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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 27-27页

作者： Erel C.T. Aydin Y. Kaleli S. 张剑萍 department of Obstetrics and Gynecology Cerrahpasa School of Medicine Istanbul University K. Sk. Nigarhanim Apt. No. 28/11 Erenkoy 81070 Istanbul Turkey

Objective: To investigate spontaneous endometrial apoptosis in women with unexplained infertility and to find out whether there is a possible relationship between endometrial apoptosis, age, and hormonal parameters. Study design: This study was designed as a prospective, case-controlled study in a University Hospital setting. A total of 34 endometrial biopsies were performed from 17 women with unexplained infertility and 17 fertile controls, who were admitted for tubal ligation. Endometrium was sampled on the seventh post-ovulatory day. On the same day of endometrial sampling, serum levels of FSH, LH, PRL, TSH, E2, progesterone, 17α - hydroxyprogesterone, testosterone and DHEA- S were determined. Endometrial glandular and stromal apoptosis were investigated by DNA nick end labeling (TUNEL) method on each sample. Endometrial apoptotic index was calculated and correlated with age and hormonal parameters. Results: There was no difference in either endometrial glandular apoptotic index (AI) or stromal AI between the groups. However, the mean glandular AI was significantly higher than the mean stromal AI (p = 0.0001). There was a strong correlation between endometrial AI and age (r = 0.91, p = 0.02). Serum T levels were significantly found to be decreased in the unexplained infertility group (p = 0.0001). In addition, serum TSH levels were positively correlated with AI in the glandular endometrium in women with unexplained infertility (r = 0.611, p = 0.009) Conclusion: Endometrial apoptosis increases with age. Serum levels of testosterone were lower in unexplained infertility. The effect of serum TSH levels on apoptosis in the glandular epithelium of the endometrium needs further studies.

关键词：子宫内膜细胞凋亡关系腺上皮细胞间质细胞输卵管结扎术羟孕酮硫酸脱氢表雄酮取材时间细胞凋亡指数细胞凋亡现象

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百脉根BIO和豌豆突变位点ELE2的比较基因组定位(英文)

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基因组学与应用生物学 2010年第1期29卷 3-9页

作者：李信赫圣博庄黎丽 Sato Shusei TabataSatoshi Ambrose Mike Rameau Catherine 杨军胡筱荷罗达上海交通大学生命科学技术学院上海200240 Kazusa DNA Research Institute 2-6-7 Kazusa-kamatariKisarazuChiba 292-0818 department of Crop Genetics John Innes CentreColneyNorwich NR47UH Station de Genetique et d'Amelioration des Plantes Institut J.P.BourginUR2541NRA 中国科学院上海生命科学研究院植物生理生态研究所植物分子遗传学国家重点实验室上海200032

豆科两侧对称花的花瓣具有背腹(DV)的分化以及可变的器官内部(IN)非对称性,在大小与形状上显示出不同的发育特征;因而花瓣的发育为克隆决定植物器官的形状与大小的关键基因提供了很好的实验系统。本研究对百脉根中BIO基因进行研究。百脉... 详细信息

豆科两侧对称花的花瓣具有背腹(DV)的分化以及可变的器官内部(IN)非对称性,在大小与形状上显示出不同的发育特征;因而花瓣的发育为克隆决定植物器官的形状与大小的关键基因提供了很好的实验系统。本研究对百脉根中BIO基因进行研究。百脉根bio突变体具有多效性,既影响花器官内部的对称性也影响器官的大小和育性,豌豆ele突变体的表型与bio相似。定位结果表明BIO和ELE2位于豆科基因组的共线性区段,提示BIO和ELE2可能是同源基因突变所致。本研究利用比较基因组定位方法,将BIO和ELE2候选基因锚定在豆科模式植物百脉根和蒺藜苜蓿基因组含有11个同源基因的BAC重叠群上。BIO和ELE2基因的克隆将有助于揭示豆科花瓣形态和大小调控的分子机理,进而为豆科作物遗传改良提供分子理论基础。

关键词：器官的形状和大小百脉根 BIO基因 ELE2基因比较基因组定位

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重组人卵泡刺激素治疗男性特发性不育症的前瞻性随机对照临床研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 36-36页

作者： Foresta C. Bettella A. Garolla A. 张剑萍(译) Dr. C. Foresta University of Padova Department of Histology Microbiology and Medical Biotechnologies Centre for Male Gamete Cryopreservation Via Gabelli 63 Padova 35121 Italy 不详

To evaluate the effects of treatment with FSH on seminal parameters and spontaneous pregnancy in male infertility. Design: Prospective, controlled, randomized clinical study. Setting: infertility center at a university hospital. Patient(s): One hundred twelve men affected by idiopathic oligozoospermia. Intervention(s): Patients were randomized into two groups: 62 subjects were treated with 100 IU of recombinant human FSH on alternate days for 3 months, and 50 patients did not receive any treatment. Semen analysis was performed in all subjects at the end of this period of treatment and after the following 3 months. Subjects who had not reached spontaneous pregnancy underwent assisted reproductive techniques. Main Outcome Measure(s): Seminal parameters, testicular cytologic analysis, FSH, LH, T, and inhibin B concentrations. Result(s): The treatment group considered as a whole did not show modifications in sperm parameters. However, a subgroup of these (30, 48.4% ) had a significant increase of sperm count (responder group). In the period including 3 months after the withdrawal of FSH therapy, we observed a significantly higher spontaneous pregnancy rate in the responder group (5 of 30 [16.7% ]) with respect to nonresponder and nontreated groups (1 of 32 [3.1% ] and 2 of 50 [4.0% ], respectively). Furthermore, the improvement of seminal parameters in the responder group allowed these patients to undergo less frequent IVF- ET/intracytoplasmic sperm injection. Conclusion(s): Results from this controlled, randomized clinical trial show that FSH therapy does not improve sperm concentration or pregnancy rate when infertile male patients are chosen solely by the clinical criteria of idiopathic oligospermia and normal FSH concentration. Subgroup analysis, however, does indicate that patients without maturation arrest in addition to the clinical scenario do benefit from medical therapy.

关键词：随机对照临床研究激素治疗特发性不育症卵泡刺激素(FSH) 卵母细胞单精子显微注射男性重组不孕症患者人卵泡特发性少精症

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采用辅助生殖技术的双卵双胎妊娠与染色体异常、宫内失调和单绒毛膜双胎胎盘形成

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 39-39页

作者： Yoon G. Beischel L.S. Johnson J.P. Jones M.C. 平智广 department of Pediatrics University of California San Diego Children's Hospital MC 5031 3020 Children's Way San Diego CA 92123 United States Dr.

Assisted reproductive technology (ART) has now become a cornerstone of treatm ent for involuntary infertility. Recent studies have raised concern regarding po tential associations between ART and chromosomal aneuploidy, imprinting anomalie s, and monochorionic placentation in dizygotic (DZ) twins. We report a case of D Z twins conceived by ART in which all three problems coexist.

关键词：双卵双胎单绒毛膜双胎辅助生殖技术胎盘形成染色体异常不孕不育症双卵双生应用技术

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两种不同剂量来曲唑行超排卵的随机试验

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 32-32页

作者： Al-Fadhli R. Sylvestre C. Buckett W. T. Tulandi 张旸 department of Obstetrics and Gynecology McGill University Women's Pavilion 687 Pine Avenue West Montreal Que. H3A 1A1 Canada Dr.

Objective: The aim of this study was to evaluate the effects of either a 2.5-mg or a 5-mg daily dose of letrozole in women undergoing superovulation and intrauterine insemination (IUI). Design: Prospective randomized trial. Setting: Academic teaching hospital. Patient(s): Women infertility of > 1 year in duration. Intervention(s): Patients were randomized into either a 2.5-mg dose of letrozole (34 patients) or a 5-mg dose of letrozole (38 patients) daily for 5 days. When the leading follicle reached 18 mm in diameter, ovulation was triggered by an injection of hCG and IUI was performed 24 and 48 hours later. Main Outcome Measure(s): The number of follicles, endometrial thickness, and pregnancy rate. Result(s): Compared with those treated with 2.5 mg of letrozole, the total number of follicles was significantly higher in patients receiving 5 mg of letrozole. No difference in the endometrial thickness was found between the two groups. The pregnancy rate per cycle in patients receiving 5 mg of letrozole was statistically higher than in patients receiving 2.5 mg of letrozole (26.3%vs 5.9%, P < .05). No multiple pregnancies occurred. Conclusion(s): Compared with the daily dose of 2.5 mg, 5 mg of letrozole is associated with more follicles and a higher pregnancy rate. It appears that 5 mg daily for 5 days is a preferable letrozole dose for superovulation.

关键词：促超排卵来曲唑卵泡数目随机试验人工受精诱导排卵不孕史子宫内膜厚度多胎妊娠教学医院

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