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Effects of meteorological elements on admission rates of cerebral infarction patients with hypertensive nephropathy from nine hospitals in Changchun city, Jilin Province

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Chinese Medical Journal 2013年第10期126卷 1934-1938页

作者： YANG Bo-yu ZHANG Yue XU Chang-yan JIA Bo-ting WANG Chun-jie JIA Zhan-jun NI Hui WANG De-hui ZHANG Zhe ZHAO Gang YANG-Li-ming department of NeorosurgeryFirst bethune Hospical Jilin University ChangchunJilin 130021 China departmentof Medical RecordFirst bethune hospital Jilin University ChangchunJilin 130021 China department of meterol medicinefirst bethune hospital Jilin University ChangchunJilin 130021 China Division of Nephrology and Hypertension Internal MedicineDepartment University of Utah UT 84132 USA department of Probability and Statistics Mathematics School &Institute Jilin University Changchun Jilin 130012 China department of Statistics School of Basic Science ChangchunIndustry University Changchun Jilin 130012 China department of Meteorological Service Strategies Jilin ProvincialMeteorological Observatory Changchun Jilin 130062 China

Background It is well recognized that meteorological factors have important influences on the onset and development of many kinds of diseases. The present study was undertaken to investigate the effects of the meteorological elements on admission rates of cerebral infarction patients with hypertensive nephropathy at Changchun city, Jilin Province, northeast China. Methods A total of 763 medical records of inpatients from nine hospitals at Changchun city, during a period from April 6 to April 17 in 2010, were reviewed. These patients were admitted to hospitals due to the occurrence of cerebral infarction. The hypertensive nephropathy was evidenced with certain diagnosis of essential hypertension and hypertension-related kidney injuries. The cerebral infarction was diagnosed according to the World Health Organization （Stroke） standard. All the meteorological data were from practical monitoring records in Jilin Province Meteorological Observatory. The relationships between the epidemiological prevalence of cerebral infarction and meteorological variables were analyzed using the time series models of statistics. Results Compared with admission rates before the violent change in meteorological status （April 6 to April 17, 2010）, the number of admission patients suffering from cerebral infarction remarkably peaked on April 12. Such an increase was highly correlated with heavy precipitation, elevation of daily average relative humidity, and reduction of average daily air temperature. With the betterment of the meteorological conditions on April 17, the admission rates of cerebral infarction patients dropped to the same level as the dates before snowing （April 6 to April 11）. Conclusions The meteorological changes are highly associated with the occurrence of cerebral infarction in patients with hypertensive renal injury in northeast China. This study also suggested that an intensive medical interference for those patients with hypertension-induced organ injuries is very nec

关键词： meteorological elements cerebral infarction time series model prevention

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Effect of metoprolol on sarcoplasmic reticulum Ca^2＋ leak in a rabbit model of heart failure

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Chinese Medical Journal 2012年第5期125卷 815-822页

作者： ZHANG Shi-jie LIU Zhi-hua ZOU Cao WANG Lei department of Laboratory medicinefirst Affiliated hospital of ZhengzhouUniversity Zhengzhou Henan 450052 China department ofEmergency First Affiliated hospital of ZhengzhouUniversity Zhengzhou Henan 450052 China department of Cardiology First Affiliated Hospital of SoochowUniversity Suzhou Jiangsu 215006 China

Background Studies have shown that B-blockers can improve cardiac performance in heart failure （HF） by reversing protein kinase A （PKA）-mediated sarcoplasmic reticulum （SR） Ca^2＋ leak. However, it is being strongly questioned as to whether the PKA-mediated ryanodine receptor （RyR2） hyper-phosphorylation is a critical regulator of SR Ca^2＋ leak. In this study, we used a rabbit HF model to investigate whether β-blockers affect SR Ca^2＋ leak by other potential mechanisms.

关键词： β-blocker heart failure Ca^2+ leak ryanodine receptor phosphorylation

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