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Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico I.Bohnen department of Radiology University of MichiganAnn ArborMIUSA department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA Institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of Excellence University of MichiganAnn ArborMIUSA department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

Molecules “buckle up” to drive layered hybrid perovskites into single-crystal nanowires in water

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Science China Chemistry 2025年第1期 3-4页

作者： Seokhyoung Kim department of Chemistry Michigan State University

Layered 2D metal halide perovskites (MHPs) are one of the most exciting candidates for next-generation light sources owing to their outstanding optoelectronic properties. These properties are readily tunable by controlling the halide composition, number of inorganic layers, and the chemistry of organic cations. Another key element that can substantially impact the materials’ functionalities is crystal morphology [1].

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Endoscopic techniques for the diagnosis of pancreatic cystic lesions

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World Journal of Gastroenterology 2025年第1期31卷 1-7页

作者： Sahib Singh Saurabh Chandan Rakesh Vinayek Jahnvi Dhar Jayanta Samanta Gabriele Capurso Ivo Boskoski Cristiano Spada Jorge D Machicado Stefano Francesco Crinò Antonio Facciorusso department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States department of Gastroenterology Sinai Hospital of BaltimoreBaltimoreMD 21215United States department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Division of Pancreato-Biliary Endoscopy and Endosonography Pancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilano 20132Italy Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino Gemelli IRCSSUniversitàCattolica del Sacro Cuore di RomaCenter for Endoscopic Research Therapeutics and TrainingRoma 00168Italy department of Gastroenterology and Endoscopy Catholic UniversityRoma 00168Italy department of Gastroenterology University of Michigan HealthAnn ArborMI 48107United States department of Endoscopy University of VeronaVerona 37121VenetoItaly Gastroenterology Unit Department of Medical and Surgical SciencesUniversity of FoggiaFoggia 71122Italy

Pancreatic cysts are mostly incidental findings on computed tomography or magnetic resonance imaging scans,with few patients presenting with abdominal pain or other *** accurate diagnosis of cysts is important as management depends on the type(neoplastic or non-neoplastic).Cross-sectional imaging is fast being replaced with endoscopic ultrasound(EUS)and various techniques based on that such as EUS-guided fine needle aspiration,EUS-guided needle confocal laser endomicroscopy,EUS-through-the-needle biopsy,and contrast-enhanced *** studies have reported varying diagnostic and adverse event rates with these *** addition,American,European,and Kyoto guidelines for the diagnosis and management of pancreatic cysts have provided different *** this editorial,we elaborate on the clinical guidelines,recent studies,and comparison of different endoscopic methods for the diagnosis of pancreatic cysts.

关键词： Endoscopic ultrasound Fine needle aspiration Needle confocal laser endomicroscopy Through-the-needle biopsy Contrast-enhanced endoscopic ultrasound

OVERCONVERGENCE AND ZEROS OF SEQUENCES OF RATIONAL FUNCTIONS

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Analysis in Theory and Applications 1993年第4期9卷 9-20页

作者： M.Simkani university of michigan-flint U.S.A.

In the present paper we consider sequences of rational functions with a bounded number or free poles con- verging uniformly with a maximum geometric rate to a holomorphic function on a regular set,and we examine the limiting distribution of the Zeros and its relations with the phenomenon of *** results further extend the well known classical theory of overconvergence and the zeros of sections of Taylor series.

关键词： OVERCONVERGENCE AND ZEROS OF SEQUENCES OF RATIONAL FUNCTIONS

Teaching the User By Learning From the User:Personalizing Movement Control in Physical Human-robot Interaction

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IEEE/CAA Journal of Automatica Sinica 2017年第4期4卷 704-713页

作者： Ali Safavi Mehrdad H.Zadeh department of Electrical and Computer Engineering Kettering UniversityFlintMI 48504USA

This paper proposes a novel approach for physical human-robot interactions(pHRI), where a robot provides guidance forces to a user based on the user performance. This framework tunes the forces in regards to behavior of each user in coping with different tasks, where lower performance results in higher intervention from the robot. This personalized physical human-robot interaction(p2HRI) method incorporates adaptive modeling of the interaction between the human and the robot as well as learning from demonstration(LfD) techniques to adapt to the users' performance. This approach is based on model predictive control where the system optimizes the rendered forces by predicting the performance of the user. Moreover, continuous learning of the user behavior is added so that the models and personalized considerations are updated based on the change of user performance over time. Applying this framework to a field such as haptic guidance for skill improvement, allows a more personalized learning experience where the interaction between the robot as the intelligent tutor and the student as the user,is better adjusted based on the skill level of the individual and their gradual improvement. The results suggest that the precision of the model of the interaction is improved using this proposed method,and the addition of the considered personalized factors to a more adaptive strategy for rendering of guidance forces.

关键词： Haptic guidance learning from demonstration(LfD) personalized physical human-robot interaction(p2HRI) user performance

A novel flavonol-based colorimetric and turn-on fluorescent probe for rapid determination of hydrazine in real water samples and its bioimaging in vivo and in vitro

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Frontiers of Chemical Science and Engineering 2023年第1期17卷 24-33页

作者： Ahui Qin Yan Zhang Shuai Gong Mingxin Li Yu Gao Xu Xu Jie Song Zhonglong Wang Shifa Wang Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China department of Natural Sciences University of Michigan-FlintFlintMI 48502USA

Hydrazine is extremely toxic and causes severe harm to human ***,a novel fluorescent probe 4-oxo-2-styryl-4H-chromen-3-yl thiophene-2-carboxylate(FHT)was synthesized for detecting hydrazine by using natural cinnamaldehyde as starting *** probe exhibited significantly enhanced fluorescence response towards hydrazine over various common metal ions,anions,and amine *** detection limit of probe FHT for hydrazine was as low as 0.14μmol·L^(-1),significantly lower than that of the threshold value of 0.312μmoi·L^(-1),imposed by the Environmental Protection ***,the proposed probe was able to detect hydrazine within wide pH(5-10)and linear detection ranges(0-110μmol·L^(-1)).This probe was employed for determining trace hydrazine in different environmental water *** probe FHT-loaded filter paper strips werea able to conveniently detect hydrazine of low concentration through distinct naked-eye and fluorescent color ***,the probe FHT with low cytotoxicitywas successfullyapplied to visualize hydrazine in living Hela cells and zebrafish.

关键词： cinnamaldehyde 3-hydroxychromone derivative hydrazine fluorescent probe

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Simulations of a logistic-type model with delays for Chagas disease with insecticide spraying

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International Journal of Biomathematics 2017年第3期10卷 41-60页

作者： Nofe Al-Asuoad Tyler Pleasant Meir Shillor Hrishikesh Munugala Daniel J. Coffield Jr. Anna Maria Spagnuolo department of Mathematics and Statistics Oakland university Rochester MI 48309 USA Harrison High School MI USA Novi High School Novi MI 48375 USA Mathematics department University of Michigan-Flint Flint MI 48502 USA

This work studies and numerically simulates a logistic-type model for the dynamics of Chagas disease, which is caused by the parasite T. cruzi and affects millions of humans and domestic mammals throughout rural areas in Central and South America. A basic model for the disease dynamics that includes insecticide spraying was developed in Spagnuolo et al. （2010） [271 and consists of a delay-differential equation for the vectors and three nonlinear ordinary differential equations for the populations of the infected vectors, infected humans and infected domestic mammals. In this work, the vector equation is modified by using a logistic term with zero, one or two delays or time lags. The aim of this study is three-fold： to numerically study the effects of using different numbers of delays on the model behavior; to find if twice yearly insecticide spraying schedules improve vector control; and to study the sensitivity of the system to the delays in the case of two delays, by introducing randomness in the delays. It is found that the vector equation with different number of delays has very different solutions. The ＂best＂ day of spraying is the middle of Spring and twice annual sprayings cause only minor improvements in disease control. Finally, the model is found to be insensitive to the values of the delays, when the delays are randomly distributed within rather narrow intervals or ranges centered on the parameter values used in Coffield et al. （2014） [8].

关键词： Chagas disease logistic equation with delays epidemic dynamics nonlinear dynamical system simulations.

基于氧传感器信号的用于研究空气/燃料比率变化的统计方法

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内燃机学报 2008年第1期26卷 11-23页

作者： Etim U Ubong Boyan Dimitrov department of Mechanical Engineering Kettering University Flint Michigan 48504 USA

给出了火花点火式发动机排气氧传感器(EGO)输出信号的实验结果。实验中采用V6、3.8 L、BUICK发动机且每个气缸中安装有一个氧传感器,以研究影响发动机消耗燃料的因素。应用LabView数据采集装置记录单个气缸废气以及主流尾气氧传感器的... 详细信息

给出了火花点火式发动机排气氧传感器(EGO)输出信号的实验结果。实验中采用V6、3.8 L、BUICK发动机且每个气缸中安装有一个氧传感器,以研究影响发动机消耗燃料的因素。应用LabView数据采集装置记录单个气缸废气以及主流尾气氧传感器的输出电压信号。对来自6个气缸变量的平均值采用统计的方法进行处理后,并与主流的EGO电压进行比较,确定了产生系统误差的因素。对左右两侧气缸信号平均值的差别进行比较发现,采用此种排气管结构的气缸中空气—燃料混合气平均值存在一些明显差别。根据数据和图表解释了统计的结果。研究表明,V字形排列的发动机两侧的气缸的空气和燃料混合气是不同的;在低速、高负荷和高辛烷燃料的情况下,右侧气缸具有比较稀的混合气;而在某些情况下两侧气缸具有相同的混合气。基于统计估计的方法,提出了一个可以用于估计V字形排列发动机左右两侧气缸中空气—燃料混合气的简单模型。此方法还可以应用于分析进气管和排气管的缺陷。

关键词：排气氧传感器气缸间空气/氧气比率变动统计分析

Stability and orientation of cecropin P1 on maleimide self-assembled monolayer(SAM) surfaces and suggested functional mutations

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Chinese Chemical Letters 2015年第4期26卷 485-490页

作者： Shuai Wei Charles L.Brooks Ⅲ department of Chemistry University of Michigan department of Biophysics University of Michigan

One of the main challenges of biosensor design is to understand the protein or peptide stability on the chip in high resolution structural detail. Since conventional experimental methods are limited by the resolution for their applications on surface tethered peptides/proteins, a recently developed coarse grained simulation method is employed to explore the peptide/surface interaction in residue-level resolution. This work shows how the coarse grained model successfully describes peptide-surface interactions by evaluating thermal stability of the peptide cecropin PI in bulk solution and on surfaces by physical adsorption and chemical tethering. The simulation also reproduces observations of peptide orientations on the self-assembled monolayer surface from earlier experimental work. Additionally, using knowledge obtained from the simulations, specific mutations are suggested and the desired structure and pose on the surface is obtained. In summary, this work sheds a light on the reasonable biosensor design that is ~uided by simulations.

关键词： Coarse grained simulationKB Go-like modelPeptide-surface interactionThermal stabilityOrientationMutation