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用于心血管医疗装置的聚合物表面构建与生物相容性研究Ⅲ——聚合物生物材料表面的凝血及抗凝血涂层改性（英文）

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中国组织工程研究 2015年第8期19卷 1277-1283页

背景:用于心血管医疗的生物材料在血液接触性条件下必须具有抗血栓性、对抗生物降解性与抗感染性。目的:研制用于心血管组织工程的新型植(介)入型聚合物材料(表面),从聚合物生物材料表面的凝血及抗凝血涂层改性方面考察各种相应改性表... 详细信息

背景:用于心血管医疗的生物材料在血液接触性条件下必须具有抗血栓性、对抗生物降解性与抗感染性。目的:研制用于心血管组织工程的新型植(介)入型聚合物材料(表面),从聚合物生物材料表面的凝血及抗凝血涂层改性方面考察各种相应改性表面的生物相容性、血液相容性和细胞相容性。方法:检索1983至2014年PubMed数据库及万方数据库。英文检索词为"biocompatibility,blood compatibility,biomedical materials,biomedical polymer materials",中文检索词为"生物相容性材料;血液相容性材料;生物医用材料;医用高分子材料"。排除与研究目的相关性差及内容陈旧、重复的文献,保留与生物医用高分子材料的血液相容性研究,进行归纳总结。结果与结论:通过对血液与植入物间的相互作用和生物材料表面的抗凝血涂层改性两个方面的归纳分析,从聚合物生物材料表面的凝血及抗凝血涂层改性方面考察了各种相应改性表面的生物相容性、血液相容性和细胞相容性。研制用于心血管组织工程的新型植(介)入型聚合物材料(表面)关键在于对聚合物生物材料表面的凝血及抗凝血涂层改性以及对其相应生物相容性与内皮细胞相容性的研究。通过对心血管医疗用聚合物生物材料的种类与应用及其心血管医疗器件和可植入性软组织替代物的深入研究可以发现表面与本体的差别则将体现在从表面向本体延伸的很多层分子上,而2种主要因素决定了其包括本体/表面差异及表面相分离在内的本体/表面行为,即表面能和分子运动性。如果考虑到对本体-表面的组成差异的理解,则还必须追加另以附加决定因素,即各组分的结晶行为。

关键词：生物材料材料相容性聚合物材料聚合物生物材料生物医用聚合物材料生物相容性血液相容性细胞相容性抗凝血涂层改性

Effect of chlorine dioxide on avian influenza A(H7N9)virus

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Biosafety and Health 2022年第1期4卷 53-57页

作者： Zhiping Sun Yun Qian Norio Ogata Xia Cai Wendong Han Youhua Xie Hirofumi Morino Koushirou Sogawa Takashi Shibata Di Qu BSL-3 Laboratory of Fudan University School of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China R&D Center Taiko Pharmaceutical Co.LtdKyotoJapan Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Department of Medical Microbiology and ParasitologySchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China

Avian influenza remains a threat to human *** derivatives are commonly used as disinfectants to prevent the spread of the *** World Health Organization(WHO)has listed chlorine dioxide(ClO_(2))as an A1‐level,safe,and efficient *** this study,we tested the efficacy of ClO_(2),in aqueous solution and gas forms,against avian influenza A(H7N9)*** virus suspension was mixed with ClO_(2) aqueous solutions of various concentrations and for various time *** of the mixture were then serially diluted,and the 50%tissue culture infective dose(TCID50)was measured with a hemagglutination test on MDCK ***_(2) gas produced from generators was introduced in a chamber containing the virus suspension in a Petri *** infective activity of the surviving virus was measured by the hemagglutination *** aqueous solution of ClO_(2) at 126μg/mL for 15 s was effective given that no surviving virus was detected with the hemagglutination ***_(2) gas at>5μL/L sustained for 1 h inactivated the virus effectively,while at 2.5μL/L for 1 h,it only partially inactivated the ***_(2) as gas or aqueous solution at a certain concentration is effective in inactivating the H7N9 virus,and can be applied for the decontamination and disinfection of environments.

关键词： Chlorine dioxide Influenza virus A H7N9 Disinfection Aqueous solution Gas ClO_(2)

The predictive value of neutrophil-to-lymphocyte ratio for short-term mortality in infective endocarditis complicated with sepsis

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South China Journal of Cardiology 2024年第04期 245-251页

作者：王晓玲谢银均廖游玩梁秀娜 department of Geriatric Intensive Medicine Guangdong Provincial Geriatrics Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Southern Medical University

Background Although neutrophil-to-lymphocyte ratio(NLR) has been extensively studied in several diseases, its predictive role in infective endocarditis(IE) complicated with sepsis remains unclear. The aim of this study was to explore the prognostic value of NLR in IE patients complicated with sepsis. Methods Patients with the diagnosis of IE complicated with sepsis was retrospectively enrolled between January 2009 to February 2020 in the Guangdong Provincial People's Hospital. Multivariate analysis was used to investigate the relationship between NLR and short-term mortality. Results A total of 496 IE patients complicated with sepsis were included and divided into three groups according to the tertiles of NLR: 8.7(n=165). Restricted cubic splines showed an approximately positive linear correlation between the level of NLR and risk of in-hospital death. Multivariate logistic regression analysis showed an independent correlation between elevated NLR and in-hospital death [odds ratio(OR): 1.04, 95% confidential interval(CI): 1.01-1.07, P=0.015]. The receiver operating characteristic curve analysis demonstrated a relatively high predictive value of NLR for identifying in-hospital death(area under curve: 0.643, 95% CI: 0.570-0.717, P11(HR: 1.57, 95% CI: 1.02-2.41, P=0.039) was independent predictor for 6-month mortality. Conclusions NLR is a feasible predictor of short-term mortality for IE patients complicated with sepsis. [S Chin J Cardiol 2024; 25(4):245-251]

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用于心血管医疗装置的聚合物材料表面构建与生物相容性研究Ⅱ-心血管医疗装置聚合物的表面构建与生物反应行为

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中国组织工程研究 2014年第21期18卷 3412-3419页

背景:用于心血管医疗的生物材料在血液接触性条件下必须具有抗血栓性、对抗生物降解性与抗感染性。目的:研制用于心血管组织工程的新型植(介)入型聚合物材料(表面),从聚合物生物材料的表面构建与生物反应行为方面考察各种相应改性表面... 详细信息

背景:用于心血管医疗的生物材料在血液接触性条件下必须具有抗血栓性、对抗生物降解性与抗感染性。目的:研制用于心血管组织工程的新型植(介)入型聚合物材料(表面),从聚合物生物材料的表面构建与生物反应行为方面考察各种相应改性表面的生物相容性、血液相容性和细胞相容性。方法:检索1984至2013年PubMed数据库及万方数据库,英文检索词为"Biocompatibility,Blood compatibility,Biomedical Materials,Biomedical polymer materials",中文检索词为"生物相容性材料;血液相容性材料;生物医用材料;医用高分子材料"。结果与结论:通过对蛋白质吸附、细胞黏附中的生物识别、凝血与纤溶过程中的酶催化作用"瀑布模型",以及生物材料表面构建与蛋白质表面吸附行为4个方面的归纳分析,研制用于心血管组织工程的新型植(介)入型聚合物材料(表面)关键在于对聚合物生物材料生物功能性表面的构建,以及对其相应生物相容性与内皮细胞相容性的研究。通过对聚合物生物材料种类与应用及其心血管医疗器件和可植入性软组织替代物的深入研究可以发现,表面与本体的差别将体现在从表面向本体延伸的很多层分子上,而两种主要因素决定了其包括本体/表面差异及表面相分离在内的本体/表面行为,即表面能和分子运动性。如果考虑到对本体-表面组成差异的理解,还必须追加附加决定因素,即各组分的结晶行为。

关键词：生物材料材料相容性血液相容性细胞相容性聚合物医用高分子材料生物识别生物材料的表面构建蛋白质的表面吸附

谐波成像对经胸超声心动图识别感染性心内膜炎及其并发症的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第7期1卷 35-35页

作者： Chirillo F. Pedrocco A. De Leo A. 宁宁 Dr. department of Cardiology Ca'Foncello Hospital Piazzale Ospedale 1 31100 Treviso Italy

Objective: To evaluate the comparative diagnostic value of harmonic imaging(HI) in the assessment of patients with suspected infective endocarditis(IE). Setting: Tertiary referral centre. Design: 139 consecutive patients were evaluated with three imaging modalities: transthoracic echocardiography with fundamental imaging(FI); HI; and transoesophageal echocardiography(TOE). Image qualitywas assessed for each modality by semiquantitative scoring(0, poor, to 3, excellent). Presence, dimension, and characteristics of vegetations were assessed separately for each imaging modality, as well as presence of abscesses. Results: 35 patients had definite IE. TOE was positive in 33 patients, HI in 28, and FI in 12(p< 0.001 for FI v HI and v TOE). Mean image quality was 1.4(0.7) for FI, 2.1(0.6) for HI(p< 0.01 v FI), and 2.6(0.4) for TOE(p< 0.001 v HI). The association between FI and TOE findings was=0.35(χ2=17.57, p=0.0014) and between HI and TOE it was=0.95(χ2=125.72, p< 0.0001; p< 0.0001 v FI). The global echo score of vegetations was 7.1(3.3) with FI, 8.5(3.4) with HI, and 11.3(3.9) with TOE(p< 0.001 v HI). Compared with TOE, FI identified only one of seven abscesses(sensitivity 14%) and HI identified two of seven abscesses(sensitivity 28%). Conclusions: HI provides an accurate assessment of suspected IE. TOE achieves superior definition of IE related abnormalities.

关键词：谐波成像经胸超声心动图感染性心内膜炎赘生物基波成像成像质量半定量评分模式评价

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疥疮

世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 1-1页

作者： Heukelbach J. Feldmeier H. 冯义国(译) 不详 Feldmeier Department of Medical Microbiology and Immunology of Infection Charit é Medical School Campus Benjamin Franklin Berlin Germany

Scabies is a neglected parasitic disease that is a major public health problem in many resource-poor regions. It causes substantial morbidity from secondary infections and post-infective complications such as acute post-streptococcal glomerulonephritis. Disease control requires treatment of the affected individual and all people they have been in contact with, but is often hampered by inappropriate or delayed diagnosis, poor treatment compliance, and improper use of topical compounds such as permethrin, lindane, or benzyl benzoate. In addition to concerns over toxicity with such compounds, parasite resistance seems to be increasing. Oral ivermectin is an alternative that has been used successfully in community control programmes. Plant derivatives such as turmeric, neem, and tea tree oil are also promising future treatments. The disease is strongly associated with poverty and overcrowding, and the associated stigma can ostracise affected individuals. Treatment of scabies in poor countries needs to integrate drug treatment programmes with efforts to improve the socioeconomic conditions and education programmes to reduce stigma. We expect the future to bring more sensitive and specific clinical and laboratory-based diagnostic methods, as well as new therapeutic strategies.

关键词：急性链球菌感染后肾小球肾炎疥疮疾病控制项目实验室诊断方法治疗药物公共卫生问题社会经济状况苯甲酸苄酯

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感染性心内膜炎心外并发症的影像学表现

国际医学放射学杂志 2009年第1期32卷 85-85页

作者： T.W. Colen M. Gunn E. Cook T. Dubinsky 王丹 department of Radiology University of Washington Medical Center 1959 NE Pacific Ave Box 357115 Seattle WA 98195 USA

感染性心内膜炎（IE）是一种具有高发病率的疾病，即使得到适当的诊断和治疗，其死亡率仍可达9％～30％。由IE所致的脓毒栓可随动脉血供累及到全身任一器官或组织，可在12％～40％的IE病人中发生。最常受累的心外部位是中枢神经系统。... 详细信息

感染性心内膜炎（IE）是一种具有高发病率的疾病，即使得到适当的诊断和治疗，其死亡率仍可达9％～30％。由IE所致的脓毒栓可随动脉血供累及到全身任一器官或组织，可在12％～40％的IE病人中发生。最常受累的心外部位是中枢神经系统。其他较常受累的部位为肺（尤其是右心IE）、脾、肾、肝和骨骼肌肉系统。此外，动脉系统本身也容易发生潜在的致命的真菌感染性动脉瘤。由于IE的心外并发症常在临床作出IE诊断前发生，因此影像学发现有利于提示IE诊断的特征性征象非常重要。此外。影像学还常用于明确已确诊的IE病人心外并发症的范围。

关键词：心内膜炎感染脓毒栓

副肿瘤性天疱疮合并小结树突细胞肉瘤的桥粒核心糖蛋白1和3抗体效价

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世界核心医学期刊文摘（皮肤病学分册） 2005年第4期1卷 61-61页

作者： SeishimaM. OdaM. Oyama Z. 田中伟 department of Dermatology Ogaki Municipal Hospital Minaminokawa-cho4-86Ogaki503-8502Japan Dr.

Background: Most paraneoplastic pemphigus (PNP) cases reported to date have been associated with lymphoproliferative neoplasms. Patients with PNP have autoantibodies against the plakin family (eg, envoplakin and periplakin). Antibodies against desmoglein 3 (Dsg3) and Dsg1, antigens for classic types of pemphigus, have also been reported to play an important role in the initial stage of PNP. Observations: We describe a patient with PNP associated with follicular dendritic cell sarcoma. Antibodies to envoplakin and periplakin were detected. When only mucosal lesions were observed at the early stage, the antibody to Dsg3 but not to Dsg1 was detected by enzyme-linked immunosorbent assay. After skin lesions appeared, antibodies to Dsg1 and Dsg3 were dete cted. These titers were elevated, with exacerbation of skin lesions. Although the patient received corticosteroid therapy, double-filtration plasmapheresis, and intravenous human immunoglobulin therapy after surgical resection of follicular dendritic cell sarcoma, she died of fungal infective lung embolisms. A direct immunofluorescence study of autopsy samples showed IgG deposition intheepidermisoftheskinandoralmucosalmembrane,butnot in the lungs and kidneys and follicular dendritic cell sarcoma of the para-aortic area. Conclusion: In this patient with PNP and follicular dendritic cell sarcoma, there was an association between the clinical phenotype and the anti-Dsg antibody profile, as seen in pemphigus vulgaris.

关键词：肿瘤性小结树突细胞桥粒酶联免疫吸附法免疫荧光检查黏膜损害 IgG 皮质类固醇增殖性血浆分离

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易于漏诊？感染性心内膜炎

英国医学杂志中文版 2011年第2期14卷 122-124页

作者： Mark Connaughton John G Rivett 李玲(译) 杜昕(校) Cardiology department St Mary's Hospital Newport Isle of Wight PO30 5TG UK 2Martins Oak Surgery Battle TN33 0EA UK Martins Oak Surgery Battle TN330EA UK 首都医科大学附属北京安贞医院心内科

感染性心内膜炎是心内膜表面或心脏假体材料感染细菌引起的。80％以上病例的致病细菌为金黄色葡萄球菌或链球菌、肠球菌的亚类。虽然感染性心内膜炎的总发病率保持相对稳定，但近年来，其流行病学发生了明显变化，更多患者的感染性心内... 详细信息

感染性心内膜炎是心内膜表面或心脏假体材料感染细菌引起的。80％以上病例的致病细菌为金黄色葡萄球菌或链球菌、肠球菌的亚类。虽然感染性心内膜炎的总发病率保持相对稳定，但近年来，其流行病学发生了明显变化，更多患者的感染性心内膜炎与人工瓣膜及院内获得性感染有关。

关键词：感染性心内膜炎金黄色葡萄球菌院内获得性感染漏诊感染细菌假体材料致病细菌总发病率