检索结果-南通市图书馆

Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui Niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu department of Orthopedic surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

维普期刊数据库

Evaluation of three lymph node staging systems for prognostic prediction in gastric cancer:A systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第3期17卷 334-348页

作者： Ming Cheng Yang Yu Takehiro Watanabe Yutaro Yoshimoto Sanae Kaji Yukinori Yube Munehisa Kaneda Hajime Orita Shinji Mine You-Yong Wu Tetsu Fukunaga department of Upper Gastroenterological surgery Juntendo University School of MedicineTokyo 113-8431Japan department of Gastrointestinal surgery The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina department of Gastrointestinal surgery Peking University Cancer HospitalBeijing 100142China

BACKGROUND Lymph node status is a critical prognostic factor in gastric cancer(GC),but stage migration may occur in pathological lymph nodes(pN)*** address this,alternative staging systems such as the positive lymph node ratio(LNR)and log odds of positive lymph nodes(LODDS)were *** To assess the prognostic accuracy and stratification efficacy of three nodal staging systems in *** A systematic review identified 12 studies,from which hazard ratios(HRs)for overall survival(OS)were *** analyses,subgroup analyses,publication bias assessments,and quality evaluations were *** enhance comparability,data from studies with identical cutoff values for pN,LNR,and LODDS were *** stratification was then applied to generate Kaplan-Meier(KM)survival curves,assessing the stratification efficacy of three staging *** The HRs and 95%confidence intervals for pN,LNR,and LODDS were 2.16(1.72-2.73),2.05(1.65-2.55),and 3.15(2.15-4.37),respectively,confirming all three as independent prognostic risk factors for *** analysis of HRs demonstrated that LODDS had superior prognostic predictive power over LNR and *** curves for pN(N0,N1,N2,N3a,N3b),LNR(0.1/0.2/0.5),and LODDS(-1.5/-1.0/-0.5/0)revealed significant differences(P<0.001)among all prognostic *** differences and standard deviations in 60-month relative survival were 27.93%±0.29%,41.70%±0.30%,and 26.60%±0.28%for pN,LNR,and LODDS,*** All three staging systems are independent prognostic factors for *** demonstrated the highest specificity,making it especially useful for predicting outcomes,while pN was the most effective in homogeneous stratification,offering better patient *** findings highlight the complementary roles of LODDS and pN in enhancing prognostic accuracy and stratification.

关键词： Gastric cancer Prognostic predictor Overall survival Meta-analysis Pathological lymph nodes Positive lymph node ratio Log odds of positive lymph nodes

Multiple liver metastases of unknown origin:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 233-238页

作者： Ying-Jin Wang Ze-Chuan Liu Jian Wang Yin-Mo Yang department of Hepatobiliary Pancreatic surgery Peking University First HospitalBeijing 100034China department of Interventional and Vascular surgery Peking University First HospitalBeijing 100034China

BACKGROUND The liver is the most common site of digestive system tumor metastasis,but not all liver metastases can be traced back to the primary *** it is unusual,syphilis can impact the liver,manifesting as syphilitic hepatitis with inflammatory nodules,which might be misdiagnosed as *** SUMMARY This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three *** definitive diagnosis of a tumor had been made in the past decades,but signs of multiple liver metastases were recognized after a computed tomo-graphy scan without evidence of primary *** positive serological tests for syphilis and a biopsy of the liver nodules,a diagnosis of hepatic syphilis was made and confirmed with follow-up nodule reduction after anti-syphilis *** Clinicians must be aware of the possibility that syphilis can cause hepatic inflam-matory masses,especially when liver metastasis is suspected without evidence of primary lesions.A definitive diagnosis should be established in conjunction with a review of the patient’s medical history for accurate therapeutic intervention.

关键词： Syphilitic hepatitis Liver nodules Liver metastasis Treponema pallidum Case report

Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming Li Jianfeng Li Guoliang Chen Tao Lin Penghui Zhang Kuileung Tong Ningning Chen Shaoyu Liu Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina department of Orthopedic surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina department of Orthopedic surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina department of Orthopedic surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2

维普期刊数据库

Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第3期28卷 439-445页

作者： Nobuo MURATA Tatsuo YAMAKAWA department of surgery Mini-invasive surgery CenterTeikyo University Mizonokuchi HospitalKawasaki 213-8507Japan

Aim:To provide experimental data for further research on the signal transductionof apoptosis in lung adenocarcinoma cells,we examined the effects of exogenousC2-ceramide administration on several members of the mitogen-activated proteinkinase(MAPK)superfamily and caspase-3 in A549 ***:Cell viabilityand apoptosis were analyzed by cell counting kit-8 assay and flow *** MAPK and caspase-3 proteins were detected by Western ***:C2-ceramide selectively altered the phosphorylation state &members ofthe MAPK superfamily,causing hyperphosphorylation ofmitogen-activated pro-tein kinase kinase(MEK)1/2 and the p38 MAPK,but not affecting the phosphory-lation ofextracellular signal-regulated kinase 1/2 and the c-Jun N-terminal ***-203580(a p38 MAPK inhibitor)and p38 siRNA,but not U0126(a MEKinhibitor),partially rescued cell death induced by C2-ceramide.C2-ceramide promoted theactivation of ***:Exogenous C2-ceramide induced apoptosisin human lung adenocarcinoma A549 *** activation of MAPK and caspase-3were involved in the mechanisms ofC2-ceramide-induced apoptosis in A549 cells.

关键词： ceramide apoptosis mitogen-activated protein kinases A549 cells

Expression significance of biomarker MORC4 in colorectal cancer patients and its relationship with pathological features and prognosis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第3期17卷 291-298页

作者： Li Wei Liang Wang Ya-Gang Liu Li-Fei Gao department of General surgery Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina department of Hepatobiliary and Pancreatic surgery Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina

BACKGROUND Colorectal cancer(CRC)is one of the most common malignant gastrointestinal tumors worldwide,with high incidence and mortality *** To investigate the expression significance of the chromatin-remodeling protein MORC family CW-type zinc finger 4(MORC4)as a biomarker in CRC patients,and to explore its relationship with pathological features and *** A total of 143 CRC specimens and 57 adjacent tissue specimens,surgically removed from our hospital between January 2020 and January 2021,were ***4 protein expression was assessed using immunohistochemistry after paraffin *** relationship between MORC4 protein expression and clinicopathological characteristics of patients was ***-Meier survival curves were plotted to analyze the relationship between MORC4 protein expression and prognosis in CRC *** Compared with adjacent tissues,the expression rate of MORC4 protein in CRC tissues was significantly higher(P0.05).However,significant differences were found in the high expression rate of MORC4 protein in patients with different degrees of differentiation,lymph node metastasis,distant metastasis,tumor-lymph node-metastasis stage,and serum carcinoembryonic antigen levels(P<0.05).Compared with patients with low MORC4 expression,patients with high MORC4 expression had a worse prognosis(P<0.05).CONCLUSION The upregulation of MORC4 expression in CRC patients is closely related to disease severity and prognosis,suggesting its potential as an evaluation biomarker,which warrants further investigation.

关键词： Colorectal cancer Biomarker MORC family CW-type zinc finger 4 Expression significance Pathological features Prognosis Relationship

Hepatic artery infusion chemotherapy:A resurgence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第2期17卷 299-303页

作者： Andrew Kai-Yip Fung Kenneth Siu Ho Chok department of surgery The Chinese University of Hong KongPrince of Wales HospitalHong Kong 999077China

In this manuscript,we comment on the article by Zhou et al,who assessed the efficacy of hepatic arterial infusion chemotherapy(HAIC)and its combination strategies for advanced hepatocellular carcinoma(HCC)using network metaanalysis *** focus specifically on the potential advantages and role of HAIC in the treatment algorithm for advanced ***,there remains numerous knowledge gaps before the role of HAIC can be *** is significant heterogeneity of HAIC regimes with difficult interpretation of the clinical ***,there is a lack of direct comparative data between HAIC,systemic chemotherapy,novel immunotherapies and targeted *** underlying biochemical mechanisms that might explain the efficacy of HAIC and its effect on the HCC microenvironment requires further *** the developing era of nanotechnology and targeted drug delivery systems,there is potential for integration of HAIC with novel technologies to effectively treat advanced HCC whilst minimising systemic complications.

关键词： Hepatocellular carcinoma Hepatic artery infusion chemotherapy Immunotherapy Targeted therapy Transarterial chemoembolisation

Temporal-specific single-cell atlas of human type A aortic dissection reveals immune cell dynamics and therapeutic targets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2025年第2期70卷 167-171页

作者： Wenting Zhao Juan Chen Yi Xia Zhixi Wei Sitong Wan Huiyuan Guo Yanling Hao Wenjian Jiang Hongjia Zhang Fazheng Ren Peng An Yongting Luo Junjie Luo department of Nutrition and Health China Agricultural UniversityBeijing 100193China department of Cardiovascular surgery Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Stanford type A aortic dissection(STAAD/AD)is a degenerative aortic remodeling disease with an extremely high mortality rate and poor prognosis[1,2].Dissections can be classified into acute(90 d)stages depending on the time interval between the onset of initial symptoms and presentations[3].Patients who survive the acute phase progress to subacute and ultimately chronic stages[4,5].

关键词： dissection acute aortic

Liver transplantation using an otherwise-wasted partial liver resection graft

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 29-34页

作者： Yong-Sheng Xiao Yi-Feng He Xiao-Wu Huang Zhao-You Tang Jia Fan Jian Zhou department of Liver surgery&Transplantation Zhongshan HospitalFudan UniversityShanghai 200032China

Liver transplantation represents a complex surgical procedure and serves as a curative treatment for patients presenting an acute or chronic end-stage liver disease, or carefully selected liver malignancy. A significant gap still exists between the number of available donor organs and potential recipients. The use of an otherwise-wasted resected liver lobe from patients with benign liver tumors is a new, albeit small, option to alleviate the allograft shortage. This review provides evidence that resected liver lobes may be used successfully in liver transplantation.

关键词： Otherwise-wasted resected liver lobe Partial liver resection graft Liver transplantation Alternative liver transplantation technique Liver resection Benign hepatic tumor Hemangioma Focal nodular hyperplasia

维普期刊数据库

Current status of drug therapy for chronic hepatitis B

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第2期31卷 1-12页

作者： Chuang Jiang Zhi-Hong Zhang Jia-Xin Li Division of Liver surgery Department of General Surgery and Laboratory of Liver Surgeryand State Key Laboratory of Biotherapy and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of General surgery Dafang County People's HospitalBijie 551600Guizhou ProvinceChina

In this editorial,we comment on the article by Meng et *** hepatitis B(CHB)is a significant global health problem,particularly in developing *** B virus(HBV)infection is one of the most important risk factors for cirrhosis and hepatocellular *** and treatment of HBV are key measures to reduce *** present,drug therapy can effectively control virus replication and slow disease progression,but completely eliminating the virus remains a ***-HBV treatment is a long-term process,and there are many kinds of antiviral drugs with different mechanisms of action,it is essential to evaluate the safety and efficacy of these drugs to reduce side effects and improve patients’*** will summarize the current status of CHB drug treatment,hoping to provide a reference for the selection of clinical antiviral drugs.

关键词： Chronic hepatitis B Hepatitis B virus Anti virus Drug treatment Therapy