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HYPERSENSITIVITY OF CASHEW NUT

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Chinese Medical Sciences Journal 1997年第3期12卷 189-192页

作者：李宏张宏誉 department of allergy PUP Allergy Diagnosis Centre Peking China

Cashew nut hypersensitivity can cause severe reactions even life threatening. In the past few years,there are more cases of cashew nut allergy than before in Beijing. Thirty patients with cashew nut allergywere analyz... 详细信息

关键词：腰果核过敏反应免疫球蛋白过敏原临床研究

Interleukin- 13 interferes with activation-induced t-ce apoptosis by repressing p53 expression

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Cellular & Molecular immunology 2016年第5期13卷 669-677页

作者： Li Yang Ling-Zhi Xu Zhi-Qiang Liu Gui Yang Xiao-Rui Geng Li-Hua Mo Zhi-Gang Liu Peng-Yuan Zheng Ping-Chang Yang department of Gastroenterology the Zhengzhou People's Hospital Zhengzhou China department of Gastroenterology the Fifth Affiliated Hospital of Zhengzhou University Zhengzhou China Shenzhen Key Laboratory of allergy and immunology Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University Shenzhen China ENT Institute of Shenzhen University Longgang Central Hospital Shenzhen China

The etiology and the underlying mechanism of CD4＋ T-cell polarization are unclear. This study sought to investigate the mechanism by which interleukin （IL）-13 prevents the activation-induced apoptosis of CD4＋ T cells. Here we report that CD4＋ T cells expressed IL-13 receptor a2 in the intestine of sensitized mice. IL-13 suppressed both the activation-induced apoptosis of CD4＋ T cells and the expression of p53 and FasL. Exposure to recombinant IL-13 inhibited activation-induced cell death （AICD） along with the expression of p53, caspase 3, and tumor necrosis factor-a in CD4＋ T cells. Administration of an anti-lL-13 antibody enhanced the effect of specific immunotherapy on allergic inflammation in the mouse intestine, enforced the expression of p53 in intestinal CD4＋ T cells, and enhanced the frequency of CD4＋ T-cell apoptosis upon challenge with specific antigens. In summary, blocking IL-13 enhances the therapeutic effect of antigen-specific immunotheraov by regulating aDoptosis and thereby enforcing AICD in CD4＋ T cells.

关键词： activation-induced cell death apoptosis interleukin 13 T lymphocytes Th2 polarization

Increased levels of lactate dehydrogenase and hypertension are associated with severe illness of COVID-19

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World Journal of Clinical Cases 2022年第1期10卷 128-135页

作者： Zhen-Mu Jin Ji-Chan Shi Mo Zheng Que-Lu Chen Yue-Ying Zhou Fang Cheng Jing Cai Xian-Gao Jiang department of Rheumatology Immunology and AllergyWenzhou Central HospitalThe Second Affiliated Hospital of Shanghai UniversityAffiliated Dingli Clinical Institute of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina department of Infectious Diseases Wenzhou Central HospitalThe Second Affiliated Hospital of Shanghai UniversityAffiliated Dingli Clinical Institute of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina department of Radiology Wenzhou Central HospitalThe Second Affiliated Hospital of Shanghai UniversityAffiliated Dingli Clinical Institute of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)is amid an ongoing *** has been shown that patients with cardiovascular comorbidities are at higher risk of severe illness of *** To find out the relationship between cardiovascular comorbidities and severe illness of *** The clinical data of 140 COVID-19 patients treated from January 22,2020 to March 3,2020 at our hospital were retrospectively *** clinical characteristics were compared between patients with mild illness and those with severe *** There were 75 male patients and 65 female patients(53.6%vs 46.4%).The mean age was 45.4±14.6 years(range,2-85 years).Most of the patients had mild illness(n=114,81.4%)and 26 patients had severe illness(18.6%).The most common symptom was fever(n=110,78.6%),followed by cough(n=82,58.6%)and expectoration(n=51,36.4%).Eight patients were asymptomatic but were positive for severe acute respiratory syndrome coronavirus 2 *** with severe illness were significantly more likely to be hypertensive than those with mild illness[(10/26,38.4%)vs(22/114,19.3%),P=0.036].The levels of lactate dehydrogenase were significantly higher in the severe illness group than in the mild illness group(299.35±68.82 vs 202.94±63.87,P<0.001).No patient died in either the severe illness or the mild illness *** Hypertension and elevated levels of lactate dehydrogenase may be associated with severe illness of COVID-19.

关键词： Pneumonia Virus COVID-19 Hypertension Lactate dehydrogenase Radiology

Retinoic acid signaling acts as a rheostat to balance Treg function

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Cellular & Molecular immunology 2022年第7期19卷 820-833页

作者： Govindarajan Thangavelu Gabriela Andrejeva Sara Bolivar-Wagers Sujeong Jin Michael C.Zaiken Michael Loschi Ethan G.Aguilar Scott N.Furlan Chrysothemis C.Brown Yu-Chi Lee Cameron McDonald Hyman Colby J.Feser Angela Panoskaltsis-Mortari Keli L.Hippen Kelli P.MacDonald William J.Murphy Ivan Maillard Geoffrey R.Hill David H.Munn Robert Zeiser Leslie S.Kean Jeffrey C.Rathmell Hongbo Chi Randolph J.Noelle Bruce R.Blazar department of Pediatrics Center for ImmunologyUniversity of MinnesotaMinneapolisMNUSA Center for Immunobiology Vanderbilt University Medical CenterNashville TNUSA department of Pediatrics University of WashingtonSeattleWAUSA Fred Hutchinson Cancer Research Center SeattleWAUSA Howard Hughes Medical Institute immunology Program and Ludwig CenterSloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA department of Microbiology and immunology.Geisel School of Medicine at Dartmouth Norris Cotton Cancer CenterLebanonUSA department of immunology Queensland Institute of Medical Research(QIMR)Berghofer Medical Research Institute and School of MedicineUniversity of QueenslandBrisbaneQLDAustralia departmentof Dermatology School of MedicineUniversity of California DavisSacramentoCAUSA Division of Hematology/Oncology Department of MedicineUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPAUSA Georgia Cancer Center Augusta UniversityAugustaGAUSA department of Haematology Oncology and Stem Cell TransplantationFaculty of MedicineFreiburg University Medical CentreFreiburgGermany Boston Children's Hospital and the Dana-Farber Cancer Institute BostonMAUSA department of immunology St.Jude Children's ResearchHospitalMemphisTNUSA

Regulatory T cells(Tregs)promote immune homeostasis by maintaining self-tolerance and regulating inflammatory *** certain inflammatory conditions,Tregs can lose their lineage stability and *** studies have reported that ex vivo exposure to retinoic acid(RA)enhances Treg function and ***,it is unknown how RA receptor signaling in Tregs influences these processes in ***,we employed mouse models in which RA signaling is silenced by the expression of the dominant negative receptor(DN)RARαin all T *** the fact that DNRARαconventional T cells are hypofunctional,Tregs had increased CD25 expression,STAT5 pathway activation,mTORC1 signaling and supersuppressor ***,DNRARαTregs had increased inhibitory molecule expression,amino acid transporter expression,and metabolic fitness and decreased antiapoptotic *** function was observed when wild-type mice were treated with a pharmacologic pan-RAR ***,Treg-specific expression of DNRARαresulted in distinct phenotypes,such that a single allele of DNRARαin Tregs heightened their suppressive function,and biallelic expression led to loss of suppression and *** loss of Treg function was not cell intrinsic,as Tregs that developed in a noninflammatory milieu in chimeric mice reconstituted with DNRARαand wild-type bone marrow maintained the enhanced suppressive *** mapping suggested that maintaining Treg stability in an inflammatory milieu requires RA *** findings indicate that RA signaling acts as a rheostat to balance Treg function in inflammatory and noninflammatory conditions in a dose-dependent manner.

关键词： Retinoic acid Tregulatory cells Autoimmunity Metabolism mTORC1 STAT5

Pathway-selective suppression of chemokine receptor signaling in B cells by LPS through downregulation of PLC-b2

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Cellular & Molecular immunology 2010年第6期7卷 428-439页

作者： Aiko-Konno Shirakawa Fang Liao Hongwei H Zhang Michael N Hedrick Satya P Singh Dianqing Wu Joshua M Farber Inflammation Biology Section Laboratory of Molecular ImmunologyNational Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMDUSA department of Pharmacology Yale University School of MedicineNew HavenCTUSA

Lymphocyte activation leads to changes in chemokine receptor *** are limited data,however,on how lymphocyte activators can alter chemokine signaling by affecting downstream *** hypothesized that B cell-activating agents might alter chemokine responses by affecting downstream signal transducers,and that such effects might differ depending on the *** found that activating mouse B cells using either anti-IgM or lipopolysaccharide(LPS)increased the surface expression of CCR6 and CCR7 with large increases in chemotaxis to their cognate *** contrast,while anti-IgM also led to enhanced calcium responses,LPS-treated cells showed only small changes in calcium signaling as compared with cells that were freshly *** particular interest,we found that LPS caused a reduction in the level of B-cell phospholipase C(PLC)-b2 mRNA and *** obtained using PLC-b22/2 mice showed that the b2 isoform mediates close to one-half the chemokine-induced calcium signal in resting and anti-IgM-activated B cells,and we found that calcium signals in the LPS-treated cells were boosted by increasing the level of PLC-b2 using transfection,consistent with a functional effect of downregulating ***,our results show activator-specific effects on responses through B-cell chemokine receptors that are mediated by quantitative changes in a downstream signal-transducing protein,revealing an activity for LPS as a downregulator of PLC-b2,and a novel mechanism for controlling chemokine-induced signals in lymphocytes.

关键词： B cells calcium chemokine chemotaxis GPCR

Single-allergen Sublingual Immunotherapy versus Multi-allergen Subcutaneous Immunotherapy for Children with Allergic Rhinitis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2017年第3期37卷 407-411页

作者：王忠喜石涵 laboratory of allergology institute of immunology department of allergy tongji hospitaltongji medical collegehuazhong university of science and technologyWuhan 430030China department of gerontology central hospital of taizhouTaizhou 380000China

It has always been controversial whether a single allergen performs better than multiple allergens in polysensitized patients during the allergen-specific immunotherapy. This study aimed to examine the clinical efficacy of single-allergen sublingual immunotherapy(SLIT) versus multi-allergen subcutaneous immunotherapy(SCIT) and to discover the change of the biomarker IL-4 after 1-year immunotherapy in polysensitized children aged 6–13 years with allergic rhinitis(AR) induced by house dust mites(HDMs). The AR polysensitized children(n=78) were randomly divided into two groups: SLIT group and SCIT group. Patients in the SLIT group sublingually received a single HDM extract and those in the SCIT group were subcutaneously given multiple-allergen extracts(HDM in combination with other clinically relevant allergen extracts). Before and 1 year after the allergen-specific immunotherapy(ASIT), the total nasal symptom scores(TNSS), total medication scores(TMS) and IL-4 levels in peripheral blood mononuclear cells(PBMCs) were compared respectively between the two groups. The results showed that the TNSS were greatly improved, and the TMS and IL-4 levels were significantly decreased after 1-year ASIT in both groups(SLIT group: P0.05; for TMS: P>0.05; for IL-4 levels: P>0.05). It was concluded that the clinical efficacy of single-allergen SLIT is comparable with that of multi-allergen SCIT in 6–13-year-old children with HDM-induced AR.

关键词： single allergen sublingual immunotherapy multi-allergen subcutaneous immunotherapy children allergic rhinitis

Virus-like particle vaccinology,from bench to bedside

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Cellular & Molecular immunology 2022年第9期19卷 993-1011页

作者： Mona O.Mohse Martin F.Bachmann department of BioMedical Research University of BernBernSwitzerland department of immunology RIA University Hospital BernBernSwitzerland Saiba Biotech AG Bahnhofstr.13CH-8808PfaeffikonSwitzerland The Jenner Institute University of OxfordOxfordUK

Virus-like particles(VLPs)have become key tools in biology,medicine and even *** their initial use to resolve viral structures at the atomic level,VLPs were rapidly harnessed to develop antiviral vaccines followed by their use as display platforms to generate any kind of *** recently,VLPs have been employed as nanomachines to deliver pharmaceutically active products to specific sites and into specific cells in the ***,we focus on the use of VLPs for the development of vaccines with broad fields of indications ranging from classical vaccines against viruses to therapeutic vaccines against chronic inflammation,pain,allergy and *** this review,we take a walk through time,starting with the latest developments in experimental preclinical VLP-based vaccines and ending with marketed vaccines,which earn billions of dollars every year,paving the way for the next wave of prophylactic and therapeutic vaccines already visible on the horizon.

关键词： vaccine virus-like particle immunology

A Novel Mutation of Notch homolog protein 2 gene in a Chinese Family with Hajdu-Cheney Syndrome

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Chinese Medical Journal 2017年第23期130卷 2883-2884页

作者： Ruo-Lan Gong Jing Wu Tong-Xin Chen department of allergy and immunology Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Division of immunology Institute of Pediatric Translational Medicine Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

Hajdu-Cheney syndrome （HCS） is a rare disorder which is characterized by developmental delay, craniofacial anomalies, congenital heart defects, hearing deficit, polycystic kidneys, and bone abnormalities, including ... 详细信息

关键词： Acroosteolysis Hajdu-Cheney Syndrome Notch homolog protein 2 gene Osteoporosis

Leukocyte adhesion defect:Where do we stand circa 2019?

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Genes & Diseases 2020年第1期7卷 107-114页

作者： Jhumki Das Avinash Sharma Ankur Jindal Vaishali Aggarwal Amit Rawat allergy immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarhIndia department of Pediatrics Dr Rajendra Prasad Government Medical CollegeTandaKangraHimachal PradeshIndia

Migration of polymorphonuclear leukocytes from bloodstream to the site of inflammation is an important event required for surveillance of foreign *** trafficking of leukocytes from bloodstream to the tissue occurs in several distinct steps and involves several adhesion *** in adhesion of leukocytes to vascular endothelium affecting their subsequent migration to extravascular space gives rise to a group of rare primary immunodeficiency diseases(PIDs)known as Leukocyte Adhesion Defects(LAD).Till date,four classes of LAD are discovered with LAD I being the most common *** I is caused by loss of function of common chain,cluster of differentiation(CD)18 of β2 integrin *** patients suffer from life-threatening bacterial infections and in its severe form death usually occurs in childhood without bone marrow *** II results from a general defect in fucose *** patients suffer from less severe bacterial infections and have growth and mental *** blood group phenotype is also observed in these *** III is caused by abnormal integrin *** III patients suffer from severe bacterial and fungal *** frequently show delayed detachment of umbilical cord,impaired wound healing and increased tendency to *** IV is the most recently described *** is caused by defects in β2 and α4β1 integrins which impairs lymphocyte *** IV patients have monogenic defect in cystic-fibrosis-transmembraneconductance-regulator(CFTR)gene,resulting in cystic *** and genetic etiology of all LAD syndromes are discussed in detail in this paper.

关键词： Neutrophilic defect Neutrophilic leukocytosis Phagocyte rolling Phagocytes Primary immunodeficiency disorders