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Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-Li Zhang Xi Zhang Wang Hua Zheng-De Xie Han-Min Liu Hai-Lin Zhang Bi-Quan Chen Yuan Chen Xin Sun Yi Xu Sai-Nan Shu Shun-Ying Zhao Yun-Xiao Shang Ling Cao Yan-Hui Jia Luo-Na Lin Jiong Li Chuang-Li Hao Xiao-Yan Dong Dao-Jiong Lin Hong-Mei Xu De-Yu Zhao Mei Zeng Zhi-Min Chen Li-Su Huang department of Infectious disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina department of Infectious disease Anhui Provincial Children's HospitalHefeiChina department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina department of Infectious disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina department of Respiratory disease Beijing Children's HospitalCapital Medical UniversityBeijingChina department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina department of Clinical Epidemiology Aarhus UniversityAarhusDenmark department of Respirology Children's Hospital of Soochow UniversitySuzhouChina department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina department of Infectious disease Hainan Women and Children's Medical CenterHaikouChina department of Infectious disease Children's Hospital of Chongqing Medical UniversityChongqingChina department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study

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Journal of Geriatric Cardiology 2024年第7期21卷 751-759页

作者： Shi-Yu ZHOU Fang-Chao LIU Shu-Feng CHEN Jian-Xin LI Jie CAO Ke-Yong HUANG Zheng-Hao TANG Feng-Chao LIANG Dong-Sheng HU Lian-Cheng ZHAO Ying LI Jian-Feng HUANG Xiang-Feng LU Bin LU Dong-Feng GU department of Epidemiology&Key Laboratory of Cardiovascular Epidemiology State Key Laboratory of Cardiovas-cular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina School of Public Health and Emergency management School of Medi-cineSouthern University of Science and TechnologyShenzhenChina department of Epidemiology and Health Stat-istics School of Public HealthZhengzhou UniversityZhengzhouChina department of Biostatistics and Epidemi-ology School of Public HealthShenzhen University Health Science CenterShenzhenChina department of Radi-ology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH) in reducing cardiovascular ***,its role in subclinical atherosclerosis(SA) progression remains *** aim to examine the association of CVH,estimated by the American Heart Association's new Life's Essential 8(LE8),with the progression of *** This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for5.7 *** LE8 score(range,0–100) consisted of blood pressure,lipids,glucose,body mass index,smoking status,diet health,physical activity and sleep health was evaluated in 1998 and 2008–*** of SA was determined by carotid plaque and coronary artery calcification(CAC) in 2008–2009 and 2013–***-binomial regression model was used to estimate the association of LE8 score with SA *** Each 10 points increment in LE8 score was associated with 15.2%(RR:0.848,95% CI:0.797–0.902),17.7%(RR:0.823,95% CI:0.766–0.884) and 12.0%(RR:0.880,95% CI:0.845–0.916) lower risks of carotid plaque,CAC and overall SA progression,*** with participants with non-ideal CVH at both visits,the participants with ideal CVH at both visits had39.1%(RR:0.609,95% CI:0.494–0.752),41.0%(RR:0.590,95% CI:0.456–0.764) and 29.7%(RR:0.703,95% CI:0.598–0.825) lower risks of carotid plaque,CAC and overall SA progression,*** Higher LE8 scores were associated with lower risks of SA ***,long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

关键词： atherosclerosis prospective cardiovascular

Changes in blood lipid levels and influencing factors among treatment-naïve adult male HlV/AlDS patients following BlC/FTC/TAF vs.3TC+EFV+TDF

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Chinese Medical Journal 2024年第12期137卷 1447-1452页

作者： Xi Wang An Liu Zaicun Li Hongwei Zhang Ruojun Esther Wu Ying Shao Jianwei Li Jiangzhu Ye Wei Liu Lijun Sun Clinic of Center for infection Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Harvard School of Dental Medicine BostonMAUSA department of Pharmacy Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Chinese Association of STD and AIDS prevention and Control Beijing 100050China

Background:Antiretroviral therapy(ART)was often associated with dyslipidemia among human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS)*** study aimed to assess treatment-naïve adult male patients with HIV/AIDS who initiated ART with either co-formulated bictegravir,emtricitabine,and tenofovir alafenamide(BIC/FTC/TAF)or lamivudine,efavirenz,and tenofovir disoproxil fumarate(3TC+EFV+TDF),monitoring at weeks 4,12,24,and ***:A case-control retrospective study was *** newly diagnosed HIV-infected individuals attending the sexual transmission disease(STD)/AIDS clinic of Beijing Youan Hospital,Capital Medical University,from January to December *** patients were divided into BIC/FTC/TAF group or 3TC+EFV+TDF ***-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),and total cholesterol(TC)at different time points over 48 weeks between two groups were compared.A multivariate Cox regression model was used to identify relevant influencing factors for the population at high risk of increased ***:A total of 870 participants,with 510 in BIC/FTC/TAF group and 360 in 3TC+EFV+TDF *** were no statistically significant differences in median age,baseline CD4/CD8 ratio,median body mass index(BMI)between the two *** both two groups,levels of TG,TC,and LDL-C were higher at 4 weeks,12 weeks,and 24 weeks of treatment(all P0.05).In addition,the differences in average changes of the level of TG,TC,HDL-C,and LDL-C from weeks 4,12,24,and 48 to baseline between two groups were not statistically significant(all P>0.05).Multivariate Cox proportional risk model analysis showed that initiating ART with HIV RNA≥10^(5)copies/mL(compared with<10^(5)copies/mL)was associated with an increased risk of elevated LDL-C(hazard ratio=1.26,95%confidence interval:1.07-1.48,

关键词： Antiretroviral therapy Blood lipids Bictegravir/emtricitabine/tenofovir alafenamide Lamivudine,efavirenz,and tenofovir disoproxil fumarate BIC/FTC/TAF 3TC+EFV+TDF HIV AIDS

The Impact of Regular Diet Recovery on Postoperative Rehabilitation After Elective Cesarean Section

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Maternal-Fetal Medicine 2024年第2期6卷 78-83页

作者： Caihong Hu Kuilin Fei Yuelan Liu Xiaoe Jiang Wenjing Yong Weishe Zhang Ping Li department of Obstetrics Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Engineering Research Center of Early Life Development and disease prevention Xiangya HospitalCentral South UniversityChangsha 410008China

Objective To determine the role of regular diet recovery after restoration of normal muscle strength of both lower extremities in promoting postoperative recovery in women undergoing elective cesarean *** This was a prospective observational cohort *** who underwent elective cesarean section at Xiangya Hospital,Central South University,from October 2022 to December 2022,were categorized into two groups based on the duration of postoperative fasting:the observation group resumed eating after regaining lower extremity muscle strength,while the control group adhered to traditional postoperative fasting guidelines,waiting 6 hours before *** outcomes included postoperative pain levels assessed by visual analog scale(VAS)pain scores and time to first *** characteristics,time to first lactation,hospital stay length,and patient satisfaction were also *** analysis was conducted using Student’s t test and Chi-squared test,with significance set at Pinfection,and readmission within 42 days(P>0.05).Conclusion Food intake after restoration of lower extremity muscle

关键词： Obstetrics Cesarean section Early food intake

Combined hepatocellular cholangiocarcinoma: A clinicopathological update

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World Journal of Hepatology 2024年第5期16卷 766-775页

作者： Mukul Vij Fadl H Veerankutty Ashwin Rammohan Mohamed Rela department of Pathology Institute of Liver Disease and TransplantationChennai 600044India Comprehensive Liver Care Institute VPS LakeshoreCochin 682040India Institute of Liver disease and Transplantation Dr.Rela Institute and Medical CentreChennai 600044India

Combined hepatocellular-cholangiocarcinoma(cHCC-CCA)is a rare primary liver cancer associated with an appalling *** diagnosis and manage-ment of this entity have been challenging to physicians,radiologists,surgeons,pathologists,and oncologists *** diagnostic and prognostic value of biomarkers such as the immunohistochemical expression of nestin,a progenitor cell marker,have been explored *** a better understanding of biology and the clinical course of cHCC-CCA,newer treatment modalities like immune checkpoint inhibitors are being tried to improve the survival of patients with this rare *** this review,we give an account of the recent developments in the pathology,diagnostic approach,and management of cHCC-CCA.

关键词： Combined hepatocellular-cholangiocarcinoma Immunotherapy Nestin Hepatocellular carcinoma Cholangiocarcinoma Liver cancer Biomarker Immune checkpoint inhibitors Pathology Genomic landscape

Advances in genotypic antimicrobialresistance testing:a comprehensive review

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Science China Life Sciences 2024年

作者： Boheng Duan Xianjun Zeng Junping Peng Huan Kui College of Nanchang University department of Imaging The Second Affiliated Hospital of Nanchang University NHC Key Laboratory of Systems Biology of Pathogens National Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical College Key Laboratory of Respiratory disease Pathogenomics Chinese Academy of Medical Sciences&Peking Union Medical College Key Laboratory of Pathogen infection prevention and Control (Ministry of Education) State Key Laboratory of Respiratory Health and MultimorbidityNational Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical College

Antimicrobial resistance (AMR) represents a substantial threat to global public health,complicating the treatment of common infections and leading to prolonged illness and escalated healthcare *** effectively combat AMR,timely and accurate detection is crucial for AMR surveillance and individual-based *** antibiotic resistance testing (AST) has long been considered the gold standard in clinical applications,serving as the foundation for clinical AMR diagnosis and optimized *** has significantly contributed to ensuring patients′health and the development of novel *** advancements in automated culture-based AST technologies,inherent limitations impede the widespread use of phenotypic AST in AMR *** AST technologies offer a promising alternative option,exhibiting advantages of rapidity,high sensitivity,and *** the continuous advancement and expanding applications of genotypic AST technologies,such as microfluidics,mass spectrometry,and high-resolution melting curve analysis,new vigor has been injected into the development and clinical implementation of genotypic AST *** this narrative review,we discuss the principles,applications,and advancements of emerging genotypic AST methods in clinical *** comprehensive review aims to highlight the significant scientific potential of emerging genotypic AST technologies in clinical AMR diagnosis,providing insights to enhance existing methods and explore novel approaches.

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Dopamine Inhibits the Expression of Hepatitis B Virus Surface and e Antigens by Activating the JAK/STAT Pathway and Upregulating Interferon-stimulated Gene 15 Expression

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 443-456页

作者： Xiaoquan Liu Xiuqing Pang Zhiping Wan Jinhua Zhao Zhiliang Gao Hong Deng department of Infectious diseases Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Key Laboratory of Liver disease Research Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou GuangdongChina Key Laboratory of Tropical disease Control(Sun Yat-sen University) Ministry of EducationGuangzhouGuangdongChina

Background and Aims:Hepatitis B virus(HBV)infection is a major risk factor for cirrhosis and liver cancer,and its treatment continues to be *** previously demonstrated that a dopamine analog inhibited the packaging of pregenomic RNA into *** present study aimed to determine the effect of dopamine on the expressions of hepatitis B virus surface and e antigens(HBsAg and HBeAg,respectively)and to elucidate the underlying ***:We used dopamine-treated HBVinfected HepG2.2.15 and NTCP-G2 cells to monitor HBsAg and HBeAg expression *** analyzed interferon-stimulated gene 15(ISG15)expression in dopamine-treated *** knocked down ISG15 and then monitored HBsAg and HBeAg expression *** analyzed the expression of Janus kinase(JAK)/signal transducer and activator of transcription(STAT)pathway factors in dopamine-treated *** used dopamine hydrochloride-treated adeno-associated virus/HBV-infected mouse model to evaluate HBV DNA,HBsAg,and HBeAg *** virus was collected from HepAD38.7 cell culture ***:Dopamine inhibited HBsAg and HBeAg expression and upregulated ISG15 expression in HepG2.2.15 and HepG2-NTCP cell ***15 knockdown increased HBsAg and HBeAg expression in HepG2.2.15 ***-treated cells activated the JAK/STAT pathway,which upregulated ISG15 *** the adeno-associated virus-HBV murine infection model,dopamine downregulated HBsAg and HBeAg expression and activated the JAK-STAT/ISG15 ***:Dopamine inhibits the expression of HBsAg and HBeAg by activating the JAK/STAT pathway and upregulating ISG15 expression.

关键词： Hepatitis B virus Dopamine JAK-STAT/ISG15 axis HBV surface antigen HBV e antigen HepG2.2.15 cell line Human NTCP-expressing HepG2 cell line HepAD38 cell line

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乙脑实验室确诊病例与临床疑似病例的差别

中华实验和临床病毒学杂志 2024年第4期38卷 463-463页

作者：殷启凯(编译) Institute of Microbiological Detection and Analyses Sichuan Center for Disease Control and Prevention Chengdu China Institute of Immunization Programme Sichuan Center for Disease Control and Prevention Chengdu China department of Arbovirus National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China

2024年1月,Frontiers of Cellular and infection Microbiology杂志发表文章介绍我国乙脑报告病例与实验室确诊病例之间差别的文章。四川省2012-2022年间共上报1558例乙脑病例,其中81%(1262/1558)病例急性期血清标本为乙脑病毒IgM抗体... 详细信息

2024年1月,Frontiers of Cellular and infection Microbiology杂志发表文章介绍我国乙脑报告病例与实验室确诊病例之间差别的文章。四川省2012-2022年间共上报1558例乙脑病例,其中81%(1262/1558)病例急性期血清标本为乙脑病毒IgM抗体检测阳性或者乙脑病毒基因检测阳性(实验室确诊乙脑病例)。

关键词：实验室确诊病例急性期血清报告病例乙脑病毒疑似病例病毒基因检测

Fault Tree Analysis:Investigation of Epidemic Hemorrhagic Fever infection Acquired in Animal Laboratories in China

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Biomedical and Environmental Sciences 2016年第9期29卷 690-695页

作者： LIU Xiao Yu XUE Kang Ning RONG Rong ZHAO Chi Hong Laboratory management department Chinese Center for Disease Control and Prevention

Epidemic hemorrhagic fever has been an ongoing threat to laboratory personnel involved in animal care and use. Laboratory transmissions and severe infections occurred over the past twenty years, even though the standards and regulations for laboratory biosafety have been issued, upgraded, and implemented in China. Therefore, there is an urgent need to identify risk factors and to seek effective preventive measures that can curb the incidences of epidemic hemorrhagic fever among laboratory personnel. In the present study, we reviewed literature that relevant to animals laboratory-acquired hemorrhagic fever infections reported from 1995 to 2015, and analyzed these incidences using fault tree analysis （FTA）.

关键词： Fault Tree Analysis