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医用生物力学 2013年第S1期28卷 89-90页

作者： Xiaoli Xu Hui Xue Weijuan Yao Zhu Zeng department of Biotechnology School of Medical BioengineeringGuiyang Medical College department of Biophysics Health Science CenterPeking University

Tumor microenvironment is composed of the tumor cells,stromal cells,microvascular tissue fluid,constitute small amount of infiltrating cells and *** recent years,more and more evidence that tumor microenvironment play an important role in *** cells,immune cells and other mesenchymal cells interact and create an immunosuppressive microenvironment through a variety of immunosuppressive factors which vascular endothelial growth factor（VEGF）,transformed growth factor-β1（TGF-β1）and interleukin-10（IL-10）),which suppress immunology functions and promote tumor cells to escape immune surveillance,ultimately leading to tumor growth and *** cells（DCs）,the most potent antigen presenting cell as now known,play a key role in the anti-tumor immune *** pre-

关键词： Interleukin microvascular infiltrating immunology interleukin surveillance cytokines ultimately suppress mature

Inhibitory Effect of Recombinant IL-25 on the Development of Dextran Sulfate Sodium-Induced Experimental Colitis in Mice

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Cellular & Molecular Immunology 2008年第6期5卷 425-431页

作者： S.S. Salum Mchenga department of Immunology College of Basic Medical Science China Medical University

The role of interleukin 25 （IL-25） in a number of human diseases still has not been extensively studied, here we attempt to evaluate the role of recombinant IL-25 （rIL-25） in the development of dextran sulfate sodium （DSS）- induced experimental colitis. Acute colitis was induced in female C57BL/6 mice by oral administration of 2.5% DSS in drinking water ad libitum. At the same time as the start of DSS exposure, mice were injected intraperitoneally with 0.4 ＋tg of rIL-25 or PBS. Then disease activity index （DAI）, histological changes and survival rate were observed. The levels of IL-17, IL-23, and TGF-β1 in colon tissues were determined by ELISA, and the production of IL-17 by CD4＋/CD8＋ T cells was detected by intracellular flow cytometry. In contrast to the DSS treated mice, DSS ＋ rIL-25 treated mice displayed a lower DAI, limited histological changes and prolonged survival. The levels of IL-23 and TGF-β1 were significantly elevated in the DSS ＋ rIL-25 treated mice compared to the DSS treated mice. There was no significant difference in the production of IL-17 in colon tissues and CD4＋/CD8＋ T cells between the DSS ＋ rIL-25 treated mice and DSS treated mice. Our findings suggest the role of IL-25 in inhibiting development and progression of acute colitis in DSS-induced mouse colitis model. Cellular ＆ Molecular Immunology. 2008;5（6）：425-431.

关键词： IL-25 dextran sulfate sodium disease activity index colitis

Expression Profiling of MicroRNAs in Hippocampus of Rats Following Traumatic Brain Injury

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Journal of Huazhong University of science and Technology(medical sciences) 2014年第4期34卷 548-553页

作者：孙婷怡陈晓瑞刘子龙赵丽丽江永祥屈国强王荣帅黄锶哲刘良 department of Forensic Medicine Tongji Medical College Huazhong University of Science and Technology Forensic Expertise Centre of Xiling District public Security Bureau

The changes of microRNA expression in rat hippocampus after traumatic brain injury（TBI） were explored. Adult SD rats received a single controlled cortical impact injury, and the ipsilateral hippocampus was harvested for the subsequent microarray assay at three time points after TBI： 1st day, 3rd day and 5th day, respectively. We characterized the microRNA expression profile in rat hippocampus using the microRNA microarray analysis, and further verified microarray results of miR-142-3p and miR-221 using quantitative real-time PCR. Totally 205 microRNAs were identified and up-/down-regu-lated more than 1.5 times. There were significant changes in 17 microRNAs at all three time points post-TBI. The quantitative real-time PCR results of miR-142-3p and miR-221 indicated good consistency with the results of the microarray method. MicroRNAs altered at different time points post-TBI. MiR-142-3p and miR-221 may be used as potentially biological markers for TBI assessment in forensic practice.

关键词： forensic clinical medicine traumatic brain injury microRNA microarray technique hippocampus

Long-term sustained clinical remission of peritoneal metastatic pancreatic ductal adenocarcinoma after sequential chemoradiation therapy: a case report

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Journal of Pancreatology 2024年第3期7卷 233-236页

作者： Sen Yang Yuze Hua Qiaofei Liu Quan Liao department of General Surgery Key Laboratory of Research in Pancreatic TumorState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina

Patients with peritoneal metastatic pancreatic ductal adenocarcinoma(pmPDAC)with high-level serum carbohydrate antigens(CAs)always suffer extremely dismal prognosis,with a median survival of several ***,we reported a case of pmPDAC with high serum CAs who had long-term clinical remission with normalization of CAs after *** November 2019,a 64-year-old male patient was admitted to our center with a solid mass measuring 2.8×2.5×2.0 cm in the body of the pancreas near the celiac *** emission tomography-computed tomography(PET-CT)revealed an standardized uptake value max(SUVmax)of *** serum CA 242 level exceeded 150.0 U/mL(normal range:0–20 U/mL),and CA 19-9 was elevated at 975.2 U/mL(normal range:0–34 U/mL).During laparotomy,the tumor was found to encircle the celiac trunk over 180°,with several small peritoneal nodules in the lesser omental *** examination confirmed the diagnosis of *** sequencing revealed RAS G12V,EGFR mutation(-),low tumor mutation burden(TMB),and microsatellite stability(MSS).The patient underwent 6 cycles of the AG regimen(gemcitabine plus nab-paclitaxel),resulting in significant tumor shrinkage and a sharp decline in *** remission was ***,due to intolerant neurotoxicity,the AG regimen was ***,synchronous oral fluorouracil(S1)and radiation therapy were *** months after radiation treatment,all CAs *** S1 was continued for an additional 3 ***,all anti-cancer drugs were *** tomography scans indicated that the tumor still surrounded the celiac trunk and common hepatic *** a thorough discussion,a wait-and-see strategy was ***,32 months after stopping anti-cancer medication,the patient remains in good health,with sustained normalization of *** the last follow-up,he had lived for 50 months,and the normalization of the CAs was sustained for 36 *** he s

关键词： Chemoradiation Clinical remission Peritoneal metastatic pancreatic cancer

具有双重靶向功能的工程仿生纳米粒子增强多发性骨髓瘤的精准治疗（英文）

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Engineering 2024年第5期 178-192页

作者：齐若谷王珊珊于佳怡陆天鸣毕志强刘伟波郭园园卞勇沈建良张雪松胡文浩 School of Medicine Nanjing University of Chinese Medicine Laboratory Animal Center Nanjing University of Chinese Medicine Key Laboratory of Carcinogenesis and Translational Research Ministry of Education/Beijing Department of Radiation Oncology Beijing Cancer Hospital department of Orthopedics The Fourth Medical Center The Chinese People's Liberation Army General Hospital State Key Laboratory of Ophthalmology Optometry and Vision Science School of Biomedical Engineering Wenzhou Medical University

Multiple myeloma(MM) is the second most prevalent hematological malignancy. Current MM treatment strategies are hampered by systemic toxicity and suboptimal therapeutic efficacy. This study addressed these limitations through the development of a potent MM-targeting chemotherapy strategy, which capitalized on the high binding affinity of alendronate for hydroxyapatite in the bone matrix and the homologous targeting of myeloma cell membranes, termed T-PB@M. The results from our investigations highlight the considerable bone affinity of T-PB@M, both in vitro and in vivo. Additionally, this material demonstrated a capability for drug release triggered by low p H conditions. Moreover, T-PB@M induced the generation of reactive oxygen species and triggered cell apoptosis through the poly(ADP-ribose) polymerase 1(PARP1)–Caspase-3–B-cell lymphoma-2(Bcl-2) pathway in MM cells. Notably, T-PB@M preferentially targeted bone-involved sites, thereby circumventing systemic toxic side effects and leading to prolonged survival of MM orthotopic mice. Therefore, this designed target-MM nanocarrier presents a promising and potentially effective platform for the precise treatment of MM.

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A Diagnostic Tool for Identification of Etiologies of Fever of Unknown Origin in Adult Patients

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Current medical science 2019年第4期39卷 589-596页

作者： Man-zhi ZHAO Qiu-rong RUAN Ming-you XING Sheng WEI Dong XU Zhu-hua WU Lin ZHU Ji-ling ZHU Cai-feng ZHENG Shi LIU Zu-jiang YU Jun-ying QI Jian-xin SONG department of Infectious Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of Epidemiology and Bio statistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of Internal Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China department of Infectious Diseases the First Affiliated Hospital of Medical College of Zhengzhou UniversityZhengzhou 450052China

The diagnosis and treatment of fever of unknown origin (FUO) are huge challenges to *** the etiologies of FUO into infectious and non-infectious disease is conducive to clinical physicians not only on making decisions rapidly concerning the prescription of suitable antibiotics but also on further analysis of the final *** order to develop and validate a diagnostic tool to efficiently distinguish the etiologies of adult FUO patients as infectious or non-infectious disease,FUO patients from the departments of infectious disease and internal medicine in three Chinese tertiary hospitals were enrolled retrospectively and *** using polynomial logistic regression analysis,the diagnostic formula and the associated scoring system were *** variables included in this diagnostic formula were from clinical evaluations and common laboratory *** proposed tool could discriminate infectious and noninfectious causes of FUO with an area under receiver operating characteristic curve (AUC) of 0.83,sensitivity of 0.80 and specificity of *** diagnosis tool could predict the infectious and non-infectious causes of FUO in the validation cohort with an AUC of 0.79,sensitivity of 0.79 and specificity of *** results suggested that this diagnostic tool could be a reliable tool to discriminate between infectious and non-infectious causes of FUO.

关键词： fever of unknown origin prediction model diagnostic tool etiology empiric therapy

Astaxanthin delayed the pathogenesis of diabetic nephropathy in type 1 diabetic rats

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BIOCELL 2022年第8期46卷 1911-1916页

作者： LIANHUAN MA SHOUPENG LIU XIAOWEN ZHEN WEIWEI QIAO LINA MA XIAOMIN ZHANG department of Diagnostics The Second School of Clinical MedicineBinzhou Medical UniversityYantai264003China School of public health and Management Binzhou Medical UniversityYantai264003China department of Nephrology Binzhou Medical University HospitalBinzhou256603China

This study was designed to investigate the protective effects of Astaxanthin(AST)in rats with diabetes mellitus(DM)induced by *** rats were divided into control group(n=5,only received normal saline),DM group(n=8)and AST+DM group(n=8;AST:50 mg/kg/day).DM rats were induced by intraperitoneal injection of streptozocin(STZ,65 mg/kg).Blood glucose level and body weight were determined at weeks 0,2,4,6 and 8,*** week 8,kidney function was determined,together with expression of P53 and dynamin-related protein-1(Drp1)by Western blot analysis and *** led to increase of body weight in rats with ***+DM group showed a significant decrease in blood glucose level at week 4 compared with DM group(P<0.05).AST improved renal function and significantly reduced expression of P53 and Drp1 in DM *** addition,AST can effectively reduce the blood glucose in DM rats,and delayed the pathogenesis of diabetic *** delay mediated by AST may be associated with the downregulation of Drp1 and P53.

关键词： Astaxanthin Diabetic nephropathy Dynamin-related protein-1 P53 Renal function

Expression of Maspin,uPA and MMP-7 in Human Gastric Carcinoma

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Chinese Journal of Cancer Research 2008年第1期20卷 62-68页

作者：邓玮易永芬杨雅莹刘丹丹林晓 department of Pathology Chongqing University of medical science

Objective： To investigate the expression of maspin, uPA and MMP-7 in gastric carcinoma and discuss their roles in tumorigenesis and progression of gastric cancer. Methods： lmmunohistochemistry SP method was used to detect expression of maspin, uPA and MMP-7 in gastric adenocarcinoma （n=30）, signet-ring cell carcinoma （n=30）, normal gastric mucosa （n=20）; in addition, reverse transcriptase PCR was carried out to compare the mRNA expression of maspin between gastric adenocarcinoma and normal mucosa. Results： The expression rates of maspin, uPA and MMP-7 protein were 50%, 70% and 80% in gastric adenocarcinoma, and 46.7%, 76.7%, and 90% in signet-ring cell carcinoma, respectively. However, the expression rates of maspin, uPA, and MMP-7 protein were 90%, 35% and 30%, respectively in normal gastric mucosa. The relative transcription level of maspin mRNA in normal gastric mucosa was higher than that in gastric adenocarcinoma （P〈0.01）. Maspin protein expression was significantly related to the depth of invasion and lymph node metastasis of gastric carcinoma, but did not relate to tumor size and TNM staging. The protein expression of uPA and MMP-7 were significantly related to invasive depth, lymph node metastasis and TNM staging of carcinoma, but not to tumor size. Maspin protein expression had a negative correlation with uPA and MMP-7, while uPA protein expression had a positive correlation with MMP-7. The relative mRNA transcription level of Maspin significantly correlated with the lymph node metastasis and the depth of invasion of carcinoma, but did not relate to TNM staging or tumor size. Conclusion： Down-regulated expression of maspin and up- regulated expression of uPA and MMP-7 play important roles in the invasion and metastasis of gastric carcinoma. They may serve as effective markers of the biopathological behavior of gastric tumor.

关键词： Maspin uPA MMP-7 Gastric carcinoma Reverse transcriptase PCR

Revolutionizing genetic disease treatment: The case of exagamglogene autotemcel

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The Innovation 2024年第3期5卷 5-6页

作者： Shuquan Rao Yao Yao Wenxuan Huo Yang Cao Lihua E.Budde State Key Laboratory of Experimental Hematology Institute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020 China 2Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing 100044 China 3Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical Sciences(2019RU029)Beijing 100044 China 4department of Hematology&Cancer Biology Research Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030 China 5department of Hematology&Hematopoietic Stem Cell Transplantation City of Hope National Medical CenterDuarteCA 91010USA

Recent approval of exagamglogene autotemcel(exa-cel)on November 16,2023,in the United Kingdom,developed by Vertex Pharmaceuticals and CRISPR Therapeutics,represents the first cell-based therapy for treatment of sickle cell disease(SCD)with recurrent vaso-occlusive crises(VOCs)or transfusion-dependentβ-thalassemia(TDT)in patients aged 12 and *** suit,the US Food and Drug Administration authorized exa-cel for the same indications on December 8,***-cel represents the first commercially approved CRISPR-based gene therapy,offering hope to approximately 25,000 eligible patients in the US and *** significance of exa-cel extends beyond revolutionizing therapeutic intervention in genetic medicine;it also raises profound ethical considerations and societal implications related to genome manipulation.

关键词： transfusion treatment manipulation

Adverse associations of sedentary behavior with cancer incidence and all-cause mortality:A prospective cohort study

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Journal of Sport and health science 2021年第5期10卷 560-569页

作者： Yuan Lin Qiong Liu Fangchao Liu Keyong Huang Jianxin Li Xueli Yang Xinyan Wang Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Xiangfeng Lu Jianfeng Huang Dongfeng Gu Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing 100037China department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Division of Epidemiology Guangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhou 510080China department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China department of Cardiology Fujian Provincial HospitalFuzhou 350014China Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinan 250062China Sichuan Center for Disease Control and Prevention Chengdu 610041China department of Epidemiology and health Statistics College of Public HealthZhengzhou UniversityZhengzhou 450001China department of Biostatistics and Epidemiology School of Public HealthShenzhen University Health Science CenterShenzhen 518071China School of Medicine Southern University of Science and TechnologyShenzhen 518055China

Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is *** study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity(MVPA)on these ***:We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified *** incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death *** ratios(HRs)and 95%confidence intervals(95%CIs)for cancer and mortality were estimated using Cox proportional hazards regression ***:During 559,002 person-years of follow-up,2388 cancer events,1571 cancer deaths,and 4562 all-cause deaths were *** behavior was associated with increased risk of developing cancer and deaths in a doseresponse *** multivariable-adjusted HRs(95%CIs)were the following:HR=1.16,95%CI:1.01-1.33;HR=1.24,95%CI:1.04-1.48;and HR=1.15,95%CI:1.04-1.28 for cancer incidence,cancer mortality,and all-cause mortality,respectively,for those having≥10 h/day of sedentary time compared with those having<6 h/day of sedentary *** populations(≥10 h/day)developed cancer or died 4.09 years and 2.79 years earlier,respectively,at the index age of 50 *** to achieve the recommended level of MVPA may further aggravate the adverse associations,with the highest cancer and mortality risks being observed among participants with both≥10 h/day of sedentary time and<150 min/week of *** of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient inciden

关键词： All-cause mortality Cancer Chinese population Cohort study Sedentary behavior