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A potent fish pathogenic bacterial killer Streptomyces *** from the soils of east coast region,South India

Journal of Coastal Life Medicine 2013年第3期 175-180页

作者： Durairaj Thirumurugan Ramasamy Vijayakumar department of microbiology bharathidasan university constituent college kurumbalur-621107 PerambalurTamilnaduIndia

Objective:To investigate the potentiality of the marine actinobacteria isolated from marine soil against fish pathogenic ***:east coast region(ECR)of Tamilnadu,South *** they were used for the isolation of actinobacteria by using conventional serial dilution technique on starch casein agar *** antibacterial activities of the actinobacteria were screened primarily by using cross streak plate method against fish pathogenic bacteria namely Vibrio alginolyticus,Vibrio parahaemolyticus,Vibrio cholera,Aeromonas *** Pseudomonas *** antimicrobial efficacy of the selected isolates was carried out with various organic solvents,and finally the active compound was subjected to chromatographic techniques including TLC and ***:In the present study,a total of 33 soil samples were collected from the Bay of Bengal,against fish pathogenic *** of 21 antibacterial isolates,the isolate ECR77 was selected for further study based on its potential activity against fish pathogenic *** the various solvents tested,the ethyl acetate extract had good antibacterial activity against the tested bacterial *** isolate ECR77 grew well on oat meal agar medium with 2%salt level at 35°***-MS study found that the presence of bioactive compounds namely tetradecanoic acid,n-hexadecanoic acid and octadecanoic *** morphological,physiological,biochemical and cultural characteristics of the potential isolate were supported the identity up to generic level asStreptomyces ***:The results obtained from this study concludes that the ECR soils of South India is a hot spot of novel bioactive compound producing marine actinobacteria with great pharmaceutical *** the 82 actinobacteria isolated,21(26%)isolates were possessed antibacterial activity.

关键词： East coast region South India Streptomyces sp.ECR77 Antibacterial activity GC-MS Decanoic acids

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Anti-enteric bacterial activity and phytochemical analysis of the seed kernel extract of Mangifera indica Linnaeus against Shigella dysenteriae(Shiga,corrig.) Castellani and Chalmers

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Asian Pacific Journal of Tropical Medicine 2011年第4期4卷 294-300页

作者： Rajan S Thirunalasundari T Jeeva S department of microbiology Srimad Andavan Arts and Science College department of Biotechnology Bharathidasan University Centre for Biodiversity and Biotechnology Department of BotanyN.M.Christian College

Objective:To evaluate the phytochemical and anti-bacterial efficacy of the seed kernel extract of Mangifera indica(***) against the enteropathogen,Shigella dysenteriae(***), isolated from the diarrhoeal stool ***:The preliminary phytochemical screening was performed by the standard methods as described by *** extraction method was employed to extract the bioactive compounds from mango seed *** diffusion method was adopted to screen antibacterial *** inhibitory concentration(MIC) was evaluated by agar dilution *** crude extracts were partially purified by thin layer chromatography(TLC) and the fractions were analyzed by high performance thin layer chromatography(HFTLC) to identify the bioactive ***:Phytochemical scrutiny of *** indicated the presence of phytochemical constituents such as alkaloids,gums, flavanoids,phenols,saponins,steroids,tannins and *** activity was observed in two crude extracts and various fractions ***,benzene,chlor of orm,methanol and *** of methanol fraction was found to be(95±11.8)μg/*** of other fractions ranged from 130-380μg/mL Conclusions:The present study confirmed that each crude extracts and fractions of *** have significant antimicrobial activity against the isolated pathogen 5. *** antibacterial activity may be due to the phytochemical constituents of the mango seed *** phytochemical tannin could be the reason for its antibacterial activity.

关键词： Antibacterial activity Mangifera indica(seed kernel) Minimum inhibitory concentration Phytochemistry Shigella dysenteriae

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Screening and antibacterial efficacy of selected Indian medicinal plants

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Asian Pacific Journal of Tropical Biomedicine 2016年第3期6卷 185-191页

作者： Suresh Mickymaray Mohammad Saleh Al Aboody Pradipta Kumar Rath Panneerselvam Annamalai Thajuddin Nooruddin department of Medical Laboratories College of Science Al-Zulfi Majmaah University department of Diagnostic microbiology and Molecular Biology Doctors' Diagnostic Centre Post Graduate & Research department of Botany & microbiology A. Veeriya Vandayar Memorial Sri Pushpam College(Autonomous) department of microbiology School of Life Sciences Bharathidasan University

Objective: To evaluate the antibacterial efficacy of five Indian medicinal plants such as Acalypha indica L.(A. indica), Aerva lanata(L.) Juss. ex Schult.(A. lanata), Clerodendrum inerme(L.) Gaertn., Pergularia daemia(Forsk.) Chiov. and Solanum surattense Burm. f. against opportunistic bacterial pathogens isolated from HIV infected patients for the potential phytoconstituents in plant ***: The opportunistic bacterial pathogens such as Escherichia coli(E. coli),Pseudomonas aeruginosa, Salmonella typhi and Serratia marcescens from Gramnegative group and Staphylococcus aureus from Gram-positive group were isolated from HIV infected patients. The antibacterial efficacy of ethanolic extracts of selected medicinal plants was carried out by disc diffusion method. The potential phytoconstituents of medicinal plant extracts were identified by gas chromatography and mass spectrometry(GC–MS) ***: Among the five medicinal plants tested, A. indica and A. lanata showed the significant antibacterial activity. A. indica showed potential activity against Staphylococcus aureus and E. coli. A. lanata significantly exhibited antibacterial activity against E. coli, Salmonella typhi and Pseudomonas aeruginosa. A total of 19 phytoconstituents were identified in the ethanolic extract of A. indica and A. lanata by GC–MS analysis ***: The results of the present investigation revealed that A. indica and A. lanata, possessed significant antibacterial activity when compared with the other plant extracts tested. The presence of 3-O-methyl-D-glucose by GC–MS analysis in both A. indica and A. lanata extracts has not been reported elsewhere in the literature and the findings in this study could be the first one to report.

关键词： Antibacterial efficacy Medicinal plants Bacterial pathogens Phytoconstituents

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Antioxidant and Cytotoxic Activities of A Novel Isomeric Molecule(PF5)Obtained from Methanolic Extract of Pleurotus Florida Mushroom

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Journal of Bioresources and Bioproducts 2021年第4期6卷 338-349页

作者： D.Menaga Pattanathu K.S.M.Rahman S.Rajakumar P.M.Ayyasamy department of microbiology Periyar UniversitySalem 636011India department of microbiology Vivekanandha College of Arts and Sciences for WomenTiruchengode 637205India Research and Development Tara Biologics LimitedWokingSurrey GU216BPUnited Kingdom department of Marine Biotechnology Bharathidasan UniversityTiruchirappalli 620024India

The Pleurotus florida is recognized as a medicinal and edible mushroom and the present study intends to reveal the active isomeric molecules from this *** *** was cultivated using different nutrient supplements:groundnut husk,maize powder,horse gram powder and coconut oil-cake *** gram supplement showed the higher mushroom yield and henceit was used for the cultivation of *** extract of *** was found to be efficient in antioxidant activity among ethanol,aqueous,ethyl acetate and hexane *** bioactive fraction 3-methoxy-4-hydroxy cinnamic acid(PF5)was isolated and purified from the methanolic extract of *** by column chromatography,thin layer chromatography(TLC)and gas chromatography-mass spectrum(GC-MS)and further it was characterized by Nuclear magnetic resonance(NMR).The PF5 was tested for its DPPH and reducing power assays,and the IC_(50) values were found to be 21.7μg/mL and 105μg/mL,*** found that the cytotoxic effect of 3-methoxy-4-hydroxy cinnamic acid was tested against the lung cancer cell line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT),sulphorodamine B(SRB)and trypan blue assays which exhibited a higher cytotoxic effect(CTC_(50),645μg/mL).These results suggested that 3-methoxy-4-hydroxy cinnamic acid from *** could be explored as a novel and potent natural antioxidant and cancer preventive agent,alternative to existing synthetic molecules.

关键词： Pleurotus florida Methanolic extract Isomeric molecule Antioxidant activity Cytotoxic activity

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Antidiarrhoeal efficacy of Mangifera indica seed kernel on Swiss albino mice

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Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 630-633页

作者： Rajan S Suganya H Thirunalasundari T Jeeva S department of microbiology M.R.Govt Arts CollegeMannargudi-614 001Thiruvarur DistrictTamilnaduIndia department of microbiology Srimad Andavan Arts and Science CollegeT.V.KoilTiruchirappalli-620 005TamilnaduIndia department of Biotechnology Bharathidasan UniversityTiruchirappalli-620 024TamilnaduIndia department of Botany Scott Christian CollegeNagercoil-629 003TamilnaduIndia

Objective:To examine the antidiarrhoeal activity of alcoholic and aqueous seed kernel extract of Mangifera indica(***) on castor oil-induced diarrhoeul activity in Swiss albino ***:Mango seed kernels were processed and extracted using alcohol and water. Antidiarrhoeal activity of the extracts were assessed using intestinal motility and faecal score ***:Aqueous and alcoholic extracts of *** significantly reduced intestinal motility and faecal score in Swiss albino ***:The present study shows the traditional claim on the use of *** seed kernel for treating diarrhoea in Southern parts of India.

关键词： Antidiarrhoeal activity Gastroenteritis Diarrhoea Mangifera indica Seed kernel extracts

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Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons

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Translational Neurodegeneration 2020年第3期9卷 393-408页

作者： Kalimuthusamy Natarajaseenivasan Santhanam Shanmughapriya Prema Velusamy Matthew Sayre Alvaro Garcia Nestor Mas Gomez Dianne Langford department of Neurosciences and Center for Neurovirology Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPA 19140USA department of microbiology Bharathidasan UniversityTiruchirappalli 620024India Heart and Vascular Institute Department of MedicineDepartment of Cellular and Molecular PhysiologyPenn State College of MedicineHersheyPA 17033USA

Background:Diseases and disorders with a chronic neuroinflammatory component are often linked with changes in brain *** neurodegenerative disorders,people living with human immunodeficiency virus(HIM)and Alzheimer's disease(AD)are particularly vulnerable to metabolic disturbances,but the mechanistic connections of inflammation,neurodegeneration and bioenergetic deficits in the central nervous system(CNS)are poorly *** particularly interesting new cysteine histidine-rich-protein(PINCH)is nearly undetectable in healthy mature neurons,but is robustly expressed in tauopathy-associated neurodegenerative diseases including HIV infection and *** robust PINCH expression has been reported in neurons in the brains of patients with HIV and AD,the molecular mechanisms and cellular consequences of increased PINCH expression in CNS disease remain largely ***:We investigated the regulatory mechanisms responsible for PINCH protein-mediated changes in bioenergetics,mitochondrial subcellular localization and bioenergetic deficits in neurons exposed to physialogical levels of TNFa or the HIV protein *** in the PINCH-ILK-Parvin(PIP)complex association with cofilin and TESK1 were assessed to identify factors responsible for actin depolymerization and mitochondrial *** and pharmacological inhibition experiments were conducted to confirm PINCH specificity and to reinstate proper protein-protein complex ***:We identified MEF2A as the PINCH transcription factor in neuroinflammation and determined the biological consequences of increased PINCH in ***-mediated activation of MEF2A via increased cellular calcium induced PINCH,leading to disruption of the PIP ternary complex,cofilin activation by TESK1 inactivation,and actin *** disruption of actin led to perinuclear mislocalization of mitochondria by destabilizing the kinesin-dependent mitochondrial transport machinery,resulting i

关键词： Neuron Mitochondria Actin PINCH Neuroinflammation

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Molecular characterization and antibacterial effect of endophytic actinomycetes Nocardiopsis sp. GRG1 (KT235640) from brown algae against MDR strains of uropathogens

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Bioactive Materials 2016年第2期1卷 140-150页

作者： Govindan Rajivgandhi Ramachandran Vijayan Marikani Kannan Malairaja Santhanakrishnan Natesan Manoharan department of Marine Science Bharathidasan UniversityTiruchirappalli 24Tamil NaduIndia School of Life Sciences Jawaharlal Nehru UniversityNew Delhi 67India department of microbiology VHNSN CollegeVirudunagar 01Tamil NaduIndia department of Marine and Coastal Studies Madurai Kamaraj UniversityMadurai 21Tamil NaduIndia

Our study is to evaluate the potential bioactive compound of Nocardiopsis ***1(KT235640)and its antibacterial activity against multi drug resistant strains(MDRS)on urinary tract infections(UTIs).Two brown algae samples were collected and were subjected to isolation of endophytic actinomycetes.100 strains of actinomycetes were isolated from algal samples based on observation of morphology and physiological characters.40 strains were active in antagonistic activity against various clinical *** the strains,10 showed better antimicrobial activity against MDRS on *** secondary metabolite of Nocardiopsis ***1(KT235640)has showed tremendous antibacterial activity against UTI pathogens compared to other *** of various growth parameters were used for synthesis of secondary metabolites,such as optimum pH 7,incubation time 5e7 days,temperature(30C),salinity(5%),fructose and mannitol as the suitable carbon and nitrogen *** 100 μg/ml concentration MIC of Nocardiopsis ***1(KT235640)showed highest percentage of inhibition against Proteus mirabilis(85%),and ***,Staphylococcus auerues,Psuedomonas aeroginasa,Enterobactor sp and Coagulinase negative staphylococci 78e85%respectively.

关键词： Endophytes Multi-drug resistant strains Urinary tract infections Minimal inhibitory concentration

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Antifungal activity of Ocimum sanctum Linn.(Lamiaceae) on clinically isolated dermatophytic fungi

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Asian Pacific Journal of Tropical Medicine 2011年第8期4卷 654-657页

作者： Balakumar S Rajan S Thirunalasundari T Jeeva S department of Chemistry and Biosciences SASTRA UniversitySrinivasa Ramanujan Centre.Kumbakonam- 612001Tamil NaduIndia department of microbiology M.R.Government Arts CollegeMannargudi.Thriuvarur District.Tamil NaduIndia department of Biotechnology Bharathidasan UniversityTiruchirappalli-620 024Tamil Nadu.India Centre for Biodiversity and Biotechnology.department of Botany Nesamony Memorial Christian College.Marthandam-629 165Tamil Nadu.India

Objective:To assess antifungal activity of Ocimum sanctum leaves against dermatophytic fungi. Methods:Antifungal activity of Ocimum sanctum leaves was measured by 38 A NCCLS method. Minimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) of various extracts and fractions of Ocimum sanctum leaves were also ***:Ocimum sanctum leaves possessed antifungal activity against clinically isolated dermatophytes at the concentration of 200μg/*** and MFC were high with water fraction(200μg/mL) against dermatophytic fungi ***:Ocimum sanctum has antifungal activity,and the leaf extracts may be a useful source for dermatophytic infections.

关键词： Antifungal activity Dermatophytosis Epidermophyton floccosum Minimum fungicidal concentration Microsporum sp Minimum inhibitory concentration Ocimum sanctum Trichophyton sp

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Antifungal activity of Aegle marmelos(L.) Correa(Rutaceae) leaf extract on dermatophytes

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Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 309-312页

作者： Balakumar S Rajan S Thirunalasundari T Jeeva S department of Chemistry and Biosciences SASTRA UniversitySrinivasa Ramanujan CentreKumbakonam- 612001Tamil NaduIndia department of microbiology Srimad Andavan Arts & Science CollegeTiruchirappalli-620 005Tamil NaduIndia department of Biotechnology Bharathidasan UniversityTiruchirappalli-620 024Tamil NaduIndia Centre for Biodiversity and Biotechnology Department of BotanyNesamony Memorial Christian CollegeMarthandam-629 165Tamil NaduIndia

Objective:To evaluate the in vitro antifungal activity of Aegle marmelos leaf extracts and fractions on the clinical isolates of dermatophytic fungi like Trichophyton mentagrophytes,Trichophyton rubrum,Microsporum canis,Microsporum gypseum and Epidermophyton ***:The minimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) of various extracts and fractions of the leaves of Aegle marmelos were measured using method of National Committee for Clinical Laboratory Standards(NCCLS).Results:Aegle marmelos leaf extracts and fractions were found to have fungicidal activity against various clinical isolates of dermatophytic *** MIC and MFC was found to be high in water and ethyl alcohol extracts and methanol fractions(200μg/mL) against dermatophytic fungi ***:Aegle marmelos leaf extracts significantly inhibites the growth of all dermatophytic fungi *** this activity is confirmed by in vivo studies and if the compound is isolated and identified,it could be a remedy for dermatophytosis.

关键词： Antifungal activity Aegle marmelos Dermatophytosis Dermatophytes

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Evaluation of antibacterial activity of zinc oxide nanoparticles synthesized using phycobilins of Anabaena variabilis NTSS17

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Journal of Coastal Life Medicine 2015年第12期 944-949页

作者： Thangaraj Ramasamy Santhoshkumar Subramaniyam Dhanasekaran Dharumadurai Kala Karuppannan Alharbi Naiyf Sultan Arunachalam Chinnathambi Ali Alharbi Sulaiman Thajuddin Nooruddin School of Life Science Department of MicrobiologyBharathidasan UniversityTiruchirappalli 620024TamilnaduIndia department of Botany Government Arts College(Autonomous)ThanthonimalaiKarur 639005TamilnaduIndia department of Botany and microbiology College of ScienceKing Saud UniversityRiyadh 11451Kingdom of Saudi Arabia

Objective:To evaluate the antibacterial activity of zinc oxide nanoparticles synthesized using phycobilins of Anabaena variabilis ***:The cyanobacterial isolate was collected from paddy field and morphologically identified as Anabaena variabilis NTSS17,that produces a pigment *** biosynthesized zinc nanoparticles were characterized by different spectroscopic and analytical techniques such as UV-visible spectrophotometer,Fourier transform infrared spectroscopy and X-ray diffraction which confirmed the formation of zinc ***:Antibacterial activity of zinc oxide nanoparticles was examined against Escherichia coli,Rhodococcus rhodochrous and Pseudomonas *** maximum zone of inhibition occurred at 5 mg/1000 mL concentration of zinc oxide ***:Due to potent antimicrobial and intrinsic properties of zinc oxide,it can be actively used for biomedical applications.

关键词： Anabaena variabilis NTSS17 Phycobilins Zinc oxide nanoparticles Antibacterial activity

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