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Journal of Geriatric Cardiology 2024年第6期21卷 658-668页

作者： Wen-Jie WANG Ke-Xin WANG Jia-Long NIU Yi-Xuan LIU Hai-Long GE Hua SHEN On behalf of CCC-ACS investigators department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

BACKGROUND Stress hyperglycemia ratio(SHR)could provide accurate information on the acute status of *** relationship between SHR and acute coronary syndrome(ACS)prognosis remains *** study was conducted to identity the association between SHR and in-hospital outcomes in patients with *** A total of 12,010 patients were eventually enrolled in the *** relationship between SHR and in-hospital major adverse cardiovascular events(MACEs)was then modeled by restricted cubic spline(RCS)curves,and all patients were divided into three groups according to the *** multivariate logistic regression analysis was used to determine the associations between the SHR and in-hospital outcomes,described as odds ratios(ORs)and 95%confidence intervals(CIs).Subgroup analyses were also performed on different *** The median age of this cohort was 63(54,71)years old,and 8942(74.5%)were *** 1 was defined as SHR1(n=5763).Compared with Group 2,Group 1(OR=1.891,95%CI:1.028-3.479,P<0.001)and Group 3(OR=1.868,95%CI:1.434-2.434,P<0.001)had higher risks of suffering from in-hospital *** was associated with higher risks of in-hospital MACEs in the subgroups of DM[OR=2.282,95%CI:1.477-3.524).CONCLUSIONS Both low and high SHR levels were independently associated with in-hospital *** males with DM,hypertension,and decreased renal function had much higher risks of suffering from SHR-correlated MACEs.

关键词： acute cardiovascular finding

Risk Factors and Predictive Nomogram for Survival in Elderly Patients with Brain Glioma

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当代医学科学（英文） 2024年第4期44卷 759-770页

作者： Zhi-cheng FAN Wen-jian ZHAO Yang JIAO Shao-chun GUO Yun-peng KOU Min CHAO Na WANG Chen-chen ZHOU Yuan WANG Jing-hui LIU Yu-long ZHAI Pei-gang JI Chao FAN Liang WANG department of Neurosurgery Tangdu HospitalFourth Military Medical UniversityXi'an 710038China department of Neurosurgery Tangdu HospitalFourth Military Medical UniversityXi'an 710038China department of Neurosurgery Shannxi University of Chinese MedineXianyang 712046China department of Neurosurgery Tangdu HospitalFourth Military Medical UniversityXi'an 710038China department of Neurosurgery Xi'an Medical UniversityXi'an 710021China

Objective:To determine the factors that contribute to the survival of elderly individuals diagnosed with brain glioma and develop a prognostic ***:Data from elderly individuals(age ≥65 years)histologically diagnosed with brain glioma were sourced from the Surveillance,Epidemiology,and End Results(SEER)*** dataset was randomly divided into a training cohort and an internal validation cohort at a 6:4 ***,data obtained from Tangdu Hospital constituted an external validation cohort for the *** identification of independent prognostic factors was achieved through the least absolute shrinkage and selection operator(LASSO)and multivariate Cox regression analysis,enabling the construction of a *** performance was evaluated using C-index,ROC curves,calibration plot and decision curve analysis(DCA).Results:A cohort of 20 483 elderly glioma patients was selected from the SEER *** prognostic factors(age,marital status,histological type,stage,and treatment)were found to significantly impact overall survival(OS)and cancer-specific survival(CSS),with tumor location emerging as a sixth variable independently linked to ***,nomogram models were developed to predict the probabilities of survival at 6,12,and 24 *** assessment findings from the validation queue indicate a that the model exhibited strong ***:Our nomograms serve as valuable prognostic tools for assessing the survival probability of elderly glioma *** can potentially assist in risk stratification and clinical decision-making.

关键词： Surveillance, Epidemiology, and End Results (SEER) elderly brain glioma nomogram prediction model prognosis

Metal-Free Photocatalytic[4+2]Annulation of Acrylamides with 2-Benzyl-2-bromocarbonyls to Assemble Tetralin-1-carboxamides

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Chinese Journal of Chemistry 2024年第2期42卷 157-163页

作者： Weicai Li Lu Tan Yijun Chen Rui Liu Zhongyu Qi Shixuan Yuan Zhanwen Huang Siping Wei Xi Du Dong Yi Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province School of PharmacySouthwest Medical UniversityLuzhouSichuan 646000China department of Chemistry School of Basic Medical ScienceSouthwest Medical UniversityLuzhouSichuan 646000China department of Pharmacy Affiliated HospitalSouthwest Medical UniversityLuzhouSichuan 646000China

Tetralin-1-carboxamides are frequently incorporated in myriad medicinally important ***,their existing synthetic routes not only suffer from some drawbacks such as tedious procedures,harsh reaction conditions,narrow substrate scope,low yields,and environmental problems,but are also based upon the elaboration of uneasily available non-linear tetralin ***,we describe a metal-and additive-free visible light-induced[4+2]annulation of two simple linear starting materials,namely acrylamides and 2-benzyl-2-bromocarbonyls,through a cascade C(sp^(3))-Br/C(sp^(2))-H bond cleavage,double C-C bond formation,and aromatization *** developed protocol provides a convenient,efficient,and green approach to a variety of tetralin-1-carboxamide derivatives with good functional group ***,the resulting products could also undergo the Licl-mediated mono-decarboxylative cyclization process to further furnish the architecturally novel bridged polycyclic imides with excellentcis-diastereoselectivities.

关键词： Annulation Metal-free Photoredox catalysis Tetralin-1-carboxamide Cyclic imides Synthetic methods C-C coupling Radical reactions Reaction mechanisms

Insights into the role of RNA m^(6)A modification in the metabolic process and related diseases

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Genes & Diseases 2024年第4期11卷 270-295页

作者： Haiming Hu Zhibin Li Xia Xie Qiushi Liao Yiyang Hu Chunli Gong Nannan Gao Huan Yang Yufeng Xiao Yang Chen department of Gastroenterology Xinqiao HospitalArmy Medical UniversityChongqing 400037China

According to the latest consensus,many traditional diseases are considered meta-bolic diseases,such as cancer,type 2 diabetes,obesity,and cardiovascular ***,metabolic diseases are increasingly prevalent because of the ever-improving living standards and have become the leading threat to human *** therapy methods have been applied to treat these diseases,which improves the quality of life of many patients,but the overall effect is still ***,intensive research on the metabolic process and the pathogenesis of metabolic diseases is imperative.N6-methyladenosine(m^(6)A)is an important modification of eukaryotic *** is a critical regulator of gene expression that is involved in different cellular functions and physiological *** studies have indi-cated that m^(6)A modification regulates the development of many metabolic processes and metabolic *** this review,we summarized recent studies on the role of m^(6)A modifica-tion in different metabolic processes and metabolic ***,we highlighted the potential m^(6)A-targeted therapy for metabolic diseases,expecting to facilitate m^(6)A-targeted strategies in the treatment of metabolic diseases.

关键词： Cancer mm^(6)A-targeted therapy Metabolic disease Metabolism N6-methyladenosine

The value of toxicological analysis in acute poisoning patients with uncertain exposure histories:a retrospective and descriptive study from an institute of poisoning

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World Journal of Emergency Medicine 2024年第2期15卷 98-104页

作者： Qifang Shi Gen Ba Zhenyu Xia Zhengsheng Mao Hao Sun Jinsong Zhang Institute of Poisoning Nanjing Medical UniversityNanjing 211100China department of Emergency Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China department of Forensic Medicine Nanjing Medical UniversityNanjing 211166China The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical UniversityNanjing 211166China

BACKGROUND:In clinical practice,some patients might not be able or unwilling to provide a thorough history of medication and poison *** aim of this study was to use toxicological analysis to examine the clinical characteristics of patients with acute poisoning whose exposure history was uncertain from a toxicological analysis ***:This was a retrospective and descriptive study from an institute of *** registration information and test reports spanning the period from April 1,2020 to March 31,2022,were *** with uncertain exposure histories and who underwent toxicological analysis were *** manifestations and categories of toxics were ***:Among the 195 patients with positive toxicological analysis results,the main causes of uncertain exposure history was disturbance of consciousness(62.6%),unawareness(23.6%)and unwillingness or lack of cooperation(13.8%).The predominant clinical manifestations were disturbed consciousness(62.6%),followed by vomiting and nausea(14.4%)and liver function abnormalities(8.7%).A comparison of clinical manifestations between patients with positive and negative(n=99)toxicological analyses results revealed significantly different proportions of disturbances in consciousness(63%vs.21%),dizziness(1.5%vs.5.1%),multi-organ failure(1.5%vs.7.1%),and local pain(0 vs 4%).The main categories of substances involved were psychiatric medications(23.1%),sedatives(20.5%),insecticides(13.8%),and herbicides(12.8%).CONCLUSION:The clinical manifestations of acute poisoning in patients with an uncertain exposure history are diverse and nonspecific,and toxicological analysis plays a pivotal role in the diagnosis and differential diagnosis of such patients.

关键词： Acute poisoning Toxic exposure Toxicological analysis Clinical manifestation

Nanoparticle targeting cGAS-STING signaling in disease therapy

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Nano Research 2024年第8期17卷 7315-7336页

作者： Lan Zhou Yu Huang Yuzhang Wu Shupei Tang Frontier medical Training Brigade Third Military Medical UniversityHutubi 831200China department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Institute of Immunology Third Military Medical UniversityChongqing 400038China Shigatse Branch Xinqiao HospitalThird Military Medical UniversityShigatse 857000China

The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon(IFN)genes(cGAS-STING)signaling pathway is crucial for sensing abnormal DNA accumulation in the *** binds to abnormal DNA,cGAS catalyzes the production of second messenger cyclic dinucleotides,followed by the activation of downstream *** activation induces the expression of type I interferon and other inflammatory cytokines,ultimately initiating an immune *** to the involvement of the cGAS-STING pathway in various diseases,including infection,tumor,autoimmune disease and kidney disease,ongoing research is focused on developing drugs and treatment methods to target and regulate this *** the development of nanotechnology,nanomedicines targeting cGAS-STING signaling are of great significance in clinical applications due to their targeted delivery,controlled drug release,improved solubility,multifunctionality,and enhanced *** comprehensive review focuses on the most recent progress of nanoplatforms targeting cGAS-STING in disease therapy,aiming to provide references and guidelines for further design and optimization of nanomedicines.

关键词： nanomedicine cGAS-STING pathway and related disease anti-tumor nanotherapy anti-viral nanotherapy

HIV encephalopathy is contributed by macrophages and microglia

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Science China(Life Sciences) 2024年第4期67卷 836-838页

作者： Si-Meng Liu Man Li Chunhui Ma Chunying Liu An Lv Qing Li Yamei Niu Peng Wang Bo Huang Wei-Min Tong department of Pathology China Medical UniversityShenyang 110122China department of Pathology Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeNeuroscience CenterChinese Academy of Medical SciencesBeijing 100005China department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Molecular Pathology Research Center Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Center For Experimental Animal Research Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China department of Immunology and National Key Laboratory of medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100010China department of Biochemistry and Molecular Biology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Dear Editor,Acquired immunodeficiency syndrome(AIDS),characterized by a significant decrease in the number of CD4^(+)T cells,causes a defective T cell immune response,which subsequently leads to various conditional pathogenic infections and tumors(Calmy et al.,2018;Seligmann et al.,1987).Neurological disorders have been reported in 70%–80%of patients with AIDS(Saylor et al.,2016)。

关键词： encephalopathy immunodeficiency

Recommendations for articles and reviews in colorectal cancerrelated research at the year-end of 2023

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World Journal of Gastroenterology 2024年第30期30卷 3548-3553页

作者： Wen-Yu Luan Hao Lin Yan-Dong Miao department of Cancer Center The Yantai Affiliated Hospital of Binzhou Medical UniversityThe Second Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

As peer reviewers of the World Journal of Gastroenterology,our weekly routine involves immersing ourselves in the newly published issue,particularly focusing on the realm of colorectal cancer(CRC)*** diligently sift through various contributions,ranging from comprehensive reviews to original articles and other scholarly *** meticulous examination,we discern the most notable papers,delving into each with careful scrutiny to distill their merits and ***,this undertaking demands considerable time and ***,it stands as an indispensable pursuit,affording us a profound comprehension of the latest breakthroughs in CRC ***,these meticulously curated selections furnish readers with invaluable resources,serving as enduring references for the nuanced exploration of this dynamic field.

关键词： Colorectal cancer Molecular mechanism Genetic marker Application of new technologies Diagnosis Treatment

Acyl-CoA thioesterase 7 is oncogenic in breast cancer by promoting oxidative phosphorylation via PGC1a

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Genes & Diseases 2024年第5期11卷 13-16页

作者： Xiangyu Sun Qiang Zhang Mozhi Wang Litong Yao Xiang Li Hongyi Cao Yingying Xu department of Breast Surgery Liaoning Cancer Hospital&InstituteShenyangLiaoning 110000China department of Breast Surgery The First Hospital of China Medical UniversityShenyangLiaoning 110000China department of Ultrasound The First Hospital of China Medical UniversityShenyangLiaoning 110000China department of Pathology The First Hospital of China Medical University and College of Basic Medical SciencesShenyangLiaoning 110000China

Metabolic reprogramming is a key feature of tumor cells and plays a key role in the adaptation of tumor cells to increased demands of biosynthesis and rapid proliferation.1 Numerous studies have shown that some key metabolic enzymes are essential for the initiation and progression of breast cancer(BC).These metabolic enzymes are involved in the regulation of many biological processes such as gene transcription,post-translational modification,and antioxidant capacity of cells,which endow tumor cells with the ability to adapt to divergent environmental stimuli.2 Therefore,it is of great significance to identify the role of important metabolic enzymes in the occurrence and development of BC to determine promising therapeutic targets.

关键词： breast cancer oxidative

Protective and Adverse Roles of DDX3X in Different Cell Types in Nonalcoholic Steatohepatitis Progression

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Research 2024年第3期6卷 561-574页

作者： Suzhen Yang Lin Zhou Tianming Zhao Hanlong Zhu Tingting Luo Kang Jiang Xiaoxiao Shi Chunyan Chen Han Zhang Si Zhao Xiaoping Zou Yuzheng Zhuge Fangyu Wang Lei Wang Mingzuo Jiang Bing Xu department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China. department of Gastroenterology and Hepatology the Affiliated Jinling Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China School of Medicine Northwest UniversityShaanxiXi’an710069China. department of Gastroenterology Nanjing Drum Tower HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeJiangsuNanjing210008China.

Persistent hepatic cellular metabolic stress and liver inflammatory stimuli are key signatures of nonalcoholic steatohepatitis(NASH).DDX3X is a vital molecule involved in cell fate decisions in both pro-survival stress granule(SG)and pro-death NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome assembly in response to stress ***,the role of DDX3X in NASH remains *** characterized the cell type-specific roles of DDX3X in *** liver tissues from NASH patients and normal control subjects were collected to assess DDX3X expression and *** steatohepatitis models were constructed by feeding macrophage-specific DDX3X knockout(DDX3^(XΔMφ)),hepatocyte-specific DDX3X knockout(DDX3X^(Δhep)),and wild-type control(DDX3X^(fl/fl))mice a high-fat and high-cholesterol(HFHC)diet,a methionine-and choline-deficient(MCD)diet,and a high-fat/high-iron/high-fructose/high-cholesterol,low-methionine,and choline-deficient(HFHIHFHC-MCD)*** study demonstrated that DDX3X was predominantly expressed in macrophages and hepatocytes in control liver tissues,and its expression was down-regulated in patients or mice with *** to DDX3X^(fl/fl) littermates,DDX3^(XΔMφ)mice showed improved liver histology in nutritional steatohepatitis *** of macrophage DDX3X inhibited NLRP3 inflammasome-mediated pyroptosis,causing anti-inflammatory M2 polarization and alleviating hepatocyte steatohepatitic ***3X^(Δhep) mice developed marked steatohepatitis in multiple nutritional steatohepatitis models compared to DDX3X^(fl/fl) ***3X-deleted hepatocytes showed impaired SG assembly,leading to increased sensitivity and intolerance to metabolic stimulation and resultant *** conclusion,DDX3X plays opposite roles in different cell types during the progression of NASH.A better understanding of the cell-specific differences in the crosstalk between SG formation and NLRP3 activation is crucial for developing pr

关键词： NLRP3 impaired inhibited