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Efficacy of acupuncture on cardiovascular complications in patients with diabetes mellitus in Korea:A nationwide retrospective cohort

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Journal of Integrative medicine 2023年第2期21卷 176-183页

作者： Hyejin Jung Tiana Won Ga-Yeon Kim Jowon Jang Sujung Yeo Sabina Lim department of meridian&acupoint College of Korean MedicineKyung Hee UniversitySeoul02447Republic of Korea WHO Collaborating Center for Traditional medicine East-West Medical Research InstituteKyung Hee UniversitySeoul02447Republic of Korea department of meridian and acupoint College of Korean MedicineSang Ji UniversityWonju26339Republic of Korea

Objective The main aim of this study is to investigate whether acupuncture could be an effective complementary treatment for reducing the risk of macrovascular complications in diabetic patients currently taking antidiabetic medications using a nationwide population-based *** We conducted a retrospective cohort study to assess the efficacy of acupuncture on cardiovascular complications in diabetic patients using data from patients between 40 and 79 years of age,newly diagnosed with diabetes between 2003 and 2006,found in the National Health Insurance Service-National Sample Cohort(NHIS-NSC)in *** the data,we identified 21,232 diabetic patients who were taking antidiabetic medication between 2003 and *** selected patients were divided into two groups-those who received acupuncture at least three times and those who received no acupuncture(non-acupuncture)in the year following their diagnosis of *** 1:1 propensity score matching(PSM),each group had 3350 patients,and the observation ceased at the occurrence of a major adverse cardiovascular event(MACE),which was defined as either myocardial infarction,stroke,or death due to cardiovascular *** After PSM,the acupuncture group had a lower incidence of MACE(hazard ratio[HR]:0.87;95%confidence interval[CI]:0.81-0.94;P=0.0003)and all-cause mortality(HR:0.77;95%CI:0.70-0.84;P<0.0001)than the non-acupuncture group;the HRs for stroke-related mortality(HR:0.75;95%CI:0.56-1.00;P=0.0485),ischemic heart disease mortality(HR:0.53;95%CI:0.34-0.84;P=0.006)and circulatory system disease mortality(HR:0.67;95%CI:0.55-0.82;P<0.0001)were lower in the acupuncture group than in the non-acupuncture group in the secondary *** Our results indicate that diabetic patients receiving acupuncture treatment might have a lower risk of MACE,all-cause mortality and cardiovascular *** population-based retrospective study suggests beneficial effects of acupuncture in preventing macro

关键词： Acupuncture Diabetes Major adverse cardiovascular event Myocardial infarction Stroke Macrovascular complication

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Moutan Cortex Radicis inhibits the nigrostriatal damage in a 6-OHDA-induced Parkinson's disease model

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Chinese Journal of Natural medicines 2018年第7期16卷 490-498页

作者： Yeong-Gon Choi Yeon-Mi Hong Li-Hua Kim Sujung Yeo Sabina Lim Laboratory of Neurodegenerative Diseases Ilsong Institute of Life Science Hallym University Research Group of Pain and Neuroscience WHO Collaborating Center for Traditional Medicine East-West Medical Research Institute Kyung Hee University department of Applied Korean medicine College of Korean Medicine Kyung Hee University department of meridian and acupoint College of Korean Medicine Sang Ji University

The traditionally used oriental herbal medicine Moutan Cortex Radicis [MCR; Paeonia Suffruticosa Andrews(Paeoniaceae)] exerts anti-inflammatory, anti-spasmodic, and analgesic effects. In the present study, we investigated the therapeutic effects of differently fractioned MCR extracts in a 6-hydroxydopamine(OHDA)-induced Parkinson's disease model and neuro-blastoma B65 cells. Ethanol-extracted MCR was fractionated by n-hexane, butanol, and distilled water. Adult Sprague-Dawley rats were treated first with 20 μg of 6-OHDA, followed by three MCR extract fractions(100 or 200 mg·kg^(-1)) for 14 consecutive days. In the behavioral rotation experiment, the MCR extract-treated groups showed significantly decreased number of net turns compared with the 6-OHDA control group. The three fractions also significantly inhibited the reduction in tyrosine hydroxylase-positive cells in the substantia nigra pars compacta following 6-OHDA neurotoxicity. Western blotting analysis revealed significantly reduced tyrosine hydroxylase expression in the substantia nigra pars compacta in the 6-OHDA-treated group, which was significantly inhibited by the n-hexane or distilled water fractions of MCR. B65 cells were exposed to the extract fractions for 24 h prior to addition of 6-OHDA for 30 min; treatment with n-hexane or distilled water fractions of MCR reduced apoptotic cell death induced by 6-OHDA neurotoxicity and inhibited nitric oxide production and neuronal nitric oxide synthase expression. These results showed that n-hexane-and distilled water-fractioned MCR extracts inhibited 6-OHDA-induced neurotoxicity by suppressing nitric oxide production and neuronal nitric oxide synthase activity, suggesting that MCR extracts could serve as a novel candidate treatment for the patients with Parkinson's disease.

关键词： Anti-inflammatory agent Neuroblastoma B65 cells 6-Hydroxydopamine Nitric oxide nNOS

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Fruits extracts of Hovenia dulcis *** lipopolysaccharide—stimulated inflammatory responses through nuclear factor—kappaB pathway in Raw 264.7 cells

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Asian Pacific Journal of Tropical medicine 2016年第4期9卷 349-355页

作者： Ju-Yeon Park Jin-Young Moon Sun-Dong Park Won-Hwan Park Hyuck Kim Jai-Eun Kim department of acupoint College of Korean Medicine.Dongguk University department of Prescription College of Korean MedicineDongguk University department of Diagnostics College of Korean Medicine.Dongguk University department of Pathology College of Korean Medicine.Dongguk University

Objective:To investigate the anti-inflammatory effects and the action mechanism of the fruits of Horenia dulcis(***) in lipopolysaccharide(LPS)-induced mouse macrophage Raw ***:The extract of *** fruits(EHDF) were extracted with 70%*** macrophages were treated with different concentrations of EHDF in the presence and absence of LPS(1 μg/mL).To demonstrate the inflammatory mediators including nitric oxide,inducible nitric oxide synthase and cyclooxygenase(COX)-2 expression levels were analyzed by usingin vitro assay ***-derived pro-inflammatory cytokines including interleukin-1 β.tumor necrosis factor- α and prostaglandin F_2 were determined using ELISA *** viability,heme oxygenase-1 expression,nuclear factor-kappaB and nuclear factor F.2-related factors 2 translocation were also ***:EHDF potently inhibited the LPS-stimulated nitric oxide,inducible nitric oxide ***-2,interleukin-1 β and tumor necrosis factor- α expression in a dose-dependent *** suppressed the phosphorylation of inhibited kappaB-alpha and p65 nuclear *** of macrophage cells with EHDF alone induced the heme oxygenase-1 and nuclear translocation of nuclear factor E2-reIated factor ***:These results suggest that the ethanol extract of *** fruit exerts its anti-inflammatory effects by inhibiting inhibited kappaBalpha phorylation and nuclear translocation of nuclear factor-kappaB.

关键词： Fruits of Hovenia dulcis Inflammation Macrophage Nuclear factor-kappaB Heme oxygenase-1

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Effects of Cordyceps militaris extract on angiogenesis and tumor growth

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Acta Pharmacologica Sinica 2004年第5期25卷 115-123页

作者： Hwa-seung YOO,Jang-woo SHIN,Jung-hyo CHO,Chang-gue SON,Yeon-weol LEE,Sang-yong PARK,Chong-kwan CHO Daejeon University Daejeon 301-724 department of East-West Cancer Center college of oriental medicine Daejeon University Daejeon 301-724 department of East-West Cancer Center college of oriental medicine Daejeon University Daejeon 301-724 department of East-West Cancer Center R&D Lab of Bulrolife Co Ltd Daejeon Korea college of oriental medicine Daejeon University Daejeon 301-724 Institute ofTraditional medicine and Bioscience Daejeon University Daejeon 301-724 department of East-West Cancer Center college of oriental medicine

AIM: To evaluate the effects of Cordyceps militaris extract (CME) on angiogenesis and tumor growth. METHODS:Human umbilical vein endothelial cells (HUVEC), HT1080, and B16-F10 cells were used. DNA fragment, angio-genic related gene expressions (MMPs, bFGF, VEGF, etc), capillary tube formation, wound healing in vitro, tumorgrowth in vivo were measured. RESULTS: CME inhibited growth of HUVECs and HT1080 (P<0.01). CME 100and 200 mg/L reduced MMP-2 gene expression in HT1080 cells by 6.0 % and 22.9 % after 3-h and 14.9 % and32.8 % after 6-h treatment. CME did not affect MMP-9 gene expression in B16-F10 melanoma cells. CME 100 and200 mg/L also reduced bFGF gene expression in HUVECs by 22.2 % and 41.3 %. CME inhibited tube formation ofendothelial cells in vitro and in vivo. CME repressed the growth of B16-F10 melanoma cells in mice compared withcontrol group (P<0.05). CONCLUSION: CME has antiangiogenetic properties.

关键词： Cordyceps militaris angiogenesis human umbilical vein endothelial cells HT1080 cells B16-F10cells matrix metalloproteinases basic fibroblast growth factor

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The inhibition effect of Chlorpromazine against the β-lactam resistance of MRSA

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Asian Pacific Journal of Tropical medicine 2016年第6期9卷 526-530页

作者： Ryong Kong Ok-Hwa Kang Yun-Soo Seo Su-Hyun Mun Tian Zhou Dong-Won Shin Dong-Yeul Kwon BK21 Plus Team Professional Graduate School of Oriental Medicine Wonkwang University department of oriental Pharmacy College of Pharmacy Wonkwang Oriental Medicines Research Institute Institute of Biotechnology Wonkwang University department of oriental medicine Resources College of Bio Industry Science Sunchon National University

Objective:To investigate the gene related to β-lactam resistance and to confirm the mechanism about a synergy effect between CPZ and β-lactam ***:To measure antibacterial activity,we performed a minimum inhibitory concentration(MIC) and synergy *** electron microscopy(TEM) was used in morphological *** analyze gene expression,we conducted reverse transcriptase polymerase chain reaction(PCR).Results:We confirmed a synergy effect between CPZ and β-lactam ***,we observed that CPZ affect the cell envelope of MRS A by using *** the gene level,CPZ reduced the expression of resistance ***:Through this result,we hypothesize that a decrease of resistance factor expressions was caused by CPZ because it disrupts the activity of a sensor protein located in the cell membrane.

关键词： Chlorpromazine PBP2a β-lactamase mecA blaZ MRSA

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Multi-omics analysis reveals the neuroprotective effect of Atractylodis Rhizoma Alba extract against Parkinson's disease in mouse

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Journal of Traditional Chinese medicine 2024年第6期44卷 1111-1117页

作者： KANG Sohi LEE Soong-In MOON Byeong Cheol SONG Jun Ho KIM Sung-Ho MOON Changjong LEE Sueun KIM Chul KIM Joong Sun department of Anatomy and Convergence Medical Science College of Medicine Institute of Health SciencesGyeongsang National University college of Veterinary medicine and BK21 FOUR Program Chonnam National University department of oriental medicine Prescription College of Oriental Medicine Dong-Shin University Herbal medicine Resources Research Center Korea Institute of Oriental Medicine department of Biology Chungbuk National University KM Data Division Korea Institute of Oriental Medicine

OBJECTIVE: To assess Atractylodis Rhizoma Alba extract(ARE) neuroprotective function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated mice and related genes. METHODS: Examined m RNA-DNA methylation changes induced by ARE in MPTP-induced Parkinson's disease(PD) model's substantia nigra. RESULTS: ARE mitigated MPTP-induced motor impairment in rotarod and open field tests and preserved tyrosine hydroxylase-positive neuronal cells in substantia nigra and striatum. Genome RNA-Sequencing and Methyl-Sequencing in substantia nigra of vehicle/ARE-treated MPTP-induced PD mice showed 84 differentially expressed genes(DEGs) and 1804 differentially methylated regions(DMRs). Upregulated genes involved zinc ion homeostasis, cilium protein localization, and transcription; downregulated genes linked to ephrin receptor signaling, somitogenesis, and gene expression regulation. Hyper/hypomethylated DMRs post-ARE treatment associated with Wnt signaling, mitochondrial organization, dopamine biosynthesis, and hindbrain development. No significant correlation between DEGs and methylated genes related to PD pathogenesis. CONCLUSION: This research has identified the epigenetic targets of ARE's therapeutic action and gives insight on how ARE protects neurons in Parkinson's disease.

关键词： 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Atractylodis Rhizoma Alba Methyl-seq Parkinson disease nerve degeneration

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A survey on the real-world clinical utilization of a traditional acupuncture in Republic of Korea:Sa-am acupuncture

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Journal of Integrative medicine 2024年第5期22卷 570-578页

作者： Ji-Yeun Park Ye-Seul Lee Hi-Joon Park Seungmin Kathy Lee Ji-Won Lee Song-Yi Kim college of Korean medicine Daejeon UniversityDaejeon 34520Republic of Korea Jaseng Spine and Joint Research Institute Jaseng Medical FoundationSeoul 06110Republic of Korea Acupuncture and meridian Science Research Center Kyung Hee UniversitySeoul 02447Republic of Korea department of Korean medicine Korean Medical CenterLusail 201184Qatar Virginia University of Integrative medicine ViennaVA 22182USA department of Anatomy and acupoint College of Korean MedicineGachon UniversitySeongnamGyeonggi 13120Republic of Korea department of Ophthalmology Otolaryngologyand DermatologyCollege of Korean MedicineDongguk UniversityGoyangGyeonggi 10326Republic of Korea

Objective This study investigated the clinical details and usage of Sa-am acupuncture in Korean medicine clinics and explored how practicing Korean medicine doctors(KMDs)think about Sa-am *** We conducted a questionnaire-based survey of KMDs who utilize Sa-am acupuncture in their *** study comprehensively investigated issues related to clinical application of Sa-am acupuncture,needling techniques used during treatment,training methods,and directions for its future *** We analyzed 572 *** average of 50%of the patients visiting Korean medicine clinics were receiving Sa-am *** most prevalent indication for Sa-am acupuncture use was digestive *** patients’appetite level and digestive function were most frequently used indicators for selecting acupuncture *** prescription compositions,Jung-Gyuk formulas were more frequently used than Seung-Gyuk *** the needle along the flow of the channel or against the flow of the channel was most *** acupuncture style most frequently used in combination with Sa-am acupuncture was Ashi point *** of Sa-am acupuncture included its versatility,easy application,and good *** included the lack of rigorous education and training programs,difficulty in applying the principles for beginners,and insufficient clinical research *** In clinics where Sa-am acupuncture is available,KMDs were providing Sa-am acupuncture to about half of their *** were not using all of the tonification and sedation techniques which may be due to time constraints or simply a lack of ***-am acupuncture demonstrated high utility in clinical practice and high satisfaction based on the efficacy and *** training programs and high-quality research are needed to help expand the use of Sa-am acupuncture.

关键词： Sa-am acupuncture Traditional East Asian medicine Acupuncture education acupoint selection

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Hepatoprotective effect of manual acupuncture at acupoint GB34 against CCl_4-induced chronic liver damage in rats

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World Journal of Gastroenterology 2006年第14期12卷 2245-2249页

作者： Yun-Kyoung Yim Hyun Lee Kwon-Eui Hong Young-Il Kim Byung-Ryul Lee Tae-Han Kim Ji-Young Yi department of meridian & acupoint college of oriental medicine Daejeon University12407 96-3Yongun-dongDong-guDaejeon 300-716South Korea department of Acupuncture & Moxibustion Dunsan oriental Hospital of Daejeon University 1136 Dunsan-dongSeo-guDaejeon 302-122South Korea

AIM： To investigate the hepatoprotective effect of manual acupuncture at Yanglingquan （GB34） on CCl4-induced chronic liver damage in rats. METHODS： Rats were injected intraperitoneally with CCh （1 mL/kg） and treated with manual acupuncture using reinforcing manipulation techniques at left GB34 （Yanglingquan） 3 times a week for 10 wk. A nonacupoint in left gluteal area was selected as a sham point. To estimate the hepatoprotective effect of manual acupuncture at GB34, measurement of liver index, biochemical assays including serum ALT, AST, ALP and total cholesterol, histological analysis and blood cell counts were conducted. RESULTS： Manual acupuncture at GB34 reduced the liver index, serum ALT, AST, ALP and total cholesterol levels as compared with the control group and the sham acupuncture group. It also increased and normalized the populations of WBC and lymphocytes. CONCLUSION： Manual acupuncture with reinforcing manipulation techniques at left GB34 reduces liver toxicity, protects liver function and liver tissue, and normalizes immune activity in CCh-intoxicated rats.

关键词： Manual acupuncture Yanglingquan (GB34) CCl4-induced liver damage Hepatoprotective effect

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Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus

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Asian Pacific Journal of Tropical medicine 2015年第7期8卷 536-540页

作者： Jang-Gi Choi Ji-Young Choi Su-Hyun Mun Ok-Hwa Kang Preeti Bharaj Dong-Won Shin Myong-Soo Chong Dong-Yeul Kwon department of oriental Pharmacy College of Pharmacy Wonkwang University Wonkwang Oriental Medicines Research Institute Center of Excellence in Infectious Disease Research Department of Biomedical Sciences Paul L. Foster School of Medicine Texas Tech University Health Sciences Center department of Third medicine Professional Graduate School of Oriental Medicine Wonkwang University BK21 Plus Team Professional Graduate School of Oriental Medicine Wonkwang University department of oriental medicine Resources Sunchon National University

Objective: To investigate the antibacterial activity of SHHextracted with either water or ethanol against methicillin-resistant Staphylococcus aureus(MRSA) and combinatory antimicrobial effect with ciprofloxacin(CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan(SHH) water extract(SHHW) and SHH ethanol extract(SHHE) ranged from 250 to 2000 μg/m L and 125 to 1000 μg/m L against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.

关键词： Sami-Hyanglyun-Hwan Methicillin-resistant Staphylococcus aureus Ciprofloxacin Synergy

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Potentiating activity of luteolin on membrane permeabilizing agent and ATPase inhibitor against methicillin-resistant Staphylococcus aureus

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Asian Pacific Journal of Tropical medicine 2016年第1期9卷 16-19页

作者： Dae-Ki Joung Young-Seob Lee Sin-Hee Han Sang-Won Lee Seon-Woo Cha Su-Hyun Mun Ryong Kong Ok-Hwa Kang Ho-Jun Song Dong-Won Shin Dong-Yeul Kwon department of oriental Pharmacy College of Pharmacy and Wonkwang-Oriental Medicines Research Institute.Wonkwang University department of Herbal Crop Research National Institute of Horticultural & Herbal ScienceRDA BK21 Plus Team Professional Graduate School of Oriental MedicineWonkwang University department of oriental medicine Resources Sunchon National University

Objective:To investigate the mechanism of antibacterial activity of luteoiin(LUT) against methicillin-resistant Staphylococcus aureus(MRSA).Methods:The mechanism of anti-MRSA activity of LUT was analyzed by the viability assay in membrane permeabilizing agent ATPase inhibitors,and peptidoglycan(PGN) derived from Staphylococcus aureus(***).Also,transmission electron microscopy was used to monitor survival characteristics and changes in *** ***:Compared to the LUT alone,the optical density of suspensions treated with the combination of 125 μg/mL Tris and 230 μg/mL DCCD were reduced to 60%and 46%,***(15.6 μg/mL) gradually impeded the activity of LUT,and PGN(62.5 μg/mL) completely blocked the activity of LUT on ***:Increased susceptibility to LUT with me Tris and DCCD combinations is evident in all tested MRSA *** results indicate LUT synergy in increasing cytoplasmic membrane permeability and inhibiting *** PGN directly blocks the antibacterial activity of LUT,suggesting the direct binding of LUT with *** findings may be validated for the development of antibacterial agent for low MRSA resistance.

关键词： Iuteolin Methicillin-resistant Staphylococcus aureus Membrane permeabilizing agent ATPase inhibitor Peptidoglycan

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