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Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo Wan Tao Wang department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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A review on membrane distillation in process engineering: design and exergy equations, materials and wetting problems

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Frontiers of Chemical Science and Engineering 2022年第5期16卷 592-613页

作者： Stefano Capizzano Mirko Frappa Francesca Macedonio Enrico Drioli Institute of membrane Technology National Research Council of ItalyRende 87036Italy department of Environmental Engineering University of CalabriaRendeItaly Nanjing Tech University College of Chemical EngineeringNanjing 211816China

One of the problems that most afflicts humanity is the lack of clean *** stress,which is the pressure on the quantity and quality of water resources,exists in many places throughout the *** represents a valid solution to the scarcity of fresh water and several technologies are already well applied and successful(such as reverse osmosis),producing about 100 million m^(3)·d^(-1) of fresh *** advances in the field of desalination can be provided by innovative processes such as membrane *** latter is of particular interest for the treatment of waste currents from conventional desalination processes(for example the retentate of reverse osmosis)as it allows to desalt highly concentrated currents as it is not limited by concentration polarization *** perspectives have enhanced research activities and allowed a deeper understanding of mass and heat transport phenomena,membrane wetting,polarization phenomena and have encouraged the use of materials particularly suitable for membrane distillation *** work summarizes recent developments in the field of membrane distillation,studies for module length optimization,commercial membrane modules developed,recent patents and advancement of membrane material.

关键词： membrane distillation recent developments heat and mass transfer wetting membrane material

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Intracellular distribution and internalization pathways of guanidinylated bioresponsive poly(amido amine)s in gene delivery

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Asian Journal of Pharmaceutical Sciences 2018年第4期13卷 360-372页

作者： Jinmina Zhang Chunxi Wang Mei Lu Haonan Xing Tianzhi Yang Cuifang Cai Xiaoyun Zhao Minjie Wei Jiankun Yu Pingtian Ding School of Pharmacy Shenyang Pharmaceutical University department of Basic Pharmaceutical Sciences School of PharmacyHusson University department of Microbiology and Cell Biology School of life Science and BiopharmaceuticsShenyang Pharmaceutical University department of Pharmacology School of PharmacyChina Medical University department of Ion Channel Pharmacology School of PharmacyChina Medical University

Guanidinylated bioresponsive poly(amido amine)s polymers, CAR-CBA and CHL-CBA, weresynthesized by Michael-type addition reaction between guanidine hydrochloride(CAR) orchlorhexidine(CHL) and N,N-cystaminebisacrylamide(CBA). Previous studies have shownthat both polymers had high transfection efficiencies as gene delivery carriers. In this study,we investigated the nucleolus localization abilities and cellular internalization pathways ofthese two polymers in gene delivery. Each polymer condensed plasmid DNA(p DNA) andformed nanoparticle complexes, and then their transfection studies were performed inMCF-7 cells. Both complexes were found enriched in nucleolus after cellular transfection,and their transfection efficiencies were significantly improved when transfection was per-formed on MCF-7 cells arrested at M phase. The transfection efficiency of CAR-CBA-pDNAwas inhibited by chlorpromazine, and cell endosomes were disrupted after being exposedto CAR-CBA-pDNA. In regards to CHL-CBA-pDNA, its transfection efficiency was not affected by three types of endocytosis inhibitors used in the study, and CHL-CBA-pDNA showed no effect on endosomes. Cellular lactate dehydrogenase release and membrane morphology were changed after cells were transfected by the two complexes. The results indicated that both CAR-CBA and CHL-CBA polymers demonstrated good nucleolus localization abilities. It was beneficial for transfection when cells were arrested at M phase. CAR-CBA-pDNA cellular internalization was involved with clathrin-mediated endocytosis pathway, and escaping from endosomal entrapment, while the cellular uptake of CHL-CBA-pDNA occurs via clathrin-and caveolae-independent mechanism.

关键词： Guanidinylated poly(amido amine)s polymers Nucleolus localization Cell cycle status Internalization pathways

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Thermodynamic and transport properties of spiro-(1,1')-bipyrrolidinium tetrafluoroborate and acetonitrile mixtures:A molecular dynamics study

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Chinese Physics B 2016年第6期25卷 317-324页

作者：张庆印谢鹏王欣于学文时志强赵世怀 The State Key Laboratory of Separation membranes and membrane Processes Department of Chemical EngineeringTianjin Polytechnic University Laboratory of Chemical Engineering Thermodynamics Department of Chemical EngineeringTsinghua University Laboratory of Fiber Modification and Functional Fiber College of Materials Science and EngineeringTianjin Polytechnic University

Organic salts such as spiro-（1,1’）-bipyrrolidinium tetrafluoroborate（[SBP][BF4]） dissolved in liquid acetonitrile（ACN） are a new kind of organic salt solution,which is expected to be used as an electrolyte in electrical double layer capacitors（EDLCs）.To explore the physicochemical properties of the solution,an all-atom force field is established on the basis of AMBER parameter values and quantum mechanical *** dynamics（MD） simulations are carried out to explore the liquid structure and physicochemical properties of [SBP][BF4] electrolyte at room *** computed thermodynamic and transport properties match the available experimental results very *** microscopic structures of [SBP][BF4] salt solution are also discussed in *** method used in this work provides an efficient way of predicting the properties of organic salt solvent as an electrolyte in EDLCs.

关键词： electrolyte self-diffusion viscosity molecular dynamics

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Study on Regeneration of MDEA Solution Using membrane Distillation

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China Petroleum Processing & Petrochemical Technology 2008年第4期10卷 45-51页

作者： Cai Pei Wang Shuli Zhao Shuhua Jiangsu Key Laboratory of Oil and Gas Storage and transport Technology Changzhou 213016 China department of Science and Technology Jiangsu Polytechnic University Changzhou 213016 China

Treating acid gases contained in natural gas by MDEA is used widely. But the efficiency of regeneration of the MDEA solution limited the development of this technology. An optimal temperature is necessary for regeneration of the MDEA solution using membrane distillation. The experiment results showed that the regeneration rate of MDEA rose with an increasing temperature. But the rate increased slowly after the regeneration temperature arrived at a certain value. This study can confirm that regeneration of the MDEA solution using membrane distillation is feasible. This technology provides more advantages as compared to conventional regeneration process.

关键词： membrane distillation regeneration MDEA solution

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Designing metal-organic framework fiber network reinforced polymer electrolytes to provide continuous ion transport in solid state lithium metal batteries

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Nano Research 2024年第4期17卷 2719-2727页

作者： Wanqing Fan Ying Huang Meng Yu Kaihang She Jingren Gou Zheng Zhang MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary Conditions School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Beijing Key Laboratory of membrane Materials and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Polyethylene oxide(PEO)-based solid-state electrolytes are considered ideal for electrolyte materials in solid-state lithium metal batteries(SSLMBs).However,practical applications are hindered by the lower conductivity and poor interfacial ***,we propose a strategy to construct a three-dimensional(3D)fiber network of metal-organic frameworks(MOFs).Composite solid electrolytes(CSEs)with continuous ion transport pathways were fabricated by filling a PEO polymer matrix in fibers containing interconnected *** 3D fiber network provides a fast Li+transport path and effectively improves the ionic conductivity(1.36×10^(-4) S·cm^(-1),30℃).In addition,the network of interconnected MOFs not only effectively traps the anions,but also provides sufficient mechanical strength to prevent the growth of Li *** from the advantages of structural design,the CSEs stabilize the Li/electrolyte interface and extend the cycle life of the Li-symmetric cells to 3000 *** assembled SSLMBs exhibit excellent cycling performance at both room and high *** addition,the constructed pouch cells can provide an areal capacity of 0.62 mA·h·cm^(-2),which can still operate under extreme *** work provides a new strategy for the design of CSEs with continuous structure and stable operation of SSLMBs.

关键词： polyethylene oxide(PEO) solid-state lithium metal batteries(SSLMBs) three-dimensional fiber network composite solid electrolytes(CSEs)

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Copolymer-assisted Polypropylene Separator for Fast and Uniform Lithium Ion transport in Lithium-ion Batteries

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Chinese Journal of Polymer Science 2020年第12期38卷 1313-1324页

作者： Yan Yan Qing-Ran Kong Chuang-Chao Sun Jia-Jia Yuan Zheng Huang Li-Feng Fang Bao-Ku Zhua You-Zhi Song Key Laboratory of Macromolecule Synthesis and Functionalization(Ministry of Education) ERC of Membrane and Water Treatment(Ministry of Education)Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Institute ofNuclear and New Energy Technology Tsinghua UniversityBeijing W0084China

In lithium-ion batteries(LIBs),separators play a vital role in lithium-ion(Li+)transport,and thus affect rate performance,battery life,and ***,a new kind of multifunctional copolymer poly(acrylonitrile-co-lithium acrylate-co-butyl acrylate)(PAAB-Li)is synthesized through soap-free emulsion polymerization,and is used to form homogeneous-covered separator based on PP matrix by a simple dip-annealing *** to the bare PP separator,the modified separators with PAAB-Li enable higher ionic conductivity,higher lithium ion transference number(increased from 0.360 to 0.525),and lower interface impedance(reduced from 155Ω to 34Ω).It has been indicated that PAAB-Li functional layer significantly promotes the fast transport of Li+and improves the compatibility of the separator/electrolyte-electrode *** LiCo02/graphite cells with the PAAB-Li-assisted separator demonstrate excellent cycle stability and rate *** addition,the Li symmetric cells with the modified separator stably cycle over 800 h,indicating the functional layer effectively suppresses the lithium dendrite *** facile strategy can be easily applied to LIBs requiring high safety and even be scalable to Li metal ***,the possible mechanism of the PAAB-Li functional layer promoting fast and uniform Li+transport is discussed in this paper.

关键词： Polyelectrolytes Polypropylene separator Lithium ion transport Dendrite-free Lithium-ion battery

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Graphene-based membranes for pervaporation processes

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Chinese Journal of Chemical Engineering 2020年第7期28卷 1755-1766页

作者： Kecheng Guan Gongping Liu Hideto Matsuyama Wanqin Jin State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Research Center for membrane and Film Technology Department of Chemical Science and EngineeringKobe University1-1 RokkodaiNadaKobe 657-8501Japan

Two-dimensional graphene and its derivatives exhibiting distinct physiochemical properties are intriguing building blocks for researchers from a large variety of scientific *** graphene-based materials into membrane layers brings great potentials for high-efficiency membrane ***,pervaporation by graphene-based membranes has been intensively studied with respect to the membrane design and *** review aims to provide an overview on the graphene-based membranes for pervaporation processes ranged from fabrication to *** or chemical decoration of graphene-based materials is elaborated regarding their effects on the microstructure and *** mass transport of pervaporation through graphene-based membranes is introduced,and relevant mechanisms are ***,performances of state-of-the-art graphene-based membranes for different pervaporation applications are ***,the perspectives of current challenges and future directions are presented.

关键词： Graphene membranes Separation Pervaporation

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A Matthew MXene(Ti_(3)C_(2)T_(x))Lamellar membrane as a Potassium-Sieving Amplifier

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Engineering 2024年第11期42卷 213-222页

作者： Zong Lu Haoyu Wu Yanying Wei Haihui Wang School of Chemistry and Chemical Engineering&Guangdong Provincial Key Lab of Green Chemical Product Technology&State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China Beijing Key Laboratory for membrane Materials and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

transport channels with ultrahigh K^(+)selectivity over other ions play a crucial role for living beings,but constructing ionic channels with promising K^(+)selectivity and permeability remains a ***,an asymmetric bilayer membrane based on MXene(Ti 3C2Tx)lamellar channels consisting of a recognition layer(RL)on top of an enhancement layer(EL)exhibits an amazing Matthew effect:amplification of the preferred transport of K^(+),resulting in an excellent K^(+)-separation *** K^(+)ion is selected by the 1-aza-18-crown-6 ether-modified RL,owing to preferential affinity energy,and then rapidly trans-ported as a hydrated ion through the EL,based on the confinement *** undesired ions such as Na^(+)are hindered from entering the RL by the preferred K^(+)occupation of the crown *** MXene(Ti_(3)C_(2)T_(x))-based Matthew membrane presents high K^(+)-permeation rates of 0.1-0.2 mol∙m2∙h1,with a significant K^(+)/Na^(+)selectivity of *** molecular separation mechanism of the Matthew membrane is investigated deeply to explore the nature of the Matthew amplification effect on K^(+)sieving,where the precise matching of the RL and EL within the membrane governs the fast K^(+)permeation with good *** asymmetric structure of our Matthew membrane is the key to understanding the biolog-ical function of ion channels for precise and fast ion transport,which will guide us in the creation of arti-ficial ion channels or membranes.

关键词： MXene(Ti_(3)C_(2)T_(x))membrane membrane separation Ion sieving K^(+)selectivity

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