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Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

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Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele Castellani Vineet gauhar Khi Yung Fong mario Sofer moisés Rodríguez Socarrás Azimdjon N Tursunkulov Lie Kwok Ying Sarvajit Biligere Ho Yee Tiong Dean Elterman Abhay mahajan mark Taratkin Sorokin Nikolai Ivanovich Tanuj Pal Bhatia Dmitry Enikeev Nariman gadzhiev mohammed Taif Bendigeri Jeremy Yuen-Chun Teoh marco Dellabella Fernando gómez Sancha Bhaskar Kumar Somani Thomas Reinhard William Herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo Lin School of medicine National University of SingaporeSingapore 117597Singapore department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel department of Urology and Robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India institute for Urology and Reproductive Health Sechenov UniversityMoscow119435Russian Federation department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India department of Urology Medical University of ViennaVienna 1090Austria department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.H.Ho UrologyCentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(group 1)versus 2-lobe/3-lobe techniques(group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQR).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(mUI).There were 1711 patients in group 1 and 3357 patients in group *** in group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in group 1 vs 70[54–90]ml in group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in group *** 1 month,overall incontinence rate was 6.3%in group 1 versus 5.3%in group 2(P=0.12),and urge incontinence was significantly higher in group 1(55.1%vs 37.3%in group 2,Pmonths,the overall rate ofincontinence was 1.7%in group 1 versus 2.3%in group 2(P=0.06),and SUI was significantly higher in group 2(55.6%vs 24.1%in group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/mUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

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COmPARISON OF OPTICAL POLARImETRY AND DIFFUSION TENSOR mR ImAgINg FOR ASSESSINg mYOCARDIAL ANISOTROPY

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Journal of Innovative Optical Health Sciences 2010年第2期3卷 109-121页

作者： mARIKA A.WALLENBURg mIHAELA POP mICHAEL F.g.WOOD NIRmALYA gHOSH gRAHAm A.WRIgHT I.ALEX VITKIN ontario cancer institute Division of Biophysics and Bioimaging University Health Network and University of Toronto Department of Medical Biophysics610 University Avenue TorontoOntarioCanada M5G 2M9 department of medical biophysics University of Toronto Sunnybrook Health Sciences Center2075 Bayview Avenue TorontoONCanadaM5N 3M5 IISER Kolkata Mohanpur CampusP.O.BCKV Campus Main Office Mohanpur 741252West BengalIndia ontario cancer institute Division of Biophysics and Bioimaging University Health Network and University of Toronto Departments of Medical Biophysics and Radiation Oncology 610 University AvenueTorontoOntarioCanada M5G 2M9

We have recently proposed an optical method for assessing heart structure that uses polarized light measurement of birefringence as an indicator of tissue *** highly aligned nature of healthy cardiac muscle tissue has a detectable effect on the polarization of light,resulting in a measurable phase shift(“retardance”).When this organized tissue structure is perturbed,for example after cardiac infarction(heart attack),scar tissue containing disorganized collagen is formed,causing a decrease in the measured retardance ***,these are dependent not only on tissue anisotropy,but also on the angle between the tissue’s optical anisotropy direction and the beam interrogating the *** remove this experimental ambiguity,we present a method that interrogates the sample at two different incident beam angles,thus yielding enough information to uniquely determine the true magnitude and orientation of the tissue optical *** use an infarcted porcine heart model to compare these polarimetryderived anisotropy metrics with those obtained with diffusion tensor magnetic resonance imaging(DT-mRI).The latter yields the anisotropy and the direction of tissue water diffusivity,providing an independent measure of tissue *** optical and mR results are thus directly compared in a common ex vivo biological model of interest,yielding reasonable agreement but also highlighting some technique-specific differences.

关键词： Birefringence mueller matrix decomposition fractional anisotropy diffusion tensor magnetic resonance imaging myocardial infarction

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Introduction to the Special Issue on Enhanced Photodynamic Therapy

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Journal of Innovative Optical Health Sciences 2022年第4期15卷 11-12页

作者： Buhong Li Lothar Lilge School of Science Hainan University Haikou 570228P.R.China department of medical biophysics university of toronto and ontario cancer institute toronto m5g 2m9 Canada

Photodynamic therapy(PDT)utilizes photosensi-tizer(PS)together with irradiation light of specific wavelength interacting with oxygen to generate cytotoxic reactive oxygen species,which has been approved for the treatment of several maligr nant and non-malignant *** recently,en-hanced PDT has been achieved by using novel nano-PSs,1 new light sources,2 oxygen supply,and synergistic therapy.

关键词： Photodynamic Therapy utilize

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ACTIVATABLE SmART PROBES FOR mOLECULAR OPTICAL ImAgINg AND THERAPY

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Journal of Innovative Optical Health Sciences 2008年第1期1卷 45-61页

作者： JONATHAN F.LOVELL gANg ZHENg institute of Biomaterials and Biomedical Engineering department of medical biophysics University of Toronto Division of biophysics and Bioimaging Ontario Cancer Institute TorontoOntario M5G 1L7Canada

Recent years have seen the design and implementation of many optical activatable smart *** probes are activatable because they change their optical properties and are smart because they can identify specific *** broad class of detection agents has allowed previously unperformed visualizations,facilitating the study of diverse biomolecules including enzymes,nucleic acids,ions and reactive oxygen *** to be robust in an in vivo environment,these probes have been used in tissue culture cells and in live small *** emerging class of smart probes has been designed to harness the potency of singlet oxygen generating *** the discrimination of activatable agents with the toxicity of photosensitizers represents a new and powerful approach to disease *** review highlights some applications of activatable smart probes with a focus on developments of the past decade.

关键词： Optical imaging photodynamic therapy activatable imaging probes

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How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

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Journal of Sport and Health Science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van Ierssel Olivia galea Kirsten Holte Caroline Luszawski Elizabeth Jenkins Jennifer O’Neil Carolyn A Emery Rebekah mannix Kathryn Schneider Keith Owen Yeates Roger Zemek Children’s Hospital of Eastern ontario Research institute OttawaON K1H 8L1Canada The Centre for Health Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Alberta Children’s Hospital Research institute university of Calgary CalgaryAB T2N 1N4Canada Hotchkiss Brain institute University of CalgaryCalgaryAB T2N 4N1Canada department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Rehabilitation Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research institute OttawaON K1N 5C8Canada departments of Pediatrics and Emergency medicine Harvard Medical SchoolBostonMA 02115USA departments of Pediatrics and Emergency medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RCTs)of non-pharmacological interventions following ***:We searched mEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up to may *** reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),Consensus on Exercise Reporting Template(CERT),and international Consensus on Therapeutic Exercise aNd Training(i-CONTENT)*** information was sought my study authors where reporting was *** of bias(ROB)was assessed with the Cochrane ROB-2 *** examining non-pharmacological interventions following ***:We included 89 RCTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck *** scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified *** completeness improved after TIDieR and CERT publication,but p

关键词： Concussion Intervention Randomized controlled trial Systematic review

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Helium Plasma Effects on Polymer Surfaces:from Plasma Parameters and Surface Properties towards Bioengineering Applications

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Chinese Journal of Polymer Science 2024年第8期42卷 1156-1166页

作者： Andrei Vasile Nastuta maria Butnaru Byron Cheatham Ramona Huzum Vasile Tiron Ionut Topala Physics and biophysics Education Research Laboratory(P&B-EduResLab) Biomedical Science DepartmentFaculty of Medical Bioengineering‘Grigore T.Popa’University of Medicine and Pharmacy IasiM.Kogalniceanu 9-13Iasi 700454Romania Faculty of medical Bioengineering ‘Grigore T.Popa’University of Medicine and Pharmacy IasiM.Kogalniceanu 9-13Iasi 700454Romania Cytoviva Inc.570 Devall Drive Suite 301Auburn 36832ALUSA Integrated Center of Environmental Science Studies in the North-Eastern Development Region(CERNESIm) Department of Exact and Natural SciencesInstitute of Interdisciplinary Research‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania Research Center on Advanced materials and Technologies(RAmTECH) Department of Exact and Natural SciencesInstitute of Interdisciplinary Research‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania Iasi Plasma Advanced Research Center(IPARC) Faculty of Physics‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania

Plasma treatment is necessary to optimize the performance of biomaterial *** enhances and regulates the performance of biomaterial su rfaces,creating an effective interface with the human *** treatments have the ability to modify the chemical com position and physical structu re of a surface while leaving its properties *** possess the ability to modify material su rfaces,eliminate contaminants,conduct investigations on cancer therapy,and facilitate wound *** subject of study in question involves the integration of plasma science and technology with biology and *** a helium plasma jet source,applying up to 18 kV,with an average power of 10 W,polymer foils were treated for 60 *** treatment has the ability to alter the chemical composition and physical structure of a su rface while maintaining its *** investigation involved the application of helium plasma at atmospheric pressure to polyamide 6 and polyethylene terephthalate *** inquiry involves monitoring and assessing the plasma source and polymer materials,as well as analyzing the impacts of plasma *** the mean power of the discharge aids in assessing the economic efficacy of the plasma *** discharge in helium at atmospheric pressure has beneficial effects in technology,where it increases the surface free energy of polymer *** biomedicine,it is used to investigate cytotoxicity and cell survival,particularly in direct blood exposure situations that can expedite *** the specific parameters that influence the plasma source in the desired manner for the intended application is of utmost im portance.

关键词： Atmopheric pressure plasmas Plasma-polymer interaction Plasma medicine Plasma diagnosis Polymer characterization

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IN VIVO NEAR-INFRAREDFLUORESCENCEImAgINg OF HUmANCOLONADENOCARCINOmABY SPECIFIC ImmUNOTARgETINgOFA TUmOR-ASSOCIATEDmUCIN

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Journal of Innovative Optical Health Sciences 2009年第4期2卷 407-422页

作者： RALPH S.DACOSTA YINg TANg TUULA KALLIOmAKI RAYmOND m.REILLY ROBERT WEERSINK ALISHA R.ELFORD NORmAN E.mARCON BRIAN C.WILSON Division of biophysics and Bioimaging Ontario Cancer Institute 610 University of TorontoTorontoOntarioM5G 2M9Canada department of medical biophysics University of Toronto Princess Margaret Hospital/Ontario Cancer Institute University Health NetworkTorontoOntarioCanada NIH/NCI Radiation Oncology Branch BethesdaMDUSA Division of Clinical Investigation and Human Physiology toronto general Hospital Research institute and University of Toronto Leslie Dan Faculty of Pharmacy TorontoOntarioCanada Laboratory for Applied Biophotonics university Health Network TorontoOntarioCanada Campbell Family institute for Breast cancer Research university Health Network/ontario cancer institute department of medical biophysics and Immunology toronto OntarioCanada St.michael’s Hospital Center for Therapeutic Endoscopy and Endoscopic Oncology toronto OntarioCanada

Background and Aims: Accurate endoscopic detection of premalignant lesions and earlycancers in the colon is essential for cure, since prognosis is closely related to lesion size andstage. Although it has great clinical potential, autofluorescence endoscopy has limited tumorto-normal tissue image contrast for detecting small preneoplastic lesions. We have developed amolecularly specific, near-infrared fluorescent monoclonal antibody (CC49) bioconjugate whichtargets tumor-associated glycoprotein 72 (TAg72), as a contrast agent to improve fluorescencebased endoscopy of colon cancer. methods: The fluorescent anti-TAg72 conjugate was evaluated in vitro and in vivo in athymic nude mice bearing human colon adenocarcinoma (LS174T)subcutaneous tumors. Autofluorescence, a fluorescent but irrelevant antibody and the free fluorescent dye served as controls. Fluorescent agents were injected intravenously, and in vivowhole body fluorescence imaging was performed at various time points to determine pharmacokinetics, followed by ex vivo tissue analysis by confocal fluorescence microscopy and histology Results: Fluorescence microscopy and histology confirmed specific LS174T cell membrane targeting of labeled CC49 in vitro and ex vivo. In vivo fluorescence imaging demonstrated significant tumor-to-normal tissue contrast enhancement with labeled-CC49 at three hours postinjection, with maximum contrast after 48 h. Accumulation of tumor fluorescence demonstratedthat modification of CC49 antibodies did not alter their specific tumor-localizing properties, andwas antibody-dependent since controls did not produce detectable tumor fluorescence. Conclusions: These results show proof-of-principle that our near-infrared fluorescent-antibody probetargeting a tumor-associated mucin detects colonic tumors at the molecular level in real time,and offer a basis for future improvement of image contrast during clinical fluorescence endoscopy.

关键词： Autofluorescence imaging endoscopy colon adenocarcinoma TAg72 CC49 mucin monoclonal antibody conjugate confocal fluorescence microscopy.

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Establishment of a cholangiocarcinoma risk evaluation model based on mucin expression levels

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World Journal of gastrointestinal Oncology 2024年第4期16卷 1344-1360页

作者： Chun-Yuan Yang Li-mei guo Yang Li guang-Xi Wang Xiao-Wei Tang Qiu-Lu Zhang Ling-Fu Zhang Jian-Yuan Luo department of Pathology Institute of Systems BiomedicineSchool of Basic Medical Sciences Peking UniversityPeking University Third HospitalPeking University Health Science CenterBeijing 100191China department of general Surgery Peking University Third HospitalBeijing 100191China department of medical genetics Department of Biochemistry and BiophysicsSchool of Basic Medical Sciences Peking UniversityPeking University Health Science CenterBeijing 100191China

BACKgROUND Cholangiocarcinoma(CCA)is a highly malignant cancer,characterized by frequent mucin ***1 has been identified as a critical oncogene in the progression of ***,the comprehensive understanding of how the mucin family influences CCA progression and prognosis is still *** To investigate the functions of mucins on the progression of CCA and to establish a risk evaluation formula for stratifying CCA *** Single-cell RNA sequencing data from 14 CCA samples were employed for elucidating the roles of mucins,complemented by bioinformatic ***-quent validations were conducted through spatial transcriptomics and *** construction of a risk evaluation model utilized the least absolute shrinkage and selection operator regression algorithm,which was further confirmed by independent cohorts and diverse data *** CCA tumor cells with elevated levels of mUC1 and mUC4 showed activated nucleotide metabolic pathways and increased ***5AC-high cells were found to promote CCA progression through WNT ***5B-high cells exhibited robust cellular oxidation activities,leading to resistance against antitumoral ***13-high cells were observed to secret chemokines,recruiting and transforming macrophages into the m2-polarized state,thereby suppressing antitumor ***16-high cells were found to promote tumor progression through interleukin-1/nuclear factor kappa-light-chain-enhancer of activated B cells signaling upon interaction with *** the expression levels of these mucins,a risk factor evaluation formula for CCA was developed and validated across multiple *** samples with higher risk factors exhibited stronger metastatic potential,chemotherapy resistance,and poorer *** Our study elucidates the functional mechanisms through which mucins contribute to CCA development,and provides tools for risk stratification in CCA.

关键词： mucin Cholangiocarcinoma Single-cell RNA sequencing Spatial transcriptomics Prognosis

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Ca^(2+) binding to the C_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

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Protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen mehar monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S.Chepurwar Regina Célia mingroni Netto Karina Lezirovitz Alfredo Tabith,Jr. Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona Julia Preobraschenski Tobias moser institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany göttingen graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of membrane Dynamics group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany molecular Architecture of Synapses group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiology group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIm32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil department of molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany multiscale Bioimaging Cluster of Excellence(mBExC) University of Göttingen37075 GöttingenGermany Functional Auditory genomics group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing genomics group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany institute of Human genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended background in Supplementary materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

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A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

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International Journal of Oral Science 2024年第2期16卷 265-279页

作者： Alfredo Torres m.Angélica michea Ákos Végvári marion Arce Valentina Pérez marcela Alcota Alicia morales Rolando Vernal mauricio Budini Roman A.Zubarev Fermín E.gonzález Laboratory of Experimental Immunology&cancer Faculty of DentistryUniversity of ChileSantiagoChile department of Conservative Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden Periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and molecular Pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases,yet its association with progressive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically monitored over twelve weeks via weekly clinical evaluations and gingival crevicular fluid(gCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RNA sequencing(scRNA-seq)dataset(gSE164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** samples from progressing and non-progressing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins,including SNCA,CA1,HBB,SLC4A1,and ANK1 was strongly associated with the clinical progression status of ***,we found specific proteins-drivers or suppressors-associated with ferroptosis(SNCA,FTH1,HSPB1,CD44,and gCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitative proteomic data with scRNA-seq analysis suggested the susceptibility of fibroblasts to *** analyses reveal proteins and processes linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progressive periodontal *** findings may le

关键词： finding progression faster

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