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Single-cell RNA sequencing to understand host-virus interactions

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Virologica Sinica 2024年第1期39卷 1-8页

作者： Jia-Tong Chang Li-Bo Liu Pei-Gang Wang Jing An department of microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Single-cell RNA sequencing(scRNA-seq)has allowed for the profiling of host and virus transcripts and host-virus interactions at single-cell *** review summarizes the existing scRNA-seq technologies together with their strengths and *** applications of scRNA-seq in various virological studies are discussed in depth,which broaden the understanding of the immune atlas,host-virus interactions,and immune ***-seq can be widely used for virology in the near future to better understand the pathogenic mechanisms and discover more effective therapeutic strategies.

关键词： Single-cell RNA sequencing(scRNA-seq) Host-virus interaction COVID-19 Flavivirus

Recent progress in MnBi2nTe3n+1 intrinsic magnetic topological insulators: crystal growth, magnetism and chemical disorder

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National Science Review 2024年第2期11卷 65-80页

作者： Chaowei Hu Tiema Qian Ni Ni department of Physics and Astronomy and California Nano systems Institute University of California-Los Angeles

The search for magnetic topological materials has been at the forefront of condensed matter research for their potential to host exotic states such as axion insulators, magnetic Weyl semimetals, Chern insulators,etc. To date, the MnBi2nTe3n+1family is the only group of materials showcasing van der Waals-layered structures, intrinsic magnetism and non-trivial band topology without trivial bands at the Fermi level. The interplay between magnetism and band topology in this family has led to the proposal of various topological phenomena, including the quantum anomalous Hall effect, quantum spin Hall effect and quantum magnetoelectric effect. Among these, the quantum anomalous Hall effect has been experimentally observed at record-high temperatures, highlighting the unprecedented potential of this family of materials in fundamental science and technological innovation. In this paper, we provide a comprehensive review of the research progress in this intrinsic magnetic topological insulator family, with a focus on single-crystal growth, characterization of chemical disorder, manipulation of magnetism through chemical substitution and external pressure, and important questions that remain to be conclusively answered.

关键词： MnBi2Te4 magnetic topological insulator magnetism tuning antiferromagnetism ferromagnetism pressure chemical doping

Hybrid Strategy of Partitioned and Monolithic Methods for Solving Strongly Coupled Analysis of Inverse and Direct Piezoelectric and Circuit Coupling

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1371-1386页

作者： Daisuke Ishihara Syunnosuke Nozaki Tomoya Niho Naoto Takayama department of Intelligent and Control systems Kyushu Institute of TechnologyFukuokaJapan

The inverse and direct piezoelectric and circuit coupling are widely observed in advanced electro-mechanical systems such as piezoelectric energy *** strongly coupled analysis methods based on direct numerical modeling for this phenomenon can be classified into partitioned or monolithic *** formulation has its advantages and disadvantages,and the choice depends on the characteristics of each coupled *** study proposes a new option:a coupled analysis strategy that combines the best features of the existing formulations,namely,the hybrid partitioned-monolithic *** analysis of inverse piezoelectricity and the monolithic analysis of direct piezoelectric and circuit interaction are strongly coupled using a partitioned iterative hierarchical *** a typical benchmark problem of a piezoelectric energy harvester,this research compares the results from the proposed method to those from the conventional strongly coupled partitioned iterative method,discussing the accuracy,stability,and computational *** proposed hybrid concept is effective for coupled multi-physics problems,including various coupling conditions.

关键词： Structure-piezoelectric-circuit interaction energy harvesting partitioned method monolithic method hybrid method

Cognitive dissonance and mindset perturbations during crisis:“ecosocio-psycho-somatic”perspectives

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World Journal of Psychiatry 2024年第2期14卷 215-224页

作者： Felix Tretter Henriette Löffler-Stastka department of systems Medicine and Healthcare systems Bertalanffy Center for the Study of Systems ScienceVienna 1040Austria department of Psychoanalysis and Psychotherapy Medical University ViennaVienna 1090Austria

Mandatory and restrictive health regulations during the corona pandemic caused psychic disorders in many people,which even led to clinically relevant mental *** the same time,there was gradually a polarization of opinions among the *** order to improve future pandemic management,an integrative understanding of these psychosocial processes therefore seems *** we start theoretically with the mental effects of inconsistencies of the information environment by referring to concepts such as the theory of cognitive *** a next step,we use the psychodynamic theory to understand the affective-motivational defense mechanisms underlying these cognitive states and ***,a broader theoretical framework of psychoanalysis seems to make sense,because self-referential processing also influences the style of *** this reason,we use a more comprehensive psychological systems theoretical framework model to integrate these different *** integrative view refers in part to basic knowledge of health psychology regarding the resistance of unhealthy ways of thinking and behaviors and the possibilities for interventions for *** then extend this model to a broader picture that also covers the relationship between men and their *** results in the perspective of a multidimensional socioecological theoretical framework,which as a heuristic reference model and related to other ecological approaches could also be helpful for various theoretical questions for public health,and could provide a better public understanding of health *** line with this perspective,we hypothesize that with regard to the coronavirus disease 2019 pandemic,the acceptance of public health narratives could be increased if a more consistent picture of the scientific descriptions and explanations of the pandemic-similar to the model proposed-could be provided,which would enable the understanding of the origin,course and countermeasur

关键词： Infodemic Affective-cognitive dissonance systems model of the mind Socioecological model

Angiogenesis in diseases:A half-century excursion from the initial therapeutic concept to current clinical benefits

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Chinese Medical Journal 2024年第6期137卷 636-637页

作者： Yihai Cao department of microbiology Tumor and Cell BiologyKarolinska InstituteStockholm 17177Sweden

Except a few tissues such as the cornea and cartilage that are avascular,blood vessels constitute a significant proportion of tissue masses in virtually all *** physiological conditions,the adult vasculature remains quiescent to retain tissue and organ homeostatic *** few or too many blood vessels are associated with the onset and progression of many *** response to injuries,most tissues undergo repair by switching on angiogenesis,a key process of new blood vessel formation.^([1])Similarly,angiogenesis is often active in pathological tissues,including tumors and ischemic tissues to aggravate disease progression.

关键词： injuries organs diseases

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Dengue hemorrhagic fever with rectus sheath hematoma:A case report

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 136-138页

作者： Boudhayan Bhattacharjee Hardik Patel Rucha Karad Vasireddy Teja Agnibho Mondal Soumendra Nath Haldar Bibhuti Saha department of Infectious Diseases and Advanced microbiology School of Tropical MedicineKolkataIndia

Rationale:Acute pain is a medical emergency that requires prompt abdominal evaluation and ***,a mosquito-borne arboviral infection,can lead to complications such as acute abdominal *** concerns:A 72-year-old hypertensive female presented with high-grade intermittent fever with chills and rigors for four *** was diagnosed with dengue fever(NS1Ag-reactive)the day before admission.A contrast-enhanced computed tomography of the abdomen showed a hematoma along the rectus sheath which was managed conservatively as per surgical ***:Dengue hemorrhagic fever with rectus sheath ***:Blood transfusion and fluid ***:Ten days after discharge,the patient reproted no pain in the right iliac fossa and the size of the hematoma was significantly ***:Although it is rarely seen as a cause of acute abdomen,complaints of adnominal pain should never be ignored in critical or convalescent phase of dengue *** investigations should be promptly conducted as hematoma is often difficult to be diagnosed *** in diagnosis of rectus sheath hematoma can be fatal.

关键词： Dengue fever Rectus sheath hematoma Surgical emergency Acute appendicitis

Olive Leaf Disease Detection via Wavelet Transform and Feature Fusion of Pre-Trained Deep Learning Models

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Computers, Materials & Continua 2024年第3期78卷 3431-3448页

作者： Mahmood A.Mahmood Khalaf Alsalem department of Information systems College of Computer and Information SciencesJouf UniversitySakakahKingdom of Saudi Arabia department of Information systems and Technology Faculty of Graduate Studies and ResearchCairo UniversityGizaEgypt

Olive trees are susceptible to a variety of diseases that can cause significant crop damage and economic *** detection of these diseases is essential for effective *** propose a novel transformed wavelet,feature-fused,pre-trained deep learning model for detecting olive leaf *** proposed model combines wavelet transforms with pre-trained deep-learning models to extract discriminative features from olive leaf *** model has four main phases:preprocessing using data augmentation,three-level wavelet transformation,learning using pre-trained deep learning models,and a fused deep learning *** the preprocessing phase,the image dataset is augmented using techniques such as resizing,rescaling,flipping,rotation,zooming,and *** wavelet transformation,the augmented images are decomposed into three frequency *** pre-trained deep learning models,EfficientNet-B7,DenseNet-201,and ResNet-152-V2,are used in the learning *** models were trained using the approximate images of the third-level sub-band of the wavelet *** the fused phase,the fused model consists of a merge layer,three dense layers,and two dropout *** proposed model was evaluated using a dataset of images of healthy and infected olive *** achieved an accuracy of 99.72%in the diagnosis of olive leaf diseases,which exceeds the accuracy of other methods reported in the *** finding suggests that our proposed method is a promising tool for the early detection of olive leaf diseases.

关键词： Olive leaf diseases wavelet transform deep learning feature fusion

Categorizing methods for integrating machine learning with executable specifications

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Science China(Information Sciences) 2024年第1期67卷 5-19页

作者： David HAREL Raz YERUSHALMI Assaf MARRON Achiya ELYASAF department of Computer Science and Applied Mathematics Weizmann Institute of Science department of Software and Information systems Engineering Ben-Gurion University of the Negev

Deep learning(DL),which includes deep reinforcement learning(DRL),holds great promise for carrying out real-world tasks that human minds seem to cope with quite *** promise is already delivering extremely impressive results in a variety of ***,while DL-enabled systems achieve excellent performance,they are far from *** has been demonstrated,in several domains,that DL systems can err when they encounter cases they had not hitherto ***,the opacity of the produced agents makes it difficult to explain their behavior and ensure that they adhere to various requirements posed by human *** the other end of the software development spectrum of methods,behavioral programming(BP) facilitates orderly system development using self-standing executable modules aligned with how humans intuitively describe desired system *** this paper,we elaborate on different approaches for combining DRL with BP and,more generally,machine learning(ML) with executable specifications(ES).We begin by defining a framework for studying the various approaches,which can also be used to study new emerging approaches not covered *** then briefly review state-of-the-art approaches to integrating ML with ES,continue with a focus on DRL,and then present the merits of integrating ML with *** conclude with guidelines on how this categorization can be used in decision making in system development,and outline future research challenges.

关键词： machine learning artificial intelligence grey box learning domain knowledge rules behavioral programming deep reinforcement learning survey

Virus-like nanoparticle vaccines for inducing long-lasting immunity against infectious diseases

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National Science Review 2024年第4期11卷 13-15页

作者： Yi-Nan Zhang Sarah Auclair Jiang Zhu department of Integrative Structural and Computational Biology The Scripps Research Institute department of Immunology and microbiology The Scripps Research Institute

Prophylactic vaccines that can generate long-lasting protective immune responses are needed for many infectious diseases. Efficient vaccination requires vaccine antigens to be retained and presented to B cells in lymp...

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