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World Journal of Gastroenterology 2024年第16期30卷 2209-2219页

作者： Na Cui Ting Dai Yang Liu Ya-Yu Wang Jia-Yu Lin Qing-Fan Zheng Dong-Dong Zhu Xue-Wei Zhu department of Otorhinolaryngology Head and Neck Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina department of Ultrasound China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina department of Gastroenterology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

Laryngopharyngeal reflux disease(LPRD)is an inflammatory condition in the laryngopharynx and upper aerodigestive tract mucosa caused by reflux of stomach contents beyond the *** commonly presents with symptoms such as hoarseness,cough,sore throat,a feeling of throat obstruction,excessive throat *** complex condition is thought to involve both reflux and reflex mechanisms,but a clear understanding of its molecular mechanisms is still ***,there is no standardized diagnosis or treatment *** strategies for LPRD mainly include lifestyle modifications,proton pump inhibitors and endoscopic *** paper seeks to provide a comprehensive overview of the existing literature regarding the mechanisms,pathophysiology and treatment of *** also provide an in-depth exploration of the association between LPRD and gastroesophageal reflux disease.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux Head neck surgery Laryngitis Otolaryngology

Effects of the Pituitary-targeted Gland Axes on Hepatic Lipid Homeostasis in Endocrine-associated Fatty Liver disease-A Concept Worth Revisiting

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 416-427页

作者： Yifang Li Meina Zheng Steven Limbara Shanshan Zhang Yutao Yu Le Yu Jian Jiao department of Gastroenterology&Hepatology China-Japan Union HospitalJilin UniversityChangchunJilinChina

Hepatic lipid homeostasis is not only essential for maintain-ing normal cellular and systemic metabolic function but is also closely related to the steatosis of the *** contro-versy over the nomenclature of non-alcoholic fatty liver dis-ease(NAFLD)in the past three years has once again sparked in-depth discussions on the pathogenesis of this disease and its impact on systemic ***-targeted gland axes(PTGA),an important hormone-regulating system,are indispensable in lipid *** review focuses on the roles of thyroid hormones,adrenal hormones,sex hor-mones,and their receptors in hepatic lipid homeostasis,and summarizes recent research on pituitary target gland axes-related drugs regulating hepatic lipid *** also calls on researchers and clinicians to recognize the concept of endocrine-associated fatty liver disease(EAFLD)and to re-examine human lipid metabolism from the macroscopic perspective of homeostatic balance.

关键词： Lipid homeostasis Metabolism Pituitary-target gland axes(PTGA) Endocrine-associated fatty liver disease(EAFLD)

Cut-off value of glycated hemoglobin A1c for detecting diabetic retinopathy in the Chinese population

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World Journal of Diabetes 2024年第7期15卷 1531-1536页

作者： Yan Wen Qing Wang department of Endocrinology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

BACKGROUND Glycated hemoglobin A1c(HbA1c)is considered the most suitable for diabetes mellitus diagnosis due to its accuracy and ***,the effect of HbA1c on diabetic retinopathy(DR)in the Han and Korean populations in Jilin,china,remains *** To determine the best cut-off of HbA1c for diagnosing DR among the *** This cross-sectional study included 1933 participants from the Yanbian area of Jilin Province,*** investigators employed a questionnaire-based survey,physical examination,laboratory tests,and fundus photography for the *** best cut-off value for HbA1c was established via the receiver operating characteristic *** factors associated with HbA1c-associated risk factors were determined via linear *** The analysis included 887 eligible Chinese Han and Korean participants,591 of whom were assigned randomly to the training set and 296 to the validation *** prevalence of DR was 3.27% in the total ***1c of 6.2% was the best cut-off value in the training set,while it was 5.9% in the validation *** both Chinese Han and Korean populations,an HbA1c level of 6.2% was the best cut-off *** optimal cut-off values of fasting blood glucose(FBG)≥7 mmol/L and<7 mmol/L were 8.1% and 6.2% respectively in Han populations,while those in Korean populations were 6.9%and 5.3%,***,body mass index,and FBG were determined as the risk factors impacting HbA1c *** HbA1c may serve as a useful diagnostic indicator for *** HbA1c level of 6.2% may be an appropriate cut-off value for DR detection in the Chinese population.

关键词： Diabetic retinopathy Glycated hemoglobin A1c Cut-off value Age Body mass index Fasting blood glucose

Bile acids,gut microbiota,and therapeutic insights in hepatocellular carcinoma

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Cancer Biology & Medicine 2024年第2期21卷 144-162页

作者： Yang Song Harry CH Lau Xiang Zhang Jun Yu Institute of Digestive disease and department of Medicine and therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongHong KongChina department of Gastroenterology Zhongshan Hospital Xiamen UniversityXiamen 361004China

Hepatocellular carcinoma(HCC)is a prevalent and aggressive liver *** interplay between bile acids(BAs)and the gut microbiota has emerged as a critical factor in HCC development and *** normal conditions,BA metabolism is tightly regulated through a bidirectional interplay between gut microorganisms and *** gut microbiota plays a critical role in BA metabolism,and BAs are endogenous signaling molecules that help maintain liver and intestinal *** note,dysbiotic changes in the gut microbiota during pathogenesis and cancer development can disrupt BA homeostasis,thereby leading to liver inflammation and fibrosis,and ultimately contributing to HCC ***,understanding the intricate interplay between BAs and the gut microbiota is crucial for elucidating the mechanisms underlying *** this review,we comprehensively explore the roles and functions of BA metabolism,with a focus on the interactions between BAs and gut microorganisms in ***,therapeutic strategies targeting BA metabolism and the gut microbiota are discussed,including the use of BA agonists/antagonists,probiotic/prebiotic and dietary interventions,fecal microbiota transplantation,and engineered *** summary,understanding the complex BA-microbiota crosstalk can provide valuable insights into HCC development and facilitate the development of innovative therapeutic approaches for liver malignancy.

关键词： Bile acid gut microbiota hepatocellular carcinoma therapeutics microbiota modulation

Bacterial Infections in Acute-on-chronic Liver Failure:Epidemiology,Diagnosis,Pathogenesis,and Management

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 667-676页

作者： Zhaoyu Xu Xiuding Zhang Jiyang Chen Yu Shi Shangwei Ji china-japan union hospital of Jilin University ChangchunJilinChina State Key Laboratory for Diagnosis and Treatment of Infectious diseases National Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina department of Infectious diseases China-Japan Union Hospital of Jilin UniversityChangchunJilinChina

Acute-on-chronic liver failure(ACLF)is a distinct condition characterized by the abrupt exacerbation of pre-existing chronic liver disease,often leading to multi-organ failures and significant short-term *** infection is one of the most frequent triggers for ACLF and a common complication following its *** impact of bacterial infections on the clinical course and outcome of ACLF underscores their critical role in the pathogenesis of systemic inflammation and organ *** addition,the evolving epidemiology and increasing prevalence of multidrug-resistant bacteria in cirrhosis and ACLF highlight the importance of appropriate empirical antibiotic use,as well as accurate and prompt microbiological *** review provided an update on recent advances in the epidemiology,diagnosis,pathogenesis,and management of bacterial infections in ACLF.

关键词： Acute-on-chronic liver failure Bacterial infection Multidrug-resistant bacteria Spontaneoous bacterial peritonitis systemic inflammation Antibiotic Albumin

Age-specific differences in the association between prediabetes and cardiovascular diseases in china:A national cross-sectional study

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World Journal of Diabetes 2024年第2期15卷 240-250页

作者： Shuo Xie Li-Ping Yu Fei Chen Yao Wang Rui-Fen Deng Xue-Lian Zhang Bo Zhang department of Endocrinology Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China department of Endocrinology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Cardiovascular disease(CVD)is a leading cause of morbidity and mortality worldwide,the global burden of which is *** is still unclear the extent to which prediabetes contributes to the risk of CVD in various age brackets among *** develop a focused screening plan and treatment for Chinese adults with prediabetes,it is crucial to identify variations in the connection between prediabetes and the risk of CVD based on *** To examine the clinical features of prediabetes and identify risk factors for CVD in different age groups in *** The cross-sectional study involved a total of 46239 participants from June 2007 through May 2008.A thorough evaluation was *** with prediabetes were categorized into two groups based on *** atherosclerotic CVD risk prediction model was employed to evaluate the risk of developing CVD over 10 *** forest was established in both age *** Additive exPlanation method prioritized the importance of features from the perspective of assessment *** In total,6948 people were diagnosed with prediabetes in this *** prediabetes,prevalences of CVD were 5(0.29%)in the younger group and 148(2.85%)in the older ***,11.11%of the younger group and 29.59% of the older group were intermediate/high-risk of CVD for prediabetes without CVD based on the Prediction for ASCVD Risk in china equation in ten *** the younger age group,the 10-year risk of CVD was found to be more closely linked to family history of CVD rather than lifestyle,whereas in the older age group,resident status was more closely *** The susceptibility to CVD is age-specific in newly diagnosed *** is necessary to develop targeted approaches for the prevention and management of CVD in adults across various age brackets.

关键词： Age Cardiovascular diseases Prediabetes Risk factors Differences

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui Niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

Mechanism and application of feedback loops formed by mechanotransduction and histone modifications

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Genes & diseases 2024年第5期11卷 198-218页

作者： Han Sun Yafang Gao Xinyu Ma Yizhou Deng Lintao Bi Lisha Li department of Hematology and Oncology China-Japan Union HospitalJilin UniversityChangchunJilin 130021China The Key Laboratory of Pathobiology Ministry of EducationCollege of Basic Medical SciencesJilin UniversityChangchunJilin 130021China

Mechanical stimulation is the key physical factor in cell *** acts as a fundamental regulator of cell behavior,regulating cell proliferation,differentiation,apoptosis,and exhibiting specific signature alterations during the pathological *** research continues,the role of epigenetic science in mechanotransduction is attracting ***,the molecular mechanism of the synergistic effect between mechanotransduction and epigenetics in physiological and pathological processes has not been *** focus on how histone modifications,as important components of epigenetics,are coordinated with multiple signaling pathways to control cell fate and disease ***,we propose that histone modifications can form regulatory feedback loops with signaling pathways,that is,histone modifications can not only serve as downstream regulators of signaling pathways for target gene transcription but also provide feedback to regulate signaling *** and epigenetic changes could be potential markers and therapeutic targets in clinical practice.

关键词： FAK Histone modifications MAPK Mechanotransduction RhoA WNT/b-catenin YAP/TAZ

Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2673-2682页

作者： Huang Chen Rui-Ying Jiang Zhan Hua Xiao-Wei Wang Xiao-Li Shi Ye Wang Qian-Qian Feng Jie Luo Wu Ning Yan-Fen Shi Da-Kui Zhang Bei Wang Jian-Zheng Jie Ding-Rong Zhong department of Pathology China-Japan Friendship HospitalBeijing 100029China department of Gastrointestinal Surgery China-Japan Friendship HospitalBeijing 100029China department of Scientific Research GeneisBeijing 100012China

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly *** To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in *** We enrolled 2271 Chinese CRC patients at the china-japan Friendship *** proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain *** status was determined using an MSI detection *** analyses were conducted using SPSS software and logistic *** The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,*** mutations were more likely to occur in patients with moderate-to-high *** mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural *** MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous ***,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,*** dMMR was more likely to occur in patients with a family history of CRC,aged<50 years,right-sided CRC,poorly differentiated histology,no perineural invasion,and with carcinoma in situ,stage I,or stage II *** This study analyzed the molecular profiles of KRAS,NRAS,BRAF,PIK3CA,and MMR/MSI in CRC,identifying key influencing factors,with implications for clinical management of CRC.

关键词： Colorectal cancer Deficient mismatch repair Microsatellite instability Gene mutation Comprehensive analysis

Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke:Insights from Network Pharmacology and in vivo Experiments

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Chinese Journal of Integrative Medicine 2024年第8期30卷 713-720页

作者： LI Zhong-hao PU Xiao-qi LI Sha-sha DONG Xiao-ke ZHANG Guo-qiang WANG Yu LIU Jin-min department of Emergency China-Japan Friendship HospitalBeijing100029China department of Neurology Beijing University of Chinese Medicine Dongfang HospitalBeijing100078China department of Radiology China-Japan Friendship HospitalBeijing100029China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To explore the neuroprotective effects and mechanism of Tanreqing Injection(TRQ)on treating ischemic stroke based on network pharmacology and in vivo experimental *** The chemical compounds of TRQ were retrieved based on published data,with targets retrieved from PubChem,Therapeutic Target Database and *** visualization and analysis were performed using Cytoscape,with protein-protein interaction networks derived from the STRING *** analysis was performed using Kyoto Encyclopedia of Genes Genomes pathway and Gene Ontology *** in vivo experiments,the middle cerebral artery occlusion(MCAO)model was *** volume was determined by 2,3,5-triphenyltetrazolium hydrochloride staining and protein expressions were analyzed by Western *** docking was performed to predict ligand-receptor *** We screened 81 chemical compounds in TRQ and retrieved their therapeutic *** the targets,116 were therapeutic targets for *** enrichment analysis showed that the apelin signaling pathway was a key pathway for ischemic ***,in in vivo experiment we found that administering with intraperitoneal injection of 2.5 mL/kg TRQ every 6 h could significantly reduce the infarct volume of MCAO rats(P<0.05).In addition,protein levels of the apelin receptor(APJ)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway were increased by TRQ(P<0.05).In addition,41 chemical compounds in TRQ could bind to *** The neuroprotective effect of TRQ may be related to the APJ/PI3K/AKT signaling ***,further studies are needed to confirm the findings.

关键词： Tanreqing Injection Chinese medicine ischemic stroke middle cerebral artery occlusion quantitative estimate of drug-likeness