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Petrology and phase equilibrium modeling of sapphirine ＋ quartz assemblage from the Napier Complex, East Antarctica: Diagnostic evidence for Neoarchean ultrahigh-temperature metamorphism

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Geoscience Frontiers 2013年第6期4卷 655-666页

作者： Hisako Shimizu Toshiaki Tsunogae M.Santosh Graduate School of life and Environmental sciences University of Tsukuba department of Geology University of Johannesburg China University of Geosciences (Beijing) division of Interdisciplinary Science Faculty of ScienceKochi University

A synthesis of the petrological characters of granulite facies rocks that contain equilibrium sapphirine ＋ quartz assemblage from two localities （Tonagh Island （TI） and Priestley Peak （PP）） in the Napier Complex,East Antarctica,provides unequivocal evidence for extreme crustal metamorphism possibly associated with the collisional orogeny during *** reaction microstructures associated with sapphirine ＋ quartz vary among the samples,probably suggesting different tectonic conditions during the metamorphic *** and quartz in TI sample were probably in equilibrium at the peak stage,but now separated by corona of Grt ＋ Sil ＋ Opx suggesting near isobaric cooling after the peak metamorphism,whereas the Spr ＋ Qtz ＋ Sil ＋ Crd ＋ Spl assemblage replaces garnet in PP sample suggesting post-peak *** application of mineral equilibrium modeling in NCKFMASHTO system demonstrated that Spr ＋ Qtz stability is lowered down to 930 ℃ due to small Fe3＋ contents in the rocks （mole Fe2O3/（FeO ＋ Fe2O3） =0.02）.The TI sample yields a peak p-T range of 950-1100 ℃ and 7.5-11 kbar,followed by cooling toward a retrograde stage of 800-950 ℃ and 8-10 kbar,possibly along a counterclockwise p-T *** contrast,the peak condition of the PP sample shows 1000-1050 ℃ and ＞12 kbar,which was followed by the formation ofSpr ＋ Qtz corona around garnet at 930-970 ℃ and 6.7-7.7 kbar,suggesting decompression possibly along a clockwise p-T *** contrasting p-T paths are consistent with a recent model on the structural framework of the Napier Complex that correlates the two areas to different crustal *** different p-T paths obtained from the two localities might reflect the difference in the tectonic framework of these rocks within a complex Neoarchean subduction/collision belt.

关键词： Ultrahigh-temperature granulite Petrology Pseudosection modeling Napier complex Antarctica

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Development of a novel myconanomining approach for the recovery of agriculturally important elements from jarosite waste

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Journal of Environmental sciences 2018年第5期30卷 356-367页

作者： Ankita Bedi Braj Raj Singh Sunil K.Deshmukh Nisha Aggarwal Colin J.Barrow Alok Adholeya TERI–Deakin Nanobiotechnology Centre Biotechnology and Management of Bioresources Division The Energy and Resources Institute(TERI) School of life and Environmental sciences Deakin University Sri Aurobindo College Department of Chemistry University of Delhi

In this study, an ecofriendly and economically viable waste management approach have been attempted towards the biosynthesis of agriculturally important nanoparticles from jarosite waste. Aspergillus terreus strain J4 isolated from jarosite（waste from Debari Zinc Smelter,Udaipur, India）, showed good leaching efficiency along with nanoparticles（NPs） formation under ambient conditions. Fourier-transform infrared spectroscopy（FT-IR） and transmission electron microscopy（TEM） confirmed the formation of NPs. Energy dispersive X-ray spectroscopy（EDX analysis） showed strong signals for zinc, iron, calcium and magnesium,with these materials being leached out. TEM analysis and high resolution transmission electron microscopy（HRTEM） showed semi-quasi spherical particles having average size of 10‐50 nm. Thus, a novel biomethodology was developed using fungal cell-free extract for bioleaching and subsequently nanoconversion of the waste materials into nanostructured form. These biosynthesized nanoparticles were tested for their efficacy on seed emergence activity of wheat（Triticum aestivum） seeds and showed enhanced growth at concentration of 20 ppm. These nanomaterials are expected to enhance plant growth properties and being targeted as additives in soil fertility and crop productivity enhancement.

关键词： Bioleaching Fourier transform infraredspectroscopy (FTIR) Transmission electronmicroscopy (TEM) JarositeNanoparticles Seed-emergence activity

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A highly selective cell-based fluorescent biosensor for genistein detection

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Engineering Microbiology 2023年第2期3卷 72-82页

作者： Lucy Fang-I Chao Dany Liu Verena Siewers department of life sciences Division of Systems and Synthetic BiologyChalmers University of TechnologyGothenburg SE-41296Sweden

Genistein,an isoflavone found mainly in legumes,has been shown to have numerous health benefits for ***,there is substantial interest in producing it using microbial cell *** aid in screening for high genistein producing microbial strains,a cell-based biosensor for genistein was developed by repurposing the Gal4DBD-ER𝛼-VP16(GEV)transcriptional activator in Saccharomyces *** the presence of genistein,the GEV sensor protein binds to the GAL1 promoter and activates transcription of a downstream GFP *** performance of the biosensor,as measured by fold difference in GFP signal intensity after external genistein induction,was improved by engineering the sensor protein,its promoter and the reporter ***-sor performance increased when the weak promoter REV1 p was used to drive GEV sensor gene expression and the VP16 transactivating domain on GEV was replaced with the tripartite VPR transactivator that had its NLS *** biosensor performance further improved when the binding sites for the inhibitor Mig1 were removed from and two additional Gal4p binding sites were added to the reporter *** genistein induction,our improved biosensor output a GFP signal that was 20 times higher compared to the uninduced *** of the 8 flavonoids tested,the improved biosensor responded only to genistein and in a somewhat linear *** improved biosensor also responded to genistein produced in vivo,with the GFP reporter intensity directly propor-tional to intracellular genistein *** combined with fluorescence-based cell sorting technology,this biosensor could facilitate high-throughput screening of a genistein-producing yeast cell factory.

关键词： Biosensor Genistein Flavonoid Isoflavone

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Changing Gly311 to an acidic amino acid in the MATE family protein DTX6 enhances Arabidopsis resistance to the dihydropyridine herbicides

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Molecular Plant 2021年第12期14卷 2115-2125页

作者： Zeyu Lv Mingming Zhao Wenjing Wang Qi Wang Mengqi Huang Chaoqun Li Qichao Lian Jinqiu Xia Ji Qi Chengbin Xiang Huiru Tang Xiaochun Ge State Key Laboratory of Genetic Engineering Department of Biochemistry and BiophysicsSchool of Life SciencesFudan UniversityShanghai 200438China School of life sciences and division of Molecular&Cell Biophysics Hefei National Science Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefeiAnhui Province 230027China

In modern agriculture,frequent application of herbicides may induce the evolution of resistance in plants,but the mechanisms underlying herbicide resistance remain largely ***,we report the char-acterization of rtp 1(resistant to paraquat 1),an Arabidopsis mutant showing strong resistance to the widely used herbicides paraquat and *** rtp1 mutant is semi-dominant and carries a point mutation in the gene encoding the multidrug and toxic compound extrusion family protein DTX6,leading to the change of glycine to glutamic acid at residue 311(G311E).The wild-type DTX6 with glycine 311 conferred weak para-quat and diquat resistance when overexpressed,while mutation of glycine 311 to a negatively charged amino acid(G311E or G311D)markedly increased the paraquat and diquat resistance of plants,whereas mutation to a positively charged amino acid(G311R or G311K)compromised the resistance,suggesting that the charge property of residue 311 of DTX6 is critical for the paraquat and diquat resistance of Arabi-dopsis ***6 is localized in the endomembrane trafficking system and may undergo the endosomal sorting to localize to the vacuole and plasma *** with the V-ATPase inhibitor ConA reduced the paraquat resistance of the rtp1 *** release and uptake assays demonstrated that DTX6 is involved in both exocytosis and vacuolar sequestration of ***6 and DTX5 show functional redundancy as the dtx5 dtx6 double mutant but not the dtx6 single mutant plants were more sen-sitive to paraquat and diquat than the wild-type ***,our work reveals a potential mecha-nism for the evolution of herbicide resistance in weeds and provides a promising gene for the manipulation of plant herbicide resistance.

关键词： paraquat diquat point mutation DTX6 gene function multidrug and toxic compound extrusion

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Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands

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Protein & Cell 2013年第4期4卷 277-285页

作者： Xiao Wang Jingpeng Ge Bao Liu Yulin Hu Maojun Yang Key Laboratory for Protein sciences of Ministry of Education Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China department of Vascular Surgery Peking Union Medical College HospitalBeijing 100005China division of Hepatobiliary-Pancreatic The First Hospital of JiLlin UniversityChangchun 130021China

Staphylococcus aureus is the most important Gram-positive colonizer of human skin and nasal passage,causing high morbidity and ***-repeat containing protein D(SdrD),an MSCRAMM(Microbial Surface Components Recognizing Adhesive Matrix Molecules)family surface protein,plays an important role in *** adhesion and pathogenesis,while its binding target and molecular mechanism remain largely *** we solved the crystal structures of SdrD N2-N3 domain and N2-N3-B1 *** structural analysis and comparisons,we characterized the ligand binding site of SdrD,and proposed a featured sequence motif of its potential *** addition,the structures revealed for the first time the interactions between B1 domain and N2-N3 domain among B domain-containing *** results may help in understanding the roles SdrD plays in *** adhesion and shed light on the development of novel antibiotics.

关键词： SdrD adhesin MSCRAMM Staphylococcus aureus

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Anionic liposomes for small interfering ribonucleic acid （siRNA） delivery to primary neuronal cells： Evaluation of alpha-synuclein knockdown efficacy

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Nano Research 2017年第10期10卷 3496-3508页

作者： Michele Schlich Francesca Longhena Gaia Faustini Caitriona M. O'Driscoll Chiara Sinico Anna Maria Fadda Arianna Bellucci Francesco Lai department of life and Environmental sciences University of Cagliari Cagliari 09124 Italy division of Pharmacology Department of Molecular and Translational Medicine University of Brescia Brescia 25123 Italy Pharmacodelivery Group School of Pharmacy University College Cork Cork Ireland

Alpha-synuclein （a-syn） deposition in Lewy bodies （LB） is one of the main neuropathological hallmarks of Parkinson＇s disease （PD）. LB accumulation is considered a causative factor of PD, which suggests that strategies aimed at reducing a-syn levels could be relevant for its treatment. In the present study, we developed novel nanocarriers suitable for systemic delivery of small interfering ribonucleic acid （siRNA） that were specifically designed to reduce neuronal α-syn by RNA interference. Anionic liposomes loaded with an siRNA-protamine complex for α-syn gene silencing and decorated with a rabies virus glycoprotein （RVG）-derived peptide as a targeting agent were prepared. The nanoparticles were characterized for their ability to load, protect, and deliver the functional siRNA to mouse primary hippocampal and cortical neurons as well as their efficiency to induce gene silencing in these cells. Moreover, the nanocarriers were evaluated for their stability in serum. The RVG-decorated liposomes displayed suitable characteristics for future in vivo applications and successfully induced α-syn gene silencing in primary neurons without altering cell viability. Collectively, our results indicate that RVG-decorated liposomes may be an ideal tool for further studies aimed at achieving efficient in vivo α-syn gene silencing in mouse models of PD.

关键词： rabies virus glycoprotein (RVG) peptide liposomes small interfering ribonudeic acid (siRNA) alpha-synuclein primary neuronal cells Parkinson's disease

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Profiling the m^(6)A-regulated RNA expression patterns and alternative splicing features in esophageal carcinoma

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Genes & Diseases 2023年第5期10卷 1812-1815页

作者： Lingsuo Kong Fei Gao Fangfang Zhao Ran Xia Cifeng Cai Weixin Wang Dabing Huang Zhenyu Li Qiyi Yi Chunbao Zang Youguang Pu department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230031China department of Radiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230031China department of Cancer Epigenetics Program The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230031China College of life and Environmental Science Wenzhou UniversityWenzhouZhejiang 325035China Hangzhou Cosmos Wisdom Biotech Co. Ltd.5th FloorBlock D198 Qidi RoadXiaoshan DistrictHangzhouZhejiang 311200China department of Oncology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230031China department of Provincial Clinical College Wannan Medical CollegeWuhuAnhui 241002China department of Nuclear Medicine School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhui 230031China department of Radiation Oncology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230031China

The m^(6)A modification involves almost all aspects of RNA biology,including the alternative splicing of mRNA precursors,mRNA transport and stability,and miRNA processing and regulation of target genes.1,2 Alternative splicing controlling the information storage and RNA translation involves the regulation of various biological processes.3,4,5 Here,we integrated the genomic information of 161 esophageal cancer(EC)samples to comprehensively evaluate the m^(6)A modification patterns and correlated the m^(6)A modification pattern with the prognosis of EC patients,where two distinct m^(6)A modification patterns were *** combined effects of high m^(6)Ascore and low TMB correlated with a better prognosis of EC *** addition,we found an inherent correlation between m^(6)A modification and the occurrence of alternative splicing events in EC ***,we established a scoring system to quantify the m^(6)A modification pattern with RNA alternative splicing events in individual EC patients(Fig.S1).

关键词： esophageal prognosis m^(6)A

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Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy

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World Journal of Gastroenterology 2015年第42期21卷 12150-12156页

作者： Shogo Ohkoshi Masahiko Yano Yasunobu Matsuda department of Internal Medicine School of Life Dentistry at Niigata The Nippon Dental University division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

A well-known tumor suppressor, p21, acts parado-xically by promoting tumor growth in some cellular conditions. These conflicting functions have been demonstrated in association with the HBx gene and in hepatocarcinogenesis. The molecular behavior of p21 depends on its subcellular localization. Nuclear p21 may inhibit cell proliferation and be proapoptotic, while cytoplasmic p21 may have oncogenic and anti-apoptotic functions. Because most typical tumor suppressive proteins also have different effects according to subcellular localization, elucidating the regulatory mechanisms underlying nucleo-cytoplasmic transport of these proteins would be significant and may lead to a new strategy for anti-hepatocellular carcinoma(HCC) therapy. Chromosome region maintenance 1(CRM1) is a major nuclear export receptor involved in transport of tumor suppressors from nucleus to cytoplasm. Expression of CRM1 is enhanced in a variety of malignancies and in vitro studies have shown the efficacy of specific inhibition of CRM1 against cancer cell lines. Interestingly, interferon may keep p21 in the nucleus; this is one of the mechanisms of its anti-hepatocarcinogenic function. Here we review the oncogenic property of p21, which depends on its subcellular localization, and discuss the rationale underlying a new strategy for HCC treatment and prevention.

关键词： p21 Tumor suppressors Oncogene Subcellular localiz

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Sequence signatures of genes with accompanying antisense transcripts in Saccharomyces cerevisiae

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Science China(life sciences) 2014年第1期57卷 52-58页

作者： LI YingXue LIU XueNing WANG XiaoWo ZHANG XueGong MOE Key Laboratory of Bioinformatics Bioinformatics Division and Center for Synthetic and Systems Biology TNLIST/Department of Automation Tsinghua University School of life sciences Tsinghua University

Recent studies have found many antisense non-coding transcripts at the opposite strand of some protein-coding *** yeast,it was reported that such antisense transcripts play regulatory roles for their partner genes by forming a feedback loop with the protein-coding *** not all coding genes have accompanying antisense transcripts,it would be interesting to know whether there are sequence signatures in a coding gene that are decisive or associated with the existence of such antisense *** collected all the annotated antisense transcripts in the yeast Saccharomyces cerevisiae,analyzed sequence motifs around the genes with antisense partners,and classified genes with and without accompanying antisense transcripts by using machine learning *** weak but statistically significant sequence features are detected,which indicates that there are sequence signatures around the protein-coding genes that may be decisive or indicative for the existence of accompanying antisense transcripts.

关键词： antisense transcript pattern recognition motif finding yeast

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Natural regression of fibrosis in chronic hepatitis B

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World Journal of Gastroenterology 2016年第24期22卷 5459-5466页

作者： Shogo Ohkoshi Haruka Hirono Kazuhiko Watanabe Katsuhiko Hasegawa Kenya Kamimura Masahiko Yano department of Internal Medicine School of Life Dentistry at Niigata The Nippon Dental University division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

The fibrosis of liver cirrhosis was considered to be irreversible before the anti-viral drugs showed that it is reversible when they lead to continuous suppression of viral replication and inflammation. However, several reports previously showed that fibrosis of type B liver cirrhosis was almost completely absorbed after the natural remission of chronic inflammation. This phenomenon might not be limited to exceptional patients, but rather occur commonly, considering the dynamic clinical features of chronic hepatitis B(CHB), where inactive carrier stage normally follows aggravation of hepatitis and progression of fibrosis at the time of HBe Ag seroconversion. Thus, fibrosis levels of CHB as a hepatocellular carcinoma(HCC)-surveillance marker, particularly those of the inactive stage, could be underestimated, because some of them might have been(pre)cirrhotic in the past and recovered with the natural regression of fibrosis. We argue that cirrhosisinduced HCC mechanisms, rather than direct action of viral genome, may be more common than generally considered in CHB patients. This may have some impact on reconsidering the surveillance rationale for HCC in CHB, from where advanced HCCs tended to be missed. In addition, a molecular marker to assess the cancer-prone characteristics of the liver will definitely be needed to resolve the issue.

关键词： Chronic hepatitis B Cirrhosis Spontaneous remission Regression of fibrosis Occult hepatitis B infection Hepatocellular carcinoma surveillance of hepatitis B virus

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