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Influence of induced ciprofloxacin resistance on efflux pump activity of Klebsiella pneumoniae

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第9期14卷 837-843页

作者： Hai-qin ZHONG Shun ZHANG Hong PAN Ting CAI department of internal medicine School of MedicineNingbo University Stem Cell Laboratory Ningbo No.2 Hospital Clinical Laboratory Ningbo No.2 Hospital Emergency department Ningbo No.2 Hospital

Objective:The efflux pump(EP) is one of the major mechanisms of antibiotic resistance in Klebsiella ***,there are few reports on the effect of the abuse of antibiotic use on the activity of *** determine whether the use of low efficacy antibiotics has any effect on the activity of EPs and induces drug resistance in ***,we investigated the effect of ciprofloxacin on the activity of EPs in *** ***:Sixteen susceptible *** strains were isolated from patients and their minimum inhibitory concentrations(MICs) of ciprofloxacin were measured in the absence and presence of the pump inhibitor carbonyl cyanide m-chlorophenyl hydrazone(CCCP).The strains were then induced with a gradient of ciprofloxacin until the MICs of the strains showed no further increase,to obtain induced resistant *** EP activities of the strains before and after induction were compared using EP inhibition and ethidium bromide(EtBr) accumulation ***:The MIC values of the strains were 16 256 times higher after induction than before *** the presence of CCCP,the MIC values of 50% of the induced strains were 2 4-fold lower than that in the absence of this *** EtBr accumulation assay showed that the fluorescence of EtBr in the induced cells was lower than that in the cells before ***:EPs are widespread in susceptible and drug-resistant *** *** with ciprofloxacin may increase the activity of EPs in *** EtBr accumulation assay is more sensitive than the EP inhibition assay in evaluating the activity of EPs in ***.

关键词： Klebsiella pneumoniae Efflux pump Ciprofloxacin Antibiotic resistance

Patients admitted in the intensive care unit after solid organ or bone marrow transplantation:Retrospective cohort study

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World Journal of Transplantation 2025年第1期15卷 95-104页

作者： Ana Vujaklija Brajkovic Iva Kosuta Lucija Batur Sara Sundalic Marijana Medic Andro Vujevic Luka Bielen Jaksa Babel department of internal medicine University Hospital Centre ZagrebZagreb 10000Croatia School of medicine University of ZagrebZagreb 10000Croatia

BACKGROUND Solid organ transplantation(SOT)and hematopoietic stem cell transplantation(HSCT)revolutionized the survival and quality of life of patients with malignant diseases,various immunologic,and metabolic disorders or those associated with a significant impairment in a patient's quality of *** To investigate admission causes and treatment outcomes of patients after SOT or HSCT treated in a medical intensive care unit(ICU).METHODS We conducted a single-center,retrospective epidemiological study in the medical ICU at the University Hospital Centre Zagreb,Croatia covering the period from January 1,2018 to December 31,*** The study included 91 patients with either SOT[28 patients(30.8%)]or HSCT[63 patients(69.2%)].The median age was 56(43.2-64.7)years,and 60.4%of the patients were *** with SOT had more comorbidities than patients after HSCT[χ^(2)(5,n=141)=18.513,P2)(1,n=91)=21.767,P2.7%in the HSCT *** need for mechanical ventilation[χ^(2)(1,n=91)=17.081,P2)(1,n=91)=36.803,P2)(1,n=91)=0.376,P=0.54].In the subgroup of patients with infection,90%had septic shock,and the majority had positive microbiological samples,mostly Gram-negative *** ICU survival of patients with sepsis/septic shock cumulatively was 15%.The survival of SOT patients with sepsis/shock was 45%.CONCLUSION Patients with SOT or HSCT are frequently admitted to the ICU due to sepsis and septic *** advancements in critical care,the mortality rate of patients with refractory septic shock and multiorgan failure in this patient population is extremely hig

关键词： Liver transplantation Kidney transplantation Hematopoietic stem cell transplantation Critical care Sepsis Septic shock Mortality

Advancements in diabetic retinopathy:Insights and future directions

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World Journal of Methodology 2025年第2期15卷 21-26页

作者： Chun-Yao Cheng Wen-Rui Hao Tzu-Hurng Cheng department of Ophthalmology Cathay General HospitalTaipei 10633TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328TaiwanChina

This editorial discusses recent advancements and ongoing challenges in diabetic retinopathy,as reviewed by Morya et al in their comprehensive *** their review,Morya et al discussed the pathophysiology of diabetic retinopathy and explored novel treatment *** editorial highlights the importance of these advancements and emphasizes the need for continued research and innovation for the enhanced management of diabetic *** also reflects upon the implications of the authors’review findings for clinical practice and future research directions,underscoring the potential of emerging therapies for improving patient outcomes and providing a deeper understanding of disease mechanisms.

关键词： Diabetic retinopathy Pathophysiology Novel treatments Review analysis Clinical implications

Improving postoperative outcomes in patients with pancreatic cancer:Inflammatory and nutritional biomarkers

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World Journal of Clinical Oncology 2025年第1期16卷 59-64页

This editorial assesses the prognostic value of preoperative inflammatory and nutritional biomarkers in patients undergoing surgical resection for pancreatic *** et al evaluated the ability of seven biomarkers to predict postoperative recovery and long-term *** biomarkers were albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,nutritional risk index,and geriatric nutritional risk *** PNI was found to be a strong predictor of both overall and recurrence-free survival,underscoring its clinical relevance in managing patients with pancreatic cancer.

关键词： Pancreatic cancer Prognostic nutritional index Systemic immune-inflammation index Postoperative recovery Prognosis

Septic shock due to cytomegalovirus colitis associated with rituximab use:A case report

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World Journal of Virology 2025年第1期14卷 118-123页

作者： Siddharth Patel Jordan Jay Prutha Pathak Mc Anto Antony Mrudula Thiriveedi department of internal medicine Decatur Morgan HospitalDecaturAL 35601United States department of medicine Alabama College of Osteopathic MedicineDothanAL 36303United States department of internal medicine North Alabama Medical CenterFlorenceAL 35630United States department of Endocrinology Diabetes and MetabolismMedical University of South Carolina/AnMed CampusAndersonSC 29621United States

BACKGROUND Cytomegalovirus(CMV)infections can cause significant morbidity and mortality in immunocompromised *** targets dysfunctional *** rituximab(RTX)therapy can cause B-lymphocyte dysfunction,increasing CMV ***,CMV infections present with critical illness such as septic *** SUMMARY A 64-year-old African American woman presented with generalized weakness and non-bloody watery diarrhea of 4-6 weeks *** did not have nausea,vomiting or,abdominal *** had been on monthly RTX infusions for neuromyelitis *** was admitted for septic shock due to *** investigations suggested pancytopenia and serology detected significantly elevated CMV *** treatment led to disease *** This case illustrates an extremely rare case of CMV colitis associated with RTX use presenting with septic *** suspicion for rare opportunistic infections is imperative in individuals with long-term RTX use.

关键词： Cytomegalovirus colitis Rituximab use Immunocompromised status Septic shock Pancytopenia Case report

Enhancing the outcomes of diabetic vitrectomy with pharmacological adjuvants

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World Journal of Methodology 2025年第2期15卷 15-20页

作者： Chun-Yao Cheng Wen-Rui Hao Tzu-Hurng Cheng department of Ophthalmology Cathay General HospitalTaipei 10633TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung City 404328TaiwanChina

This editorial offers insights from a minireview by Venkatesh et al,who explored pharmacological adjuvants for diabetic ***,they synthesized current knowledge and evaluated the efficacy of various adjunctive therapies in improving the outcomes of diabetic retinopathy and managing associated ***,we highlight the key roles of pharmacological adjuvants in optimizing surgical techniques,minimizing intraoperative challenges,and enhancing postoperative *** further discuss the potential implications of this approach for clinical practice and future research directions in this evolving ***,this editorial underscores the importance of incorporating pharmacological adjuvants into standard diabetic vitrectomy care to improve surgical outcomes and thus patients’quality of life.

关键词： Diabetic vitrectomy Pharmacological adjuvants Surgical outcomes Diabetic retinopathy Clinical implications

Application of virtual reality technology improves the functionality of brain networks in individuals experiencing pain

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World Journal of Clinical Cases 2025年第3期13卷 66-68页

作者： Takahiko Nagamine department of Psychiatric internal medicine Sunlight Brain Research CenterHofu 7470066YamaguchiJapan

Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and ***,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)*** has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been *** precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be ***,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain *** salience network is diminished,while the default mode network is ***,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and *** research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.

关键词： Virtual reality Pain Anxiety Salience network Default mode network

Epidemiological Profile of Autoimmune Diseases in Thiès, Senegal: About a Descriptive Observational Study over 11 Years in 2 internal medicine departments and a Dermatology department

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Open Journal of internal medicine 2023年第3期13卷 162-172页

作者： Faye Fulgence Abdou Bammo Mariama Guèye Amina Dia Elame Hugues Diallo Bachir Berthé Adama Dioussé Pauline Touré Papa Souleymane Diop Madoky Magate Diop Bernard Marcel Ka Mamadou Mourtala Training and Research Unit of Health Sciences Alioune Diop University of Bambey Bambey Senegal Training and Research Unit of Health Sciences Iba Der Thiam University Thiès Senegal department of internal medicine Regional Hospital Thiès Senegal department of Dermatology Regional and University Hospital Thiès Senegal department of internal medicine Abdou Aziz SyDabakh Hospital Tivaouane Senegal department of internal medicine Saint Jean de Dieu of Thiès Hospital Thiès Senegal

Introduction: Autoimmune diseases are characterized by a very large clinical polymorphism that can lead to a diagnostic wandering. So, we aimed to determine their epidemiological profile outside the context of Dakar (capital of Senegal) where the technical plateau is more elevated. Methodology: We conducted a retrospective descriptive and observational study from January 1, 2007 to December 31, 2017. All patients admitted or followed in outpatient in the internal medicine departments of the Saint Jean de Dieu and Regional Hospitals of Thiès as well as in the dermatology department of the CHRT (Regional Hospital Center of Thiès), and who met the MAI criteria (autoimmune diseases) have been included. The data were collected on a standardised sheet and analysed by EPI INFO version 7.2. Results: A total of 121 patients were included out of 25951 records i.e a prevalence of 0.46% in internal medicine departments. In dermatology, out of 31973 patients, 95 had MAIS (systemic autoimmune diseases): 0.29% as hospital prevalence. The average age was 40.7 years in internal medicine departments compared to 37.66 years 14.8 years in the dermatology department. Patients aged 30 to 59 years represented 57.89% of the study population. The sex ratio (H/F) was 0.3 in the internal medicine departments compared to 0.17 in the dermatology department. Circumstances of discovery were incidental in 16.52% and clinical in 3.30%. Biermer disease accounted for 29.75% of organ-specific MAI. Concerning systemic presentations, rheumatoid arthritis (RA) was present in 23.14%. Lupus was more representative in dermatology (65.2%) as well as systemic scleroderma (21%), dermatomyositis (6.3%). Cytopenia was found in 105 patients, showing in detail anemia (42.9%);leukopenia (14.8%);thrombocytopenia (2.4%). Autoantibodies were tested in 58 patients (47.9%). Skin histology was contributory in all cases of systemic scleroderma and in 5 cases of lupus. The main therapy prescribed was corticosteroid therapy

关键词： Systemic Autoimmune Diseases internal medicine Dermatology Senegal

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li Hui Ye Xue-Zhi Zhang Jian-Xiang Liu Hong Cheng department of Gastroenterology Peking University First HospitalBeijing 100034China School of medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China department of Traditional Chinese medicine and Integrative medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly