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EGFR-targeted and gemcitabine-incorporated chemogene for combinatorial pancreatic cancer treatment

Nano Research 2024年第2期17卷 848-857页

作者： Miao Xie Qiushuang Zhang Yuanyuan Guo Lijuan Zhu Xinyuan Zhu Chuan Zhang School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Molecular MedicineSixth people’s HospitalSchool of MedicineShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China department of Radiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200233China Institute of Molecular Medicine Shanghai Jiao Tong University Affiliated Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Pancreatic cancer stands out as a recognized intractable tumor due to its high malignancy and mortality rates,which are largely attributed to the insensitivity of current clinical chemotherapies or *** chemo and gene therapy that integrates different therapeutic targets,may increase the chemosensitivity of pancreatic cancer and synergistically enhance the antitumor ***,conventional co-delivery of gene and chemo drugs is intensively dependent on complex nanoparticle delivery systems,thus would be limited by unstable drug packaging,nonspecific biodistribution,and biosafety ***,we rationally designed an epidermal growth factor-receptor(EGFR)-targeted and gemcitabine-incorporated oligonucleotide(termed as chemogene)with anti-Bcl-2 sequence,which achieves simple and precise integration of gemcitabine into a gene regulative agent,as well as the EGFR-targeted delivery for pancreatic cancer *** solid-phase synthesis,gemcitabine,as the first-line chemodrug for pancreatic cancer,is introduced to the antisense oligonucleotide to replace all cytosine nucleosides to obtain the gemcitabine-integrated chemogene(Ge-ASO^(Bcl-2)).Thereafter,Ge-ASO^(Bcl-2)is covalently coupled with EGFR nanobody to construct the final targeted chemogene without any exogenous ***,this nanobody-conjugated chemogene exhibits remarkable tumor targeting capability and antitumor effects both in vitro and in vivo,which initiates a first step toward the application of combinatorial chemo and gene therapy for future pancreatic cancer treatment.

关键词： antisense oligonucleotide chemogene nanobody drug delivery system pancreatic cancer

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Experimental investigation on the permeability of gap-graded soil due to horizontal suffusion considering boundary effect

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1072-1084页

作者： Xuwei Wang Yeshuang Xu State Key Laboratory of Ocean Engineering School of Naval ArchitectureOceanand Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China shanghai Key Laboratory for Digital Maintenance of Buildings and Infrastructure Department of Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China

The boundary condition is a crucial factor affecting the permeability variation due to *** experimental investigation on the permeability of gap-graded soil due to horizontal suffusion considering the boundary effect is conducted,where the hydraulic head difference(DH)varies,and the boundary includes non-loss and soil-loss *** samples are filled into seven soil storerooms connected in *** evaluation,the variation in content of fine sand(ΔR_(f))and the hydraulic conductivity of soils in each storeroom(C_(i))are *** the non-loss test,the soil sample filling area is divided into runoff,transited,and accumulated areas according to the negative or positive ΔR_(f) values.ΔR_(f) increases from negative to positive along the seepage path,and Ci decreases from runoff area to transited area and then rebounds in accumulated *** the soil-loss test,all soil sample filling areas belong to the runoff area,where the gentle-loss,strengthened-loss,and alleviated-loss parts are further divided.ΔR_(f) decreases from the gentle-loss part to the strengthened-loss part and then rebounds in the alleviated-loss part,and C_(i) increases and then decreases along the seepage *** relationship between ΔR_(f) and Ci is different with the boundary *** exponentially decreases with ΔR_(f) in the non-loss test and increases with ΔR_(f) generally in the soil-loss test.

关键词： Suffusion Permeability Experimental investigation Boundary effect Horizontal seepage

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Operando investigation of particle re-entrainment mechanism in electrostatic capture process on the lab-on-a-chip

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Journal of Environmental Sciences 2024年第2期136卷 337-347页

作者： Yong Zhu Yikun Zhang Xiaoyong Yang Shanlong Tao Mingxia Chen Wenfeng Shangguan Research Center for Combustion and Environmental Technology School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Inhalable particle is a harmful air pollutant that causes a significant threat to people's health and ecological environments,which should be removed to purify air,but there exists limited removal efficiency due to particle ***,Operando observation system based on microscopic visualization method is developed to make in situ test of particle migration,deposition and re-entrainment characteristics on a lab-on-a-chip to achieve the investigation in micro-level *** deposition evolution of charged particles is recorded in electric field region intuitively,which confirms the fracture of particle chain occurs during the growth process of deposited *** captures the instantaneous process that a larger particle with micron size due to the coagulation of submicron particles fractures from main body of the particle chain for the first *** analysis of migration behavior of a single submicron particle near electrode surface demonstrates the direct influence of drag force on the fracture of particle *** work is the first-time visualization of dynamic process and mechanism elucidation of particle re-entrainment at the micron level,and the findings will provide the theory support for the particle re-entrainment mechanism and bring inspires of enhancing capture efficiency of inhalable particle.

关键词： Inhalable particle Re-entrainment mechanism Operando observation Lab-on-a-chip Capture efficiency

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Multi-Agent Path Planning Method Based on Improved Deep Q-Network in Dynamic Environments

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Journal of shanghai jiaotong university(Science) 2024年第4期29卷 601-612页

作者： LI Shuyi LI Minzhe JING Zhongliang School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai200240China

The multi-agent path planning problem presents significant challenges in dynamic environments,primarily due to the ever-changing positions of obstacles and the complex interactions between agents’*** factors contribute to a tendency for the solution to converge slowly,and in some cases,diverge *** addressing this issue,this paper introduces a novel approach utilizing a double dueling deep Q-network(D3QN),tailored for dynamic multi-agent environments.A novel reward function based on multi-agent positional constraints is designed,and a training strategy based on incremental learning is performed to achieve collaborative path planning of multiple ***,the greedy and Boltzmann probability selection policy is introduced for action selection and avoiding convergence to local *** match radar and image sensors,a convolutional neural network-long short-term memory(CNN-LSTM)architecture is constructed to extract the feature of multi-source measurement as the input of the *** algorithm’s efficacy and reliability are validated in a simulated environment,utilizing robot operating system and *** simulation results show that the proposed algorithm provides a real-time solution for path planning tasks in dynamic *** terms of the average success rate and accuracy,the proposed method is superior to other deep learning algorithms,and the convergence speed is also improved.

关键词： multi-agent path planning deep reinforcement learning deep Q-network

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Theoretical study on the effect of H_(2)O on the formation mechanism of NO_(x) precursors during indole pyrolysis

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 99-112页

作者： Ziqi Wang Jun Shen Xuesong Liu Sha Wang Shengxiang Deng Hai Zhang Yun Guo School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The incineration technology of kitchen waste is one of the effective technologies to achieve the resource utilization of municipal solid *** is an important stage of *** is a rich initial product in the pyrolysis process of kitchen waste,and the presence of H_(2)O has a significant impact on the decomposition of indole to form NO_(x) ***,this study uses density functional theory method to study the effect of H_(2)O on the thermal decomposition of indole to produce NH_(3),HNCO,and *** H_(2)O participates in the reaction,it can provide oxidative groups to generate a new product HNCO,which is different from the previous findings by indole pyrolysis without the presence of H_(2)***,this study theoretically proves that NH_(3) is easier to form than *** is consistent with the phenomenon that NH_(3) release is higher than HCN release in pyrolysis *** addition,compared with the individual pyrolysis of indole,the participation of H_(2)O reduces the energy barriers for the formation of NH_(3) and HCN during indole pyrolysis,thereby promoting the formation of NH_(3) and HCN.

关键词： indole pyrolysis H_(2)O NO_(x)precursors DFT

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Characteristics of Particulate Matter Emissions for Low-Sulfur Heavy Oil Used in Low-Speed Two-Stroke Diesel Engines of Ocean-Going Ships

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Journal of Thermal Science 2024年第2期33卷 739-750页

作者： WU Gang MA Qianli WEI Lijiang JIANG Guohe WANG Tengfei LI Tie Merchant Marine College Shanghai Maritime UniversityShanghai201306China State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai200240China

In this work,particulate matter(PM) emissions from a large two-stroke,low-speed marine diesel engine were investigated when the engine was operated with low-sulfur heavy fuel oil(HFO) at various *** samples were collected in situ from the engine exhaust to determine the detailed physical and chemical *** nanostructure and morphology of the nanoparticles were analyzed using transmission electron microscopy images(TEM).The results show that volatile organic carbon(OC) accounts for more than 80% in the HFO particles and leads to an increase in particle *** thermodynamic conditions of a low-speed engine favor the behavior of capturing the soluble organic components.A large number of spherical char HFO particles with aerodynamic diameters of 0.2 μm-0.5 μm and a suspected inner metal core were *** two peak aerodynamic diameters of the HFO nanoparticles are 15 nm and 86 *** morphological differences among the HFO nanoparticles in varied engine conditions represent the formation process from primary nascent particles to mature graphitized particles caused by *** above study will be valuable for understanding the characteristics of PM emissions from low-sulfur HFO to achieve the ship PM emissions reduction target.

关键词： low-speed diesel engine maritime regulations heavy fuel oil TEM particles size and distribution

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Finger-actuated wireless-charging wearable multifunctional sweatsensing system for levodopa and vitamin C

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Nano Research 2024年第4期17卷 3096-3106页

作者： Qihong Ning Shaoqing Feng Qingwen Sun Ruoyao Yu Tangan Li Hao Xu Daxiang Cui Kan Wang School of Sensing Science and Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityKey Laboratory of Thin Film and Microfabrication Technology(Ministry of Education)Shanghai 200240China department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China School of Naval Architecture Ocean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Efficient portable wearable sweat sensors allow the long-term monitoring of changes in the status of biomarkers in sweat,which can be useful in diagnosis,medication,and nutritional *** this study,we designed and tested a wireless,battery-free,flexible,self-pumping sweat-sensing system that simultaneously tracks levodopa and vitamin C levels in human sweat and detects body *** system includes a microfluidic chip with a self-driven pump and anti-reflux valve,a flexible wireless circuit board,and a purpose-designed smartphone *** microfluidic chip is used for the efficient collection of sweat and the drainage of excess *** dual electrochemical sensing electrodes in the chip are modified with functional materials and appropriate enzymatic reagents,achieving excellent selectivity and *** sensitivities of the levodopa sensor and the vitamin C sensor are 0.0073 and 0.0018μA·μM^(-1),respectively,and the detection correlation coefficients of both exceed *** sensors have a wide linear detection range of 0–100 and 0–1000μM,respectively,and low detection limits of 0.28 and 17.9μM,*** flexible wireless circuit board is equipped with the functions of wireless charging,electrical signal capture and processing,and wireless *** data recorded from each sensor are displayed on a smartphone via a self-developed app.A series of experimental results confirmed the reliability of the sweat-sensing system in noninvasively monitoring important biomarkers in the human body and its potential utility in the comprehensive assessment of biological health.

关键词： self-pumping microfluidic channel wireless charging wearable sensor health monitoring

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Ultra-efficient and parameter-free computation of submicron thermal transport with phonon Boltzmann transport equation

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Fundamental Research 2024年第4期4卷 907-915页

作者： Yue Hu Yongxing Shen Hua Bao university of Michigan-shanghai jiao tong university Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China

Understanding thermal transport at the submicron scale is crucial for engineering applications,especially in the thermal management of electronics and tailoring the thermal conductivity of thermoelectric *** the submicron scale,the macroscopic heat diffusion equation is no longer valid and the phonon Boltzmann transport equation(BTE)becomes the governing equation for thermal ***,previous thermal simulations based on the phonon BTE have two main limitations:relying on empirical parameters and prohibitive computational ***,the phonon BTE is commonly used for qualitatively studying the non-Fourier thermal transport phenomena of toy *** this work,we demonstrate an ultra-efficient and parameter-free computational method of the phonon BTE to achieve quantitatively accurate thermal simulation for realistic materials and *** properly integrating the phonon properties from first-principles calculations,our method does not rely on empirical material properties *** can be generally applicable for different materials and the predicted results can match well with experimental ***,by developing a suitable ensemble of advanced numerical algorithms,our method exhibits superior numerical *** full-scale(from ballistic to diffusive)thermal simulation of a 3-dimensional fin field-effect transistor with 13 million degrees of freedom,which is prohibitive for existing phonon BTE solvers even on supercomputers,can now be completed within two hours on a single personal *** method makes it possible to achieve the predictive design of realistic nanostructures for the desired thermal *** also enables accurately resolving the temperature profiles at the transistor level,which helps in better understanding the self-heating effect of electronics.

关键词： Submicron thermal transport Boltzmann transport equation Deterministic numerical method Phonon transport Transistors Nanostructured materials

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Silicon photonic integrated interrogator for fiber-optic distributed acoustic sensing

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Photonics Research 2024年第3期12卷 465-473页

作者： ZHICHENG JIN JIAGENG CHEN YANMING CHANG QINGWEN LIU ZUYUAN HE State Key Laboratory of Advanced Optical Communication System and Networks Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Distributed acoustic sensing(DAS)technology has been a promising tool in various ***,the large size and relatively high cost of DAS equipment composed of discrete devices restrict its further popularization to some degree,and the photonic integration technology offers a potential *** this paper,we demonstrate an integrated interrogator for DAS on the silicon-on-insulator(SOI)*** design of the chip revolves around a Mach–Zehnder modulator(MZM)transmitter and a dual-quadrature and dualpolarization coherent *** integrated interrogator supports multiple DAS schemes,including the time-gated digital optical frequency domain reflectometry(TGD-OFDR),which is adopted for system performance evaluation.59■strain resolution in 12.1km sensing fiber with 1.14 m spatial resolution(SR)is ***,along 49.0 km sensing fiber,81■strain resolution with 3.78 m SR is *** results show that the integrated interrogator has comparable performance to the discrete DAS *** the best of our knowledge,this is the first dedicated on-chip DAS interrogator,which validates the effectiveness of the blend of photonics integration and DAS technology.

关键词： fiber polarization modulator

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AI for tribology:Present and future

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Friction 2024年第6期12卷 1060-1097页

作者： Nian YIN Pufan YANG Songkai LIU Shuaihang PAN Zhinan ZHANG State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China department of Mechanical Engineering University of UtahSalt Lake CityUT 84112USA

With remarkable learning capabilities and swift operational speeds,artificial intelligence(AI)can assist researchers in swiftly extracting valuable patterns,trends,and associations from subjective *** behaviors are characterized by dependence on systems,evolution with time,and multidisciplinary *** friction process involves a variety of phenomena,including mechanics,thermology,electricity,optics,magnetics,and so ***,tribological information possesses the distinct characteristics of being multidisciplinary,multilevel,and multiscale,so that the application of AI in tribology is highly *** delineate the scope,classification,and recent trends of AI implementation in tribology,this review embarks on exploration of the tribology research *** comprehensively outlines the utilization of AI in basic theory of tribology,intelligent tribology,component tribology,extreme tribology,bio-tribology,green tribology,and other ***,considering the emergence of"tribo-informatics"as a novel interdisciplinary field,which combines tribology with informatics,this review elucidates the future directions and research framework of"AI for tribology".In this paper,tribo-system information is divided into 5 categories:input information(I),system intrinsic information(S),output information(O),tribological state information(Ts),and derived state information(Ds).Then,a fusion method among 5 types of tribo-system information and different AI technologies(regression,classification,clustering,and dimension reduction)has been proposed,which enables tribo-informatics methods to solve common problems such as tribological behavior state monitoring,behavior prediction,and system *** purpose of this review is to offer a systematic comprehension of tribo-informatics and to inspire new research ideas of ***,it aspires to enhance the efficiency of problem-solving in tribology.

关键词： artificial intelligence(AI) tribology machine learning tribo-informatics AI for tribology

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