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Extensive calcifications in portal venous system in a patient with hepatocarcinoma

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World Journal of Gastroenterology 2014年第43期20卷 16377-16380页

作者： Cheng-En Wang Cheng-Jian Sun Shuai Huang Yan-Hua Wang Ling-Ling Xie department of interventional radiology Affiliated Hospital of Qingdao University

Calcification of the portal venous system is a rare entity that can be incidentally discovered during computed tomography (CT). We describe a case of extensive calcifications in the portal venous system in a middle-aged male patient with hepatocellular carcinoma (HCC). This patient presented with epigastric pain that had no obvious origin prior to admission. Laboratory examinations were positive for hepatitis B surface antigen and α-fetoprotein, and severe esophageal and gastric varices were detected during gastroscopy. Abdominal X-ray plain film showed well-defined linear and track-like calcification, with irregular margins directed along the course of the portal venous system. CT revealed extensive calcifications along the course of the portal, splenic, superior mesenteric and gastroesophageal veins. He underwent splenectomy 22 years ago due to splenomegaly and partial hepatectomy seven months before because of HCC of low-grade differentiation, confirmed by pathology. Finally, the patient was diagnosed with postoperative recurrent HCC and extensive portal venous system calcification after selective hepatic angiography under digital subtraction angiography.

关键词： Portal vein Calcification Portal hypertension Hepatocarcinoma Hepatocellular carcinoma

A correlative study of iron metabolism based on q-Dixon MRI in benign prostatic hyperplasia and prostate cancer

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Asian Journal of Andrology 2022年第6期24卷 671-674页

作者： Zhen Tian Yong-Gang Li Guang-Zheng Li Zhi-Hao Huang Wen-Hao Dail Xue-Dong Wei Wei-Jie Zhang Zhen-Yu Fu Yu-Hua Huang department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000China department of radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215000China department of Urology Changshu No.2 People's HospitalChangshu 215500China

Clinical staging,Gleason score,and prostate-specific antigen(PSA)have been accepted as factors for evaluating the prognosis of prostate cancer(PCa).With the in-depth study of iron metabolism and the development of multiparametric magnetic resonance imaging technology,we used q-Dixon magnetic resonance imaging(MRI)to measure the iron content of the PCa patients'lesions,and used enzyme-linked immunosorbent assay(ELISA)to measure the iron metabolism indicators in the patients'serum samples,combined with the patients'postoperative clinical data for *** found that the serum indexes were correlated with the T2 star values,International Society of Urological Pathology(ISUP)grade,and pathological classification in PCa patients(all PO.05).The utilization of q-Dixon-based MRI and serum indexes allows the noninvasive measurement of iron content in prostate lesions and the assessment of differential iron metabolism between PCa and BPH,which may be helpful for evaluating the prognosis of PCa.

关键词： iron metabolism prostate cancer q-Dixon MRl serum index

Ultrasound virtual endoscopy: Polyp detection and reliability of measurement in an in vitro study with pig intestine specimens

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World Journal of Gastroenterology 2016年第12期22卷 3355-3362页

作者： Jin-Ya Liu Li-Da Chen Hua-Song Cai Jin-Yu Liang Ming Xu Yang Huang Wei Li Shi-Ting Feng Xiao-Yan Xie Ming-De Lu Wei Wang department of Medical Ultrasonics Institute of Diagnostic and Interventional Ultrasound The First Affiliated Hospital of Sun Yat-Sen University department of radiology The First Affiliated Hospital of Sun Yat-Sen University

AIM: To present our initial experience regarding the feasibility of ultrasound virtual endoscopy(USVE) and its measurement reliability for polyp detection in an in vitro study using pig intestine ***: Six porcine intestine specimens containing 30 synthetic polyps underwent USVE, computed tomography colonography(CTC) and optical colonoscopy(OC) for polyp detection. The polyp measurement defined as the maximum polyp diameter on twodimensional(2D) multiplanar reformatted(MPR) planes was obtained by USVE, and the absolute measurement error was analyzed using the direct measurement as the reference ***: USVE detected 29(96.7%) of 30 polyps, remaining a 7-mm one missed. There was one falsepositive finding. Twenty-six(89.7%) of 29 reconstructedimages were clearly depicted, while 29(96.7%) of 30 polyps were displayed on CTC with one false-negative finding. In OC, all the polyps were detected. The intraclass correlation coefficient was 0.876(95%CI: 0.745-0.940) for measurements obtained with USVE. The pooled absolute measurement errors ± the standard deviations of the depicted polyps with actual sizes ≤ 5 mm, 6-9 mm, and ≥ 10 mm were 1.9 ± 0.8 mm, 0.9 ± 1.2 mm, and 1.0 ± 1.4 mm, ***: USVE is reliable for polyp detection and measurement in in vitro study.

关键词： Three-dimensional ultrasound In vitro Virtual endoscopy Intestinal polyps Technical feasibility

In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles

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Journal of Materials Science & Technology 2017年第5期33卷 469-474页

作者： Shanshan Chen Lili Tan Bingchun Zhang Yonghui Xia Ke Xu Ke Yang Institute of Metal Research Chinese Academy of Sciences department of radiology The First Affiliated Hospital of China Medical University Key Laboratory of Diagnostic Imaging and Interventional RadiologyLiaoning Province

When an orthopedics device is implanted into bone injury site, it will contact the soft tissue （skeletal muscle, fascia, ligament etc.） except for bone. Magnesium based biodegradable metals are becoming an important research object in orthopedics due to their bioactivity to promote bone healing. In this study, pure Mg rods with and without chemical conversion coating were implanted into the muscle tissue of rabbits. Implants and their surrounding tissues were taken out for weight loss measurement, cross- sectional scanning electron microscopy observation, elemental distribution analysis and histological examination. The results showed that the chemical conversion coating would increase the in vivo cor- rosion resistance of pure Mg and decrease the accumulation of calcium （Ca） and phosphorus （P） elements around the implants. For the bare magnesium implant, both Ca and P contents in the surrounding tissues increased at the initial stage of implantation and then decreased at 12 weeks implantation, while for the magnesium with chemical conversion coating, Ca and P contents in the surrounding tissues de- creased with the implantation time, but were not significant. The histological results demonstrated that there was no calcification in the muscle tissue with implantation of magnesium for up to 12 weeks. The chemical conversion coating not only increased the in vivo corrosion resistance of pure Mg, but also avoided the depositions of Ca and P in the surrounding tissues, meaning that pure magnesium should be biosafe when contacting with muscle tissues,

关键词： Pure magnesium Degradation behavior Histologic response Muscle tissue

Addition of prokinetics to PPI therapy in gastroesophageal reflux disease:A meta-analysis

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World Journal of Gastroenterology 2014年第9期20卷 2412-2419页

作者： Li-Hua Ren Wei-Xu Chen Li-Juan Qian Shuo Li Min Gu Rui-Hua Shi department of Gastroenterology the First Affiliated Hospital of Nanjing Medical University department of Gastroenterology the First Affiliated Hospital of Soochow University

AIM: To investigate the efficacy of adding prokinetics to proton pump inhibitors (PPIs) for the treatment of gastroesophageal reflux disease (GERD).

关键词： Gastroesophageal reflux diseases Proton pump inhibitors Prokinetics GABA-B receptor agonists Treatment Meta-analysis

Biomimetic melatonin-loaded silk fibroin/GelMA scaffold strengthens cartilage repair through retrieval of mitochondrial functions

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Journal of Materials Science & Technology 2023年第15期146卷 102-112页

作者： Mingzhuang Hou Yijian Zhang Yang Liu Xiaoyang Ge Xiayu Hu Zhijian Zhao Xin Tian Tao Liu Huilin Yang Xi Chen Fan He Xuesong Zhu department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou 215007China department of Pathology The Third Affiliated Hospital of Soochow UniversityChangzhou 213003China

Articular cartilage injury induced by collision or trauma is a common sports-related condition that may progress to pain,dysfunction,and secondary osteoarthritis(OA).Limited by self-renewal potential,cartilage regeneration faces a quandary while bio-inspired novel strategies are urgently *** this study,by a soft freezing method and surface modification technique,a multi-functional silk fibroin(SF)plus gelatin methacrylate(GelMA)scaffold laden with melatonin(MT)was ***-GelMA@MT scaffold demonstrated enhanced biomechanical characteristics and long-acting melatonin *** vitro treatment with SF-GelMA@MT induced the synthesis of cartilage extracellular matrix(ECM)***,sustained release of melatonin yielded robust chondroprotective effects via improving mitochondrial polarization and antioxidant ***-GelMA@MT implantation boosted cartilage renascence in a full-thickness cartilage defect model via mitochondria-associated sirtuins 1(SIRT1)-superoxide dismutase 2(SOD2)signaling pathway in *** summary,this research proposed a welldesigned bionic composite scaffold that promotes cartilage regeneration via mitochondrial function enhancement,which is of tremendous potential for cartilage tissue engineering.

关键词： Cartilage injury Silk fibroin Gelatin methacrylate Melatonin Mitochondri

Clinical significance of changes in the Th17/Treg ratio in autoimmune liver disease

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World Journal of Gastroenterology 2017年第21期23卷 3832-3838页

作者： Ting-Ting Feng Ting Zou Xin Wang Wei-Feng Zhao Ai-Lan Qin department of Infectious Diseases the First Affiliated Hospital of Soochow University

AIM To investigate the levels, ratios, and clinical significance of T helper 17(Th17) cells and regulatory T(Treg) cells in the peripheral blood of patients with autoimmune liver disease(AILD). METHODS F o r t y-t w o A I L D p a t i e n t s w e r e i n c l u d e d i n t h e experimental group(group E), and 11 healthy subjects were recruited as the control group(group C). Flow cytometry was performed to determine the percentages of Th17 and Treg cells in peripheral blood lymphocytes. Furthermore, a range of biochemical indices was measured simultaneously in the blood of group E patients. RESULTS The percentage of Th17 cells and the Th17/Treg ratio were higher in group E than in group C(P hospitalization showed significantly higher baseline values of the Th17 percentage and the Th17/Treg ratio than those detected in patients who improved after treatment(P < 0.05). The results suggested that imbalance in the Th17/Treg ratio plays an important role in the pathogenesis and development of *** A high Th17/Treg ratio appears to predict poor shortterm prognosis in patients with AILD in the active stage.

关键词： Autoimmune liver disease Helper T cell 17 Regulatory T cells Short-term prognosis

Influence of adriamycin on changes in Nanog, Oct-4, Sox2, ARID1 and Wnt5b expression in liver cancer stem cells

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World Journal of Gastroenterology 2014年第22期20卷 6974-6980页

作者： Ding Sun Lei Qin Yang Xu Jian-Xia Liu Li-Ping Tian Hai-Xin Qian department of General Surgery The First Affiliated Hospital of Soochow University

AIM: To determine the influence of Adriamycin (ADM) on the changes in Nanog, Oct4, Sox2, as well as, in ARID1 and Wnt5b expression in liver cancer stem cells.

关键词： Liver cancer cell Adriamycin Stem cell related gene Western blot Liver cancer stem cell

Restenosis after recanalization for Budd-Chiari syndrome: Management and long-term results of 60 patients

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World Journal of Clinical Cases 2020年第14期8卷 2930-2941页

作者： Wei Zhang Yu-Long Tian Qiao-Zheng Wang Xiao-Wei Chen Qi-Yang Li Jin-Hang Han Xu-Dong Chen Ke Xu department of interventional radiology Shenzhen People’s Hospitalthe Second Affiliated Hospital of Jinan UniversityShenzhen 518020Guangdong ProvinceChina department of interventional radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Budd-Chiari syndrome is defined as hepatic venous outflow tract *** Asian Budd-Chiari syndrome patients,the major treatment modality is recanalization(percutaneous transluminal angioplasty with or without stent implantation).The cumulative 1-,5-,and 10-year primary patency rates and survival rates are reported to be excellent or satisfactory,but the long-term outcome of patients with restenosis(the most common complication after recanalization)is *** To explore the treatment strategy for restenosis in patients with Budd-Chiari syndrome after interventional therapy and to evaluate the long-term follow-up *** The clinical data and follow-up results of 60 patients with restenosis after interventional therapy from November 1983 to December 2013 were retrospectively *** Sixty patients with restenosis were retrospectively divided into a percutaneous transluminal angioplasty(PTA)group(40 patients)and a PTA+stent group(20 patients)according to the primary recanalization *** the patients with restenosis in the PTA group,13 refused treatment,and 27 received further treatment;among these patients,five had a second restenosis,two had a third restenosis,and one had a fourth *** the patients with restenosis in the PTA+stent group,nine refused treatment,ten received PTA alone,and the other received PTA+stent *** the patients who received further treatment,five had a second restenosis,three had a third restenosis,and one had a fourth *** 1-,5-,10-,20-,and 25-year cumulative survival rates of the 38 patients who received further treatment after restenosis were 100%,78.3%,78.3%,70.5%,and 70.5%,respectively;however,for the 22 patients who refused treatment,the survival rates were 72.7%,45.9%,30.6%,10.2%,and unavailable,respectively(Pinterventional therapy is very *** treatment for patients with restenosis can improve prognosis,an

关键词： Budd-Chiari syndrome Restenosis Long-term follow-up Treatment strategy