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Photocatalytic Synthesis of Gold Nanoparticles Using Preyssler Acid and Their Photocatalytic Activity

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催化学报 2011年第6期32卷 978-982页

作者： Ali AYATI Ali AHMADPOUR Fatemeh F.BAMOHARRAM Majid M.HERAVI Hamed RASHIDI department of Chemical Engineering Ferdowsi University of Mashhad department of chemistry School of SciencesIslamic Azad University department of chemistry School of SciencesAlzahra University

Preyssler acid H14[NaP5W30O110] was used as reducing agent and stabilizer for the synthesis of gold nanoparticles by photolysis of Au(III)/Preyssler acid/propan-2-ol *** acid plays both the role of transferring electrons from propan-2-ol to Au(III) and stabilizing the ***-2-ol was used as sacrificial reagent for the photoformation of reduced Preyssler *** nanoparticles (Au NPs) were characterized by UV-Vis spectroscopy,transmission electron microscopy (TEM),and particle size distribution (PSD) *** synthesized Au NPs had a uniform hexagonal morphology and their size was about 17 *** catalytic performance of these NPs for photodegradation of methyl orange (MeO) was investigated in aqueous ***-Vis studies showed that Au NPs can catalyze photodegradation of this azo *** pseudo-first-order rate constants were also calculated for this reaction.

关键词：固体超强碱氧化钙硝酸钾氧化铝氧化锆氢氧化钾硝酸钙

Study on the drug resistance and the binding mode of HIV-1 integrase with LCA inhibitor

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Science China chemistry 2007年第5期50卷 665-674页

作者： HU JianPing1,2, CHANG Shan1, CHEN WeiZu1 & WANG CunXin1 1 College of life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China 2 department of chemistry & life sciences, Leshan Normal University, Leshan 614004, China College of life Science and Bioengineering Beijing University ofTechnologyBeijing 100022China department of chemistry & life sciences Leshan NormalUniversityLeshan 614004China

Human immunodeficiency virus type 1 (HIV-1) integrase (IN) is an essential enzyme in the lifecycle of this virus and also an important target for the study of anti-HIV drugs. The binding mode of the wild type IN core domain and its G140S mutant with L-Chicoric acid (LCA) inhibitor were investigated by using multiple conformation molecular docking and molecular dynamics (MD) simulation. Based on the binding modes, the drug resistance mechanism was explored for the G140S mutant of IN with LCA. The results indicate that the binding site of the G140S mutant of IN core domain with LCA is different from that of the core domain of the wild type IN, which leads to the partial loss of inhibition potency of LCA. The flexibility of the IN functional loop region and the interactions between Mg2+ ion and the three key residues (i.e., D64, D116, E152) stimulate the biological operation of IN. The drug resistance also lies in several other important effects, such as the repulsion between LCA and E152 in the G140S mutant core domain, the weakening of K159 binding with LCA and Y143 pointing to the pocket of the G140S mutant. All of the above simulation results agree well with experimental data, which provide us with some helpful information for designing the drug of anti-HIV based on the structure of IN.

关键词： molecular docking, MD simulation, HIV-1 IN, drug design

Microcalorimetric Studies of the Toxic Action of La^(3+) on Halobacterium Halobium R1 Growth

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Chinese Journal of chemistry 2003年第6期21卷 693-697页

作者：刘鹏刘义谢之雄陈酉贵赵儒铭沈萍屈松生 department of chemistry College of Chemistry and Molecular Sciences Wuhan University Wuhan Hubei 430072 China School of life sciences Wuhan University Wuhan Hubei 430072 China

A microcalorimetric technique was used to evaluate the influence of La 3+ on Halobacterium halobium R1 growth. By means of LKB 2277 bioactivity monitor, ampoule method at 37 ℃, the thermogenic curves of Halobacterium halobium R1 growth were obtained. In order to analyze the results, the maximum power P m and the growth rate constants k were determined, showing that values of P m and k are linked to the concentration of La 3+ . Addition of low concentration of La 3+ can cause a decrease of the maximum heat production and growth rate constant. However, high concentration of La 3+ may promote growth of Halobacterium halobium R1, but at much higher concentration of La 3+ , the growth of Halobacterium halobium R1 is inhibited again. For comparison, the shapes of Halobacterium halobium R1 cell were observed by means of transmission electron microscope. According to the thermogenic curves and TEM photos of Halobacterium halobium R1 under different conditions, it is clear that metabolic mechanism of Halobacterium halobium R1 growth is changed with the addition of La 3+ .

关键词： Halobacterium halobium R1 microcalorimetry ther mokinetics metabolism La 3+

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Thermodynamic Analysis of the Interaction between Cationic Porphyrins and Human Serum Albumin by an Optical Biosensor

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Chinese Journal of chemistry 2005年第8期23卷 1095-1099页

作者：秦艺旻潘逆娜简永兴李早英邹国林 department of Biotechnology College of Life Sciences Wuhan University Wuhan Hubei 430072 China department of chemistry College of Chemistry and Molecular Sciences Wuhan University Wuhan Hubei 430072 China 不详

An optical biosensor with a stirred cuvette has been used to monitor the interaction between immobilized human serum albumin （HSA） and three water-soluble cationic porphyrins. The binding constants at 25℃ obtained from biosensor analysis were compared with those from fluorescence spectroscopy. The interactions were further investigated at temperatures from 15℃ to 30℃. The thermodynamics parameters, changes of free energy （△G）, enthalpy （△H） and entropy （△S）, were evaluated from equilibrium data. It appeared that the binding process was governed primarily by electrostatic forces.

关键词： porphyrin human serum albumin interaction optical biosensor

Insights from an academic endeavor into central nervous system drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An M.Voets Tim Vanmierlo Rudy Schreiber BIOMED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University MS Center(UMSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013).

关键词： academic approval consequences

Health hazards related to conidia of Cladosporium—biological air pollutants in Poland, central Europe

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Journal of Environmental sciences 2018年第3期30卷 271-281页

作者： Elzbieta Weryszko-Chmielewska Idalia Kasprzyk Malgorzata Nowak Aneta Sulborska Joanna Kaczmarek Agata Szymanska Weronika Haratym Miroslaw Gilski Malgorzata Jedryczka department of Botany Lublin University of Life Sciences department of Environmental Biology University of Rzeszow Laboratory of Aeropalynology Faculty of Biology Adam Mickiewicz University department and Clinic of Dermatology University of Medical Sciences Institute of Plant Genetics Polish Academy of Sciences Institute of Bioorganic chemistry Polish Academy of Sciences department of Crystallography Faculty of Chemistry Adam Mickiewicz University

The spores of Cladosporium Link. are often present in the air in high quantities and produce many allergenic proteins, which may lead to asthma. An aerobiological spore monitoring program can inform patients about the current spore concentration in air and help their physicians determine the spore dose that is harmful for a given individual. This makes it possible to develop optimized responses and propose personalized therapy for a particular sensitive patient. The aim of this study was to assess the extent of the human health hazard posed by the fungal genus Cladosporium. For the first time, we have determined the number of days on which air samples in Poland exceeded the concentrations linked to allergic responses of sensitive patients, according to thresholds established by three different groups（2800/3000/4000 spores per 1 m^3 of the air）. The survey was conducted over three consecutive growing seasons（April–September, 2010–2012） in three cities located in different climate zones of Poland（Poznan, Lublin and Rzeszow）. The average number of days exceeding 2800 spores per cubic meter（the lowest threshold） ranged from 61（2010） through 76（2011） to 93（2012）, though there was significant variation between cities. In each year the highest concentration of spores in the air was detected in either Poznan or Lublin, both located on large plains with intensive agriculture. We have proposed that an effective, science-based software platform to support policy-making on air quality should incorporate biological air pollutant data,such as allergenic fungal spores and pollen grains.

关键词： Environmental contaminant Biological air pollution Inhalant allergy AsthmaAllergen Conidium

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期 125-143页

作者： Md Al Raihan C.Adam Dyker department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

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Crystal Structure of 6β,7β,14β-Trihydroxy-1α-acetoxy-7α,20-epoxy-ent-kaur-16-en-15-one

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Chinese Journal of Structural chemistry 2007年第4期26卷 457-461页

作者：汪涛丁兰郭国聪 department of chemistry and Chemical Engineering Heze University College of life sciences Northwest Normal University State Key Laboratory of Structural chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences

6β,7β,14β-Trihydroxy- 1α-acetoxy-7α,20-epoxy-ent-kaur- 16-en- 15-one was isolated from the natural plant of Isodonjaponica （Burm.f）, Haravar. galaucocalyx （maxim） Hara. The structure was elucidated by means of spectral and chemical studies. In addition, its crystal was determined by single-crystal X-ray diffraction analysis. It crystallizes in triclinic, space group P1, Z = 2, a = 6.3506（4）, b = 13.5766（8）, c = 15.2777（9） A, α = 80.506（1）, β = 83.856（1）, γ, = 88.307（1）°, C25H3609, Mr= 480.54, V = 1291.64（13） A^3, Z = 2, Dc = 1.236 g/cm^3, F（000） = 516, p = 0.093 mm^-1, S = 0.988, the final R = 0.0761 and wR = 0.1955. Flack factor is 0.02（19）, and the largest peak and deepest hole on the final difference Fourier map are 0.556 and -0.265 e/A^3, respectively. The X-ray diffraction shows the existence of intermolecular C-H-＂O （DA） hydrogen bonds between adjacent molecules.

关键词： single-crystal crystal structure diterpenoid