检索结果-南通市图书馆

Hepatitis B virus infection and metabolic dysfunction associated steatotic liver disease:Rising pandemic with complex interaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2025年第1期17卷 172-175页

作者： Ammara A Majeed Amna S Butt department of medicine Aga Khan University HospitalKarachi 74800Pakistan

Due to sedentary lifestyle and rising prevalence of obesity,patients with general population and those who are infected with chronic hepatitis B are found to have metabolic dysfunction associated steatotic liver disease(MASLD).Both chronic hepatitis B virus(HBV)infection and MASLD can damage hepatocytes in their own way,but concomitant HBV-MASLD has its own clinical *** on top is the presence of diabetes mellitus,hypertension or obesity which added more chances of unfavorable outcomes in these *** this article,we co-mment on the article by Wang et al published in the recent *** article provides a comprehensive overview of the complex interaction between HBV-MASLD,HBV alone and MASLD alone *** discuss key findings from recent studies,including the promising outcomes observed in patients with concurrent HBV and MASLD,warrants further *** insights presented here offer renewed understanding of this complex interaction.

关键词： Chronic hepatitis B virus infection Obesity Metabolic syndrome Liver fibrosis Steatotic liver disease

Rising incidence of acute hepatitis A among adults and clinical characteristics in a tertiary care center of Pakistan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Virology 2025年第1期14卷 73-82页

作者： Yumna Shahid Amna Subhan Butt Iqra Jamali Faisal Wasim Ismail Division of Gastroenterology Department of MedicineAga Khan University HospitalKarachi 74800Pakistan department of medicine Aga Khan University HospitalKarachi 74800Pakistan

BACKGROUND For decades,hepatitis A virus(HAV)has been a leading cause of acute hepatitis among children and was less prevalent among ***,recently a paradigm shift has been observed in the epidemiology of HAV,as evident by cases of acute hepatitis due to HAV among *** To estimate frequency of HAV in acute viral hepatitis and compare characteristics in HAV and hepatitis E virus(HEV)*** This was a trend analysis conducted at aga khan university hospital Karachi(Sindh,Pakistan)from February 2024 to May *** aged 18 years and older diagnosed with acute viral hepatitis attributed to hepatotropic viruses in 2024 were *** compare the trend patients admitted with acute hepatitis during 2019-2023 were also *** regarding clinical and laboratory parameters were *** yearly trend of acute hepatitis due to HAV and HEV was analyzed,and comparative analysis was done between HAV and HEV cases among *** A total of 396 patients were found to have acute hepatitis during our study *** was diagnosed in 234 patients(59%)while 157 patients(39.6%)were found to have acute HEV ***,acute hepatitis B virus infection was identified in 3 patients(0.7%),whereas acute hepatitis C virus infection was found in 2(0.5%)cases of acute *** trends showed increasing occurrence of HAV infection among adults over last 5 *** patients with acute HAV were younger than patients with HEV(28 years±8 years vs 30 years±8 years;P<0.01).Higher levels of total bilirubin were seen in HEV infection,while higher levels of alanine transaminase were seen in HAV ***,a higher proportion of acute liver failure(ALF),coagulopathy,and mortality were observed in *** An increase in acute hepatitis A cases among adults shows less severity than hepatitis E,highlighting the need for better sanitation,hygiene,and adult hepatitis A vaccination programs.

关键词： Acute hepatitis Hepatitis A virus Hepatitis E virus Acute liver failure Hepatotropic virus Vaccination

Spectrum of venous thromboembolism in adult patients with ulcerative colitis in Pakistan:A single center retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第6期13卷 9-13页

作者： Masood Muhammad Karim Hafsa Shaikh Faisal Wasim Ismail department of medicine The Aga Khan University HospitalKarachi 74800Pakistan department of General Surgery The Aga Khan University HospitalKarachi 74800Pakistan

BACKGROUND Patients with inflammatory bowel disease are at a 2-8-fold higher risk of deve-loping venous thromboembolism(VTE)as compared to the general *** the exact pathogenesis is unclear,the literature suggests that increased risk of thromboembolic events in such patients occurs as a result of increased coagulation factors,inflammatory cytokines,and reduction in anticoagulants leading to a prothrombotic *** To assess the prevalence,risk factors,management,and outcome of ulcerative colitis(UC)patients who develop *** This was a retrospective chart review done in The Gastroenterology department of The aga khan university *** was collected from medical records for all patients admitted with a diagnosis of UC from January 2012 to December *** Seventy-four patients fulfilled the inclusion *** mean±SD of age at presentation of all UC patients was 45 years±10 years whereas for those who developed VTE,it was 47.6 years±14.7 *** and diabetes were the most common co-morbid seen among UC patients with a frequency of 17(22.9%)and 12(16.2%),respectively.A total of 5(6.7%)patients developed *** venous thrombosis was the most common thromboembolic phenomenon seen in 3(60%)*** the patients with UC and concomitant VTE were discharged home(5;100%).CONCLUSION The prevalence of VTE with UC in Pakistani patients corresponds with the international ***,multi-centric studies are required to further explore these results.

关键词： Deep venous thrombosis Inflammatory bowel disease Low-middle-income country Anticoagulation Protein C deficiency

Antidepressive and anxiolytic effects of a combination of Saffron and Chamomile in rats and their relationship with serotonin using in vivo methods

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese medicine 2025年第1期45卷 49-56页

作者： Faiq Amin Saara Ahmad Muhammad Wasim Asra khan Fazal Manzoor Arain Zehra Batool Saiqa Tabassum Saima Khaliq Noreen Samad Saida Haider department of Biological and Biomedical Sciences the Aga Khan University Maternal and Children's Health Research Institute Shunde Women and Children's HospitalGuangdong Medical University Dr.Panjwani Center for Molecular medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of Karachi department of Biosciences Shaheed Zulfikar Ali Bhutto Institute of Science and Technology department of Biochemistry Federal Urdu University of ScienceArts and Technology department of Biochemistry Bahauddin Zakariya University department of Biochemistry University of Karachi

OBJECTIVE: To explore the potential of combining natural herbs like chamomile and saffron for the management of anxiety and depression. METHODS: A rodent model of Major Depressive Disorder(MDD) and anxiety, secondary to streptozotocin-induced diabetes mellitus was made. A total of 6 rat groups were chosen; healthy and diseased controls; and diseased test groups of fluoxetine, saffron, chamomile, and combined saffron and chamomile treated(n = 6/group). Activity by forced swim test(FST), elevated plus maze test(EPMT), and correlations with biochemical markers like serum glucose, tryptophan, C-reactive protein(CRP), brain derived neurotrophic factor(BDNF) and 5-hydroxytryptamine 2C receptor(5HT2CR) expression, were assessed at the end of the 3rd week of the treatment. A one-way analysis of variance with a post-hoc Tukey's test was applied. RESULTS: The combined herbal treatment group showed significantly better(P < 0.05) than all other groups in terms of anti-hyperglycemic effect. All treatments improved the CRP levels; however, the combination group was also significantly better than fluoxetine and the individual herb groups. Only the herb groups showed efficacy in the FST with added benefits of the combination group over the healthy controls and similar trends in the EPMT. However, expression of 5HT2CR was repressed while BDNF was elevated through treatment. CONCLUSION: This study shows that in comparison to treatment with a SSRI, and individual herbs, the combination of chamomile and saffron showed overall improved outcomes.

关键词： chamomile crocus depression diabetes mellitus

Therapeutic potential of Carum carvi in depression,memory loss,and hippocampal sclerosis reversal in temporal lobe epilepsy

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Traditional medicine Research 2025年第3期10卷 1-7页

作者： Muhammad Wasim Syeda Arfa Mairaj Hasan Salman Siddiqi Mahwish Fatima Saara Ahmad Fazal Manzoor Arain department of Biological and Biomedical Sciences The Aga Khan UniversityKarachi 74800Pakistan Maternal and Children's Health Research Institute Shunde Women and Children's HospitalGuangdong Medical UniversityFoshan 528300China

Background:Epilepsy is a disease characterized by unprovoked seizures,and it affects around 70 million people *** treatment is ineffective in one third of all epilepsy *** Lobe Epilepsy with Hippocampal Sclerosis(TLE-HS)is the most drug-resistant form of epilepsy,and it also impacts physical,mental,and psychological well-being of *** carvi extract has demonstrated anti-convulsant,anti-depressant,and anxiolytic *** study was designed to investigate if Carum carvi extract can alleviate depression and memory loss symptoms in a TLE-HS animal ***:Male Sprague Dawley rats were used to create a model of TLE-HS and Carum carvi extract treatment,along with appropriate controls,was used to test the efficacy of this herbal extract in reducing the symptoms of depression and memory ***:Forced swim test showed that Carum carvi extract treated TLE-HS rats resulted in significant improvement of the symptoms of ***,novel object recognition test showed that memory improvement did not ***:Depression significantly impacts the quality of life in TLE-HS patients,and this study has shown that Carum carvi extract should be explored further as an adjuvant treatment for TLE-HS patients to improve their quality of life.

关键词： epilepsy Carum carvi depression memory loss hippocampal sclerosis

Safety and efficacy of sodium bicarbonate for treating metabolic acidosis in chronic kidney disease:A systematic review and metaanalysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Nephrology 2025年第1期14卷 138-148页

作者： Abdul Hannan Siddiqui Fizzah Batool Shayan khan Syed Shabbeer Rizvi Saad Usman Huzaifa Jawed Muhammad Hammad Ali Tatheer Zehra Abdul Rafay Adil Masifah Anwar Areeba Hanif Saad Khalid Hassan Mark William Noble Abdul Moeed Salim Surani department of Internal medicine Dow University of Health SciencesKarachi 74200SindhPakistan department of Internal medicine United Medical and Dental CollegeKarachi 74200SindhPakistan department of Internal medicine Jinnah Sindh Medical UniversityKarachi 74200SindhPakistan department of Internal medicine Karachi Medical and Dental CollegeKarachi 74200SindhPakistan department of Internal medicine Jinnah Medical and Dental CollegeKarachi 74200SindhPakistan department of medicine Kings College Hospital LondonDubai 25314DubayyUnited Arab Emirates department of medicine and Pharmacology Texas A and M UniversityCollege StationTX 77843United States

BACKGROUND Kidney dysfunction and reduced filtration capacity due to chronic kidney disease(CKD)lead to a shift in the body's acid-base balance,ultimately causing metabolic acidosis(MA).Sodium bicarbonate has been used as a supplement to alleviate the symptoms and reverse the acidosis,and it may even slow the progression of ***,its safety profile and overall effectiveness are *** To conduct a systematic review and meta-analysis of clinical trials assessing sodium bicarbonate's safety and efficacy for treating CKD-induced *** Medline,Scopus,EMBASE,and Cochrane Central were systematically searched from inception until May 2024 to select all relevant randomized control trials(RCTs)and non-RCT(NRCTs)evaluating the effectiveness of sodium bicarbonate in correcting MA in end-stage renal disease *** addition,***,***,and Google Scholar were searched for other literature.A random-effects meta-analysis was performed to derive mean differences(MD)and risk ratios(RR)with their 95%CI for continuous and dichotomous outcomes *** Following a systematic search of the databases,20 RCTs and 2 and NRCTs comprising 2932 patients were included in our *** results revealed that sodium bicarbonate significantly increased serum bicarbonate in CKD patients(MD:2.59,95%CI:0.95-4.22;P=0.02;I2=95%).However,there was a non-significant increase in estimated glomerular filtration rate(eGFR)in patients on sodium bicarbonate therapy(MD:0.93,95%CI:-1.88-3.75;P=0.52;I2=93%).Upon assessment of the safety profile of sodium bicarbonate,no significant association was found in the outcomes of death/prolonged hospitalization(RR:1.05,95%CI:0.84-1.32;P=0.66;I2=0%),or gastrointestinal disorders(RR:1.64,95%CI:0.35-7.66;P=0.53;I2=76%),or worsening edema(RR:1.26,95%CI:0.94-1.68;P=0.12;I2=37%)when compared to *** Sodium bicarbonate therapy may halt worsening kidney function by correcting serum bicarbonate levels and treatin

关键词： Chronic kidney disease Metabolic acidosis Safety and efficacy Sodium bicarbonate

Validating a point of care lactate meter in adult patients with sepsis presenting to the emergency department of a tertiary care hospital of a low-to middle-income country

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Emergency medicine 2017年第3期8卷 184-189页

作者： Muhammad Akbar Baig Hira Shahzad Erfan Hussain Asad Mian department of Emergency medicine Aga Khan University Hospital department of medicine Aga Khan University Hospital Adult Critical Care Services Aga Khan University Hospital department of Emergency medicine Pediatrics and Child Health Aga Khan University Hospital

BACKGROUND: Timely identifi cation of high blood lactate levels in septic patients may allow faster detection of those patients requiring immediate resuscitation. Point-of-care(POC) testing is being increasingly utilized in the emergency department(ED). We examined the accuracy and timesaving effect of a handheld POC lactate device for the measurement of fingertip and whole blood lactate as compared with reference laboratory blood testing in septic ED ***: A convenience sample of adult ED patients receiving serum lactate testing were enrolled prospectively in the ED of a multidisciplinary tertiary care hospital serving the population of one of the major cities of Pakistan. Participants underwent fi ngertip POC lactate measurement with a portable device and simultaneous whole blood sampling for analysis by both the POC lactate device and standard laboratory method. Lactate measurements were compared by intraclass correlation(ICC) and Bland and Altman ***: Forty-three septic patients were included in the study. The fingertip POC & whole blood POC lactate measurements each correlated tightly with the reference method(ICC=0.93 & ICC=0.92, respectively). Similarly at 6 hours, the fingertip POC & whole blood POC lactate measurements demonstrated satisfactory correlation with the reference method(ICC=0.95 & ICC=0.97, respectively).CONCLUSION: Fingertip POC lactate measurement is an accurate method to determine lactate levels in septic ED *** WORDS: Sepsis; Point of care; Lactate; Emergency department;

关键词： Sepsis Point of care Lactate Emergency department Pakistan

W_(18)O_(49)Crystal and ICG Labeled Macrophage:An Efficient Targeting Vector for Fluorescence Imagingguided Photothermal Therapy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2025年第1期38卷 100-105页

作者： Yang Bai Guoqing Feng Muskan Saif khan Qingbin Yang Tingting Hua Haolin Guo Yuan Liu Bowen Li Yiwen Wu Bin Zheng Niansong Qian Qing Yuan department of Stomatology Tianjin Medical University General HospitalHeping DistrictTianjin 300052China Academy of Medical Engineering and Translational medicine Tianjin UniversityTianjin 300072China School of Traditional Chinese medicine Beijing University of Chinese MedicineBeijing 102401China Tianjin Anding hospital Tianjin 300222China Beijing National Day School Beijing 100000China department of Respiratory the Eighth Medical Center of Chinese PLA General HospitalBeijing 100853China department of Urology The Third Medical CenterChinese People’s Liberation Army(PLA)General HospitalBeijing 100853China

Photothermal therapy(PTT)uses heat generated by photothermal agents to efficiently kill cancer cells in the least invasive *** nanoparticles,such as precious metals and carbon nanoparticles,have been extensively studied for their ability to convert near-infrared(NIR)light(700-900 nm)into heat[1].However,these nanoparticles are easily captured by the reticuloendothelial system,which severely limits their clinical applications[2].Despite targeted and stealth modifications,these issues remain unresolved;therefore,researchers are seeking more effective methods.

关键词： seeking thermal spite

Metabolic dysfunction-associated fatty liver disease and low muscle strength: A comment

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第17期30卷 2371-2373页

作者： Masood Muhammad Karim Amna Subhan Butt department of Gastroenterology The Aga Khan University HospitalKarachi 74800SindhPakistan department of medicine Aga Khan University HospitalKarachi 74800Pakistan

The diagnosis of non-alcoholic fatty liver disease(NAFLD)and metabolic dysfunction-associated fatty liver disease only on the basis of laboratory parameter score such as Hepatic Steatosis Index which includes liver enzymes,gender,basal metabolic index,and presence of diabetic mellitus is not sufficient to exclude other causes of deranged liver enzymes especially medications and autoimmune related liver *** the guideline suggests ultrasound is the preferred first-line diagnostic procedure for imaging of NAFLD,as it provides additional diagnostic information and the combination of biomarkers/scores and transient elastography might confer additional diagnostic accuracy and evident from previous similar studies too.

关键词： Non-alcoholic fatty liver disease Metabolic dysfunction associated fatty liver disease Low muscle strength Hepatic Steatosis Index Letter to the editor