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Journal of Biosciences and Medicines 2019年第8期7卷 119-133页

作者： sanabria Kinski Annunziato Maria Antonieta Chacon Nicolas Inatti Alfredo department of nanotechnology of laboratories leti s.a.v. GuarenasVenezuela department of Research and Development Laboratories Biocontrolled C.A.GuarenasVenezuela

In this trial, a topical formulation of a 1% liposome TH cream was compared to a conventional TH formulation. Permeation was evaluated through a synthetic membrane. The study provided information on the rate of diffusion and percentage of drug release and also compared the penetration dynamics in the layers of the stratum corneum of both formulations. Liposome TH cream was able to deliver the active ingredient to a larger number of sC layers, with a higher amount of drug, which is very promising for the treatment of superficial mycoses.

关键词： Antifungal Franz Diffusion Cell Tape striping Method Liposome Terbinafine HCl Drug Carrier systems stratum Corneum

Acyclovir-Loaded solid Lipid Nanoparticles: A Permeation and Penetrability study

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Journal of Biosciences and Medicines 2024年第10期12卷 316-327页

作者： Anyoli Taly Adriana Camino Cirana Rodriguez Evelyn Pena Alfredo Inatti Xenon serrano department of R&D Nanotechnology Laboratory Industrias Biocontrolled Grupo Leti S.A.V. Guarenas Venezuela department of Clinical Research Industrias Biocontrolled Grupo Leti S.A.V. Guarenas Venezuela

Herpes simplex virus type I is a cutaneous infection treated with acyclovir. The topical treatment has therapeutic challenges due to the deficient delivery of the drug through epithelial barriers. This results in an inadequate drug-virus interaction in the basal epidermis (virus replication site). For this reason, it is essential to generate drug carrier systems that overcome these limitations. In this study, we evaluated the permeation (through in vitro test Franz cells) and penetration (by ex vivo test Tape stripping) of a topical formulation of acyclovir loaded in solid lipid nanoparticles and a conventional formulation (Aciclor®). The acyclovir solid lipid nanoparticles were prepared using hot homogenization and sonication methods. The results yielded a particle size of 85 ± 2 nm, a polydispersity index of 0.24 ± 0.01, a zeta potential of −16 ± 2 mv, and 94% ± 3% of encapsulated drug. The in vitro test revealed that the permeability of acyclovir solid lipid nanoparticles formulation was superior compared to reference formulation, with values of 1473.74 ± 30.14 µg/cm2 for the solid lipid nanoparticles and 893.36 ± 38.09 µg/cm2 for the reference formulation. The ex vivo test demonstrated that acyclovir solid lipid nanoparticles exhibited superior penetrability through the stratum corneum compared to the reference formulation, with total amounts of 3767 µg for the solid lipid nanoparticles and 2162 µg for the reference formulation. These findings seem promising in advancing new effective therapies against herpes generated by herpes simplex virus type I.

关键词： Herpes Acyclovir solid Lipid Nanoparticles Franz Cells Tape stripping

Betamethasone Dipropionate Loaded in Nanoliposomes vs Conventional Betamethasone Dipropionate: Comparative study of Permeability and Penetrability in vitro and ex vivo

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Journal of Biosciences and Medicines 2024年第10期12卷 140-156页

作者： Cirana Rodriguez Adriana Camino Anyoli Taly Evelyn Peña Alfredo Inatti Xenon serrano department of R&D Nanotechnology Laboratory Industrias Biocontrolled Grupo Leti S.A.V. Guarenas Venezuela

A betamethasone dipropionate (BD) liposomal cream was developed to treat rheumatological, inflammatory, allergic diseases and psoriasis. BD is a corticosteroid, anti-inflammatory, and immunosuppressant. However, adverse effects are associated with prolonged topical use. For this reason, liposomes were loaded with BD because they offer excellent biocompatibility, bio adhesiveness, and penetrability that improve the effects caused by the conventional drug. Liposomal dispersions were prepared by emulsification using phospholipid 90 (lipid) and Tween 80 (surfactant). The particle size, polydispersity index (PDI), and zeta potential were measured using a particle analyzer. The betamethasone (BM) percentage of encapsulated active (EA) ingredient was also determined through High Performance Liquid Chromatography (HPLC). The Franz cell and tape stripping characterized these in vitro and ex vivo. Then the final formulation reached a particle size of 70.80 ± 3.31 nm, a PDI of 0.242 ± 0.038, a zeta potential of −11.68 ± 0.77 mv and encapsulate active of 83.1% ± 2.4, complying with the parameters of a nanotechnological formulation. In vitro and ex vivo studies confirmed significantly efficacy of the cream over the commercial product, through the greater penetration into the pig ear skin, resulting in an improved drug. Finally, the liposomal cream demonstrated significant potential for enhanced percutaneous absorption, attributed to its nanometric size. This innovative nanotechnology approach aims to reduce the frequency of topical applications, thereby minimizing the side effects associated with psoriasis treatment.

关键词： nanotechnology Betamethasone Dipropionate Psoriasis Liposomes Drug Carrier systems

A Bioequivalence study of Empagliflozin/Metformin Fixed-Dose Combination in Healthy subjects under Fasting Conditions

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Journal of Biosciences and Medicines 2024年第9期12卷 235-250页

作者： Evelyn Pena Alfredo Inatti Anyoly Taly José Chacón Xenon serrano-Martin department of Clinical Research Industrias Biocontrolled C.A. Grupo Leti S.A.V. Guarenas Venezuela department of Research & Development Industrias Biocontrolled C.A. Grupo Leti S.A.V. Guarenas Venezuela department of Medical Megat Laboratories Quito Ecuador

Background: This study evaluated the bioequivalence of empagliflozin 12.5 mg/metformin 1000 mg tablets compared to synjardy® (Empagliflozin 12.5 mg/metformin 1000 mg) tablets in healthy male subjects under fasting conditions. Methods: This was a phase I, randomized, single-dose, two-period, two-sequence, crossover study to evaluate the bioequivalence (BE) profiles of two fixed-dose combinations (FDCs) of empagliflozin/metformin. Cmax, AUC0-t and AUC0-∞ from test and reference formulations were evaluated to access BE. The plasma concentrations were measured using a validated liquid chromatography-mass spectrometry (LC-Ms/Ms) method. Of the 24 subjects enrolled, 23 completed both periods of the study. The two formulations test and reference were considered bioequivalent if 90% confidence interval (CI) fell within 80.00% - 125.00% for Cmax, AUC0-t and AUC0-∞. Tolerability and safety were assessed throughout the study. Results: The pharmacokinetic (PK) parameters were similar between the test product (T) and reference product (R) synjardy®. The 90% CI of the test/reference ratios of log-transformed PK parameters point estimates was Cmax: 89.87% (85.68% - 94.27%), AUC0-t: 87.91% (83.65% - 92.39%) and AUC0-∞: 87.16% (82.80% - 91.75%) to empagliflozin and Cmax: 92.19% (87.95% - 96.65%), AUC0-t: 91.38% (84.42% - 98.91%) and AUC0-∞: 93.78% (83.82% - 104.93%) to metformin respectively (90% CI for all PK parameters fell within 80.00% - 125.00%). Conclusion: Our results demonstrated BE between the test and reference formulations of oral tablets of empagliflozin 12.5 mg/metformin 1000 mg (FDC) in healthy male subjects under fasting conditions.

关键词： Bioequivalence Fix Dose Combinations Pharmacokinetic Empagliflozin

Effective N-methyl-2-pyrrolidone wet cleaning for fabricating highperformance monolayer Mos2 transistors

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Nano Research 2019年第2期12卷 303-308页

作者： Po-Chun Chen Chih-Pin Lin Chuan-Jie Hong Chih-Hao Yang Yun-Yan Lin Ming-Yang Li Lain-Jong Li Tung-Yuan Yu Chun-Jung su Kai-shin Li Yuan-Liang Zhong Tuo-Hung Hou Yann-Wen Lan department of Physics "National Taiwan Normal University" Taipei 11677 Taiwan China department of Electronics Engineering and Institute of Electronics "National Chiao Tung University' Hsinchu 30010 Taiwan China department of Physics and Center for nanotechnology Chung Yuan Christian University Chungli 32023 Taiwan China Research Center for Applied sciences Academia Siriica: Taipei 11529 Taiwan China Physical sci. and Eng. King Abdullah University of Sci.and Technology Thuwal 23955 Kingdom of Saudi Arabia "National Nano Device laboratories:"National Applied Research laboratories" Hsinchu 30078 Taiwan China

Two-dimensional semiconductors,such as Mos2 are known to be highly susceptible to diverse molecular adsorbates on the surface during fabrication,which could adversely affect device *** ensure high device yield,uniformity and performance,the semiconductor industry has long employed wet chemical cleaning strategies to remove undesirable surface contaminations,adsorbates,and native oxides from the surface of si wafers.A similarly effective surface cleaning technique for two-dimensional materials has not yet been fully *** this study,we propose a wet chemical cleaning strategy for Mos2 by using *** cleaning process not only preserves the intrinsic properties of monolayer Mos2,but also significantly improves the performance of monolayer Mos2 *** device on current of 12 μA·μm-1 for a channel length of 400 nm,contact resistance of 15 kΩ·μm,field-effect mobility of 15.5 cm^2·v^-1·s^-1,and the average on-off current ratio of 10^8 were successfully demonstrated.

关键词： monolayer M0s2 devices standard wet cleaning field-effect transistors N-methyl-2-pyrrolidone

Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

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Bioactive Materials 2023年第11期29卷 151-176页

作者： Filipe v.Ferreira Alana G.souza Rubina Ajdary Lucas P.de souza Jo˜ao H.Lopes Daniel s.Correa Gilberto siqueira Hernane s.Barud Derval dos s.Rosa Luiz H.C.Mattoso Orlando J.Rojas nanotechnology National Laboratory for Agriculture(LNNA) Embrapa Instrumentation-Rua XV de Novembro1452S˜ao CarlosSP13560-979Brazil Center for Engineering Modelingand Applied Social Sciences(CECS)Federal University of ABC(UFABC)Santo Andr´eBrazil department of Bioproducts and Biosystems School of Chemical EngineeringAalto UniversityP.O.Box 16300AaltoEspooFIN-00076Finland College of Engineering and Physical sciences Aston Institute of Materials ResearchAston UniversityBirminghamUK department of Chemistry Division of Fundamental Sciences(IEF)Technological Institute of Aeronautics(ITA)S˜ao Jose dos CamposSPBrazil Laboratory for Cellulose&Wood Materials Empa-Swiss Federal Laboratories for Materials Science and TechnologyÜberlandstrasse 1298600DübendorfSwitzerland Biopolymers and Biomaterials Laboratory(BIOPOLMAT) University of Araraquara(UNIARA)Araraquar114801-340S˜ao PauloBrazil Bioproducts Institute Department of Chemical&Biological EngineeringDepartment of Chemistry andDepartment of Wood ScienceThe University of British Columbi12360 East MallVancouverBCV6T 1Z3Canada

We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure-property-function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

关键词： Cellulose nanofibrils Cellulose nanocrystals Regenerative medicine Biomaterial sustainable materials Green nanomaterials

Antioxidant,antimicrobial,and α-glucosidase inhibitory activities of saponin extracts from walnut(Juglans regia L.) leaves

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Asian Pacific Journal of Tropical Biomedicine 2023年第2期13卷 60-69页

作者： Youssef Elouafy Adil El Yadini salma Mortada Mohamed Hnini Hicham Harhar Asaad Khalid Ashraf NAbdalla Abdelhakim Bouyahya Khang Wen Goh Long Chiau Ming My El Abbes Faouzi Mohamed Tabyaoui Laboratory of Materials Nanotechnology and EnvironmentFaculty of SciencesMohammed V University in RabatRabatMorocco laboratories of Pharmacology and Toxicology Pharmaceutical and Toxicological Analysis Research TeamFaculty of Medicine and PharmacyMohammed V University in RabatRabatMorocco Center of Plant and Microbial Biotechnology Biodiversity and EnvironmentMicrobiology and Molecular Biology TeamFaculty of SciencesMohammed V University in RabatRabatMorocco substance Abuse and Toxicology Research Center Jazan UniversityJazan 45142Saudi Arabia Medicinal and Aromatic Plants and Traditional Medicine Research Institute National Center for ResearchKhartoumSudan department of Pharmacology and Toxicology College of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Laboratory of Human Pathologies Biology Faculty of SciencesMohammed V University in RabatMorocco Faculty of Data science and Information Technology INTI International UniversityNilaiMalaysia school of Medical and Life sciences Sunway UniversitySunway CityMalaysia

Objective:To investigate the relationship between triterpenoid saponin content and antioxidant,antimicrobial,and α-glucosidase inhibitory activities of 70%ethanolic,butanolic,aqueous,supernate and precipitate extracts of Juglans regia ***:Triterpenoid saponins of different Juglans regia leaf extracts were measured by the vanillin *** activity was evaluated against DPPH and ABTs free *** also assessed α-glucosidase inhibitory and antimicrobial activities of the leaf ***’s correlation coefficient was evaluated to determine the correlation between the saponin content and biological ***:The butanolic extract was most effective against DPPH with an IC50of 6.63μg/mL,while the aqueous extract showed the highest scavenging activity against ABTs free radical with an IC50of 42.27μg/***’s correlation analysis indicated a strong negative correlation (r=-0.956) between DPPH radical scavenging activity (IC50) and the saponin content in the samples *** addition,the aqueous extract showed the best α-glucosidase inhibitory activity compared with other *** the extracts had fair antibacterial activity against Bacillus subtilis,Escherichia coli,and Klebsiella pneumoniae except for the aqueous ***:Juglans regia extracts show potent antioxidant,antimicrobial,and α-glucosidase inhibitory *** is a correlation between saponin levels in Juglans regia leaf extracts and the studied ***,additional research is required to establish these relationships by identifying the specific saponin molecules responsible for these activities and elucidating their mechanisms of action.

关键词： Juglans regia leaves Triterpenoid saponin Antioxidant activity DPPH ABTs Antidiabetic activity α-Glucosidase Antimicrobial activity

synthesis and characterization of ZnO–CuO nanocomposites powder by modified perfume spray pyrolysis method and its antimicrobial investigation

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Journal of semiconductors 2018年第3期39卷 1-7页

作者： D.saravanakkumar s.sivaranjani K.Kaviyarasu A.Ayeshamariam B.Ravikumar s.Pandiarajan C.veeralakshmi M.Jayachandran M.Maaza Research and Development Center Bharathiyar UniversityCoimbatore641046India department of Physics SBM College of Engineering&TechnologyDindigul624001India UNEsCO-UNIsA Africa Chair in Nanoscience's/nanotechnology laboratories College of Graduate StudiesUniversity of South Africa(UNISA)Muckleneuk RidgePretoriaSouth Africa Nanosciences African network(NANOAFNET) Materials Research Group(MRG)iThemba LABS-National Research Foundation(NRF)Somerset WestWestern Cape ProvinceSouth Africa department of Physics Khadir Mohideen CollegeAdirampattinam614701India department of Physics Devanga Arts CollegeAruppukkottai626101India department of Physics Sethu Institute of TechnologyPullorKariapatti626115India

Pure ZnO, ZnO–CuO nanocomposites can be synthesized by using a modified perfume spray pyrolysis method（MsP）. The crystallite size of the nanoparticles（NPs） has been observed by X-ray diffraction pattern and is nearly 36 nm. Morphological studies have been analyzed by using Field Emission scanning Electron Microscopy（FEsEM） and its elemental analysis was reported by Elemental X-ray Analysis（EDX）; these studies confirmed that ZnO and CuO have hexagonal structure and monoclinic structure respectively. Fourier Transform Infrared（FTIR） spectra revealed that the presence of functional frequencies of ZnO and CuO were observed at 443 and 616 *** average bandgap value at 3.25 e v using Uv–vis spectra for the entitled composite has described a blue shift that has been observed here. The antibacterial study against both gram positive and negative bacteria has been studied by the disc diffusion method. To the best of our knowledge, it is the first report on ZnO–CuO nanocomposite synthesized by a modified perfume spray pyrolysis method.

关键词： MsP method XRD FTIR FEsEM CuO nanoparticles

Nonlinear frequency conversion in optical nanoantennas and metasurfaces:materials evolution and fabrication

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Opto-Electronic Advances 2018年第10期1卷 1-12页

作者： Mohsen Rahmani Giuseppe Leo Igal Brener Anatoly v. Zayats stefan A. Maier Costantino De Angelis Hoe Tan valerio Flavio Gili Fouad Karouta Rupert Oulton Kaushal vora Mykhaylo Lysevych Isabelle staude Lei Xu Andrey E. Miroshnichenko Chennupati Jagadish Dragomir N. Neshev Research school of Physics and Engineering The Australian National University Canberra ACT 2601 Australia Matériaux et Phénomènes Quantiques Université Paris Diderot-Sorbonne Paris Cité 10 rue A. Domon et L. Duquet 75013 Paris France Center for Integrated Nanotechnologies Sandia National Laboratories Albuquerque New Mexico 87185 United States department of Physics King’s College London Strand London WC2R 2LS United Kingdom The Blackett Laboratory Department of Physics Imperial College London London SW7 2AZ United Kingdom Chair in Hybrid Nanosystems Nano Institute Munich Fakultat für Physik Ludwig-Maximilians-Universitat München München Germany Deptartment of Information Engineering Universitàdegli Studi di Brescia and INO-CNR Via Branze 38 25123 Brescia Italy Institute of Applied Physics Abbe Center of Photonics Friedrich Schiller University Jena 07745 Jena Germany school of Engineering and Information Technology University of New South Wales Canberra ACT 2600 Australia

Nonlinear frequency conversion is one of the most fundamental processes in nonlinear *** has a wide range of applications in our daily lives,including novel light sources,sensing,and information *** is usually assumed that nonlinear frequency conversion requires large crystals that gradually accumulate a strong ***,the large size of nonlinear crystals is not compatible with the miniaturisation of modern photonic and optoelectronic ***,shrinking the nonlinear structures down to the nanoscale,while keeping favourable conversion efficiencies,is of great importance for future photonics *** the last decade,researchers have studied the strategies for enhancing the nonlinear efficiencies at the nanoscale,*** employing different nonlinear materials,resonant couplings and hybridization *** this paper,we provide a compact review of the nanomaterials-based efforts,ranging from metal to dielectric and semiconductor nanostructures,including their relevant nanofabrication techniques.

关键词： nonlinear nanophotonics metallic nanoantennas dielectric nanoantennas III-v semiconductor nanoantenna nanofabrication

Pharmacokinetics and Bioequivalence Comparison of Two Fixed-Dose Combination of Rosuvastatin/Ezetimibe Formulations: A Randomized, Crossover, Open-Label study in Healthy volunteers

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Journal of Biosciences and Medicines 2024年第10期12卷 119-139页

作者： José Gregorio Chacón Evelyn Peña Alfredo Inatti department of Clinical Research Industrias Biocontrolled C.A. Caracas Venezuela

Objective: To evaluate the bioequivalence (BE) of two fixed-dose combination (FDC) formulations of Rosuvastatin and Ezetimibe: Cresadex® EZE 20/10 mg (Abbott laboratories) as the reference formulation (R), and Racor® Duo 20/10 mg (Laboratorios leti, s.a.v.) as the test formulation (T). Method: A randomized, single-dose, two-period, two-sequence, open-label, crossover design was employed. subjects received a single oral dose of either the Test or Reference formulation under fasting conditions, with a 12-day washout period between treatments. Male subjects aged 18 - 45 years with normal health and laboratory values were included. Exclusion criteria encompassed any medical conditions, recent surgery, drug or alcohol use, and hypersensitivity to the study drugs. Blood samples were collected at pre-dose and multiple post-dose time points and analyzed using a validated LC-Ms/Ms method to quantify Rosuvastatin and Ezetimibe concentrations in plasma. Descriptive statistics were used to summarize pharmacokinetic (PK) parameters. ANOvA was conducted to compare the ln-transformed values of Cmax, AUC0−t, and AUC0−∞. schuirmann’s two one-sided t-tests were applied to assess bioequivalence (BE). Results: The 90% Confidence Intervals for the ln-transformed ratios of Cmax, AUC0−t, and AUC0−∞ fell within the acceptance range of 80% to 125%, demonstrating bioequivalence between the Test and Reference formulations. Both formulations were well-tolerated, with no serious.a.v.rse events reported. Conclusions: The results of this study confirm the bioequivalence of the two tested FDC Rosuvastatin/Ezetimibe formulations: Cresadex® EZE (Abbott laboratories) and Racor® Duo (Laboratorios leti, s.a.v.). These findings endorse the therapeutic interchangeability of these products, providing clinicians with greater flexibility in the treatment of hyperlipidemia.

关键词： Bioequivalence Pharmacokinetics Rosuvastatin Ezetimibe FDC