检索结果-南通市图书馆

Genes & Diseases 2024年第3期11卷 484-484页

作者： De-Ping Wang Fang-Ying Jiang Xian-Yan Zeng Yu-Jie Liu Rong Zhao Mei-Yue Wang Jing Luo Chen Chen Yong Zhu Ji-Min Cao Key Laboratory of Cellular physiology at Shanxi Medical University Ministry of Educationand the Department of PhysiologyShanxi Medical UniversityTaiyuanShanxi 030001China College of Life Sciences Chongqing Medical UniversityChongqing 400016China department of Biochemistry and molecular Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin300070China department of Rheumatology The Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China

We're very sorry for missing a funding program in funding ***,we would like to add this program:The Natural Science Foundation of Tianjin(China)(No.21JCQNJCO1890)from Tianjin Science and Technology in the first *** au... 详细信息

关键词： section. Tianjin funding

Towards Characterization of the Chloroplast NAD（P）H Dehydrogenase Complex

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

molecular Plant 2009年第6期2卷 1127-1140页

作者： Marjaana Suorsa Sari Sirpio Eva-Mari Aro department of Biology Plant Physiology and Molecular Biology University of Turku FI-20014 Turku Finland

The NAD（P）H dehydrogenase （NDH） complex in chloroplast thylakoid membranes functions in cyclic electron transfer, and in chlororespiration. NDH is composed of at least 15 subunits, including both chloroplast- and nuclear-encoded proteins. During the past few years, extensive proteomic and genetic research on the higher plant NDH complex has been carried out, resulting in identification of several novel nuclear-encoded subunits. In addition, a number of auxiliary proteins, which mainly regulate the expression of chloroplast-encoded ndh genes as well as the assembly and stabilization of the NDH complex, have been discovered and characterized. In the absence of detailed crystallographic data, the structure of the NDH complex has remained obscure, and therefore the role of several NDH-associated nuclear-encoded proteins either as auxiliary proteins or structural subunits remains uncertain. In this review, we summarize the current knowledge on the subunit composition and assembly process of the chloroplast NDH complex. In addition, a novel oligomeric structure of NDH, the PSI/NDH supercomplex, is discussed.

关键词： Arabidopsis maize tobacco NAD(P)H dehydrogenese chloroplast thylakoid membrane cyclic electron transfer photosystem I.

Genomic characterization of peritoneal lavage cytology-positive gastric cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2024年第1期36卷 66-77页

作者： Zhouqiao Wu Tingfei Gu Changxian Xiong Jinyao Shi Jingpu Wang Ting Guo Xiaofang Xing Fei Pang Ning He Rulin Miao Fei Shan Yuan Zhou Ziyu Li Jiafu Ji Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Gastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China department of Biomedical Informatics Department of Physiology and PathophysiologyCenter for Noncoding RNA MedicineMOE Key Lab of Cardiovascular SciencesSchool of Basic Medical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchGastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: Positive peritoneal lavege cytology(CY1) gastric cancer is featured by dismal prognosis, with high risks of peritoneal metastasis. However, there is a lack of evidence on pathogenic mechanism and signature of CY1and there is a continuous debate on CY1 therapy. Therefore, exploring the mechanism of CY1 is crucial for treatment strategies and targets for CY1 gastric ***: In order to figure out specific driver genes and marker genes of CY1 gastric cancer, and ultimately offer clues for potential marker and risk assessment of CY1, 17 cytology-positive gastric cancer patients and 31matched cytology-negative gastric cancer patients were enrolled in this study. The enrollment criteria were based on the results of diagnostic laparoscopy staging and cytology inspection of exfoliated cells. Whole exome sequencing was then performed on tumor samples to evaluate genomic characterization of cytology-positive gastric ***: Least absolute shrinkage and selection operator(LASSO) algorithm identified 43 cytology-positive marker genes, while Mut Sig CV identified 42 cytology-positive specific driver genes. CD3G and CDKL2 were both driver and marker genes of CY1. Regarding mutational signatures, driver gene mutation and tumor subclone architecture, no significant differences were observed between CY1 and negative peritoneal lavege cytology(CY0).Conclusions: There might not be distinct differences between CY1 and CY0, and CY1 might represent the progression of CY0 gastric cancer rather than constituting an independent subtype. This genomic analysis will thus provide key molecular insights into CY1, which may have a direct effect on treatment recommendations for CY1and CY0 patients, and provides opportunities for genome-guided clinical trials and drug development.

关键词： Cytology gastric carcinoma peritoneal metastasis whole exome sequencing

Role of neuronal gap junctions in NMDA receptor-mediated excitotoxicity and ischemic neuronal death

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第1期11卷 75-76页

作者： Andrei B.Belousov Joseph D.Fontes department of molecular and Integrative physiology University of Kansas Medical Center department of Biochemistry and molecular Biology University of Kansas Medical Center

In the mammalian central nervous system（CNS）coupling of neurons by gap junctions and the expression of neuronal gap junction protein,connexin 36（Cx36）rapidly increases（usually during 1–2 hours）following a wide range of neuronal injuries,including ischemia,traumatic brain injury（TBI）,spinal cord injury and epilepsy（reviewed in Belousov and Fontes,2013）.Pharmacological blockade or genetic elimi-nation of Cx36-containing gap junctions dramatically re- duce neuronal death in animal models of ischemia, TBI and epilepsy and prevent NMDA receptor （NMDAR）-mediated excitotoxicity （Belousov and Fontes, 2014）.

关键词： neuronal epilepsy junction connexin traumatic NMDA injuries cortical mammalian minutes

Ischemia-reperfusion injury:molecular mechanisms and therapeutic targets

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第2期9卷 558-596页

作者： Meng Zhang Qian Liu Hui Meng Hongxia Duan Xin Liu Jian Wu Fei Gao Shijun Wang Rubin Tan Jinxiang Yuan The Collaborative Innovation Center Jining Medical UniversityJiningShandong 272067China Clinical Medical College Jining Medical UniversityJiningShandong 272067China Second Clinical Medical College Jining Medical UniversityJiningShandong 272067China Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital and Institutes of Biomedical SciencesFudan UniversityShanghaiChina Institute of Zoology Chinese Academy of SciencesBeijingChina department of physiology Basic medical schoolXuzhou Medical UniversityXuzhou 221004China

Ischemia-reperfusion(I/R)injury paradoxically occurs during reperfusion following ischemia,exacerbating the initial tissue *** limited understanding of the intricate mechanisms underlying I/R injury hinders the development of effective therapeutic *** Wnt signaling pathway exhibits extensive crosstalk with various other pathways,forming a network system of signaling pathways involved in I/R *** review article elucidates the underlying mechanisms involved in Wnt signaling,as well as the complex interplay between Wnt and other pathways,including Notch,phosphatidylinositol 3-kinase/protein kinase B,transforming growth factor-β,nuclear factor kappa,bone morphogenetic protein,N-methyl-D-aspartic acid receptor-Ca2+-Activin A,Hippo-Yes-associated protein,toll-like receptor 4/toll-interleukine-1 receptor domain-containing adapter-inducing interferon-β,and hepatocyte growth factor/mesenchymal-epithelial transition *** particular,we delve into their respective contributions to key pathological processes,including apoptosis,the inflammatory response,oxidative stress,extracellular matrix remodeling,angiogenesis,cell hypertrophy,fibrosis,ferroptosis,neurogenesis,and blood-brain barrier damage during I/R *** comprehensive analysis of the mechanisms involved in Wnt signaling during I/R reveals that activation of the canonical Wnt pathway promotes organ recovery,while activation of the non-canonical Wnt pathways exacerbates ***,we explore novel therapeutic approaches based on these mechanistic findings,incorporating evidence from animal experiments,current standards,and clinical *** objective of this review is to provide deeper insights into the roles of Wnt and its crosstalk signaling pathways in I/R-mediated processes and organ dysfunction,to facilitate the development of innovative therapeutic agents for I/R injury.

关键词： therapeutic reperfusion damage

Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2010年第1期1卷 22-32页

作者： Jiyue Zhu Yuanjun Zhao Shuwen Wang department of Cellular and molecular physiology Pennsylvania State University College of MedicineHersheyPA 17033USA

Telomerase expression and telomere maintenance are critical for long-term cell proliferation and survival,and they play important roles in development,aging,and *** evidence has indicated that regulation of the rate-limiting subunit of human telomerase reverse transcriptase gene(hTERT)is a complex process in normal cells and many cancer *** addition to a number of transcriptional activators and repressors,the chromatin environment and epigenetic status of the endogenous hTERT locus are also pivotal for its regulation in normal human somatic cells and in tumorigenesis.

关键词： telomerase transcriptional regulation chromatin epigenetic regulation cancer

Dendrimer nanocarriers drug action: perspective for neuronal pharmacology

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第7期10卷 1029-1031页

作者： Felipe Vidal Leonardo Guzman Laboratory of molecular Neurobiology Department of PhysiologyFaculty of Biological Sciences University of Concepcion

General aspects：Currently,several strategies have been used to overcome common problems found in pharmacological therapies,such as insolubility,reduced bioavailability and low specificity of *** of the most promising alternatives proposed is the use of dendrimeric drug nanocarriers,polymeric chemical structures of diverse nature that contain,transport and deliver the desired drug in biological systems.

关键词： PAMAM perspective for neuronal pharmacology

DJ-1 as a deglycating enzyme:a unique function to explain a multifaceted protein?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第11期12卷 1797-1798页

作者： Federica De Lazzari Marco Bisaglia molecular physiology and Biophysics Unit Department of BiologyUniversity of PadovaPadovaItaly

The Parkinson＇s disease （PD）-associated protein DJ-1 is considered a multifunctional protein involved in oxidative stress responses. Although a large variety of functions has been attributed to DJ- 1, currently no consensus has been found on its effective cellular activity. Indeed, the protein has been described as a transcriptional modulator, a regulator of mitochondrial activity, a stabilizer of the nuclear factor erythroid 2-related factor （Nrf2）, a chaperone, a pro- tease, and a glutathione （GSH）-independent glyoxalase （Ariga et al., 2013）. Very recently, the additional participation of the protein to carbonvl stress defense has been emereing （Richarme et al., 2015）.

关键词： DJ-1 as a deglycating enzyme multifaceted protein

Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第8期12卷 1262-1267页

作者： Rebecca M.Heidker Mitchell R.Emerson Steven M.Le Vine department of molecular and Integrative physiology University of Kansas Medical Center department of Pharmaceutical Sciences College of Pharmacy-Glendale Midwestern University

Unlike relapsing remitting multiple sclerosis, there are very few therapeutic options for patients with progressive forms of multiple sclerosis. While immune mechanisms are key participants in the pathogenesis of relapsing remitting multiple sclerosis, the mechanisms underlying the development of progressive multiple sclerosis are less well understood. Putative mechanisms behind progressive multiple sclerosis have been put forth： insufficient energy production via mitochondrial dysfunction, activated microglia, iron accumulation, oxidative stress, activated astrocytes, Wallerian degeneration, apoptosis, etc. Furthermore, repair processes such as remyelination are incomplete. Experimental therapies that strive to improve metabolism within neurons and glia, e.g., oligodendrocytes, could act to counter inadequate energy supplies and/or support remyelination. Most experimental approaches have been examined as standalone interventions; however, it is apparent that the biochemical steps being targeted are part of larger pathways, which are further intertwined with other metabolic pathways. Thus, the potential benefits of a tested intervention, or of an established therapy, e.g., ocrelizumab, could be undermined by constraints on upstream and/or downstream steps. If correct, then this argues for a more comprehensive, multifaceted approach to therapy. Here we review experimental approaches to support neuronal and glial metabolism, and/or promote remyelination, which may have potential to lessen or delay progressive multiple sclerosis.

关键词： acetyl-coenzyme A carboxylase biotin estrogen iron Kynurenine pathway mitochondria thyroidhormone remyelination stem cells vitamin D

pathology-induced NG2 proteoglycan expression in microglia

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第4期18卷 801-802页

作者： Erika Meyer Anja Scheller molecular physiology Center for Integrative Physiology and Molecular MedicineUniversity of SaarlandHomburgGermany(Meyer EScheller A)Laboratory of Brain Ischemia and NeuroprotectionDepartment of Pharmacology and TherapeuticsState University of MaringáMaringáBrazil

Oligodendrocyte precursor cells(OPCs)and microglia are two very fascinating cell types with a multitude of important but different *** a first glance,they appear not to share many cellular properties,nor are directly related to one another or derived from a common *** all differences,emerging data show that both cell types express the protein nerve/glial antigen 2(NG2)after pathological insults(Figure 1).For years,it remained controversial whether microglia really could express NG2 upon injury,with contradictory results reported among different disease *** this question,we could recently show by using triple transgenic knock-in mice and either an acute injury model(stab wound injury)or the middle cerebral artery occlusion combined with immunohistochemistry that a subset of microglia activates the cspg4 gene in a disease dependent manner leading to a bonafide microglia-specific NG2 protein expression besides OPCs and *** data show that the cspg4 gene not only gets transcribed in microglia based on reporter expression after recombination,but also the protein itself is expressed(Huang et al.,2020).

关键词： NG2 wound Figure