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Chinese Chemical Letters 2024年第7期35卷 319-324页

作者： Zengchao Guo Weiwei Liu Tengfei Liu Jinpeng Wang Hui Jiang Xiaohui Liu Yossi Weizmann Xuemei Wang State Key Laboratory of Digital medical engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China department of Chemistry Ben-Gurion University of the NegevBeer-Sheva 8410501Israel

With the increasing emergence of bacterial infections,especially multidrug-resistant(MDR)bacteria,poses an urgent *** study demonstrated a novel multifunctional nanotheranostics platform developed by the strategic integration of both in-situ bio-assembly imaging and target bacteria *** the introduction of copper ions into bacteria,the Cu^(2+)could spontaneously bio-selfassembled into a multifunctional copper nanoclusters(NCs)which efficiently enhanced epigallocatechin gallate(EGCG)uptake into *** visualizing the bacteria,the developed theranostic nanoplatform exhibited highly efficient disinfection activities with negligible side effects as reflected by higher cell viability and insignificant hemolytic ***,the exosomal formulation of EGCG integrated with Cu^(2+)showed an increased intracellular antibacterial activity,which could eliminate most of the methicillin-resistant Staphylococcus aureus(MRSA)phagocytosed by macrophages,guide macrophages toward M2-like phenotype polarization and alleviate inflammation,without exhibiting obvious cytotoxicity on host *** regimen could be viewed as an effective strategy for the sterilization of intractable bacterial infections.

关键词： In situ self-assembled Exosome Antibacterial agents Bioimaging Intracellular infection

Film Flow of Nano-Micropolar Fluid with Dissipation Effect

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Computer Modeling in engineering & Sciences 2024年第9期140卷 2487-2512页

作者： Abuzar Abid Siddiqui Mustafa Turkyilmazoglu department of Basic Sciences&Humanities Faculty of Engineering&TechnologyBahauddin Zakariya UniversityMultanPakistan department of Mathematics Hacettepe UniversityAnkaraTürkiye department of medical Research China Medical University HospitalChina Medical UniversityTaichungTaiwan

The physical problem of the thin film flow of a micropolar fluid over a dynamic and inclined substrate under the influence of gravitational and thermal forces in the presence of nanoparticles is *** different types of nanoparticle samples are accounted for in this current study,namely gold Au,silver Ag,molybdenum disulfide MoS2,aluminum oxide Al2O3,and silicon dioxide ***,a micropolar fluid,serves as the common base *** exact closed-form solution for this problem is derived for the first time in the *** results are particularly validated against those for the Newtonian fluid and show excellent *** was found that increasing values of the spin boundary condition and micropolarity lead to a reduction in both the thermal and momentum boundary layers.A quantitative decay in the Nusselt number for a micropolar fluid,as compared to a Newtonian one for all the tested nanoparticles,is *** and silver nanoparticles(i)intensify in the flow parameter as the concentration of nanoparticles increases(ii)yield a higher thermal transfer rate,whereas molybdenum disulfide,aluminum oxide,and silicon dioxide exhibit a converse attitude for both Newtonian and micropolar *** reduction in film thickness for fluid comprising gold particles,as compared to the rest of the nanoparticles,is remarkable.

关键词： Thin film flow micropolar fluid nanoparticles molybdenum disulfide inclined substrate

Falcon Optimization Algorithm-Based Energy Efficient Communication Protocol for Cluster-Based Vehicular Networks

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Computers, Materials & Continua 2024年第3期78卷 4243-4262页

作者： Youseef Alotaibi B.Rajasekar R.Jayalakshmi Surendran Rajendran department of Software engineering College of ComputingUmm Al-Qura UniversityMakkah21955Saudi Arabia department of Electronics and Communication engineering Sathyabama Institute of Science and TechnologyChennai600119India department of Computer Science and engineering Panimalar Engineering CollegeChennai600123India department of Computer Science and engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical ScienceChennai602105India

Rapid development in Information Technology(IT)has allowed several novel application regions like large outdoor vehicular networks for Vehicle-to-Vehicle(V2V)*** networks give a safe and more effective driving experience by presenting time-sensitive and location-aware *** communication occurs directly between V2V and Base Station(BS)units such as the Road Side Unit(RSU),named as a Vehicle to Infrastructure(V2I).However,the frequent topology alterations in VANETs generate several problems with data transmission as the vehicle velocity differs with ***,the scheme of an effectual routing protocol for reliable and stable communications is *** research demonstrates that clustering is an intelligent method for effectual routing in a mobile ***,this article presents a Falcon Optimization Algorithm-based Energy Efficient Communication Protocol for Cluster-based Routing(FOA-EECPCR)technique in *** FOA-EECPCR technique intends to group the vehicles and determine the shortest route in the *** accomplish this,the FOA-EECPCR technique initially clusters the vehicles using FOA with fitness functions comprising energy,distance,and trust *** the routing process,the Sparrow Search Algorithm(SSA)is derived with a fitness function that encompasses two variables,namely,energy and distance.A series of experiments have been conducted to exhibit the enhanced performance of the FOA-EECPCR *** experimental outcomes demonstrate the enhanced performance of the FOA-EECPCR approach over other current methods.

关键词： Vehicular networks communication protocol clustering falcon optimization algorithm routing

Multi-omics analysis of adamantinomatous craniopharyngiomas reveals distinct molecular subgroups with prognostic and treatment response significance

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Chinese medical Journal 2024年第7期137卷 859-870页

作者： Xianlong Wang Chuan Zhao Jincheng Lin Hongxing Liu Qiuhong Zeng Huadong Chen Ye Wang Dapeng Xu Wen Chen Moping Xu En Zhang Da Lin Zhixiong Lin department of Bioinformatics School of Medical Technology and EngineeringKey Laboratory of Medical BioinformaticsKey Laboratory of Ministry of Education for Gastrointestinal CancerFujian Medical UniversityFuzhouFujian 350122China department of Neurosurgery Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China

Background:Adamantinomatous craniopharyngioma(ACP)is the commonest pediatric sellar *** effective drug is available and interpatient heterogeneity is *** study aimed to identify distinct molecular subgroups of ACP based on the multi-omics profiles,imaging findings,and histological features,in order to predict the response to anti-inflammatory treatment and ***:Totally 142 Chinese cases diagnosed with craniopharyngiomas were profiled,including 119 ACPs and 23 papillary ***-exome sequencing(151 tumors,including recurrent ones),RNA sequencing(84 tumors),and DNA methylome profiling(95 tumors)were *** clustering and non-negative matrix factorization were used for subgrouping,and Cox regression were utilized for prognostic evaluation,***:Three distinct molecular subgroups were identified:WNT,ImA,and *** WNT subgroup showed higher Wnt/β-catenin pathway activity,with a greater number of epithelial cells and more predominantly solid *** ImA and ImB subgroups had activated inflammatory and interferon response pathways,with enhanced immune cell infiltration and more predominantly cystic ***-activated protein kinases(MEK/MAPK)signaling was activated only in ImA samples,while IL-6 and epithelial-mesenchymal transition biomarkers were highly expressed in the ImB group,mostly consisting of *** degree of astrogliosis was significantly elevated in the ImA group,with severe finger-like protrusions at the invasive front of the *** molecular subgrouping was an independent prognostic factor,with the WNT group having longer event-free survival than ImB(Cox,P=0.04).ImA/ImB cases were more likely to respond to immune checkpoint blockade(ICB)therapy than the WNT group(P<0.01).In the preliminary screening of subtyping markers,CD38 was significantly downregulated in WNT compared with ImA and ImB(P=0.01).Conclusions:ACP comprises three molecular subtypes with distinct

关键词： Craniopharyngioma Central nervous system tumor Precision medicine beta Catenin Proto-Oncogene Proteins B-raf

An artificial intelligence diabetes management architecture based on 5G

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Digital Communications and Networks 2024年第1期10卷 75-82页

作者： Ruochen Huang Wei Feng Shan Lu Tao shan Changwei Zhang Yun Liu department of Geriatrics The First Affiliated Hospital of Nanjing Medical UniversityNanjing210096China department of Information The First Afliated Hospital of Nanjing Medical UniversityNanjing210096China department of medical Informatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing211166China department of Outpatient The First Affiliated Hospital of Nanjing Medical UniversityNanjing210096China Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing210003China

Along with the development of 5G network and Internet of Things technologies,there has been an explosion in personalized healthcare *** the 5G and Artificial Intelligence(Al)is introduced into diabetes management architecture,it can increase the efficiency of existing systems and complications of diabetes can be handled more effectively by taking advantage of *** this article,we propose a 5G-based Artificial Intelligence Diabetes Management architecture(AIDM),which can help physicians and patients to manage both acute complications and chronic *** AIDM contains five layers:the sensing layer,the transmission layer,the storage layer,the computing layer,and the application *** build a test bed for the transmission and application ***,we apply a delay-aware RA optimization based on a double-queue model to improve access efficiency in smart hospital wards in the transmission *** application layer,we build a prediction model using a deep forest *** on real-world data show that our AIDM can enhance the efficiency of diabetes management and improve the screening rate of diabetes as well.

关键词： Diabetes 5G Artificial intelligence Deep forest Smart hospital ward

Efficacy of Daoyin combined with lower limb robot as a comprehensive rehabilitation intervention for stroke patients: a randomized controlled trial

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Journal of Traditional Chinese Medicine 2024年第3期44卷 530-536页

作者： TIAN Haolin YANG Yuanbin ZHANG Hu ZHAO Wenjing ZHOU Jing TIAN Jingfeng HE Long LI Xuechao SHEN Qinxuan SHUAI Mei department of First Rehabilitation Wangjing Hospital of China Academy of Chinese Medical Sciences department of Rehabilitation Shunyi HospitalBeijing Traditional Chinese Medicine Hospital School of Biological Science and medical engineering Beihang University

OBJECTIVE: To assess the effectiveness of a comprehensive rehabilitation approach combining Traditional Chinese Medicine Daoyin with lower limb robotics during the recovery phase of stroke ***: Stroke patients meeting the specified criteria were randomly assigned to one of four groups using a random number table: Control group, Daoyin group, lower limb robot group(LLR group), and Daoyin and lower limb robot group(DLLR group). Each group received distinct treatments based on conventional rehabilitation *** treatment duration spanned two weeks with two days of rest per week. Pre-and post-intervention assessments included various scales: Fugl-Meyer Assessment(FMA),Berg balance scale(BBS), Barthel index(BI), Fatigue Scale-14(FS-14), Pittsburgh sleep quality index(PSQI),Hamilton Anxiety Scale(HAMA), and Hamilton Depression Scale(HAMD).RESULTS: Statistically significant differences were observed in the lower limb function measured by FAM between the Control group(15 ± 5) and the DLLR group(18 ± 5)(P = 0.049). In the Barthel index, a statistically significant difference was noted between the Control group(54 ± 18) and the DLLR group(64 ± 11)(P = 0.041).Additionally, significant differences were found in the Berg balance scale between the Control group(21 ± 10)and the DLLR group(27 ± 8)(P = 0.024), as well as between the Control group(21 ± 10) and the LLR group(26 ± 10)(P = 0.048).CONCLUSION: The findings of this study suggest that the combined use of Daoyin and robotics not only enhances motor function in stroke patients but also has a positive impact on fatigue, sleep quality, and mood. This approach may offer a more effective rehabilitation strategy for stroke patients.

关键词： Daoyin lower limb robot randomized controlled trial rehabilitation stroke

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Test of the Brans–Dicke theory with GW200105 and GW200115

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Communications in Theoretical Physics 2024年第07期76卷 85-95页

作者： Qin Fei Yingjie Yang department of Mathematics and Physics School of Biomedical Engineering Southern Medical University School of Mathematics and Physics Hubei Polytechnic University

We study whether it is possible to constrain the Brans–Dicke（BD） theory from the measurement of gravitational waves（GW） released in neutron star-black hole collisions. Considering the scalar field modifications through monopole and dipole radiations, we find additional contributions to the phase evolution in the emitted gravitational waveform. After effectively calculating such effect in the post-Newtonian order, we are in a position to measure the scalar field and give bounds on the BD coupling parameter ωBD. We derive the analytical expression for the phase modification due to the orbital eccentricity of eccentric binaries in both general relativity and BD theory. Employing the Bayesian analysis, we obtain the constraints on ωBDfrom the GW events, GW200105 and GW200115.

关键词： Brans-Dicke theory cosmology gravitational wave

Visualizing Wallerian degeneration in the corticospinal tract after sensorimotor cortex ischemia in mice

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Neural Regeneration Research 2024年第3期19卷 636-641页

作者： Jiao Mu Liufang Hao Zijue Wang Xuyang Fu Yusen Li Fei Hao Hongmei Duan Zhaoyang Yang Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina

Stroke can cause Wallerian degeneration in regions outside of the brain,particularly in the corticospinal *** investigate the fate of major glial cells and axons within affected areas of the corticospinal tract following stroke,we induced photochemical infarction of the sensorimotor cortex leading to Wallerian degeneration along the full extent of the corticospinal *** first used a routine,sensitive marker of axonal injury,amyloid precursor protein,to examine Wallerian degeneration of the corticospinal *** antibody to amyloid precursor protein mapped exclusively to proximal axonal segments within the ischemic cortex,with no positive signal in distal parts of the corticospinal tract,at all time *** improve visualization of Wallerian degeneration,we next utilized an orthograde virus that expresses green fluorescent protein to label the corticospinal tract and then quantitatively evaluated green fluorescent protein-expressing *** this approach,we found that axonal degeneration began on day 3 post-stroke and was almost complete by 7 days after *** addition,microglia mobilized and activated early,from day 7 after stroke,but did not maintain a phagocytic state over ***,astrocytes showed relatively delayed mobilization and a moderate response to Wallerian ***,no anterograde degeneration of spinal anterior horn cells was observed in response to Wallerian degeneration of the corticospinal *** conclusion,our data provide evidence for dynamic,pathogenic spatiotemporal changes in major cellular components of the corticospinal tract during Wallerian degeneration.

关键词： corticospinal tract green fluorescent protein microglia spinal anterior horn cells stroke virus trace Wallerian degeneration

Quantification of grain boundary effects on the geometrically necessary dislocation density evolution and strain hardening of polycrystalline Mg-4Al using in situ tensile testing in scanning electron microscope and HR-EBSD

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Journal of Magnesium and Alloys 2024年第5期12卷 1815-1829页

作者： Eunji Song Mohsen Taheri Andani Amit Misra department of Materials Science and engineering University of Michigan department of Mechanical engineering University of Michigan

In situ tensile testing in a scanning electron microscope(SEM) in conjunction with high-resolution electron backscatter diffraction(HR-EBSD) under load was used to characterize the evolution of geometrically necessary dislocation(GND) densities at individual grain boundaries as a function of applied strain in a polycrystalline Mg-4Al alloy. The increase in GND density was investigated at plastic strains of 0 %,0.6 %, 2.2 %, 3.3 % from the area including 76 grains and correlated with(i) geometric compatibility between slip systems across grain boundaries, and(ii) plastic incompatibility. We develop expressions for the grain boundary GND density evolution as a function of plastic strain and plastic incompatibility, from which uniaxial tensile stress-strain response of polycrystalline Mg-4Al are computed and compared with experimental measurement. The findings in this study contribute to understanding the mechanisms governing the strain hardening response of single-phase polycrystalline alloys and more reliable prediction of mechanical behaviors in diverse microstructures.

关键词： Mg Al alloys Grain boundaries Geometrically necessary dislocations Strain gradient plasticity HR-EBSD

Pyramid-resolution person restoration for cross-resolution person re-identification

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Science China(Information Sciences) 2024年第6期67卷 451-452页

作者： Chunlei PENG Bo WANG Decheng LIU Nannan WANG Xinbo GAO State Key Laboratory of Integrated Services Networks Xidian University School of Cyber engineering Xidian University School of Telecommunications engineering Xidian University Chongqing Key Laboratory of image Cognition Chongqing University of Posts and Telecommunications

Person images captured by surveillance cameras are typically with various resolutions and are susceptible to pose changes,occlusion and background variations,thus affecting the performance of person Re *** approaches[1,2]either use an image restoration model to restore the lowresolution images to obtain a corresponding high-resolution image,

关键词： Restoration

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