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可编织、可穿戴的宽带聚合物超声换能器

Science China Materials 2024年第8期67卷 2653-2660页

作者：邹君逸郭星奕吴家琦徐冬梅许凯亮陈培宁他得安彭慧胜 State Key Laboratory of molecular Engineering of Polymers department of Macromolecular Science Institute of Fiber Materials and DevicesLaboratory of Advanced MaterialsFudan UniversityShanghai 200438China department of Biomedical Engineering Yiwu Research Institute and Shanghai Poda Medical Technology Co.Ltd.Fudan UniversityShanghai 200438China

新兴的物联网技术推动了可穿戴健康监测设备的快速发展.目前,医学超声技术在严重慢性疾病的长时间监测方面具有广阔的应用前景.然而,商用超声探头一般都是刚性的,需要手持,难以满足医疗可穿戴设备对柔性化、小型化和舒适性的要求.本文... 详细信息

新兴的物联网技术推动了可穿戴健康监测设备的快速发展.目前,医学超声技术在严重慢性疾病的长时间监测方面具有广阔的应用前景.然而,商用超声探头一般都是刚性的,需要手持,难以满足医疗可穿戴设备对柔性化、小型化和舒适性的要求.本文提出了一种可编织、可穿戴的聚合物超声换能器,该换能器由匹配层、背衬层和压电层组成.聚合物压电材料的带宽(93%)是压电陶瓷的7倍,并且可以承受超过10,000次的弯曲和扭曲变形.该传感器能监测颈动脉血液流速,心脏血液流速和心脏血管的血管厚度,并具有与商用探头相当的信噪比.它的宽带特性(3.68–10.08 MHz)使其能通过调整频率来监测不同的组织.可编织超声换能器可以制成纤维形式,并编织成透气织物,在不牺牲穿戴舒适性的情况下进行实时血管监测.

关键词：血液流速超声换能器可穿戴设备超声探头扭曲变形匹配层慢性疾病压电材料

Hydroxysafflor Yellow A Attenuate LipopolysaccharideInduced Endothelium Inflammatory Injury

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Chinese Journal of Integrative Medicine 2016年第1期22卷 36-41页

作者：金鸣孙春燕臧宝霞 department of Pharmacology Beijing Institute of Heart Lung and Blood Vessel DiseasesBeijing Anzhen HospitalCapital Medical University

Objective： This study observed attenuating effect of hydroxysafflor yellow A （HSYA）, an effective ingredient of aqueous extract of Carthamus tinctorius L, on lipopolysaccharide （LPS）-induced endothelium inflammatory injury. Methods： Eahy926 human endothelium cell （EC） line was used; thiazolyl blue tetrazolium bromide （MTT） test was assayed to observe the viability of EC; Luciferase reporter gene assay was applied to measure nuclear factor- κB （NF- κ B） p65 subunit nuclear binding activity in EC; Western blot technology was used to monitor mitogen activated protein kinase （MAPKs） and NF- κ B activation. Reverse transcription polymerase chain reaction （RT-PCR） method was applied to observe intercellular cell adhesion molecule-1 （ICAM-1） and E-selectin mRNA level; EC surface ICAM-1 expression was measured with flow cytometry and leukocyte adhesion to EC was assayed with Rose Bengal spectrophotometry technology. Results： HSYA protected EC viability against LPS-induced injury （P〈0.05）. LPS-induced NF- κ B p65 subunit DNA binding （P〈0.01） and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor α （I κ B α） phosphorylation was inhibited by HSYA. HSYA attenuated LPS triggered ICAM-1 and E-selectin mRNA levels elevation and phosphorylation of p38 MAPK or c-Jun N-terminal kinase MAPK. HSYA also inhibited LPS-induced cell surface ICAM-1 protein expression （P〈0.01） and leukocyte adhesion to EC （P〈0.05）. Conclusion： HSYA is effective to protect LPS-induced high expression of endothelium adhesive molecule and inflammatory signal transduction.

关键词： hydroxysafflor yellow A lipopolysaccharide endothelium cell inflammation adhesive molecule

Impact of Cerebrovascular disease Mortality on Life Expectancy in China

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Biomedical and Environmental Sciences 2014年第3期27卷 169-175页

作者： LI Guo Qi FAN Jie LIU Jing WANG Wei WANG Miao QI Yue XIE Wu Xiang LIU Jun ZHAO Fan LI Yan ZHAO Dong department of Epidemiology Beijing An Zhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel Diseases

Objective To evaluate the impact of cerebrovascular disease mortality on life expectancy （LE） in China in 2010 compared with 2005, and to identify the high-risk population （age, sex, and region） where cerebrovascular disease mortality has had a major impact on LE. Methods LE and cause-eliminated LE were calculated by using standard life tables which used adjusted mortality data from the Death Surveillance Data Sets in 2005 and 2010 from the National disease Surveillance System. Decomposition was used to quantitate the impact of cerebrovascular disease in different age groups. Results LE in China was 73.24 years in 2010, which was higher in women and urban residents compared with men and rural residents. The loss of LE caused by cerebrovascular disease mortality was 2.26 years, which was higher in men and rural residents compared with women and urban residents. More than 30% of the loss of LE were attributed to premature death from cerebrovascular disease in people aged 〈65 years. Compared with 2005, LE in 2010 increased by 0.92 years. The reduction of cerebrovascular disease mortality in urban residents contributed 0.45 years to the increase of LE, but the increase of cerebrovascular disease mortality caused a 0.12-year loss of LE in rural residents. Conclusion Cerebrovascular disease mortality had a major impact on LE in China, with a significant difference between urban and rural residents. LE is likely to be further increased by reducing cerebrovascular disease mortality, and special attention should be paid to reducing premature deaths in people aged 〈65 years.

关键词： Cerebrovascular disease Life expectancy Loss of Life

Protective Effect of Hydroxysafflor Yellow A on Inflammatory Injury in Chronic Obstructive Pulmonary disease Rats

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Chinese Journal of Integrative Medicine 2019年第10期25卷 750-756页

作者： JIN Ming XUE Chang-jiang WANG Yu DONG Fang PENG Yuan-yuan ZHANG Ya-dan ZANG Bao-xia TAN Li department of Pharmacology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases

Objective: To investigate the attenuating effect of Hydroxysafflor yellow A(HSYA) on inflammatory injury in chronic obstructive pulmonary disease(COPD). Methods: Rats were randomly assigned to 7 groups according to body weight including normal control group, HSYA blank group(76.8 mg/kg), COPD group, COPD+HSYA(30, 48, 76.8 mg/kg) groups and COPD+dexamethasone(2 mg/kg), 10 in each group. Passive cigarette smoke and intratracheal instil ation of lipopolysaccharides were used to establish a COPD model in rats. Hematoxylin and eosin staining of lung tissue sections was used, real-time polymerase chain reaction(PCR) was used to assay m RNA levels of some cytokines in lung tissues, the cytokines in bronchoalveolar lavage fluid(BALF) were measured by enzyme-linked immunosorbent assay(ELISA), Western blot analysis was used to determine phosphorylated p38 mitogen-activated protein kinase(MAPK) levels in lung tissues, and nuclear factor-κB(NF-κB) p65 protein levels in lung tissues were detected by immunohistochemistry. Results: lung alveolar septa destruction, alveolus fusion, inflammatory cel infiltration, and bronchiole exudation were observed. These pathological changes were al eviated in the COPD+HSYA group. The m RNA expression of inflammatory factors were significantly increased in lung tissues from COPD rats(all Plung tissues of COPD rats were significantly increased(al Plungs of COPD rats. HSYA could inhibit inflammatory cytokine expression, and increase phosphorylation of p38 MAPK and NF-κB p65 in the lungs of COPD rats. The protective mechanism of HSYA to inhibit COPD i

关键词： Hydroxysafflor yellow A chronic obstructive pulmonary disease inflammation p38 mitogenactivated protein kinase nuclear factor-κB

Platelet Distribution Width on Admission Predicts In-Stent Restenosis in Patients with Coronary Artery disease and Type 2 Diabetes Mellitus Treated with Percutaneous Coronary Intervention

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Chinese Medical Journal 2018年第7期131卷 757-763页

作者： Cheng-Ping Hu Yu Du Yong Zhu Chao Shi Zheng Qin Ying-Xin Zhao department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Disease Capital Medical University Beijing 100029 China

Background： It is known that there is a definite association between platelet distribution width （PDW） and poor prognosis in patients with coronary artery disease （CAD） and type 2 diabetes mellitus （T2DM）. However, there are no data available regarding the prognostic significance of PDW for in-stent restenosis （ISR） in patients with CAD and T2DM. We aimed to determine the value of PDW on admission that predicted ISR in patients with CAD and T2DM. Methods： Between January 2012 and December 2013, a total of 5232 consecutive patients diagnosed with CAD and T2DM undergoing percutaneous coronary intervention were admitted. Three years of retrospective tbllow-up was undertaken. A total of 438 patients with second angiography operations were included. ISR was defined as ≥50% luminal stenosis of the stent or peri-stent segments. Continuous data were presented as the mean ± standard deviation or median （P25, P75） and were compared by one-way analysis of variance or Kruskal-Wallis H-test. Categorical variables were presented as percentages and were compared by Chi-square test or Fisher＇s exact test. The association between PDW and ISR was calculated by logistic regression analysis. A two-sided value of P 〈 0.05 was considered statistically significant. Statistical analyses were pertbrmed by SPSS version 22.0 for windows. Results： Fifty-nine patients with ISR, accounting for 13.5% of the total, were included. ISR was significantly more frequent in patients with higher PDW quartiles compared with lower quartiles. We observed that PDW had a strong relationship with mean platelet volume （r=0.6474 95% confidence interval [CI]： 0.535-0.750, P 〈 0.0001 ）. The receiver-operating characteristic curves showed that the PDW cutoffvalue for predicting ISR rate was 13.65 fl with sensitivity of 59.3% and specificity of 72.4% （area under curve [AUC] = 0.701,95% CI： 0.625-0.777, P 〈 0.001 ）. Multivariate analysis showed that the risk of ISR increased approximately 30% when PDW increased one u

关键词： blood Platelet Coronary Restenosis Mean Platelet Volume Percutaneous Coronary Intervention

Protective Effect of Hydroxysafflor Yellow A on Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Rats

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Chinese Journal of Integrative Medicine 2018年第1期24卷 32-39页

作者： JIN Ming WANG Lin WU Yan ZANG Bao-xia TAN Li department of Pharmacology Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing Anzhen HospitalCapital Medical University

Objective： To observe the effect of hydroxysafflor yellow A （HSYA）, an active ingredient of a traditional Chinese herbal medicine Carthamus tinctorius L., on lung inflammation and pulmonary fibrosis induced by bleomycin （BLM） in rats. Methods： Animals were divided into 6 groups including normal group, model group, three HSYA groups and dexamethasone （DXM） group. Three doses of HSYA （35.6, 53.3, and 80.0 mg？kg–1？day–1） were intraperitoneally （i.p.） injected in rats for 3 weeks after BLM administration and DXM was used as the positive control （n=8 or 12）. Arterial blood gas was assayed and morphological changes were observed. lung mRNA expressions of tumor necrosis factor （TNF）-α, interleukin （IL）-1β, IL-6 and some cytokines in lung tissue were detected by real-time polymerase chain reaction. Nuclear factor-κB p65 or α-smooth muscle actin （α-SMA） protein distribution in rat lung tissue was observed by immunohistochemistry. Results： On the 7th day after BLM administration, lung tissue showed serious inflammation. Treatment with HSYA or DXM ameliorated lung inflammation. After treatment with HSYA or DXM, oxygen partial pressure （PaO2） increased （HSYA 80.0 mg？kg–1, P〈0.01） and CO2 partial pressure （PaCO2） decreased （HSYA 53.3, 80.0 mg？kg–1, P〈0.05）. Moreover, the mRNA expression of TNF-α, IL-1β, and IL-6; and the number of NF-κB p65 positive cells was lower in HSYA 53.3 and 80.0 mg？kg–1 groups than those in the model group （all P〈0.05）. Twenty-one days after BLM administration, HSYA or DXM treatment ameliorated fibrosis, increased PaO2 （HSYA 53.3, 80.0 mg？kg–1, P〈0.01）, and decreased PaCO2 （53.3 and 80.0 mg？kg–1, P〈0.05）. Further, the mRNA expression of TGF-β1, α-SMA, and collagen Ⅰ as well as the number of α-SMA positive cells increased in the model group and HSYA can attenuate these changes （53.3, 80.0 mg？kg–1, P〈0.05）. Hematoxylin and eosin and Masson＇s trichrome staining indicated that the fibrosis and collagen deposition were ameliorated in HSYA groups （53.3, 80.0 m

关键词： hydroxysafflor yellow A pulmonary fibrosis pulmonary inflammation nuclear factor- K B p65,α-smooth muscle actin Chinese medicine

Impact of Cardiovascular disease Deaths on Life Expectancy in Chinese Population

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Biomedical and Environmental Sciences 2014年第3期27卷 162-168页

作者： FAN Jie LI Guo Qi LIU Jing WANG Wei WANG Miao QI Yue XIE Wu Xiang LIU Jun ZHAO Fan LI Yan ZHAO Dong department of Epidemiology Beijing An Zhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel Diseases

Objective We aimed to analyze the impact of cardiovascular disease （CVD） deaths on life expectancy （LE） in Chinese population and estimate the percentage reduction in CVD mortality needed to increase LE by 1 year from the current level, a national target of health improvement. Methods We used life tables, cause-elimination life tables, and age decomposition of LE with corrected mortality data from the National disease Surveillance System in 2010. Results LE at birth of Chinese people was 73.24 years in 2010. Women had a longer LE than men, and urban population had a longer LE than rural population. CVD deaths resulted in a 4.79-year LE loss and premature deaths in people aged 25 to 64 years were responsible for a substantial part of LE loss from CVD. Death from ischemic heart disease and cerebrovascular diseases accounted for 69.2% of LE loss from CVD deaths and death from cerebrovascular diseases was the largest contributor. In rural men, 51.1% LE loss from CVD deaths was caused by cerebrovascular diseases. If there were no changes in mortality rates for all other diseases, a 27.4% reduction in CVD mortality would increase LE by i year in Chinese population. Conclusion There is a considerable impact of CVD deaths on LE. A 1-year LE increase in the future requires at least a 27.4% reduction in CVD mortality from the current level. Targeting the rural population and tackling cerebrovascular diseases are important for reaching the national goal of health improvement.

关键词： Life expectancy Cardiovascular disease Age decomposition of life expectancy

Serine-threonine protein kinase activation may be an effective target for reducing neuronal apoptosis after spinal cord injury

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Neural Regeneration Research 2015年第11期10卷 1830-1835页

作者： Mu Jin Yan-wei Yang Wei-ping Cheng Jia-kai Lu Si-yu Hou Xiu-hua Dong Shi-yao Liu department of Anesthesiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases

The signaling mechanisms underlying ischemia-induced nerve cell apoptosis are poorly understood. We investigated the effects of apoptosis-related signal transduction pathways following ischemic spinal cord injury, including extracellular signal-regulated kinase（ERK）, serine-threonine protein kinase（Akt） and c-Jun N-terminal kinase（JNK） signaling pathways. We established a rat model of acute spinal cord injury by inserting a catheter balloon in the left subclavian artery for 25 minutes. Rat models exhibited notable hindlimb dysfunction. Apoptotic cells were abundant in the anterior horn and central canal of the spinal cord. The number of apoptotic neurons was highest 48 hours post injury. The expression of phosphorylated Akt（pAkt） and phosphorylated ERK（p-ERK） increased immediately after reperfusion, peaked at 4 hours（p-Akt） or 2 hours（p-ERK）, decreased at 12 hours, and then increased at 24 hours. Phosphorylated JNK expression reduced after reperfusion, increased at 12 hours to near normal levels, and then showed a downward trend at 24 hours. Pearson linear correlation analysis also demonstrated that the number of apoptotic cells negatively correlated with p-Akt expression. These findings suggest that activation of Akt may be a key contributing factor in the delay of neuronal apoptosis after spinal cord ischemia, particularly at the stage of reperfusion, and thus may be a target for neuronal protection and reduction of neuronal apoptosis after spinal cord injury.

关键词： nerve regeneration ischemic spinal cord injury cell apoptosis neurological function serine-threonine protein kinase extracellular signal-regulated kinase c-Jun N-terminal kinase neural regeneration

Geographic Variation in Cardiovascular Health as Analyzed from the China Cardiovascular Health Index Study——31 PLADs,China,2017-2021

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China CDC weekly 2022年第13期4卷 265-270页

作者： Fan Mao Yingying Jiang Jing Liu Yan Zhang Yong Jiang Linhong Wang Dong Zhao Yong Huo Junbo Ge Maigeng Zhou National Center for Chronic and Non-communicable disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Beijing institute of heart Lung&Blood Vessel DiseasesBeijing Anzhen HospitalCapital Medical UniversityBeijingChina department of Cardiology Peking University First HospitalBeijingChina Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Shanghai institute of Cardiovascular diseases Zhongshan HospitalFudan UniversityShanghaiChina

Summary What is already known about this topic?The prevalence of cardiovascular disease(CVD)in China is high,while effective prevention and proper management is *** available indicators were found before 2016 that cou... 详细信息

关键词： prevention cardiovascular Cardiovascular