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Scaffold protein RACK1A positively regulates leaf senescence by coordinating the EIN3-miR164-ORE1 transcriptional cascade in Arabidopsis

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Journal of Integrative Plant Biology 2023年第7期65卷 1703-1716页

作者： Jan Masood Wei Zhu Yajuan Fu Zhiyong Li Yeling Zhou Dong Zhang Huihui Han Yan Yan Xing Wen Hongwei Guo Jiansheng Liang Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes Institute of Plant and Food SciencesDepartment of BiologySchool of Life SciencesSouthern University of Science and Technology518055ShenzhenChina

Plants have adopted versatile scaffold proteins to facilitate the crosstalk between multiple signaling pathways. Leaf senescence is a well-programmed developmental stage that is coordinated by various external and internal signals. However,the functions of plant scaffold proteins in response to senescence signals are not well understood. Here, we report that the scaffold protein RACK1A(RECEPTOR FOR ACTIVATED C KINASE1A) participates in leaf senescence mediated by ethylene signaling via the coordination of the EIN3-miR164-ORE1 transcriptional regulatory cascade. RACK1A is a novel positive regulator of ethylene-mediated leaf senescence. The rack1a mutant exhibits delayed leaf senescence, while transgenic lines overexpressing RACK1A display early leaf senescence. Moreover, RACK1A promotes EIN3(ETHYLENE INSENSITIVE 3) protein accumulation, and directly interacts with EIN3 to enhance its DNA-binding activity. Together, they then associate with the miR164 promoter to inhibit its transcription, leading to the release of the inhibition on downstream ORE1(ORESARA 1) transcription and the promotion of leaf *** study reveals a mechanistic framework by which RACK1A promotes leaf senescence via the EIN3-miR164-ORE1 transcriptional cascade, and provides a paradigm for how scaffold proteins finely tune phytohormone signaling to control plant development.

关键词： Arabidopsis ethylene signaling leaf senescence RACK1 scaffold protein transcriptional cascade

Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis

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Protein & Cell 2012年第3期3卷 173-181页

作者： Yuan Yuan Peng Li Jing Ye department of Pathology Xijing HospitalFourth Military Medical UniversityXi'an 710032China Tsinghua-Peking Center for life sciences School of Life SciencesTsinghua UniversityBeijing 100084China

Atherosclerosis is a chronic,inflammatory disorder characterized by the deposition of excess lipids in the arterial *** formation of macrophage-derived foam cells in a plaque is a hallmark of the development of *** homeostasis,especially cho-lesterol homeostasis,plays a crucial role during the formation of foam ***,lipid droplet-associated proteins,including PAT and CIDE family proteins,have been shown to control the development of athero-sclerosis by regulating the formation,growth,stabiliza-tion and functions of lipid droplets in macrophage-derived foam *** review focuses on the potential mechanisms of formation of macrophage-derived foam cells in atherosclerosis with particular emphasis on the role of lipid homeostasis and lipid droplet-associated *** the process of foam cell for-mation will aid in the future discovery of novel thera-peutic interventions for atherosclerosis.

关键词： macrophage foam cell atherosclerosis cholesterol lipid droplet-associated proteins

Mycosynthesis,characterization and antibacterial properties of AgNPs against multidrug resistant(MDR)bacterial pathogens of female infertility cases

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Asian Journal of Pharmaceutical sciences 2015年第2期10卷 138-145页

作者： Ponnusamy Manogaran Gopinath Ganesan Narchonai Dharumadurai Dhanasekaran Anandan Ranjani Nooruddin Thajuddin department of Microbiology School of Life SciencesBharathidasan UniversityTiruchirappalli 620024India

Recently,biosynthesis of silver nanoparticles using bacteria,fungus and plants has emerged as a simple and viable alternative to more complex physical and chemical synthetic *** present investigation explains rapid and extracellular synthesis of silver nanoparticles using fungus Fusarium oxysporum NGD and characterization of the synthesized silver nanoparticles using UV-Vis spectroscopy,scanning electron microscopy,energy dispersive spectroscopy and X-ray diffraction *** size range of the synthesized silver nanoparticles was around 16.3e70 *** FTIR studies showed major peaks of proteins involved in the synthesis of silver ***,antibacterial effect of the silver nanoparticles against multidrug resistant pathogens Enterobacter *** 02[HM803168],Pseudomonas aeruginosa ANT 04[HM803170],Klebsiella pneumoniae ANT 03[HM803169]and Escherichia coli ANT 01[HM803167]was tested using turbidometric assay at 10,20,30,40 mg AgNPs/ml alone and in combination with ampicillin using agar well diffusion *** the resistant bacteria were found to be susceptible to the antibiotic in the presence of the silver nanoparticles.

关键词： Multidrug resistance Silver nanoparticles Fusarium oxysporum AgNPs-Ampicillin complex Infertility

Establishment and application of a surrogate model for human Ebola virus disease in BSL-2 laboratory

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Virologica Sinica 2024年第3期39卷 434-446页

作者： Wanying Yang Wujian Li Wujie Zhou Shen Wang Weiqi Wang Zhenshan Wang Na Feng Tiecheng Wang Ying Xie Yongkun Zhao Feihu Yan Xianzhu Xia Hebei Key Lab of Laboratory Animal Science Department of Laboratory Animal ScienceHebei Medical UniversityShijiazhuang050017China Key Laboratory of Jilin Province for Zoonosis Prevention and Control Changchun Veterinary Research InstituteChinese Academy of Agricultural SciencesChangchun130122China College of Veterinary Medicine Jilin UniversityChangchun130062China College of Veterinary Medicine Jilin Agricultural UniversityChangchun130118China

The Ebola virus(EBOV)is a member of the Orthoebolavirus genus,Filoviridae family,which causes severe hemorrhagic diseases in humans and non-human primates(NHPs),with a case fatality rate of up to 90%.The development of countermeasures against EBOV has been hindered by the lack of ideal animal models,as EBOV requires handling in biosafety level(BSL)-4 ***,accessible and convenient animal models are urgently needed to promote prophylactic and therapeutic approaches against *** this study,a recombinant vesicular stomatitis virus expressing Ebola virus glycoprotein(VSV-EBOV/GP)was constructed and applied as a surrogate virus,establishing a lethal infection in *** infection with VSV-EBOV/GP,3-week-old female Syrian hamsters exhibited disease signs such as weight loss,multi-organ failure,severe uveitis,high viral loads,and developed severe systemic diseases similar to those observed in human EBOV *** animals succumbed at 2–3 days post-infection(dpi).Histopathological changes indicated that VSV-EBOV/GP targeted liver cells,suggesting that the tissue tropism of VSV-EBOV/GP was comparable to wild-type EBOV(WT EBOV).Notably,the pathogenicity of the VSV-EBOV/GP was found to be species-specific,age-related,gender-associated,and challenge ***,equine anti-EBOV immunoglobulins and a subunit vaccine were validated using this ***,this surrogate model represents a safe,effective,and economical tool for rapid preclinical evaluation of medical countermeasures against EBOV under BSL-2 conditions,which would accelerate technological advances and breakthroughs in confronting Ebola virus disease.

关键词： Ebola virus(EBOV) Recombinant vesicular stomatitis virus Pathogenicity Syrian hamster Surrogate models Vaccine evaluation and drug screening

Supersymmetry and SWKB Approach to Dirac Equation with Hyperbolic Scarf Potential

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Communications in Theoretical Physics 2016年第7期65卷 49-52页

作者： N.Akbarzadeh A.Chenaghlou department of Physics Faculty of Sciences Sahand University of Technology

By using the supersymmetric quantum mechanics and shape invariance concept, we study the Dirac equation with the hyperbolic Scarf potential and the exact energy spectrum is obtained. Also, we calculate the bound state... 详细信息

关键词： Dirac equation supersymmetric quantum mechanics supersymmetric WKB hyperbolic Scarf potential

Berry Phase of Composite System Induced by Time-Dependent Interaction

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Communications in Theoretical Physics 2010年第4期53卷 631-634页

作者：杨林广邵彬邹健 department of Physics School of Sciences Beijing Institute of Technology

The Berry phase in a composite system induced by the time-dependent interaction is discussed. We choose two coupled spin-1/2 systems as the composite system： one of the subsystems is subjected to a static magnetic field, and the coupling parameters between two spins are controllable in time. We show that the time-dependent interaction can induce the Berry phase in a similar way as that a spin-1/2 system （qubit） is driven by an effective time-dependent magnetic field. Furthermore, using two consecutive cycles with opposite directions of both the static magnetic field as well as opposite signs of the coupling parameters, a nontrivial two-qubit unitary transformation purely based on Berry phases can be constructed.

关键词： Berry phase time-dependent interaction Dzyaloshinskii-Moriya interaction

Designing of improved drugs for COVID-19:Crystal structure of SARS-CoV-2 main protease M^(pro)

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1873-1874页

作者： Hylemariam Mihiretie Mengist Xiaojiao Fan Tengchuan Jin department of Obstetrics and Gynecology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China230001 HefeiAnhuiChina Laboratory of Structural Immunology CAS Key Laboratory of Innate Immunity and Chronic DiseaseDivision of Life Sciences and MedicineUniversity of Science and Technology of China230027 HefeiAnhuiChina

Recently,Zhang and colleagues published a study in Science which reports about the crystal structure of the main protease(Mpro,3CLpro)of *** authors reported the X-ray structure of unliganded SARS-CoV-2 Mpro and its complex withα-ketoamide inhibitor after a modification from the previously designed inhibitor through incorporating P3-P2 amide bond into pyridone ring so as to increase its half-life in *** the authors demonstrated that the crystal structure of Mpro provides a basis for designing of a potent inhibitor to the protease with a marked tropism to the lung and with ease of administration through inhalation.

关键词： structure crystal designing

Evaluation of nest site preferences of a nest dismantler,the Hair-crested Drongo(Dicrurus hottentottus) in Dongzhai National Nature Reserve of central China

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Chinese Birds 2016年第2期7卷 125-131页

作者： Andrew Cantrell Lei Lv Yong Wang Jianqiang Li Zhengwang Zhang College of Agricultural Life and Natural Sciences Alabama A&M University School of life sciences Beijing Normal University

Background:The Hair-crested Drongo(Dicrurus hottentottus) exhibits a unique nest-dismantling behavior after the fledging of the *** hypothesis explaining this behavior is dismantling one's own nest may reduce potential competition for nest sites in the following breeding season because suitable breeding habitat might be limited,and sites are often ***:By comparing the habitat features at nest and random locations,we determined the nest habitat preference of the Hair-crested Drongo within Dongzhai National Nature Reserve,Henan,*** also compared habitat features with nesting success to determine if any trends could be ***:We found that nest tree height,diameter at breast height,live crown ratio,tree rank,and presence of overstory were significantly higher at nesting locations than random locations;slope,leaf litter cover percentage and depth,presence of understory and midstory,and number of trees per hectare were significantly lower at nest sites than random *** preferred to use some tree species,such as Metasequoia glyptostroboides,Castanea mollissima,and Pterocarya stenoptera for *** nests were often associated with habitat with higher percentage of leaf litter on the ***:Our data support that selection of nest sites does occur for this species at this site and therefore support the hypothesis that breeding habitat limitation could be one of the driving forces for the development of the nestdismantling behavior in this species.

关键词： Hair-crested Drongo Nest dismantling behavior Nest site selection China Dongzhai National Nature Reserve

Helium Plasma Effects on Polymer Surfaces:from Plasma Parameters and Surface Properties towards Bioengineering Applications

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Chinese Journal of Polymer Science 2024年第8期42卷 1156-1166页

作者： Andrei Vasile Nastuta Maria Butnaru Byron Cheatham Ramona Huzum Vasile Tiron Ionut Topala Physics and Biophysics Education Research Laboratory(P&B-EduResLab) Biomedical Science DepartmentFaculty of Medical Bioengineering‘Grigore T.Popa’University of Medicine and Pharmacy IasiM.Kogalniceanu 9-13Iasi 700454Romania Faculty of Medical Bioengineering ‘Grigore T.Popa’University of Medicine and Pharmacy IasiM.Kogalniceanu 9-13Iasi 700454Romania Cytoviva Inc.570 Devall Drive Suite 301Auburn 36832ALUSA Integrated Center of Environmental Science Studies in the North-Eastern Development Region(CERNESIM) Department of Exact and Natural SciencesInstitute of Interdisciplinary Research‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania Research Center on Advanced Materials and Technologies(RAMTECH) Department of Exact and Natural SciencesInstitute of Interdisciplinary Research‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania Iasi Plasma Advanced Research Center(IPARC) Faculty of Physics‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania

Plasma treatment is necessary to optimize the performance of biomaterial *** enhances and regulates the performance of biomaterial su rfaces,creating an effective interface with the human *** treatments have the ability to modify the chemical com position and physical structu re of a surface while leaving its properties *** possess the ability to modify material su rfaces,eliminate contaminants,conduct investigations on cancer therapy,and facilitate wound *** subject of study in question involves the integration of plasma science and technology with biology and *** a helium plasma jet source,applying up to 18 kV,with an average power of 10 W,polymer foils were treated for 60 *** treatment has the ability to alter the chemical composition and physical structure of a su rface while maintaining its *** investigation involved the application of helium plasma at atmospheric pressure to polyamide 6 and polyethylene terephthalate *** inquiry involves monitoring and assessing the plasma source and polymer materials,as well as analyzing the impacts of plasma *** the mean power of the discharge aids in assessing the economic efficacy of the plasma *** discharge in helium at atmospheric pressure has beneficial effects in technology,where it increases the surface free energy of polymer *** biomedicine,it is used to investigate cytotoxicity and cell survival,particularly in direct blood exposure situations that can expedite *** the specific parameters that influence the plasma source in the desired manner for the intended application is of utmost im portance.

关键词： Atmopheric pressure plasmas Plasma-polymer interaction Plasma Medicine Plasma diagnosis Polymer characterization