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Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes

National Science Review 2024年第1期11卷 161-173页

作者： Feng Xue Fei Li Ke-ming Zhang Lufeng Ding Yang Wang Xingtao Zhao Fang Xu Danke Zhang Mingzhai Sun Pak-Ming Lau Qingyuan Zhu Pengcheng Zhou Guo-Qiang Bi department of Precision Machinery and Precision Instruments University of Science and Technology of China Hefei National Laboratory for Physical sciences at the Microscale University of Science and Technology of China Interdisciplinary Center for Brain Information the Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Faculty of Life and Health sciences Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences School of Life sciences University of Science and Technology of China Institute of Semiconductors Chinese Academy of Sciences department of Modern Life sciences and Biotecnology Xiongan Institute of Innovation Xiongan New Area Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Suzhou Institute for Advanced Research University of Science and Technology of China Institute of Artiflcial Intelligence Hefei Comprehensive National Science Center

To investigate the circuit-level neural mechanisms of behavior, simultaneous imaging of neuronal activity in multiple cortical and subcortical regions is highly desired. Miniature head-mounted microscopes offer the capability of calcium imaging in freely behaving animals. However, implanting multiple microscopes on a mouse brain remains challenging due to space constraints and the cumbersome weight of the ***, we present TINIscope, a Tightly Integrated Neuronal Imaging microscope optimized for electronic and opto-mechanical design. With its compact and lightweight design of 0.43 g, TINIscope enables unprecedented simultaneous imaging of behavior-relevant activity in up to four brain regions in ***-of-concept experiments with TINIscope recorded over 1000 neurons in four hippocampal subregions and revealed concurrent activity patterns spanning across these regions. Moreover, we explored potential multi-modal experimental designs by integrating additional modules for optogenetics, electrical stimulation or local field potential recordings. Overall, TINIscope represents a timely and indispensable tool for studying the brain-wide interregional coordination that underlies unrestrained behaviors.

关键词： miniature microscope multiple sites calcium imaging multimodal integration hippocampus

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An Ion-Pumping Interphase on Graphdiyne/Graphite Heterojunction for Fast-Charging Lithium-Ion Batteries

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CCS Chemistry 2024年第1期6卷 110-124页

作者： Juan An Fan Wang Jia-Yue Yang Guoxing Li Yuliang Li Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion Science Center for Material Creation and Energy ConversionSchool of Chemistry and Chemical EngineeringInstitute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237 Optics&Thermal Radiation Research Center Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237 Institute of Chemistry The Chinese Academy of SciencesBeijing 100190 University of Chinese Academy of sciences Beijing 100049

The sluggish lithium-ion(Li-ion)transport kinetics in graphite anode hinders its application in fast-charging Li-ion batteries(LIBs).Here,we develop an ionpumping interphase(IPI)on graphdiyne(GDY)/graphite heterojunction anodes to boost the ionic transport kinetics and enable high-performance,fast-charging *** IPI changed the ion solvation/desolvation environment by covalent/non-covalent interactions with Li ions or solvents to optimize solid-electrolyte interphase(SEI)and regulate Li-ion transport *** studied the in situ growth of few-layer GDY on graphite surface(GDY/graphite)as the IPI and found that the strong interaction between GDY and Li ions enabled surface-induced modification of the ion solvation behavior and surface-assisted desolvation effect to accelerate the Li-ion desolvation process.A functional anion-derived SEI layer with improved Li-ion conductivity was *** with the generated built-in electric field at GDY/graphite hetero-interface self-pumping Li ions to intercalate into the graphite,the Li-ion transport kinetics was significantly enhanced to effectively eliminate Li plating and large voltage polarization of the graphite anodes.A fast Li intercalation in GDY/graphite without Li oversaturation at the edge of the graphite was directly *** superior performance with high capacity(139.2 mA h g^(-1))and long lifespan(1650 cycles)under extremely fast-charging conditions(20 C,1 C=372 mA g^(-1))was achieved on GDY/graphite *** at low temperatures(-20℃),a specific capacity of 128.4 mA h g^(-1) was achieved with a capacity retention of 80%after 500 cycles at a 2 C rate.

关键词： extreme fast-charging lithium-ion batteries lithium-ion transport kinetics ion-pumping interphase graphdiyne/graphite heterojunction

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Role of pituitary adenylate cyclase-activating polypeptide in peripheral nerve regeneration:a cellular and molecular perspective

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Neural Regeneration Research 2024年第7期19卷 1429-1430页

作者： Grazia Maugeri Velia D’Agata Section of Anatomy Histology and Movement SciencesDepartment of Biomedical and Biotechnological SciencesUniversity of CataniaCataniaItaly

Neuro regeneration is a very complex phenomenon characterized by the generation of new neurons and synapses,involving connections between adjacent cells and axonal *** supplies additional longterm resources to replace... 详细信息

关键词： replace functional regeneration

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A UNIFORM CONVERGENT PETROV-GALERKIN METHOD FOR A CLASS OF TURNING POINT PROBLEMS

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Journal of Computational Mathematics 2024年第5期42卷 1356-1379页

作者： Li Feng Zhongyi Huang department of Mathematical sciences Tsinghua UniversityBeijing 100084China

In this paper,we propose a numerical method for turning point problems in one dimension based on Petrov-Galerkin finite element method(PGFEM).We first give a priori estimate for the turning point problem with a single boundary turning *** we use PGFEM to solve it,where test functions are the solutions to piecewise approximate dual *** prove that our method has a first-order convergence rate in both L∞h norm and a discrete energy norm when we select the exact solutions to dual problems as test *** results show that our scheme is efficient for turning point problems with different types of singularities,and the convergency coincides with our theoretical results.

关键词： Turning point problem Petrov-Galerkin finite element method Uniform convergency

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Scree conglomerate and its derivatives in the Upper Cretaceous Kallankurichchi Limestone,Ariyalur Group,Cauvery Basin,South India

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Journal of Palaeogeography 2024年第3期13卷 495-508页

作者： Shilpa Srimani department of Geological sciences Jadavpur UniversityKolkata700032India

The repetitive influx of coarse clastics of mixed composition,siliciclastics and carbonates,locally common in the lower part of the Upper Cretaceous marine Kallankurichchi Limestone specifies a resurgence of tectonic unrest in the Cauvery rift basin,*** basin-margin scree and its derivatives elicit diverse modes of emplacement and differ in many ways from denoting it only as basal *** study meticulously reveals the depositional history of these basin-margin coarse *** scree conglomerate bodies are wedge-shaped in appearance and often have flat,eroded *** places,their surfaces,tops and flanks,are encrusted with Inoceramus although internally,they are mostly *** are clast-supported and extremely poorly sorted,having interstitial spaces filled by sand-sized grains at the basal *** clasts can be traced into the underlying Sillakuddi Sandstone and the granitic *** clasts derived from the sandstone are angular and measure up to 60 cm in length,while the basement-derived clasts dominate the smaller(maximum diameter measured 5 cm)and more rounded *** elongated clasts are chaotically arranged,even oriented sub-vertically,reclining on other *** lowermost scree conglomerate has a sharp base,and the pebbles sunk into the underlying sandstone,although no discernible impact laminae wrapping their bottom were ever ***,the scree fans were initiated under the sea,which permitted the slow sinking of assorted rock fragments dropped from *** sporadic occurrence of marine fossils further corroborates this *** scree conglomerates at different stratigraphic levels transitioned laterally into conglomerates of mass flow origin and then to massive calcarenite,together forming wedge-shaped *** initial alignment of clasts parallel to bedding transforms to a chaotic alignment representing the transition from internally sheared flow to debris flow and associated ***

关键词： Scree conglomerate Kallankurichchi Limestone Tectonic subsidence Flow transformation Cauvery Basin

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GLOBAL SOLUTIONS IN THE CRITICAL SOBOLEV SPACE FOR THE LANDAU EQUATION

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Acta Mathematica Scientia 2024年第4期44卷 1347-1372页

作者： Hao WANG department of Mathematical sciences Tsinghua UniversityBeijing 100084China

The Landau equation is studied for hard potential with-2≤γ≤*** a perturbation setting,a unique global solution of the Cauchy problem to the Landau equation is established in a critical Sobolev space H_(x)^(d)L_(v)^(2)(d>3/2),which extends the results of[11]in the torus domain to the whole space R_(x)^(3).Here we utilize the pseudo-differential calculus to derive our desired result.

关键词： Landau equation nonlinear energy method global existence pseudo-differential calculus

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Tocotrienol isoforms:The molecular mechanisms underlying their effects in cancer therapy and their implementation in clinical trials

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Journal of Integrative Medicine 2024年第1期22卷 1-11页

作者： Maria Younes Ghady Loubnane Christopher Sleiman Sandra Rizk department of Natural sciences Lebanese American UniversityByblosLebanon

Tocotrienols are found in a variety of natural sources,like rice bran,annatto seeds and palm oil,and have been shown to have several health-promoting properties,particularly against chronic diseases such as *** incidence of cancer is rapidly increasing around the world,not only a result of continued aging and population growth,but also due to the adoption of aspects of the Western lifestyle,such as high-fat diets and low-physical *** literature provides strong evidence that tocotrienols are able to inhibit the growth of various cancers,including breast,lung,ovarian,prostate,liver,brain,colon,myeloma and pancreatic *** findings,along with the reported safety profile of tocotrienols in healthy human volunteers,encourage further research into these compounds’potential use in cancer prevention and *** current review provided detailed information about the molecular mechanisms of action of different tocotrienol isoforms in various cancer models and evaluated the potential therapeutic effects of different vitamin E analogues on important cancer hallmarks,such as cellular proliferation,apoptosis,angiogenesis and ***/PubMed and Scopus databases were used to identify recently published articles that investigated the anticancer effects of vitamin E derivatives in various types of cancer in vitro and in vivo along with clinical evidence of adjuvant chemopreventive *** an overview of pre-clinical studies,we describe several completed and ongoing clinical trials that are paving the way for the successful implementation of tocotrienols in cancer chemotherapy.

关键词： Vitamin E Tocotrienols Cancer Molecular mechanism Clinical trials

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Host-guest cocrystals boost thermally activated delayed fluorescence materials

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Science China Chemistry 2024年第10期67卷 3179-3180页

作者： Wenzhi Yang Jiong Zhou department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China

Organic light-emitting diodes(OLEDs)play an important role in organic display and lighting *** activated delayed fluorescence(TADF)materials have shown great potential in the OLED field because they can theoretically ... 详细信息

关键词： Host diodes delayed

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Tunable quantum anomalous Hall effects in ferromagnetic van der Waals heterostructures

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National Science Review 2024年第3期11卷 100-107页

作者： Feng Xue Yusheng Hou Zhe Wang Zhiming Xu Ke He Ruqian Wu Yong Xu Wenhui Duan Beijing Academy of Quantum Information sciences State Key Laboratory of Low Dimensional Quantum Physics Department of Physics Tsinghua University Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices Center for Neutron Science and Technology School of Physics Sun Yat-sen University State Key Laboratory of Surface Physics Key Laboratory of Computational Physical Sciences and Department of PhysicsFudan University frontier Science Center for Quantum Information department of Physics and Astronomy University of California-Irvine Tencent Quantum Laboratory Tencent Technology(Shenzhen)Co.Ltd RIKEN Center for Emergent Matter Science(CEMS) Institute for Advanced Study Tsinghua University

The quantum anomalous Hall effect（QAHE） has unique advantages in topotronic applications, but it is still challenging to realize the QAHE with tunable magnetic and topological properties for building functional devices. Through systematic first-principles calculations, we predict that the in-plane magnetization induced QAHE with Chern numbers C = ±1 and the out-of-plane magnetization induced QAHE with high Chern numbers C = ±3 can be realized in a single material candidate, which is composed of van der Waals（vdW）coupled Bi and MnBi2Te4monolayers. The switching between different phases of QAHE can be controlled in multiple ways, such as applying strain or（weak） magnetic field or twisting the vdW materials. The prediction of an experimentally available material system hosting robust, highly tunable QAHE will stimulate great research interest in the field. Our work opens a new avenue for the realization of tunable QAHE and provides a practical material platform for the development of topological electronics.

关键词： quantum anomalous Hall effect topological quantum phase transition van der Waals heterostructures tunable Chern number high Chern number

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The spectrum and stability of travelling pulses in a coupled FitzHugh-Nagumo equation

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Science China Mathematics 2024年第5期67卷 975-1010页

作者： Qi Qiao Xiang Zhang School of Mathematical sciences Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Scientific and Engineering Computing(Ministry of Education) and Shanghai Frontier Science Center of Modern Analysis(CMA-Shanghai)Shanghai Jiao Tong UniversityShanghai 200240China

For a coupled slow-fast FitzHugh-Nagumo(FHN)equation derived from a reaction-diffusionmechanics(RDM)model,Holzer et al.(2013)studied the existence and stability of the travelling pulse,which consists of two fast orbit arcs and two slow ones,where one fast segment passes the unique fold point with algebraic decreasing and two slow ones follow normally hyperbolic critical curve *** and Zhang(2021)obtained the existence of the travelling pulse,whose two fast orbit arcs both exponentially decrease,and one of the slow orbit arcs could be normally hyperbolic or not at the ***,we characterize both the nonlinear and spectral stability of this travelling pulse.

关键词： coupled FitzHugh-Nagumo equation singular perturbation travelling pulse spectrum nonlinear stability spectral stability

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