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Context-dependent role of sirtuin 2 in inflammation

Neural Regeneration Research 2025年第3期20卷 682-694页

作者： NoemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado Elena Puerta department of Pharmaceutical sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain Navarra Institute for Health Research(IdiSNA) PamplonaSpain

Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(NLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关键词： interferon inflammation lipopolysaccharide neuroinflammation NLRP3 nuclear factorκB sirtuin 2

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha Lee Kyoungho Suk department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of life sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Immobilization of Escherichia coli for detection of phage T4 using surface plasmon resonance

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Science China chemistry 2012年第9期55卷 1931-1939页

作者： XIAO ChangQing JIANG FengLei ZHOU Bo LI Ran LIU Yi State Key Laboratory of Virology Key Laboratory of Analytical Chemistryfor Biology and Medicine(Ministry of Edueation)College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China department of chemistry and life Science Hubei University of EducationWuhan 430205China department of chemistry and life sciences Xianning UniversityXianning 437005China

Phage contamination is a very serious and unavoidable problem in modem fermentation industry. It is necessary to develop sensitive and rapid phage detection methods for the early detection of phage contamination. In the present work, a real-time, rapid, specific and quantitative phage T4 detection method based on surface plasmon resonance （SPR） technique has been in- troduced. Escherichia coli was immobilized onto the preformed MPA self-assembled monolayer （SAM） through the widely used EDC/NHS cross-linking reaction as the recognition element. The bacteria immobilization was verified efficiently through the electrochemical measurements and fluorescence microscopy observations. The specific adsorption was much stronger than the non-specific adsorption of phage T4 binding to the biosensor surface modified by E. coli, and the latter could be neglected. The detection sensitivity reached 1×10^7 PFU/mL within 10 min. Within the experimental phage concentrations, the linear cor- relation between the SPR response and the phage concentration was good. The results suggest that the SPR technique is a po- tentially powerful tool for the phage or other virus detections, as a label-free, real-time, and rapid method.

关键词： phage detection virus detection surface plasmon resonance (SPR) microbe-based biosensor self-assembled monolayer(SAM)

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Chemical synthesis of proteins using hydrazide intermediates

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National Science Review 2016年第1期3卷 107-116页

作者： Yi-Chao Huang Ge-Min Fang Lei Liu Tsinghua-Peking Center for life sciences Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education)Department of ChemistryTsinghua University

Protein chemical synthesis offers useful and otherwise-difficulty-to-obtain biomacromolecules for biological and pharmaceutical studies. Recently, the hydrazide chemistry has drawn attentions in this field as peptide or protein hydrazides can be used as key intermediates for different synthesis and modification purposes. Besides being a traditional bioorthogonal chemical handle, a hydrazide group can serve as a readily accessible precursor of a thioester. This strategy significantly improves the efficiency and scope of native chemical ligation for protein chemical synthesis. Here we review the chemical transformations of peptide or protein hydrazides and total/semi/enzymatic protein synthesis methods involving peptide or protein hydrazides. Several examples of protein chemical synthesis using peptide hydrazides as key intermediates are described.

关键词： protein chemistry protein chemical synthesis peptide hydrazide protein hydrazide native chemical ligation

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Photosensitive peptide hydrogels as smart materials for applications

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Chinese Chemical Letters 2018年第7期29卷 1098-1104页

作者： Dongdong Wu Xian Xie Adnan A.Kadi Yan Zhang State Key Laboratory of Analytical chemistry for life sciences School of Chemistry and Chemical Engineering Nanjing University department of Pharmaceutical chemistry College of Pharmacy King Saud University

Photosensitive peptide hydrogels(PPHs) which allow photo-modulation on the self-assembly of peptides were broadly developed over the recent decades. The real-time and spatial modulation of hydrogel properties upon non-contact light illumination, allow the PPHs serving as super "smart" soft ***, we briefly summarized the PPHs preparing from the integration of diverse photosensitive moieties with peptides through gelation abilities, "smart" manner and applications. Moreover, a novel type of PPHs based on intramolecular biorthogonal photo-click reaction developed by our group has been demonstrated with relative mechanism and applications.

关键词： Photosensitive hydrogel Peptide Self-assembly Smart materials Tetrazole

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Synthesis of unnatural amino acids through palladium-catalyzed C(sp^3)-H functionalization

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Chinese Chemical Letters 2016年第3期27卷 305-311页

作者： Xi Lu Bin Xiao Rui Shang Lei Liu Tsinghua-Peking Center for life sciences Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education)Department of ChemistryTsinghua University department of chemistry University of Science and Technology of China

Unnatural a-amino acids have been extensively used in the modern drug discovery and protein engineering studies. They have also found applications in the development of chiral molecular catalysts and the total synthesis of diverse natural products. Accordingly the development of cost-effective approaches for the preparation of unnatural a-amino acids has received increasing attentions. Among all the available methods for this purpose, direct C–H functionalization of simple amino acids represents one of the most attractive approaches because it exhibits good atom-economy and step-efficiency. In particular, selective functionalization of either the primary or secondary C（sp^3）–H bonds in the amino acids has been explored to make versatile C–C, C–N, C–O, C–B and C–F bonds to modify the side chain of amino acids and even peptides. The present review surveys the recent advances of synthesis of chiral unnatural a-amino acids and peptides through palladium-catalyzed functionalization of un-activated C（sp^3）–H bonds.

关键词： Palladium C–H functionalization Unnatural amino acids Carbon-carbon coupling Carbon-heteroatom coupling

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Context-dependency in medicine:how neuronal excitability influences the impact of dopamine on cognition

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Neural Regeneration Research 2025年第11期20卷 3225-3226页

作者： Mahboubeh Ahmadi Nahid Rouhi Javad Mirnajafi-Zadeh Bechara J.Saab department of Physiology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran Mobio Interactive Pte.Ltd. SingaporeRepublic of Singapore

Dopamine,often termed the"feel-good"neurotransmitter,plays a crucial role in myriad physiological and psychological brain *** dopamine is primarily associated with pleasure,reward,and motivation,its effects can be quite complex;and this complexity is further compounded when examining how dopamine functions in typical versus disease-affected neural *** pa rticula r,epilepsy,characte rized by heightened brain excitability,is linked to cognitive dysfunction,and dopamine is implicated in elements of both its pathology and *** has been successful in describing the synaptic abnormalities believed to contribute to memory issues in epilepsy,aiding in the search for effective therapies for what persists as a major medical issue.

关键词： dopamine epilepsy primarily

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Convenient and Efficient Synthesis of L-Rhamnopyranosyl Phosphoramidates via H-Phosphonate

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Chinese Chemical Letters 2003年第7期14卷 685-688页

作者： Qi SUN Qiang XIAO Yong JU Yu Fen ZHAO The Key Laboratory of Bioorganic Phosphorus chemistry of Education Ministry Department of ChemistrySchool of Life Sciences and EngineeringTsinghua UniversityBeijing 100084

The a-L-rhamnopyranosyl phosphomonoesters conjugated with L-amino acid methyl esters were stereoselectively synthesized in a convenient route by utilizing H-phosphonate intermediate.

关键词： H-Phosphonate L-rhamnose phosphoramidate.

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Effect of slab width on choice of appropriate casting speed in steel production

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Journal of Iron and Steel Research International 2022年第1期29卷 71-79页

作者： Daniel Christopher Merten Marc-Thorsten Hütt Yilmaz Uygun department of Mathematics and Logistics Jacobs University BremenBremen 28759Germany department of life sciences and chemistry Jacobs University BremenBremen 28759Germany

In steel continuous casting(CC),the choice of the appropriate speed at which the slab is cast can be influenced by many different factors and *** the slab thickness seems to have the biggest impact,other features like the slab width have been consistently *** fact,the slab width practically limits the casting speed via the mass flow constraint which governs the input and output balance at the ***,we present a case study that aims at analyzing steel production data from the perspective of casting speed *** studying the speed fluctuations of an industrial CC machine,we identify a strategic regime change toward a stricter consideration of the mass flow *** regime change manifests itself in a significant increase in the correlation between the actual casting speed and the maximal speed associated with the mass flow *** the surface,taking greater account of the input and output balance at the tundish has reduced the productivity of the continuous caster;however,one can argue that the lessened yield is compensated by a diminished risk of eventual slab *** the perspective of this trade-off,we establish a visualization technique that enables us to pinpoint the boundary beyond which one strategic regime becomes economically more advantageous than the other.

关键词： Continuous casting Casting speed Slab width Slab thickness Mass flow constraint Machine length constraint

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Theoretical Study of the Sensitivity-Improvement Effect of Phosphoryl Group in Mass Spectrometry of Small Peptides

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Chinese Chemical Letters 2001年第9期12卷 807-808页

作者： Yang JIANG Bo TAN Yu Fen ZHAO The Key Laboratory of Bioorganic Phosphorus chemistry Ministry of EducationDepartment of ChemistrySchool of Life Sciences and EngineeringTsinghua UniversityBeijing 100084

It was found that phosphorylation of small peptide could improve the sensitivity in mass spectrometry. Density functional theory calculations showed that the energy for the protonation of N-(O,O'-dimethyl) phosphoryl ... 详细信息

关键词： Phosphoryl group small peptide mass spectrometry relative energy

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