Research Centre Indian Institute of Sci-enceBengaluruIndia department of Genetic Engineering SRM Institute of Science and TechnologyKattankulathur 603203India Zebrafish Genetics Laboratory Department of Genetic EngineeringSRM Institute of Science and TechnologyKattankulathur 603203India

Acetylcholinesterase(AChE)inhibitors increase the retention of acetylcholine(ACh)in *** they allevi-ate cognitive deficits in Alzheimer’s disease,their limited benefits warrant investigations of plant extracts with similar *** studied the anti-AChE activity of Convolvulus pluricaulis(CP)in a zebrafish model of cognitive impair-ment induced by scopolamine(SCOP).CP is a perennial herb with anti-amnesiac and anxiolytic *** contains alkaloid,anthocyanin,coumarin,flavonoid,phytosterol and triterpenoid ***(ISOX)was used as a positive control for AChE ***-treated 168 hpf larvae showed a similar pattern of AChE inhibition(in the myelencephalon and somites)as that of ISOX-treated *** was superior to ISOX as evidenced by the retention of avoidance response behavior in adult *** docking studies indicated that ISOX binds Ser203 of the catalytic triad on the human *** active components of CP-scopoletin and kaempferol-were bound by His447 of the catalytic triad,the anionic subsite of the catalytic center,and the peripheral anionic *** suggested the ability of CP to mediate both competitive and non-competitive modes of ***,SCOP showed AChE inhibition in larvae,possibly mediated via the choline-binding ***+SCOP induced a concentration-dependent increase in AChE inhibition and ACh *** motor responses were observed with ISOX,CP,ISOX+SCOP,and CP+SCOP,indicative of undesirable effects on the peripheral cholinergic *** study proposes the examination of CP,SCOP,and CP+SCOP as potential AChE inhibitors for their ability to modulate cognitive deficits.

关键词： Alzheimer’s disease Acetylcholinesterase Zebrafish Convolvulus pluricaulis Scopolamine Isoxazole

Effect of Dietary EGCG on Normal and Vitamin E and Selenium Deficient Rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and nutrition sciences 2013年第8期4卷 163-173页

作者： Juan E. Andrade John R. Burgess department of Food science and Human nutrition University of Illinois Champaign-Urbana USA department of nutrition sci- ence Purdue University West Lafayette USA.

The tea catechin EGCG has been postulated to provide health benefits in humans, to some extent, as an antioxidant. The dose-response effect of dietary EGCG (0, 30, 60, or 120 mg/kg diet) was tested in rats under high versus low oxidative stress conditions that were created by feeding diets adequate in vitamin E and Se (Lox), or deficient in both (Hox) for six weeks. Effects on growth, quinone reductase (NQO1) activity, F2-isoprostanes and nutrient antioxidant amounts in the liver were evaluated as markers of nutrient deficiency and oxidative status. Under Hox conditions consumption of EGCG only at the lowest dose was partially associated with a protection against oxidative stress, reflected by a delay in growth deceleration, but no protection against lipid oxidation. Elevated liver NQO1 activity was observed in this group (>4-fold) increasing with the dose;but it was not associated with antioxidant protection. In contrast, under Lox conditions consumption of EGCG was associated with antioxidant activity reflected in a reduction (>30%) in F2-isoprostanes and protection of CoQ reduced status in the liver. Overall these results suggest that the antioxidant effect of EGCG in vivo depends on the level of oxidative stress and the presence of other nutrient antioxidants.

关键词： Vitamin E Deficiency Oxidative Stress EGCG Flavonoid Rat Antioxidant

Small cell lung cancer transformations from non-small cell lung cancer: Biological mechanism and clinical relevance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第1期2卷 42-47页

作者： Yang Yang Songqing Fan department of Pathology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China

Lung cancer is a leading cause of cancer deaths worldwide,consisting of two major histological subtypes:small-cell lung cancer(SCLC)and non-small-cell lung cancer(NSCLC).In some cases,NSCLC patients may undergo a histological transformation to SCLC during clinical treatments,which is associated with resistance to targeted therapy,immunotherapy,or *** review provides a comprehensive analysis of SCLC transfor-mation from NSCLC,including biological mechanism,clinical relevance,and potential treatment options after transformation,which may give a better understanding of SCLC transformation and provide support for further research to define better therapy options.

关键词： Small cell transformation Non-small cell lung cancer EGFR-TKI treatment Epidermal growth factor receptor tyrosine kinase inhibitor Immunotherapy Small-cell lung cancer

NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2024年第2期44卷 251-272页

作者： Yue Yao Yi Xu Liang Yu Ting-Mao Xue Zhi-Jie Xiao Pui-Chi Tin Hiu-Ling Fung Hoi-Tang Ma Jing-Ping Yun Judy Wai Ping Yam department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China department of Endocrinology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of Oncology in South China Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China department of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(HCC)progression via multifaceted *** success of cell entry determines the effect of sEV on recipient ***,we aimed to delineate the mechanisms underlying the uptake of sEV in ***:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transporting 9A;BCECF-AM,2’,7’-bis-(2-barboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester;BSA,bovine serum albumin;CCMR,Centre for Comparative Medicine Research;CRISPR,clustered regularly interspaced short palindromic repeats;CTL,ctrl;CXCR4,C-X-C Chemokine Receptor Type 4;DAPI,4′,6-diamidino-2-phenylindole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycycline;EEA1,early endosome antigen 1;EIPA,5-(N-ethyl-N-isopropyl)-amiloride;FBS,fetal bovine serum;FITC,fluorescein isothiocyanate;GAPDH,glyceraldehyde-3-phosphate dehydrogenase;GM130,Golgi matrix protein 130;HCC,hepatocellular carcinoma;HEPES,4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;IAA,indole-3-acetic acid;KD,knockdown;KO,knockout;mAID,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;OS,overall survival;PBS,phosphate-buffered saline;PCR,polymerase chain reaction;pHe,endosomal pH;pHi,intracellular pH;PKH67,Paul Karl Horan 67;Rab21,Ras-associated binding protein 21;RIPA,radioimmunoprecipitation assay;SAM,synergistic activation mediator;SEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;SLC9,solute carrier gene 9;SLiCE,Seamless Ligation Cloning Extract;TCGA,The Cancer Genome Atlas;TCL,total cell lysates;TGN,trans-Golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TSG101,tumor susceptibility gene *** Yao an

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger