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Anthrax lethal toxin and tumor necrosis factor-a synergize on intestinal epithelia to induce mouse death

Protein & Cell 2024年第2期15卷 135-148页

作者： Xinhe Gao Teng Teng Yifei Liu Tingting Ai Rui Zhao Yilong Fu Peipei Zhang Jiahuai Han Yingying Zhang State Key laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Research Unit of Cellular Stress of CAMS Xiang'an Hospital of Xiamen UniversityCancer Research Center of Xiamen UniversitySchool of MedicineFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China laboratory Animal Center Faculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China

Bacillus anthracis lethal toxin(LT)is a determinant of lethal *** function in myeloid cells is required for bacterial dissemination,and LT itself can directly trigger dysfunction of the cardiovascular *** interplay between LT and the host responses is important in the pathogenesis,but our knowledge on this interplay remains *** necrosis factor-a(TNF-a)is a pleiotropic pro-inflammatory cytokine induced by bacterial *** LT accumulates and cytokines,predominantly TNF,amass during *** infection,co-treatment of TNF+LT in mice was used to mimic in vivo conditions for LT to function in inflamed *** marrow transplantation and genetically engineered mice showed unexpectedly that the death of intestinal epithelial cells(IECs)rather than that of hematopoietic cells led to LT+TNF-induced *** of p38a mitogen-activated protein kinase(MAPK)signaling by LT in IECs promoted TNF-induced apoptosis and necroptosis of IECs,leading to intestinal damage and mouse ***,p38a inhibition by LT enhanced TNF-mediated cell death in human colon epithelial HT-29 *** intestinal damage is one of the leading causes of lethality in anthrax patients,the IEC damage caused by LT+TNF would most likely be a mechanism underneath this clinical manifestation and could be a target for interventions.

关键词： lethal toxin TNF p38a intestinal epithelial cell cell death

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Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study

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Journal of Geriatric Cardiology 2024年第7期21卷 751-759页

作者： Shi-Yu ZHOU Fang-Chao LIU Shu-Feng CHEN Jian-Xin LI Jie CAO Ke-Yong HUANG Zheng-Hao TANG Feng-Chao LIANG Dong-Sheng HU Lian-Cheng ZHAO Ying LI Jian-Feng HUANG Xiang-Feng LU Bin LU Dong-Feng GU department of Epidemiology&Key laboratory of Cardiovascular Epidemiology State Key Laboratory of Cardiovas-cular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina School of Public health and Emergency Management School of Medi-cineSouthern University of Science and TechnologyShenzhenChina department of Epidemiology and health Stat-istics School of Public HealthZhengzhou UniversityZhengzhouChina department of Biostatistics and Epidemi-ology School of Public HealthShenzhen University Health Science CenterShenzhenChina department of Radi-ology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH) in reducing cardiovascular ***,its role in subclinical atherosclerosis(SA) progression remains *** aim to examine the association of CVH,estimated by the American Heart Association's new Life's Essential 8(LE8),with the progression of *** This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for5.7 *** LE8 score(range,0–100) consisted of blood pressure,lipids,glucose,body mass index,smoking status,diet health,physical activity and sleep health was evaluated in 1998 and 2008–*** of SA was determined by carotid plaque and coronary artery calcification(CAC) in 2008–2009 and 2013–***-binomial regression model was used to estimate the association of LE8 score with SA *** Each 10 points increment in LE8 score was associated with 15.2%(RR:0.848,95% CI:0.797–0.902),17.7%(RR:0.823,95% CI:0.766–0.884) and 12.0%(RR:0.880,95% CI:0.845–0.916) lower risks of carotid plaque,CAC and overall SA progression,*** with participants with non-ideal CVH at both visits,the participants with ideal CVH at both visits had39.1%(RR:0.609,95% CI:0.494–0.752),41.0%(RR:0.590,95% CI:0.456–0.764) and 29.7%(RR:0.703,95% CI:0.598–0.825) lower risks of carotid plaque,CAC and overall SA progression,*** Higher LE8 scores were associated with lower risks of SA ***,long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

关键词： atherosclerosis prospective cardiovascular

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Modelling and optimization of nonylphenol biosorption by novel lowcost magnetic Chlorella vulgaris

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Emerging Contaminants 2024年第3期10卷 170-180页

作者： Fatemeh Rahmani Nooshin Sajjadi Mohammad Hadi Dehghani Mozhgan Zaeimdar Environmental Science and Technology department Marine Science and Technology FacultyNorth Tehran BranchIslamic Azad UniversityTehranIran department of Environmental health Engineering School of Public HealthTehran University of Medical SciencesTehranIran Center for Solid Waste Research Institute for Environmental ResearchTehran University of Medical SciencesTehranIran

Discharging untreated wastewater causes environmental *** research examined the efficiency of removal and the adsorption process of Emerging Contaminant nonylphenol(NP)using magnetic Chlorella vulgaris(M-Chlorella vulgaris).The characterization of M-Chlorella vulgaris involved XRD,FESEM,EDS-Mapping,BET,FTIR,and VSM *** impact of four different parametersdpH,MChlorella vulgaris dose,initial concentration of NP,and contact time on the biosorption process was *** model and optimize the study while minimizing costs and the number of experiments,Response Surface Methodology(RSM)with Central Composite Design(CCD)was *** to the findings,the quadratic model with adjusted R^(2)=0.96 was the best fitted among the other *** pH=3.5,dosage=2.5 g/l,NP concentration=4 mg/l,and reaction time=70 min,which are the optimal parameters,the maximum removal effectiveness was about 91%.The Langmuir model(R^(2)=0.998)and pseudo-second-order model(R^(2)=0.997)exhibited the best fits for the adsorption isotherm and kinetic studies,*** characteristics of M-Chlorella vulgaris were determined to facilitate a spontaneous nature,and thermodynamic experiments indicated that the process of adsorption of nonylphenol is *** inexpensiveness and availability of adsorbent,suitable efficiency in the biosorption of pollutant and magnetic collection of pollutant from the aquatic environment can be mentioned as the advantages of this process.

关键词： RSM-CCD Nonylphenol Biosorption Algea Emerging contaminants M-Chlorella vulgaris

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Bilateral adrenal histoplasmosis in a Malaysian tertiary hospital:Report of four cases

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 91-94页

作者： Kang WH Norasyikin Abdul Wahab department of Medicine Faculty of Medicine and Health SciencesUniversity Tunku Abdul RahmanMalaysia department of Medicine Pusat Perubatan Universiti KebangsaanMalaysia

Rationale:Adrenal histoplasmosis can present as bilateral adrenal enlargement with constitutional symptoms and/or adrenal *** these patients are initially investigated as secondary adrenal metastases before eventually their diagnosis established by histopathological examination of the adrenal *** concerns:We report 4 cases of patients aged 55-78 who presented with hypocortisolism and bilateral adrenal ***:Bilateral adrenal ***:Three patients received antifungal treatment for at least one year while 1 patient passed away before the initiation of antifungal ***:Two patients’adrenal function recovered not requiring any steroid replacement,while 1 patient still requires long-term steroid ***:Adrenal histoplasmosis should be excluded in patients from endemic areas presenting with bilateral adrenal masses and adrenal *** patients have an exposure to bird droppings,bat guano or soil contaminated with histoplasmosis *** examination of biopsied adrenal tissues is still the gold standard investigation as serology and molecular diagnostic methods are still not widely available in most centers in Malaysia.

关键词： Adrenal histoplasmosis Histoplasmosis Bilateral adrenal masses

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Novel Investigation of Stochastic Fractional Differential Equations Measles Model via the White Noise and Global Derivative Operator Depending on Mittag-Leffler Kernel

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Computer Modeling in Engineering & sciences 2024年第6期139卷 2289-2327页

作者： Saima Rashid Fahd Jarad department of Mathematics Government College UniversityFaisalabad38000Pakistan department of Natural sciences School of Arts and SciencesLebanese American UniversityBeirut11022801Lebanon department of Mathematics Faculty of Arts and ScienceÇnkaya UniversityAnkara06790Turkey department of medical Research China Medical UniversityTaichung40402TaiwanChina

Because of the features involved with their varied kernels,differential operators relying on convolution formulations have been acknowledged as effective mathematical resources for modeling real-world *** this paper,we constructed a stochastic fractional framework of measles spreading mechanisms with dual medication immunization considering the exponential decay and Mittag-Leffler *** this approach,the overall population was separated into five ***,the descriptive behavior of the system was investigated,including prerequisites for the positivity of solutions,invariant domain of the solution,presence and stability of equilibrium points,and sensitivity *** included a stochastic element in every cohort and employed linear growth and Lipschitz criteria to show the existence and uniqueness of *** numerical simulations for various fractional orders and randomization intensities are illustrated.

关键词： Measles epidemic model Atangana-Baleanu Caputo-Fabrizio differential operators existence and uniqueness qualitative analysis Newton interpolating polynomial

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From Entry to Evasion:A Comprehensive Analysis of Host-Virus Interactions for Monkeypox

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Infectious Microbes & Diseases 2024年第2期6卷 56-64页

作者： Vahideh Hamidi Sofiani Mohammad Rezaei Zadeh Rukerd Javad Charostad Mohammad Pardeshenas Reza Ghazi Nasir Arefinia Sara Shafieipour Faranak Salajegheh Mohsen Nakhaie department of Microbiology Golestan University of Medical SciencesGorganIran Gastroenterology and Hepatology Research Center Institute of Basic and Clinical Physiology SciencesKerman University of Medical SciencesKermanIran Universal Scientific Education and Research Network(USERN) TehranIran department of Microbiology Faculty of MedicineShahid Sadoughi University of Medical SciencesYazdIran department of Microbiology School of MedicineKerman University of Medical SciencesKermanIran department of Biotechnology Golestan University of Medical SciencesGorganIran Student Research Committee Jiroft University of Medical SciencesJiroftIran Physiology Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKermanIran Clinical Research Development Unit School of MedicineAfzalipour HospitalKerman University of Medical SciencesKermanIran

Monkeypox(Mpox)has posed a novel challenge and emerged as a threat to global public health since the onset of its outbreak in *** is spreading throughout the world in both endemic and non-endemic countries,indicating that its behavior is *** prevalence of Mpox and the risk of a global pandemic necessitate a better understanding of Mpox virus replications and interactions with the ***,we attempted to provide a detailed comprehensive review of Mpox virus behavior at the molecular level from the entry level to the establishment of a successful infection,including attachment and entry,DNA replication,protein expression and viron assembly and *** review also describes its strategies to evade host immune responses and inhibit apoptosis,and uncovers underlying molecular mechanisms such as subverted signaling pathways and cellular factors behind host-viral interactions.

关键词： monkeypox immunity apoptosis virus-host interaction

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Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis

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Frontiers of Medicine 2024年第2期18卷 285-302页

作者： Di He Xunzhe Yang Liyang Liu Dongchao Shen Qing Liu Mingsheng Liu Xue Zhang Liying Cui department of Neurology Peking Union Medical College Hospital(PUMCH)Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China medical Doctor Program Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing100730China McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing100730China Neuroscience Center Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China

Amyotrophic lateral sclerosis(ALS)is a progressive neurogenerative disorder with uncertain *** evidence implicates N6-methyladenosine(m6A)modification in ALS *** RNA immunoprecipitation sequencing(MeRIP-seq)and liquid chromatography–mass spectrometry were utilized for m6A profiling in peripheral immune cells and serum proteome analysis,respectively,in patients with ALS(n=16)and controls(n=6).The single-cell transcriptomic dataset(GSE174332)of primary motor cortex was further analyzed to illuminate the biological implications of differentially methylated genes and cell communication *** of peripheral immune cells revealed extensive RNA hypermethylation,highlighting candidate genes with differential m6A modification and expression,including C-X3-C motif chemokine receptor 1(CX3CR1).In RAW264.7 macrophages,disrupted CX3CR1 signaling affected chemotaxis,potentially influencing immune cell migration in *** proteome analysis demonstrated the role of dysregulated immune cell migration in *** type-specific expression variations of these genes in the central nervous system(CNS),particularly microglia,were *** communication between neurons and glial cells was selectively altered in ALS *** integrated approach underscores m6A dysregulation in immune cells as a potential ALS contributor.

关键词： amyotrophic lateral sclerosis N^(6)-methyladenosine epi-transcriptome proteome single cell RNA sequencing analysis CX3CR1

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Quaternionic Monge–Ampère Measure on Pluripolar Set

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1431-1457页

作者： Hichame AMAL Saïd ASSERDA Fadoua BOUKHARI department of Mathematics Laboratory LaREAMIRegional Centre of Trades of Education and TrainingKenitraMorocco Ibn Tofail University Faculty of SciencesDepartment of MathematicsPO 242 KenitraMorroco

In this paper, we prove that in a hyperconvex domain Ω in H^(n), if a non-negative Borel measure is dominated by a quaternionic Monge–Ampère measure, then it is a quaternionic Monge–Ampère measure of a function i... 详细信息

关键词： Quaternion space Monge-Amp`ere operator plurisubharmonic function

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Epigenetics and environmental health

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Frontiers of Medicine 2024年第4期18卷 571-596页

作者： Min Zhang Ting Hu Tianyu Ma Wei Huang Yan Wang Key laboratory of Cancer and Microbiome State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Beijing Key laboratory of Cancer Invasion and Metastasis Research Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCapital Medical UniversityBeijing100069China

Epigenetic modifications including DNA methylation,histone modifications,chromatin remodeling,and RNA modifications complicate gene regulation and heredity and profoundly impact various physiological and pathological *** recent years,accumulating evidence indicates that epigenetics is vulnerable to environmental changes and regulates the growth,development,and diseases of individuals by affecting chromatin activity and regulating gene *** exposure or induced epigenetic changes can regulate the state of development and lead to developmental disorders,aging,cardiovascular disease,Alzheimer's disease,cancers,and so ***,epigenetic modifications are *** use of specific epigenetic inhibitors targeting epigenetic changes in response to environmental exposure is useful in disease ***,we provide an overview of the role of epigenetics in various ***,we summarize the mechanism of epigenetic alterations induced by different environmental exposures,the influence of different environmental exposures,and the crosstalk between environmental variation epigenetics,and genes that are implicated in the body's ***,the interaction of multiple factors and epigenetics in regulating the initiation and progression of various diseases complicates clinical *** discuss some commonly used epigenetic drugs targeting epigenetic modifications and methods to prevent or relieve various diseases regulated by environmental exposure and epigenetics through diet.

关键词： epigenetics environmental exposure health prevention and therapy

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A review of whole-medical systems and holistic care approach for type 2 diabetes and associated metabolic syndrome

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Journal of Integrative Medicine 2024年第3期22卷 199-209页

作者： Loveness Makoni Idah T.Manduna Alaisa L.Mbiriri department of health sciences Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Centre for Applied Food Sustainability and Biotechnology(CAFSaB) Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Adventist Development and Relief Agency(ADRA) 5 Cecil RoadGreendaleHarare 0000Zimbabwe

Whole-person care and holistic care approach has been proposed for complementary and integrative health care for type 2 diabetes ***,some doubts still exist on the feasibility of replicating processes followed in clinical trials and observational studies in real-world *** narrative literature review summarized and assessed existing clinical evidence(clinical trials,observational studies,and case reports)describing holistic and integrated care approach in adult and adolescent individuals with type 2 diabetes mellitus in clinical *** goal was to highlight existing evidence for implementation and outcomes of whole-medical systems and holistic integrated care approach for type 2 diabetes mellitus.A nonsystematic literature search was performed on Google Scholar,PubMed,Web of Science,ProQuest and ScienceDirect to identify clinical evidence from different parts of the world,evaluating the use of whole-medical systems and/or holistic care interventions in clinical practice for management of type 2 diabetes *** keywords were used in the *** were analyzed using content analysis and simple descriptive statistics(percentages).Most of the studies(64%)were mainly conducted in Eastern countries(India,China and Israel)while 36%of the studies were conducted in the Western countries(USA,Netherlands,Canada and Mexico).Lifestyle medicine and integrated naturopathy were shown to be the commonly used whole-medical systems for type 2 diabetes mellitus *** improvements in type 2 diabetes parameters,medication use,other symptoms,and overall feeling of wellness were observed in all *** review study revealed limited utilization and/or documentation of whole-medical systems or holistic care treatments for type 2 diabetes mellitus in regions of the world other than eastern *** medicine,naturopathy,yoga,Ayurveda and traditional Chinese medicine were shown to be effective for type 2 diabetes mellitu

关键词： Complementary and alternative medicine Holistic care Integrative medicine Type 2 diabetes mellitus Team-based intervention

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