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Biodesign Research to Advance the Principles and Applications of Biosystems Design

BioDesign Research 2019年第1期2019卷 1-4页

作者： Xiaohan Yang Lei S.Qi Alfonso Jaramillo Zong-Ming(Max)Cheng Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTN 37831USA department of Bioengineering Stanford UniversityStanfordCA 94305USA department of Chemical and Systems Biology Stanford UniversityStanfordCA 94305USA Stanford ChEM-H Stanford UniversityStanfordCA 94305USA Warwick Integrative Synthetic Biology Centre(WISB)and School of Life sciences University of WarwickCV47AL CoventryUK ISSB CNRSUniv EvryCEAUniversitéParis-Saclay91025 EvryFrance Institute for Integrative Systems Biology(I2SysBio) University of Valencia-CSIC46980 PaternaSpain department of Plant sciences University of TennesseeKnoxvilleTN 37996USA Nanjing Agricultural University NanjingJiangsu ProvinceChina

Over the course of civilization,humans have increasingly expanded their freedom to live a better *** comparison with the primitive society,our modern society has many more choices of life-supporting resources,such as yearround food supply,permanent shelters,diverse energy sources,and effective preventive and curing ***,our society is currently still heavily relying on the resources provided by Mother Nature,which cannot meet the future global needs in terms of both quantity and quality under the pressure of population growth,natural resource reduction,and environmental *** example,the food sources originating from plants,animals,or microbes do not have the nutrition balance for optimal human health[1–3].Climate change and environmental deterioration threaten the food security[4–6].Increasingly,infectious diseases(e.g.,HIV/AIDS),genetic diseases(e.g.,cancer),and improper lifestyle-related disorders(e.g.,obesity)become more prevalent and remain challenging to be prevented,controlled,and *** medical technologies and modern medicine development are also meeting the ceiling.

关键词： expanded supporting deterioration

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脑卒中后计算机化认知评估与康复系统的现状及研究进展

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机器人外科学杂志（中英文） 2021年第3期2卷 220-224页

作者：陈安天王晨雨刘威刘欣郑斌段晓琴中国医学科学院北京协和医学院北京协和医院心内科北京100730 德克萨斯大学奥斯汀分校计算机科学学院奥斯汀TX 78705美国吉林大学第二医院康复医学科吉林长春130041 北京科技大学计算机与通信工程学院北京100083 加拿大阿尔伯塔大学医学与牙学院外科仿真研究实验室埃德蒙顿T6G 2E1加拿大

认知障碍是脑卒中患者的严重症状之一。传统的认知评估方法主要基于认知量表,认知的恢复有赖于传统意义上的认知功能训练。但传统方法存在着数据不易整理、效率较低、康复训练受人员及场所限制等问题。近年来,计算机技术的发展使得计算... 详细信息

认知障碍是脑卒中患者的严重症状之一。传统的认知评估方法主要基于认知量表,认知的恢复有赖于传统意义上的认知功能训练。但传统方法存在着数据不易整理、效率较低、康复训练受人员及场所限制等问题。近年来,计算机技术的发展使得计算机化的认知评估及康复训练成为了可能。本文旨在对认知评估的发展及脑卒中后计算机化认知评估、康复训练进行综述。

关键词：卒中计算机化认知评估康复

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Skin models of cutaneous toxicity,transdermal transport and wound repair

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Burns & Trauma 2023年第1期11卷 393-407页

作者： Inês Vilela de Sousa Miguel J.S.ferreira Luís B.Bebiano Sandra Simões Ana filipa Matos Rúben f.Pereira Pedro L.granja i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoRua Dr.Manuel Pereira da Silva4200-393 PortoPortugal INEB-Instituto de Engenharia Biomédica Universidade do PortoRua do Campo Alegre8234150-180 PortoPortugal ICBAS-Instituto de Ciências Biomédicas Abel Salazar Universidade do PortoRua de Jorge Viterbo Ferreira 2284050-313 PortoPortugal fEUP-faculdade de Engenharia da Universidade do Porto Rua Dr.Roberto Frias4200-465 PortoPortugal department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringFaculty of Science and Engineering&Henry Royce InstituteEngineering Building AThe University of ManchesterOxford RoadManchester M139PLUK ISEP-Instituto Superior de Engenharia do Porto Universidade do PortoRua Dr.António Bernardino de Almeida 4314200-072 PortoPortugal iMed.ULisboa Faculty of PharmacyUniversidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal faculty of Pharmacy Universidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal

Skin is widely used as a drug delivery route due to its easy access and the possibility of using relatively painless methods for the administration of bioactive ***,the barrier properties of the skin,along with its multilayer structure,impose severe restrictions on drug transport and ***,bioengineered models aimed at emulating the skin have been developed not only for optimizing the transdermal transport of different drugs and testing the safety and toxicity of substances but also for understanding the biological processes behind skin *** though in vivo research is often preferred to study biological processes involving the skin,in vitro and ex vivo strategies have been gaining increasing relevance in recent ***,there is a noticeably increasing adoption of in vitro and ex vivo methods by internationally accepted ***,microfluidic organ-on-a-chip devices are nowadays emerging as valuable tools for functional and behavioural skin *** in miniaturization,automation and reliability still need to be addressed in order to create skin models that can predict skin behaviour in a robust,high-throughput manner,while being compliant with regulatory issues,standards and *** this review,skin models for transdermal transport,wound repair and cutaneous toxicity will be discussed with a focus on high-throughput *** microfluidic strategies driven by advancements in microfabrication technologies will also be revised as a way to improve the efficiency of existing models,both in terms of complexity and throughput.

关键词： Skin In vitro models Ex vivo models Transdermal transport assays Wound healing assays Toxicity assays Microfluidic chip Skin-on-a-chip

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