检索结果-南通市图书馆

Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione:Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2021年第6期11卷 791-798页

作者： Agnieszka Potega Michal Kosno Zofia Mazerska department of Pharmaceutical Technology and Biochemistry Faculty of ChemistryGda nsk University of TechnologyGdansk80-233Poland

Unsymmetrical bisacridines(UAs) are a novel potent class of antitumor-active therapeutics.A significant route of phase II drug metabolism is conjugation with glutathione(GSH),which can be non-enzymatic and/or catalyzed by GSH-dependent *** aim of this work was to investigate the GSHmediated metabolic pathway of a representative UA,***-supplemented incubations of C-2028 with rat,but not with human,liver cytosol led to the formation of a single GSH-related ***,it was also revealed with rat liver *** formation was NADPH-independent and was not inhibited by co-incubation with the cytochrome P450(CYP450) inhibitor ***,the direct conjugation pathway occurred without the prior CYP450-catalyzed bioactivation of the *** turn,incubations of C-2028 and GSH with human recombinant glutathione S-transferase(GST) P1-1 or with heat-/ethacrynic acid-inactivated liver cytosolic enzymes resulted in the presence or lack of GSH conjugated form,*** findings proved the necessary participation of GST in the initial activation of the GSH thiol group to enable a nucleophilic attack on the substrate *** C-2028-GSH S-conjugate was also formed during non-enzymatic *** GSH S-conjugates were characterized by combined liquid chromatography/tandem mass *** for their formation were *** ability of C-2028 to GST-mediated and/or direct GSH conjugation is suspected to be clinically *** may affect the patient’s drug clearance due to GST activity,loss of GSH,or the interactions with GSH-conjugated ***,GST-mediated depletion of cellular GSH may increase tumor cell exposure to reactive products of UA metabolic transformations.

关键词： Antitumor agent Unsymmetrical bisacridine metabolic detoxification Glutathione S-Conjugate Glutathione S-transferase Non-enzymatic conjugation

Key progresses of MOE key laboratory of macromolecular synthesis and functionalization in 2020

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第4期33卷 1650-1658页

作者： Jie Ren Xiao Shu Ya Wang Di Wang Guangpeng Wu Xinghong Zhang Qiao Jin Jianzhao Liu Ziliang Wu Zhen Xu Chang-Zhi Li Hanying Li MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

In 2020, the MOE Key Laboratory of Macromolecular Synthesis and Functionalization in Zhejiang university had made progresses in several aspects. First, a series of metal-free organoboron catalysts had been designed and synthesized facilely, exhibiting outstanding reactivity, thermalstability and productivity in different kinds of polymerization and cycloaddition reactions. Second, a variety of chalcogen(O, S, Se)-rich polymers had been synthesized via organocatalysis and fabricated to be the ionic conductive and photoluminescent materials. Third, diverse microenvironment-sensitive nanoparticles had been designed,and novel strategies had been realized, to enhance the therapeutic efficacy in cancer as well as biofilmassociated infections. Fourth, m6 A modification on cellular transcriptome-wide messenger RNA had been successfully mapped at single base resolution using a metabolic labeling method. Fifth, a hydrogel-based robot had been developed, showing swift locomotion as a response to dynamic light stimulations. Sixth,the conformation-size scaling law and the conformation evolution map of 2 D macromolecules in solution had been elucidated experimentally, in the single-layer graphene oxide model. Seventh, semitransparent polymer solar cells, promising as building-integrated photovoltaics, have been developed with the fine balance among power conversion efficiency, visible light transparency and infrared photon radiation rejection. Finally, long-range ordered bulk-heterojunctions of organic semiconductors had been achieved,and their superior optoelectronic properties and potential application in photoelectric conversion had been revealed. The related work progresses are reviewed in this paper.

关键词： Polymer Catalyst Drug nanocarrier RNA methylation Gel 2D Macromolecule Organic optoelectronics

The challenges of future foods from prevention of nutrient deficiencies to the management of diabetes

在线全文

学校读者我要写书评

暂无评论

Journal of Future Foods 2021年第1期1卷 47-57页

作者： Christian Hamrick Guoxun Chen department of Nutrition University of Tennessee at KnoxvilleKnoxvilleTennesseeUSA

With rise of globa1 populations,food demand is expected to increase ***,the number of people with chronic metabolic diseases,specifically diabetes,is also on the *** the discovery of insulin exactly 100 years ago,every aspect of society including food industry has evolved ***,and pesticides have been introduced constantly to increase food production for ***,the changes of biodiversity in agriculhure might have incorporated certain foods and excluded others selectively in diets,which probably results in the production of food with more calories,but 1ess essentia1 *** might have affected systemic functions in the body and contributed to the development of chronic metabolic ***,genetic and epigenetic factors have had impacts on disease susceptibility,which has challenged the protective mechanisms that have been estab1ished in the human genome during ***,we try to summarize certain changes of systematic,environmenta1,metabolic,and physiological factors that may have potential effects on human diets and metabolism,and in turn,contributed to the current epidemic of chonic metabolic diseases such as type 2 *** so doing,we hope to bring the attention of colleagues to develop future foods that not only eliminate malnutnition,but also reduce the incidence of metabolic diseases.

关键词： Food Nutrition Insulin Diabetes Agriculhure metabolic diseases

In Vitro Study on Mg-Sn-Mn Alloy as Biodegradable Metals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2014年第7期30卷 675-685页

作者： Zhen Zhen Tingfei Xi Yufeng Zheng Li Li Lugee Li Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary StudiesPeking University Biomedical Engineering Research Center Shenzhen InstitutePeking University department of Materials Science and Engineering College of EngineeringPeking University Center for Biomedical Materials and Engineering Harbin Engineering University Dongguan EONTEC Company Ltd

The mechanical properties, chemical properties and biocompatibility of Mg-3Sn-0.5Mn alloy were tested. A series of in vitro evaluations such as tensile test, static and dynamic immersion test, hemocompatibility test as well as cytotoxicity test were presented, with commercial magnesium alloy WE43 as the control. Mg-3Sn-0.5Mn alloy possesses suitable strength and superior ductility compared with WE43 and AZ31. Static immersion and dynamic degradation tests showed more uniform degradation with a more moderate rate for Mg-3Sn-0.5Mn alloy （0.34 mm/y in static condition and 0.25 mm/y in dynamic condition） compared with WE43 alloy （0.42 mm/y in static condition and 0.33 mm/y in dynamic condition） in Hank＇s solution. Blood compatibility evaluation suggested that Mg-3Sn-0.5Mn alloy had no destructive effect on erythrocyte and showed excellent anti-thrombogenicity to blood system. Besides, Mg-3Sn-0.5Mn alloy showed no inhibition effect to L929 metabolic activity and mild toxicity to vascular smooth muscle cell （VSMC） in preliminary cell viability assessment. By considering its excellent mechanical strength, corrosion resistance, low ion release rate and good biocompatibility, Mg-3Sn-0.5Mn alloy may be a promising economical candidate as biomedical implant material for load-bearing clinical applications in the future.

关键词： Mg-3Sn-0.5Mn alloy Corrosion Dynamic immersion Static immersion Biodegradable material

Type 2 diabetes mellitus:From a metabolic disorder to an inflammatory condition

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2015年第4期6卷 598-612页

作者： Iqra Hameed Shariq R Masoodi Shahnaz A Mir Mudasar Nabi Khalid Ghazanfar Bashir A Ganai department of Biochemistry University of Kashmir department of Endocrin-ology Sher-I-Kashmir Institute of medical Sciences Division of Endocrinology Diabetes and NutritionUniversity of Maryland School of Medicine Centre for Research and Development Uni-versity of Kashmir

Diabetes mellitus is increasing at an alarming rate and has become a global *** resistance intarget tissues and a relative deficiency of insulin secretion from pancreatic β-cells are the major features of type 2 diabetes(T2D).Chronic low-grade inflammation in T2 D has given an impetus to the field of immuno-metabolism linking inflammation to insulin resistance and β-cell *** factors advocate a causal link between metabolic stress and *** cellular factors trigger inflammatory signalling cascades,and as a result T2 D is at the moment considered an inflammatory disorder triggered by disordered *** mechanisms like activation of Tolllike receptors,Endoplasmic Reticulum stress,and inflammasome activation are related to the nutrient excess linking pathogenesis and progression of T2 D with *** paper aims to systematically review the metabolic profile and role of various inflammatory pathways in T2 D by capturing relevant evidence from various *** perspectives include suggestions for the development of therapies involving the shift from metabolic stress to homeostasis that would favour insulin sensitivity and survival of pancreatic β-cells in T2 D.

关键词： Diabetes mellitus Inflammation Insulinresistance β-cell dysfunction Adipose tissue

A Self-test Prediction Model to Determine the Probability Risk of Non-alcoholic Fatty Liver Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2020年第11期33卷 857-861页

作者： LI Qiang SHEN Qun Lun XU Chao Nan LI Ming Liang MA Zhi Min ZHANG Shan CHEN Shuo ZHANG Min Ying ZHANG Jing Bo LIU Feng YANG Xing Hua Beijing Physical Examination Center Beijing 100077China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Medical Engineering department Peking University Third HospitalBeijing 100191China School of Public Health Beijing Municipal Key Laboratory of Clinical EpidemiologyCapital Medical UniversityBeijing 100069China Cente Of Quality Control and Improvement for Physical Check Up Beijing MunicipalityBeijing 100077China School of medicine Nankai UniversityTianjin 300071China

Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease in *** studies have shown that NAFLD is associated with obesity,insulin resistance,type 2 diabetes,hypertension,hyperlipidemia,and metabolic syn... 详细信息

关键词： NAFLD Probability Liver

Recent developments of lactic acid bacteria and their metabolites on foodborne pathogens and spoilage bacteria:Facts and gaps

在线全文

学校读者我要写书评

暂无评论

Food Bioscience 2022年第3期47卷 1312-1329页

作者： Hafize Fidan Tuba Esatbeyoglu Vida Simat Monica Trif Giulia Tabanelli Tina Kostka Chiara Montanari Salam A.Ibrahim FatihÖzogul department of Tourism and Culinary Management University of Food Technologies4002PlovdivBulgaria Institute of Food Science and Human Nutrition Gottfried Wilhelm Leibniz University HannoverAm Kleinen Felde 3030167HannoverGermany university department of Marine Studies University of SplitRuđera Boškovića 3721000SplitCroatia Centre for Innovative Process Engineering (CENTIV) GmbH 28857SykeGermany department of Agricultural and Food Sciences University of Bologna40127BolognaItaly Food Microbiology and Biotechnology Laboratory North Carolina Agricultural and Technical State UniversityGreensboroNC27411USA department of Seafood Processing Technology Faculty of FisheriesCukurova University01330AdanaTurkey

Lactic acid bacteria(LAB)are common microorganisms found in various ecosystems including in plants,fermented foods,and the human *** the biodiversity of lactic acid microflora and characterization of LAB is a new approach to form a variety of starter communities to create innovative nutritional food *** has been growing interest in LAB isolated from non-dairy environments as these bacteria exhibit significant metabolic diversity and have unique taste-forming *** may be prevented,or treated by LAB but the treatment of disease conditions with LAB is highly dependent on the host's microbiome and diet and varies in both effectiveness and side effects from individual to *** perspectives on the study of LAB may be related to the expansion of our knowledge in the fields of genetics and genetic *** application of genetic science may help to improve existing strains and develop new strains with characteristics designed for specific ***,the preservative effects of LAB and their metabolites,as well as their interaction on the growth of food borne pathogens and food spoilage microorganisms were *** addition,the competitive models for microbial growth between LAB and other microorganisms as well as the role of LAB in the elimination of toxic compounds in food products were ***,the review provided an overview of the risks and benefits of using LAB in the food industry.

关键词： Lactic acid bacteria Starter culture Fermented products Food-borne pathogens Microbial interaction

Practical Use of Stairs to Assess Fitness, Prescribe and Perform Physical Activity Training

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2016年第13期8卷 1402-1410页

作者： Jasem Ramadan Al Kandari Salman Mohammad Ruqayyah Al-Hashem Girma Telahoun Mario Barac-Nieto department of Physiology Faculty of Medicine Kuwait University Al-Khaldiya Kuwait department of Physical Education College of Basic Education The Public Authority of Applied Education and Training Adailiyah Kuwait

Aim: Evaluating climbing stairs for prescription and implementation of physical activity regimes. Methods: Healthy females (F, n = 14), and males (M, n = 15) participated. By climbing 100 steps of stairs with 0.173 m height, Heart rate (HR) and oxygen uptake were measured throughout the floors;Blood pressure (BP) was measured at ground and the 5th floors only. Results: Energy increased from 2 to 7.6 was metabolic equivalents (METs = 3.5 ml O2/***) at 17.3 m elevation in 2 min. at the 5th floor, and percent Heart Rate Reserve (%HRR) was 66.17% in F and 48.7% in M, proportional to their aerobic efforts. Average climbing efficiency was 15.8 ± 2.3% (n = 29). Aerobic capacity estimated dividing the highest work rate (17.3 Kg.m/*** × 0.00239 = 0.0207 Kcal/***), by fractional effort (F = 0.6617, M = 0.487) and fractional efficiency (0.158), at 5 Kcal/L O2 was 0.040 in F and 0.054 L O2/*** in M. Minimum training intensity reached at the 3rd floor by F. In M the highest %HRR reached was 48.7% at the 5th floor, insufficient for training. Conclusions: Stairs used for submaximal evaluation of aerobic capacity and for target intensity prescription. Training, levels climbed, repetitions per day (if 5, 100 Kcal per day, ascending) and number of days/week are adjusted. Full regime requires up to 7.6 METs, a total of 532 and 140 ***/week ascending and descending, respectively. Intensities >7.6 MET, climbing rate should be >8.65 m/min. Limiting ascent to 1 (3.5 METs) or 2 (5.5 METs) floors or only descents (2 - 3 METs) may be used for unfit subjects. This method is useful for those with no access to sophisticated facilities.

关键词： Stair Climbing Descent Heart Rate Reserve Aerobic Effort Oxygen Cost Work Output Efficiency Aerobic Capacity Exercise Prescription Training

Intervention of cGAS‒STING signaling in sterile inflammatory diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2022年第2期14卷 1-17页

作者： Ze Hong Jiahao Mei Hanli Guo Juanjuan Zhu Chen Wang State Key Laboratory of Natural medicines Department of Life Science and TechnologyChina Pharmaceutical UniversityNanjing 211198China

Sterile inflammation characterized by unresolved chronic inflammation is well established to promote the progression of multiple autoimmune diseases,metabolic disorders,neurodegenerative diseases,and cardiovascular diseases,collectively termed‘sterile inflammatory diseases’.By recognizing host-derived DNA,cyclic guanosine monophosphate–adenosine monophosphate synthase(cGAS)activates endoplasmic reticulum-associated stimulator of interferon genes(STING),which leads to the induction of type I interferons and inflammatory cytokines or immunogenic cell death that promotes sterile ***,the DNA/cGAS-independent mode of STING activation has also been characterized in the progression of several sterile inflammatory *** review focuses on the molecular mechanism of cGAS-dependent and cGAS-independent STING signaling under various disease conditions,particularly highlighting the diverse initiators upon this signaling *** also summarize recent advances in the discovery of antagonists targeting cGAS and STING and the evaluation of their efficiencies in preclinical ***,we discuss potential differences in the clinical applications of the specific antagonists,which may shed light on the precision therapeutic interventions.

关键词： cGAS STING DNA sterile inflammatory disease antagonist