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Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation

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Bone Research 2022年第4期10卷 826-837页

作者： Yugo Morita Motoo Saito Javier Rangel-Moreno Anthony M.Franchini John R.Owen John C.Martinez John L.Daiss Karen L.de Mesy Bentley Stephen L.Kates Edward M.Schwarz Gowrishankar Muthukrishnan Center for Musculoskeletal Research University of Rochester Medical CenterRochesterNYUSA Division of allergy Immunology and RheumatologyDepartment of MedicineUniversity of Rochester Medical CenterRochesterNYUSA department of Environmental Medicine University of Rochester School of Medicine and DentistryRochesterNYUSA department of Orthopedic Surgery Virginia Commonwealth UniversityRichmondVAUSA department of Orthopedics University of Rochester Medical CenterRochesterNYUSA department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA

Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial,and its role in patients with *** osteomyelitis is *** address this knowledge gap,we completed a clinical study and observed elevated serum IL-27 levels(20-fold higher,P<0.05)in patients compared with healthy ***,IL-27 serum levels were 60-fold higher in patients immediately following septic death than in uninfected patients(P<0.05),suggesting a pathogenic role of *** test this hypothesis,we evaluated *** osteomyelitis in WT and IL-27Rα^(−/−)mice with and without exogenous IL27 induction by intramuscular injection of rAAV-IL-27p28 or rAAV-GFP,*** found that IL-27 was induced at the surgical site within 1 day of *** infection of bone and was expressed by M0,M1 and M2 macrophages and osteoblasts but not by ***,exogenous IL-27p28(~2 ng·mL^(−1) in serum)delivery ameliorated soft tissue abscesses and periimplant bone loss during infection,accompanied by enhanced local IL-27 expression,significant accumulation of RORγt^(+)neutrophils at the infection site,a decrease in RANK^(+) cells,and compromised osteoclast *** effects were not observed in IL-27Rα^(−/−)mice compared with WT mice,suggesting that IL-27 is dispensable for immunity but mediates redundant immune and bone cell functions during *** vitro studies and bulk RNA-seq of infected tibiae showed that IL-27 increased nos1,nos2,il17α,il17f,and rorc expression but did not directly stimulate ***,these results identify a novel phenomenon of IL-27 expression by osteoblasts immediately following *** infection of bone and suggest a protective role of systemic IL-27 in osteomyelitis.

关键词： abscess protective immunity

The IL-33/ST2 axis is specifically required for development of adipose tissue-resident regulatory T cells

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Cellular & Molecular immunology 2015年第5期12卷 521-524页

作者： Zhi-Qing Hu Wei-Hua Zhao department of Microbiology and immunology Showa University School of Medicine TokyoJapan

Currently, T cells dedicated to medi- ating immunosuppression and homeostasis are called regulatory T （Treg） cells. Treg cells are closely assoc- iated with infection, allergy, autoimmunity, tumor immunity, fetal-maternal tolerance, and organ transplantation. Treg cells exert their immunosuppressive functions by directly killing or inhibiting T cells and antigen-presenting cells （dendritic cells, macrophages,

关键词： specifically required development

Is Human Cytomegalovirus Infection Associated With Diabetes?A Meta-analysis

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Is Human Cytomegalovirus Infection Associated With Diabetes?...

Prevalence of Epstein Barr Virus Infection and Characteristics of Lymphocyte Subsets in Newly Onset Juvenile Dermatomyositis

浙江省免疫学会第十次学术大会

作者： Zheng Qi Lu Meiping department of Rheumatology immunology and allergy Children’s HospitalZhejiang University School of Medicine

Objective:Human cytomegalovirus(HCMV) is a ubiquitous pathogen that infects a majority of the world’s population,which is also suspected to be one of the environmental factors implicated in the development of diabetes-a common autoimmune *** confirming the correlation between CMV and diabetes has some difficulties since patients infected by HCMV often experience a long period of time between infection and the clinical onset of diabetes,either positive or negative relationship was found in different *** performed a meta-analysis to derive a more precise estimation of the association of HCMV infection and ***:We conducted a computerized literature search of the MEDLINE database using the terms "cytomegalovirus" and "diabetes mellitus" or "diabetes".Odds ratio(OR) with 95%confidence interval(CI) was used to assess the strength of association between the incidence of HCMV infection and diabetes risk Heterogeneity assumption was checked by the chi-square-based Q-test(8).Funnel plot asymmetry was assessed by the method of Egger’s linear regression test,a linear regression approach to measure the funnel plot asymmetry on the natural logarithm scale of the *** p-values were 2-tailed,with statistical significance set at 0.05 for the overall estimates *** of the calculations were performed using STATA version 11.0(STATA Corporation,College Station,TX,USA).Results:A total of six publications involving 1290 diabetes cases and 1103 controls met the inclusion criteria and were ultimately *** analysis of studies according to types of Diabetes Mellitus is *** no significant association between CMV infection and DM was *** subgroup analysis of relation between CMV infection and Type Ⅱ Diabetes displayed a possible intersection with the null line which may indicate that more samples were needed in the future to confirm the real correlation of CMV infection and Type Ⅱ ***:No significant association

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Prevalence of Epstein Barr Virus Infection and Characteristi...

Epidemiology of small intestinal bacterial overgrowth

浙江省免疫学会第六次会员代表大会暨第十一次学术大会

作者： Zheng Qi Lu Meiping department of Rheumatology Immunology and Allergy Children’s Hospital of Zhejiang University School of Medicine

Background:The underlying etiology of juvenile dermatomyositis(JDM)is unknown.T cell deficiency as well as Epstein Barr Virus(EBV)infection has been suspected to be involvement in the pathogenesis,but it has been poorly evaluated in JDM ***:This study describes the traits of lymphocyte subpopulation in newly onset JDM patients and compares the incidence of EBV infection in JDM patients with match *** and Methods:Newly developed JDM patients from 2014-2018 were *** information including age,gender,chief complain,physical examination,medical history,date of disease onset,date of first admission and laboratory findings were ***(CD3、CD4、CD8、CD 19 and CD56)were tested with flow cytometry in the first admission or after 6 months of *** analysis was conducted to compare the EBV infection in the group of JDM patients and ***:Totally 27 patients who fulfilled the Bohan and Peter criteria for JDM and 30 match controls were recruited in this *** suggest a median age at onset of 7.0 years,with 56% of children>8 years of age and a female-to-male ratio was 1:*** was especially common from the 8 th to the 12 th *** also displayed that JDM patients had higher positive rate of EBNA-IgG(p<0.0001)as well as EBVCA-IgG(p<0.05)than normal ***3-CD16+CD56+lymphocyte was found extremely low in early stage of JDM patients,but increased after 6 months of treatment(p=0.0091).The percentage of CD8+ T lymphocytes in early onset JDM patients(26.02+7.54%)were found in normal range according to the reference ***:In conclusion,level of CD3-CD16+CD56+ cells may associate with the clinical course of *** may act as a pathogenic factor predisposing patients to the development of JDM.

关键词： Juvenile dermatomyositis Epstein Barr Virus Lymphocytes

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World Journal of Gastroenterology 2023年第22期29卷 3400-3421页

作者： Irina Efremova Roman Maslennikov Elena Poluektova Ekaterina Vasilieva Yury Zharikov Andrey Suslov Yana Letyagina Evgenii Kozlov Anna Levshina Vladimir Ivashkin department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia The Scientific Community for Human Microbiome Research Moscow 119435Russia department of Human Anatomy and Histology Sechenov UniversityMoscow 125009Russia N.V.Sklifosovsky Institute of Clinical Medicine Sechenov UniversityMoscow 119991Russia department of Clinical immunology and allergy Sechenov UniversityMoscow 119991Russia

Small intestinal bacterial overgrowth(SIBO)is defined as an increase in the bacterial content of the small intestine above normal *** presence of SIBO is detected in 33.8%of patients with gastroenterological complaints who underwent a breath test,and is significantly associated with smoking,bloating,abdominal pain,and *** pump inhibitor therapy is a significant risk factor for *** risk of SIBO increases with age and does not depend on gender or *** complicates the course of a number of diseases and may be of pathogenetic significance in the development of their *** is significantly associated with functional dyspepsia,irritable bowel syndrome,functional abdominal bloating,functional constipation,functional diarrhea,short bowel syndrome,chronic intestinal pseudo-obstruction,lactase deficiency,diverticular and celiac diseases,ulcerative colitis,Crohn’s disease,cirrhosis,metabolic-associated fatty liver disease(MAFLD),primary biliary cholangitis,gastroparesis,pancreatitis,cystic fibrosis,gallstone disease,diabetes,hypothyroidism,hyperlipidemia,acromegaly,multiple sclerosis,autism,Parkinson’s disease,systemic sclerosis,spondylarthropathy,fibromyalgia,asthma,heart failure,and other *** development of SIBO is often associated with a slowdown in orocecal transit time that decreases the normal clearance of bacteria from the small *** slowdown of this transit may be due to motor dysfunction of the intestine in diseases of the gut,autonomic diabetic polyneuropathy,and portal hypertension,or a decrease in the motor-stimulating influence of thyroid *** a number of diseases,including cirrhosis,MAFLD,diabetes,and pancreatitis,an association was found between disease severity and the presence of *** work on the effect of SIBO eradication on the condition and prognosis of patients with various diseases is required.

关键词： Gut microbiota Gut-liver axis Breath test Lactulose Methane Hydrogen

Aptamer against Man LAM promotes M1 macrophage and Th1 cell polarization and enhances immunogenicity and immunoprotective effects of BCG

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Aptamer against Man LAM promotes M1 macrophage and Th1 cell ...

Etiopathogenesis of primary biliary cirrhosis

第十届全国免疫学学术大会

作者： Xiao-Lian Zhang Xiao-Ming Sun Qi-Long Wang Qin Pan department of immunology State Key Laboratory of Virology Hubei Province Key Laboratory of Allergy and Immunology Wuhan University School of Medicine

Introduction:Currently Tuberculosis(TB)is still a serious public health challenge that contributes significantly to illness and death around the *** Calmette-Guerin(BCG),the only available TB vaccine,decreases TB in children but gives little protection against TB in *** major surface lipoglycan of Mycobacterium tuberculosis(***),including BCG,mannose-capped lipoarabinomannan(Man LAM),has been implicated as an immunosuppressive epitope.

关键词： BCG Man LAM aptamers immunoadjuvant M1 macrophage Th1 cell polarization

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World Journal of Gastroenterology 2008年第21期14卷 3328-3337页

作者： Ana Lleo Pietro Invernizzi Ian R Mackay Harry Prince Ren-Qian Zhong M Eric Gershwin Division of Internal Medicine and Liver Unit San Paolo Hospital School of Medicine University of Milan Milan 20142 Italy Division of Rheumatology Allergy and Clinical Immunology University of California at Davis Davis CA 95616 United States department of Biochemistry & Molecular Biology Monash University Clayton Victoria 3800 Australia Focus Diagnostics 5785 Corporate Avenue Cypress CA 90630 United States Laboratory Diagnostics of Changzheng Hospital Second Military Medical University and Clinical Immunology Center of PLA Shanghai 200003 China

Primary biliary cirrhosis(PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver *** serological hallmark of the disease is the presence of circulating antimitochondrial antibodies(AMA).These reflect the presence of autoreactive T and B cells to the culprit antigens,the E2 subunits of mitochondrial 2-oxo-acid dehydrogenase enzymes,chiefly pyruvate dehydrogenase(PDC-E2).The disease results from a combination of genetic and environmental risk *** predisposition is indicated by the higher familial incidence of the disease particularly among siblings and the high concordance rate among monozygotic *** triggering events appear crucial to disrupt a pre-existing unstable immune tolerance of genetic origin allowing,after a long latency,the emergence of clinical *** mimetopes of the vulnerable epitope of the PDC-E2 autoantigen can be derived from microbes that utilize the PDC enzyme or,alternatively,environmental xenobiotics/chemical compounds that modify the structure of native proteins to make them immunogenic.A further alternative as a source of antigen is PDC-E2 derived from apoptotic *** the effector phase the biliary ductular cell,by reason of itsproclivity to express the antigen PDC-E2 in the course of apoptosis,undergoes a multilineage immune attack comprised of CD4+ and CD8+ T cells and *** this article,we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data,new developments and theories,and nominate directions for future research.

关键词： Autoantibodies Autoreactive T cells 2-oxoacid dehydrogenase Biliary epithelial cells Primary biliary cirrhosis

CCR10 and its ligands in regulation of epithelial immunity and diseases

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Protein & Cell 2012年第8期3卷 571-580页

作者： Na Xiong Yaoyao Fu Shaomin Hu Mingcan Xia Jie Yang Center for Molecular immunology and Infectious Diseases and department of Veterinary and Biomedical Sciences The Pennsylvania State UniversityPA 16802USA

Epithelial tissues covering the external and internal surface of a body are constantly under physical,chemical or biological *** protect the epithelial tissues and maintain their homeostasis,multiple layers of immune defense mechanisms are *** the epithelial tissue-resident immune cells that provide the first line of defense,circulating immune cells are also recruited into the local tissues in response to *** and chemokine receptors regulate tissue-specific migration,maintenance and functions of immune *** them,chemokine receptor CCR10 and its ligands chemokines CCL27 and CCL28 are uniquely involved in the epithelial ***27 is expressed predominantly in the skin by keratinocytes while CCL28 is expressed by epithelial cells of various mucosal ***10 is expressed by various subsets of innate-like T cells that are programmed to localize to the skin during their developmental processes in the *** T cells might be imprinted by skin-associated antigen-presenting cells to express CCR10 for their recruitment to the skin during the local immune *** the other hand,IgA antibody-producing B cells generated in mucosa-associated lymphoid tissues express CCR10 for their migration and maintenance at mucosal *** evidence also found that CCR10/ligands are involved in regulation of other immune cells in epithelial immunity and are frequently exploited by epithelium-localizing or-originated cancer cells for their survival,proliferation and evasion from immune ***,we review current knowledge on roles of CCR10/ligands in regulation of epithelial immunity and diseases and speculate on related important questions worth further investigation.

关键词： CCR10 epithelial immunity epithelial diseases

SURVEY OF AIRBORNE POLLEN IN HUBEI PROVINCE OF CHINA

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Chinese Medical Sciences Journal 2008年第4期23卷 212-217页

作者： Guang-hui Liu Rong-fei Zhu Wei Zhang Wen-jing Li Zhong-xi Wang Huan Chen department of allergy Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030

Objective To study the genera and seasonal distribution of airborne pollen in Hubei province of China, and its relationship with pollinosis. Methods From November 2003 to October 2004, an airborne pollen investigation was performed in 16 chosen areas in 12 cities of Hubei province using gravity sedimentation technique. Meanwhile, univalent skin prick tests of pollens were performed and the invasion season was studied on 2 300 patients with pollinosis. Among them, 352 cases underwent the airway responsiveness measurements, and the correlation between airway responsiveness and results of pollen count was analyzed. Results A total of 61 pollen genera were observed and 257 520 pollens were collected. The peak of airborne pollen distribution occurred in two seasons each year: spring (March and April) and autumn (from August to October). The attack of pollinosis corresponded to the peak of pollen distribution. There was a significantly negative relationship between the provocation dose causing a 20% decrease of forced expiratory volume in one second (FEV1) from baseline and airborne pollen concentration (r = -0.6829, P < 0.05). Conclusion This study provides useful information for airborne pollen epidemiology of Hubei province, and it provides important insights to clinical prevention, diagnosis, and treatment of pollen-related allergic diseases.

关键词： airborne pollen pollinosis airway responsiveness