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China CDC weekly 2023年第23期5卷 505-510页

作者： Shuangbo Xia Yushan Du Ziyang Ren Jinjuan Zhang Suhong Gao Jiamei Wang Zhiwen Li Xiaohong Liu Jufen Liu department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Institute of Reproductive and child health/National health Commission Key Laboratory of Reproductive health Peking UniversityBeijingChina department of child health Beijing Haidian Maternal and Child Health HospitalBeijingChina department of Gynaecology and Obstetrics Beijing Haidian Maternal and Child Health HospitalBeijingChina

Summary What is already known about this topic?Inconsistent results have been reported on the association between periconceptional folic acid only(FAO)or multiple micronutrients containing folic acid(MMFA)supplementation and the risk of gestational diabetes mellitus(GDM)in previous research.What is added by this report?In a prospective cohort study conducted among pregnant women in Haidian District,Beijing Municipality,it was observed that those who took MMFA demonstrated a higher likelihood of developing GDM in comparison to those who consumed FAO periconceptionally.Interestingly,the increased risk for GDM in pregnant women supplemented with MMFA compared to FAO was primarily due to changes in fasting plasma glucose.What are the implications for public health practice?It is highly recommended that women prioritize the use of FAO in order to yield potential benefits in the prevention of GDM.

关键词： prevention Diabetes conception

Pediatric stricturing Crohn's disease

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World Journal of Gastroenterology 2024年第12期30卷 1651-1654页

作者： Alessandro Boscarelli Matteo Bramuzzo department of Pediatric Surgery and Urology Institute for Maternal and Child Health-IRCCS“Burlo Garofolo”Trieste 34137Italy department of Gastrointestinal Endoscopy and Nutrition Institute for Maternal and Child Health-IRCCS"Burlo Garofolo"Trieste 34137Italy

Crohn’s disease(CD)is a chronic inflammatory disease of the digestive tract.The incidence of pediatric CD is increasing and is currently 2.5-11.4 per 100000 world-wide.Notably,approximately 25%of children with CD develop stricturing CD(SCD)that requires intervention.Symptomatic stricturing diseases refractory to pharmacological management frequently require non-pharmacological interventions.Non-pharmacological therapeutic strategies include endoscopic balloon dilatation,stricturoplasty,and surgical resection of the strictured seg-ment.However,strictures tend to recur postoperatively regardless of treatment modality.The lifetime risk of surgery in patients with childhood SCD remains at 50%-90%.Thus,new and emerging strategies,advanced diagnostic tools,and minimally invasive approaches are under investigation to improve the outcomes and overall quality of life of pediatric patients with SCD.

关键词： Stricturing Crohn’s disease Pediatrics Insights Future perspectives

Eye-movement Patterns of Chinese children with Developmental Dyslexia during the Stroop Test

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Biomedical and Environmental Sciences 2018年第9期31卷 677-685页

作者： WU Yu Jia YANG Wen Han WANG Qing Xiong YANG De Sheng HU Xiao Yun JING Jin LI Xiu Hong Department of Maternal and Child Health School of Public Health Sun Yat-sen University

Objective To compare the eye-movement patterns of Chinese children with developmental dyslexia（DD children） with those of non-dyslexic children as they perform the Stroop Color and Word Test（SCWT）, and to explore the relationship between their eye-movement patterns and interference effect. Methods An EyeLink II was used to record the eye-movement parameters of 32 DD children and 37 non-dyslexic children as they performed the SCWT. The independent samples t-test and repeated measures were used to analyze behavioral and eye-movement parameters. Results Compared to the control group, Chinese DD children presented lower accuracy（F = 8.488）, slower response time（F = 25.306）, and larger interference effect（t = 2.29）; Chinese DD children also exhibited lower frequency of fixations（F = 6.069）, greater numbers of saccades（F = 7.914） and fixations（F = 5.272）, and shorter mean saccade distance（F = 4.03）. All behavioral and eye-movement parameters differed significantly among the three tasks in the SCWT. There was significant interaction between groups and tasks in accuracy（F = 5.844）, and marginally significant interaction in response time（F = 3.040）. Chinese DD children tended to have lower accuracy and longer response time than the control group in the ＇color-word naming＇ task. Conclusion Compared to non-dyslexic children, Chinese DD children are subject to a stronger interference effect. When performing the SCWT, Chinese DD children exhibit abnormal eye-movement patterns, namely shorter mean saccade distance, lower frequency of fixations, and more fixations and saccades. These abnormal eye movements may be relatively stable oculomotor patterns of DD children performing visual processing, and not influenced by impaired interference effect.

关键词： Developmental dyslexia Chinese children Eye movement Stroop Color and Word Test

Unexplained fetal tachycardia:A case report

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World Journal of Clinical Cases 2024年第9期12卷 1698-1703页

作者： Hui Wang Run-Zi Duan Xin-Jiu Bai Bing-Ting Zhang Jie Wang Wen-Xia Song department of Nutrition Changzhi Maternal and Child Health Care Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina department of Obstetrics Changzhi Maternal and Child Health Care Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina department of Gynaecology Changzhi Maternal and Child Health Care Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina department of Medical Genetic Changzhi Maternal and Child Health Care Hospital Affiliated to Changzhi Medical CollegeChangzhi 046011Shanxi ProvinceChina

BACKGROUND This study aimed to explore the possible etiology and treatment of severe fetal tachycardia in the absence of organic disease and provide a reference for clinical management of severe fetal tachycardia.CASE SUMMARY A 29-year-old pregnant woman,with a gravidity 1 parity 0,presented with a fetal heart rate(FHR)of 243 beats per minute during a routine antenatal examination at 31+2 wk of gestation.Before termination of pregnancy at 38 wk of gestation,the FHR repeatedly showed serious abnormalities,lasting more than 30 min.However,the pregnant woman and the fetus had no clinical symptoms,and repeated examination revealed no organic lesions.The mother and the baby were regularly followed up.CONCLUSION This was a case of severe fetal tachycardia with no organic lesions and management based on clinical experience.

关键词： Fetal heart rate disorder Fetal tachycardia Severe tachycardia Case report

Male reproductive system and simulated high-altitude environment:preliminary results in rats

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Asian Journal of Andrology 2023年第3期25卷 426-432页

作者： Xiu-Yun Li Mei-Hua Zhang Zhao-Wen Chen Bin Zhang Gang Bai He-Feng Wang Key Laboratory of Birth Regulation and Control Technology of National health Commission of China Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao UniversityJinan 250014China department of Obstetrics Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao UniversityJinan 250014China department of Ophthalmology Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao UniversityJinan 250014China Center for Reproductive Medicine Shandong UniversityJinan 250012China department of Pediatric Surgery Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao UniversityJinan 250014China

This study assessed the effects of a simulated high-altitude environment on the reproductive system of prepubertal male rats and the reversibility of these effects upon return to a normal environment.Three-week-old male Wistar rats were randomly allocated to 4 groups that were exposed to different conditions:a normal environment for 6 weeks and 12 weeks,respectively,hypobaric hypoxia for 6 weeks,and hypobaric hypoxia for 6 weeks followed by a normal environment for 6 weeks.Multiple pathophysiological parameters were evaluated at the histological,endocrine,and molecular levels.Hypobaric hypoxia exposure for 6 weeks during the prepubertal phase significantly altered physiological parameters,body functions,blood indices,and reproductive potential.Six weeks after returning to a normal environment,the damaged reproductive functions partially recovered due to compensatory mechanisms.However,several changes were not reversed after returning to a normal environment for 6 weeks,including disorders of body development and metabolism,increased red blood cells,increased fasting blood glucose,abnormal blood lipid metabolism,decreased testicular and epididymis weights,abnormal reproductive hormone levels,excessive apoptosis of reproductive cells,and decreased sperm concentration.In summary,a hypobaric hypoxic environment significantly impaired the reproductive function of prepubertal male rats,and a return to normal conditions during the postpubertal phase did not fully recover these impairments.

关键词： high altitude hypobaric hypoxia male rats reproductive potential testis

Stressful life events,psychosocial health and general health in preschool children before age 4

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World Journal of Pediatrics 2023年第3期19卷 243-250页

作者： Jie Luo Amy van Grieken Shuang Zhou Yuan Fang Hein Raat department of Public health Erasmus MCDr.Molewaterplein 403015 GD RotterdamThe Netherlands Department of Maternal and Child Health School of Public HealthPeking UniversityBeijingChina

Background The impact of stressful life events(SLEs)in early childhood is often ignored.We aimed to examine longitudinal associations between SLEs and psychosocial and general health in preschool children.Methods Twelve SLEs occurring before the age of 24 months were assessed and categorized by frequency(no events,1-2 SLEs,and>2 SLEs)and overall tension(no events,low,and high)(n=1431).Psychosocial and general health were meas-ured three times at the age of 24,36 and 45 months.The associations were examined by logistic regression models using generalized estimating equations to handle repeated measurements.Results Half(48.4%)of the families experienced SLEs,and 23.8%perceived high-tension SLEs before the children were aged 24 months.Gender differences were observed in the association between SLEs and psychosocial health.Compared to girls without SLEs,girls who experienced>2 SLEs[OR=3.31,95%confidence interval(CI)2.05-5.35]or high-tension SLEs(OR=3.01,95%CI 2.07-4.39)had higher odds of psychosocial problems from 24 to 45 months.The odds ratios in boys were 2.10(95%CI 1.36-3.24)and 1.47(95%CI 1.06-2.03),respectively.Moreover,only girls'risk of psychosocial problems increased after experiencing 1-2 SLEs(OR=2.15,95%CI 1.54-3.00)or low-tension SLEs(OR=1.90,95%CI 1.31-2.74).Regarding general health,children who experienced>2 SLEs(OR=1.96,95%CI 1.21-3.18)and high-tension SLEs(OR=1.60,95%CI 1.12-2.28)had higher odds of poor general health from 24 to 45 months.Conclusions The findings emphasized that young children's psychosocial and general health can be impacted by experienc-ing SLEs in early childhood.Attention and adequate support for families experiencing SLEs are needed to minimize the potential negative effect of SLEs on child health,particularly in girls.

关键词： child health Preschool children Stressful life event

Diagnosis of a Chinese man with 45,X/46,X,i（Y）（q10）/47,X,i（Y）（q10） ×2 mosaic Turner syndrome

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Asian Journal of Andrology 2018年第2期20卷 205-207页

作者： Yan-Wei Sha Lu Ding Zhi-Yong Ji Yun-Sheng Ge Hui Kong Qing Zhang Yu-Lin Zhou Ping Li department of Reproductive Medicine Maternal and Child Health Hospital of Xiamen Xiamen 361005 China Genetics Laboratory Maternal and Child Health Hospital of Xiamen Xiamen 361005 China

Turner syndrome （TS）, characterized by the complete or partial absence of an X chromosome, is the only known viable chromosomal monosomy. It is one of the most common sex chromosome abnormalities in women, but it ca...

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Performance of non-invasive prenatal screening for sex chromosome aneuploidies and parental decision-making

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Chinese Medical Journal 2020年第13期133卷 1617-1619页

作者： Jie-Ping Song Yu-Fei Jiang Tang-Xin-Zi Gao Yan-Yi Yao Li-Jun Liu Run-Hong Xu Mei-Qi Yi Chun-Jiao Yu Wei-Peng Wang Hui Li Clinical Laboratory Maternal and Child Health Hospital of Hubei ProvinceWuhanHubei 430070China Prenatal Diagnosis Center Maternal and Child Health Hospital of Hubei ProvinceWuhanHubei 430070China department of health Care Maternal and Child Health Hospital of Hubei ProvinceWuhanHubei 430070China

To the Editor:Sex chromosomal aneuploidies(SCAs)are common chromosomal aberrations that are normally diagnosed after birth.It results in abnormal physical development or infertility.The prenatal incidence is as high as 1/435 and is usually identified by karyotyping.SCAs are characterized by an abnormal number of sex chromosomes and include monosomy(45,X),trisomy(47,XXX,47,XXY,and 47,XYY),other aneuploidies and various forms of sex chromosome mosaicism.The phenotypes of SCA patients are diverse.The prenatal diagnosis of fetal SCAs affects the parents and there is a need for clinical counseling.What's more,early diagnosis is important as it provides opportunities for early treatment and future healthcare for children with SCAs.

关键词： diagnosis prenatal abnormal

Is autophagy an elective strategy to protect neurons from dysregulated cholesterol metabolism?

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Neural Regeneration Research 2019年第4期14卷 582-587页

作者： Elisa Piscianz Liza Vecchi Brumatti Alberto Tommasini Annalisa Marcuzzi department of Medicine Surgery and Health Sciences University of Trieste Institute for maternal and child health-IRCCS "Burlo Garofolo"

The balance of autophagy, apoptosis and necroptosis is crucial to determine the outcome of the cellular response to cholesterol dysregulation. Cholesterol plays a major role in regulating the properties of cell membranes, especially as regards their fluidity, and the regulation of its biosynthesis influences the shape and functions of these membranes. Whilst dietary cholesterol can easily be distributed to most organs, the central nervous system, whose membranes are particularly rich in cholesterol, mainly relies on de novo synthesis. For this reason, defects in the biosynthesis of cholesterol can variably affect the development of central nervous system. Moreover, defective synthesis of cholesterol and its intermediates may reflect both on structural cell anomalies and on the response to inflammatory stimuli. Examples of such disorders include mevalonate kinase deficiency, and Smith-Lemli-Opitz syndrome, due to deficiency in biosynthetic enzymes, and type C Niemann-Pick syndrome, due to altered cholesterol trafficking across cell compartments. Autophagy, as a crucial pathway dedicated to the degradation of cytosolic proteins and organelles, plays an essential role in the maintenance of homeostasis and in the turnover of the cytoplasmic material especially in the presence of imbalances such as those resulting from alteration of cholesterol metabolism. Manipulating the process of autophagy can offer possible strategies for improving neuronal cell viability and function in these genetic disorders.

关键词： cholesterol inflammation apoptosis autophagy neurons inherited disease necroptosis neuronal dysfunction

Launch of “maternal and child health in China” Campaign

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China Population Today 2014年第6期31卷 46-46页

作者： Department of Maternal and Child Health of National health and Family Planning Commission Department of Maternal and Child Health of National health and Family Planning Commission

On the morning of June 28,2014,under the joint guidance of National health and Family Planning Commission(NHFPC)and All-China Women's Federation,the launching ceremony of "maternal and child health in China"campaign was held in Beijing.It was jointly organized by maternal and child health Center of Chinese Center for Disease Control and Prevention,China Women Activity Center and

关键词：儿童健康中国计划生育疾病预防妇幼保健活动中心签字仪式委员会