检索结果-南通市图书馆

Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: A systematic review with meta-analysis

引用

World Journal of Gastroenterology 2019年第33期25卷 4999-5016页

作者： Ya-Ting Li Hong Xu Jian-Zhong Ye Wen-Rui Wu Ding Shi Dai-Qiong Fang Yang Liu Lan-Juan Li State Key Laboratory for the Diagnosis and Treatment of infectious diseases The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Collaborative Innovation center for the Diagnosis and Treatment of infectious diseases School of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina department of Orthopedics Xiaoshan Traditional Chinese Medical HospitalHangzhou 310003Zhejiang ProvinceChina department of Orthopedics Clinical SciencesLundLund UniversityLund 22185Sweden

BACKGROUND Diarrhea is a major infectious cause of childhood morbidity and mortality *** clinical trials,Lactobacillus rhamnosus GG ATCC 53013(LGG)has been used to treat ***,recent randomized controlled trials(RCTs)found no evidence of a beneficial effect of LGG *** To evaluate the efficacy of LGG in treating acute diarrhea in *** The EMBASE,MEDLINE,PubMed,Web of Science databases,and the Cochrane Central Register of Controlled Trials were searched up to April 2019 for metaanalyses and *** Cochrane Review Manager was used to analyze the relevant *** Nineteen RCTs met the inclusion criteria and showed that compared with the control group,LGG administration notably reduced the diarrhea duration[mean difference(MD)-24.02 h,95%confidence interval(CI)(-36.58,-11.45)].More effective results were detected at a high dose≥1010 CFU per day[MD-22.56 h,95%CI(-36.41,-8.72)]vs a lower dose.A similar reduction was found in Asian and European patients[MD-24.42 h,95%CI(-47.01,-1.82);MD-32.02 h,95%CI(-49.26,-14.79),respectively].A reduced duration of diarrhea was confirmed in LGG participants with diarrhea for less than 3 d at enrollment[MD-15.83 h,95%CI(-20.68,-10.98)].High-dose LGG effectively reduced the duration of rotavirus-induced diarrhea[MD-31.05 h,95%CI(-50.31,-11.80)]and the stool number per day[MD-1.08,95%CI(-1.87,-0.28)].CONCLUSION High-dose LGG therapy reduces the duration of diarrhea and the stool number per *** at the early stage is *** trials are expected to verify the effectiveness of LGG treatment.

关键词： Lactobacillus rhamnosus GG Acute diarrhea Children Rotavirus Probiotics Systematic review Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PADI3 induces cell cycle arrest via the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer

引用

Cancer Biology & Medicine 2019年第4期16卷 729-742页

作者： Xiaotian Chang Zhengbin Chai Jiaorui Zou Hongxing Wang Yao Wang Yabing Zheng Hui Wu Chunyan Liu Medical Research center The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014 Medical Research center of the hospital Affiliated to Qingdao university Qingdao 266000China department of Laboratory Medicine Jinan Infectious Disease HospitalShandong UniversityJinan 250021China

Objective:As a member of the peptidyl arginine deiminase(PAD)family,PADI3 is weakly expressed in colon cancer tissues and highly expressed in adjacent colon cancer ***,the role of PADI3 in colon cancer is *** this study,we investigated the function and molecular mechanism of PADI3 in colon cancer ***:Western blot and real-time PCR were used to detect the expression levels of several ***-8,flow cytometry(FCM)and colony formation assays were used to examine cell proliferation,the cell cycle and colony formation *** analysis was used to study the molecular mechanism of PADI3 in tumorigenesis.A truncation mutation experiment was performed to determine the key functional domain of ***:PADI3 overexpression inhibited cell proliferation and colony formation and led to G1 phase arrest in both HCT116(originating from primary colon cancer)and LoVo(originating from metastatic tumor nodules of colon cancer)***3-expressing HCT116 cells had a lower tumor formation rate and produced smaller tumors than control ***3 significantly decreased Sirtuin2(Sirt2)and Snail expression and AKT phosphorylation and increased p21 expression,and Sirt2 overexpression partly reversed the effects induced by PADI3 *** showed that PADI3 is mainly localized in the *** mutation experiments showed that the C-domain is the key domain involved in the antitumor activity of ***:PADI3 suppresses Snail expression and AKT phosphorylation and promotes p21 expression by downregulating Sirt2 expression in the cytoplasm,and the C-domain is the key domain for its antitumor activity.

关键词： PADI3 Sirt2 colon cancer cell cycle C-domain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Manipulating the Gut Microbiome to Alleviate Steatotic Liver Disease:Current Progress and Challenges

引用

Engineering 2024年第9期40卷 51-60页

作者： Ernesto Saenz Nathally Espinosa Montagut Baohong Wang Christoph Stein-Thöringer Kaicen Wang Honglei Weng Matthias Ebert Kai Markus Schneider Lanjuan Li Andreas Teufel Division of Hepatology Division of Clinical BioinformaticsDepartment of Medicine ⅡMedical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Clinical Cooperation Unit Healthy Metabolism Center for Preventive Medicine and Digital HealthMedical Faculty MannheimHeidelberg UniversityMannheim 68167Germany School of Medicine Universidad de Los AndesBogotá111711Colombia State Key Laboratory for Diagnosis and Treatment of infectious diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Internal MedicineⅠ University Clinic Tuebingen&CoE CMFI(Controlling Microbes to Fight Infections)Tuebingen 72074Germany department of MedicineⅡ Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany DKFZ Hector Cancer Institute at the university Medical center Mannheim 69120Germany Molecular Medicine Partnership Unit European Molecular Biology LaboratoryHeidelberg 69117Germany department of MedicineⅢ University Hospital RWTH AachenAachen 52074Germany

The prevalence of metabolic-dysfunction-associated steatotic liver disease(MASLD)is alarmingly high;it is estimated to affect up to a quarter of the global population,making it the most common liver disorder *** is characterized by excessive hepatic fat accumulation and is commonly associated with comorbidities such as obesity,dyslipidemia,and insulin resistance;however,it can also manifest in lean ***,it is crucial to develop effective therapies for this complex ***,there are no approved medications for MASLD treatment,so there is a pressing need to investigate alternative *** research has characterized MASLD as a multifaceted disease,frequently linked to metabolic disorders that stem from dietary *** suggests that changes in the gut microbiome play a fundamental role in the development and progression of MASLD from simple steatosis to steatohepatitis and even hepatocellular carcinoma(HCC).In this review,we critically examine the literature on the emerging field of gut-microbiota-based therapies for MASLD and metabolicdysfunction-associated steatohepatitis(MASH),including interventions such as fecal microbiota transplantation(FMT),probiotics,prebiotics,short-chain fatty acids,antibiotics,metabolic pathway targeting,and immune checkpoint kinase blockade.

关键词： Microbiome Fecal microbiota transplantation Metabolic-dysfunction-associated steatotic liver disease Fatty liver

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients

引用

World Journal of Gastroenterology 2013年第9期19卷 1387-1395页

作者： Walaa H Ahmed Norihiro Furusyo Saad Zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi department of Environmental Medicine and infectious diseases Kyushu University Hospital Fukuoka 812-8582 Japan department of General Internal Medicine Kyushu University Hospital Fukuoka 812-8582 Japan department of Tropical Medicine and Gastroenterology Assiut University Hospital Assuit 71515 Egypt National center for Treatment of Chronic Hepatitis C Ministry of Health Assiut 71329 Egypt

AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) ***:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate anal

关键词： Anemia Dose reduction Hepatitis C Inosine triphosphate Ribavirin Rs1127354

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comprehensive lifestyle intervention vs soy protein-based meal regimen in non-alcoholic steatohepatitis

引用

World Journal of Gastroenterology 2019年第9期25卷 1116-1131页

作者： Peter Deibert Adhara Lazaro Denise Schaffner Aloys Berg Daniel Koenig Wolfgang Kreisel Manfred W Baumstark Daniel Steinmann Martin Buechert Thomas Lange Faculty of Medicine Department of MedicineInstitute of Exercise and Occupational MedicineMedical CenterUniversity of Freiburg department of Nutrition Institute for Sports and Sports ScienceUniversity of Freiburg Faculty of Medicine Department of MedicineDivision of GastroenterologyHepatologyEndocrinology and Infectious DiseasesMedical CenterUniversity of Freiburg university hospital of Freiburg Occupational Medicine Faculty of Medicine Department of Radiology-Medical PhysicsMedical CenterUniversity of Freiburg

BACKGROUND Non-alcoholic steatohepatitis(NASH) has become one of the leading causes of liver disease in the western world. In obese patients weight reduction is recommended. Up to now there are no specific guidelines for weight loss in order to reduce hepatic fat *** To investigate the effects of a 24-wk guided lifestyle intervention program compared to a meal replacement regimen based on soy *** Twenty-six subjects with NASH participated in a randomized single-center study. They were randomly assigned to either meal replacement group(MR-G)with soy-yogurt-honey preparation or to guided lifestyle change group(LC-G)with endurance activity and nutrition counselling. Serum alanine transaminase(ALT), aspartate transaminase(AST), lipid parameters, and adipokines were measured. Liver fat content and lipid composition were determined by magnetic resonance imaging and magnetic resonance spectroscopy. Body fat mass and lean body mass were assessed using Bod Pod? device. Pre-and post-intervention monitoring of parameters was performed. Statistical analyses were conducted with SPSS software, results were expressed as median(interquartile range).RESULTS Twenty-two subjects(MR-G, n = 11 and LC-G, n = 11) completed the study(9 women, 13 men; age 52.1(15.0) years, body mass index(BMI) 32.3(3.3) kg/m^2).In both groups a significant weight loss was achieved(MR-G:-6.4(3.6) kg, P <0.01; LC-G:-9.1(10.4) kg, P < 0.01). BMI dropped in both groups(MR-G:-2.3(1.5)kg/m^2, P = 0.003; LC-G:-3.0(3.4) kg/m^2, P = 0.006). Internal fat and hepatic lipid content were markedly reduced in both groups in comparable amount. There was a strong correlation between reduction in liver fat and decrease in ***, both groups showed an improvement in glycemic control and lipid profile. Changes in adipokines, particularly in adiponectin and leptin were closely related to intrahepatic lipid *** Comprehensive lifestyle intervention and meal replacement regimen have compar

关键词： Non-alcoholic steatohepatitis Meal replacement therapy Soy protein Lifestyle change Weight reduction Obesity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

引用

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2350-2361页

作者： Min Yao Rong-Fei Fang Qun Xie Min Xu Wen-Li Sai Deng-Fu Yao department of Immunology Medical School of Nantong University and Research Center of Clinical MedicineThe Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina department of Gastroenterology The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina department of infectious diseases Haian People’s HospitalHaian 226600Jiangsu ProvinceChina Research center of Clinical Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

The prevention and early diagnosis of liver cancer remains a global medical *** the malignant transformation of hepatocytes,a variety of oncogenic cellular signalling molecules,such as novel high mobility group-Box 3,angiopoietin-2,Golgi protein 73,glypican-3,Wnt3a(a signalling molecule in the Wnt/β-catenin pathway),and secretory clusterin,can be expressed and secreted into the *** signalling molecules are derived from different signalling pathways and may not only participate in the malignant transformation of hepatocytes but also become early diagnostic indicators of hepatocarcinogenesis or specific targeted molecules for hepatocellular carcinoma *** article reviews recent progress in the study of several signalling molecules as sensitive biomarkers for monitoring hepatocarcinogenesis.

关键词： Hepatocarcinogenesis Cell signals Specific biomarkers Early diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lipids, lipid metabolism and Kaposi's sarcoma-associated herpesvirus pathogenesis

引用

Virologica Sinica 2017年第5期32卷 369-375页

作者： Lu Dai Zhen Lin Wei Jiang Erik K.Flemington Zhiqiang Qin department of Genetics Louisiana State University Health Sciences Center Louisiana Cancer Research Center New Orleans 70112 USA department of Pediatrics East Hospital Tongji University School of Medicine Shanghai 200120 China Research center for Translational Medicine and Key Laboratory of Arrhythmias East Hospital TongjiUniversity School of Medicine Shanghai 200120 China department of Pathology Tulane University Health Sciences Center Tulane Cancer CenterNew Orleans 70112 USA department of Microbiology and Immunology Division of Infectious Diseases Department of MedicineMedical University of South Carolina Charleston 29425 USA

Lipids are essential for mammalian cells to maintain many physiological functions. Emerging evidence has shown that cancer cells can develop specific alterations in lipid biosynthesis and metabolism to facilitate their survival and various malignant behaviors. To date, the precise role of cellular lipids and lipid metabolism in viral oncogenesis is still largely unclear with only a handful of literature covering this topic to implicate lipid metabolism in oncogenic virus associated pathogenesis. In this review, we focus on the role of lipid biosynthesis and metabolism in the pathogenesis of the Kaposi's sarcoma-associated herpesvirus, a common causative factor for cancers arising in the immunocompromised settings.

关键词： Kaposi’s sarcoma-associated herpesvirus(KSHV) herpesvirus lipid metabolism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neutralization of five SARS-CoV-2 variants of concern by convalescent and BBIBP-CorV vaccinee serum

引用

Virologica Sinica 2022年第6期37卷 831-841页

作者： Yuqi Zhu Xinyi Yang Jingna Xun Jun Liu Qing Wen Yixiao Lin Xiaoting Shen Jun Chen Songhua Yuan Xiaying Zhao Jing Wang Hanyu Pan Jinlong Yang Zhiming Liang Yue Liang Qinru Lin Huitong Liang Min Li Jianping Liu Yinzhong Shen Xiaoyan Zhang Pengfei Wang Daru Lu Chunhua Yin Jianqing Xu Shibo Jiang Hongzhou Lu Huanzhang Zhu State Key Laboratory of Genetic Engineering and Engineering Research center of Gene Technology Ministry of EducationInstitute of GeneticsSchool of Life SciencesFudan UniversityShanghai200438China Scientific Research center Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Fubio(Suzhou)Biomedical Technology Co. LtdSuzou215300China department of infectious diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesFudan UniversityShanghai200032China department of infectious diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People's Hospital of ShenzhenShenzhen518112China

The prevalence of SARS-CoV-2 variants of concern(VOCs) is still escalating throughout the world. However, the level of neutralization of the inactivated viral vaccine recipients’ sera and convalescent sera against all VOCs,including B.1.1.7(Alpha), B.1.351(Beta), P.1(Gamma), B.1.617.2(Delta), and B.1.1.529(Omicron) remains to be lack of comparative analysis. Therefore, we constructed pseudoviruses of five VOCs using a lentiviral-based system and analyzed their viral infectivity and neutralization resistance to convalescent and BBIBP-CorV vaccinee serum at different times. Our results show that, compared with the wild-type strain(WT), five VOC pseudoviruses showed higher infection, of which B.1.617.2 and B.1.1.529 variant pseudoviruses exhibited higher infection rates than wild-type or other VOC strains, respectively. Sera from 10 vaccinated individuals at the 1, 3and 5-month post second dose or from 10 convalescent at 14 and 200 days after discharge retained neutralizing activity against all strains but exhibited decreased neutralization activity significantly against the five VOC variant pseudoviruses over time compared to WT. Notably, 100%(30/30) of the vaccinee serum samples showed more than a 2.5-fold reduction in neutralizing activity against B.1.1.529, and 90%(18/20) of the convalescent serum samples showed more than 2.5-fold reduction in neutralization against B.1.1.529. These findings demonstrate the reduced protection against the VOCs in vaccinated and convalescent individuals over time, indicating that it is necessary to have a booster shot and develop new vaccines capable of eliciting broad neutralization antibodies.

关键词： SARS-CoV-2 Variants of concern(VOCs) Convalescent BBIBP-CorV vaccine Neutralization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy of integrated Traditional Chinese Medicine and anti-retroviral therapy on immunological nonresponse in patients with human immunodeficiency virus/acquired immunodeficiency syndrome: a Meta-analysis of randomized controlled trials

引用

Journal of Traditional Chinese Medicine 2021年第5期41卷 669-676页

作者： TAO Zhuang HUANG Xiaojie LIU Ying WANG Ru DONG Jipeng LIANG Biyan ZOU Wen GAO Guojian WANG Zhuo ZHANG Ke WU Hao ZHANG Tong WANG Jian Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China center for infectious diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Research center of AIDS Treatment with Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China center of Cardiovascular diseases Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Dermatology department of Qingdao university hospital Qingdao 266000China

OBJECTIVE:To explore the efficacy of integrating Traditional Chinese Medicine(TCM)and anti-retroviral therapy(ART),a customized combination of different classes of medications which was also called cock-tail treatment,on the immunological nonresponse(INR)in people living with human immunodeficiency virus(HIV)(PLWH).METHODS:Relevant literature in databases such as China National Knowledge Infrastructure Database(CNKI),Wanfang Digital Journal,Chinese Medical Journal Database(CMJD),Chinese Biomedical Literature Database(CBM),Pub Med,Cochrane,and Embase was reviewed by two independent *** were extracted from the studies according to the eligible criteria and analyzed using Review Manager ***:Nine randomized controlled trials(RCTs)with 1078 patients were *** analyses showed that CD4 T cell counts in the treatment group improved compared with that in the control group[mean difference(MD)=13.51,95%confidence interval(CI):7.42-19.60,P<0.0001].There was no significant difference between the treated and control groups after 3 months(MD=25.31,95%CI:-2.78 to 53.41,P=0.08).However,after 6 and 12 months,the response of the treatment group was superior to the control group(MD=27.45,95%CI:7.09-47.81,P=0.008 and MD=27.34,95%CI:6.31–48.37,P=0.01,respectively).The clinical efficacy of the treatment group was also higher than that of the control group(RR=1.75,95%CI:1.16-2.65,P=0.007).However,CD45 RO and CD45 RA T cell counts did not differ significantly between the two groups(MD=12.37,95%CI:-6.71 to 31.45,P=0.20 and MD=5.67,95%CI:-3.00 to14.35,P=0.20,respectively).CONCLUSION:The combined treatment strategy of integrated TCM and Western Medicine promotes long-term reconstitution of the immune system and thus,is beneficial and has potential use for improving INR in ***,large-scale RCTs are required to provide evidence for optimal intervention strategies.

关键词： Medicine,Chinese Traditional HIV acquired immunodeficiency syndrome immunological nonresponse anti-retroviral agents Metaanalysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese guidelines on the management of liver cirrhosis(abbreviated version)

引用

World Journal of Gastroenterology 2020年第45期26卷 7088-7103页

作者： Xiao-Yuan Xu Hui-Guo Ding Wen-Gang Li Jing-Hang Xu Ying Han Ji-Dong Jia Lai Wei Zhong-Ping Duan En-Qiang Ling-Hu Hui Zhuang department of infectious diseases Peking University First HospitalBeijing 100034China Hepatology and Digestion center Beijing You-An HospitalCapital Medical UniversityBeijing 100069China department of Liver Oncology Cancer Radiation Therapy CenterFifth Medical CenterPLA General HospitalBeijing 100039China department of Immunology and Liver diseases Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Hepatology center Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Internal Medicine of Hepatopancreatobiliary Beijing Tsinghua Changgung HospitalBeijing 102218China Artificial Liver center Beijing You-An HospitalCapital Medical UniversityBeijing 100069China department of Gastroenterology First Medical CenterPLA General HospitalBeijing 100853China department of Pathogenic Biology Peking University Health Science CenterBeijing 100191China

Based on reviews of the literature and experts’consensus,the Chinese Society of Hepatology developed guidelines for the diagnosis and treatment of liver cirrhosis,in order to improve clinical *** addition to what has been covered in previously published guidelines on the management of cirrhosis complications,these guidelines add new sections and provide *** guidelines emphasize the early diagnosis of the cause and assessment of *** treatments including etiological treatment and complication management should be initiated *** addition,regular monitoring,especially surveillance of hepatocellular carcinoma,is crucial for managing patients.

关键词： Liver cirrhosis Diagnosis Therapy Guidelines Hypertension portal Recompensated stage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：