检索结果-南通市图书馆

A chromosome-level genome assembly reveals that a bipartite gene cluster formed via an inverted duplication controls monoterpenoid biosynthesis in Schizonepeta tenuifolia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2023年第3期16卷 533-548页

作者： Chanchan Liu Samuel J.Smit Jingjie Dang Peina Zhou Grant T.Godden Zheng Jiang Wukun Liu Licheng Liui Wei Lin Jinao Duan Qinan Wu Benjamin R.Lichman School of Pharmacy Nanjing University of Chinese MedicineNanjingChina Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing University of Chinese MedicineNanjingChina Centre for Novel Agricultural Products Department of BiologyUniversity of YorkYork YO105DDUK Florida Museum of Natural History University of FloridaGainesileFLUSA department of pathogen biology School of Medicine and Holistic Integrative MedicineNanjing University of Chinese MedicineNanjngChina

Biosynthetic gene clusters(BGCs)are regions of a genome where genes involved in a biosynthetic pathway are in *** origin and evolution of plant BGCs as well as their role in specialized metabolism remain largely *** this study,we have assembled a chromosome-scale genome of Japanese catnip(Schizonepeta tenuifolia)and discovered a BGC that contains multiple copies of genes involved in four adjacent steps in the biosynthesis of p-menthane *** BGC has an unprecedented bipartite structure,with mirrored biosynthetic regions separated by 260 *** bipartite BGC includes identical copies of a gene encoding an old yellow enzyme,a type of flavin-dependent *** vitro assays and virus-induced gene silencing revealed that this gene encodes the missing isopiperitenone *** enzyme evolved from a completely different enzyme family to isopiperitenone reductase from closely related Mentha spp.,indicating convergent evolution of this pathway *** analysis revealed that this bipartite BGC has emerged uniquely in the *** lineage and through insertion of pathway genes into a region rich in monoterpene *** cluster gained its bipartite structure via an inverted *** discovered bipartite BGC for p-menthane biosynthesis in *** has similarities to the recently described duplicated p-menthane biosynthesis gene pairs in the Mentha longifolia genome,providing an example of the convergent evolution of gene *** work expands our understanding of plant BGCs with respect to both form and evolution,and highlights the power of BGCs for gene discovery in plant biosynthetic pathways.

关键词： specialized metabolism monoterpenoids biosynthetic gene cluster Lamiaceae biosynthesis chromosomal inversion

Research Progress of Parasite Telomerase and Its Interacting Proteins

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research Progress of Parasite Telomerase and Its Interacting...

Experts’Consensus on the Management of Respiratory Disease Syndemic

作者： Kaisong Hu Jiaqi Zhang Jingtong Zheng department of pathogen biology College of Basic Medical Sciences Jilin University

Telomerase is a nucleoprotein that contains reverse transcriptase activity. It is reversely transcribed into DNA at the end of its chromosome using its own RNA as a template to ensure the length and stability of telomeres. Its physiological function is closely related to the life process of cells. In recent years, the research on telomeres and telomerase has become a new hotspot, people have a more in-depth research and scientific understanding of their structures and functions, and scientists have also attached great importance to the research progress of telomerase increasingly. Researchers in parasite-related research have successively discovered a large number of telomere and telomerase sequences in a variety of different parasites. These achievements have greatly facilitated the scientific research of diseases caused by parasitic infections, providing a solid research basis for the preparation of new drugs, while enriching the treatment protocols of parasitic diseases, and opening new worlds for the prevention of certain diseases and epidemic transmission. This paper reviews the current research progress of telomerase.

关键词： Telomerase Telomeres Parasites Research Progress

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

China CDC weekly 2024年第8期6卷 131-138页

作者： Weizhong Yang Zhongjie Li Ting Yang Yanming Li Zhengde Xie Luzhao Feng Zhibin Peng Jue Liu School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Respiratory Health and Multimorbidity BeijingChina Key Laboratory of pathogen Infection Prevention and Control Peking Union Medical CollegeMinistry of EducationBeijingChina National Center for Respiratory Diseases State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Pulmonary and Critical Care MedicineCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijingChina department of Pulmonary and Critical Care Medicine National Center of GerontologyBeijing HospitalInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016National Key Discipline of Pediatrics(Capital Medical University)Beijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Chinese Center for Disease Control and Prevention BeijingChina department of Epidemiology and Biostatistics School of PublicHealthKey Laboratory of Epidemiology of Major DiseasesMinistry of EducationPeking University Health Science Center-Weifang Joint Research Center for Maternal and Child HealthPeking UniversityBeijingChina

The global burden of respiratory diseases is a significant and increasing threat to individuals *** 2017,there were 544.9 million cases of chronic respiratory diseases,a 39.8%increase since 1990(1).These diseases were the third leading cause of global mortality in 2017,accounting for 7.0%of all deaths,an 18.0%increase compared to 1990.

关键词： diseases respiratory mortality

The microbiota-gut-brain axis and neurodevelopmental disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2023年第10期14卷 762-775页

作者： Qinwen Wang Qianyue Yang Xingyin Liu State Key Laboratory of Reproductive Medicine and offspring Health School of Public HealthNanjing Medical UniversityNanjing 211166China department of pathogen biology-Microbiology Division Key Laboratory of Pathogen of Jiangsu Province Key Laboratory of Human Functional Genomics of Jiangsu ProvinceNanjing Medical UniversityNanjing 211166China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversityNanjing 211166China department of Microbiota Medicine The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 211166China

The gut microbiota has been found to interact with the brain through the microbiota-gut-brain axis,regulating various physiological *** recent years,the impacts of the gut microbiota on neurodevelopment through this axis have been increasingly *** gut microbiota is commonly considered to regulate neurodevelopment through three pathways,the immune pathway,the neuronal pathway,and the endocrine/systemic pathway,with overlaps and crosstalks in *** studies have identified the role of the microbiota-gut-brain axis in neurodevelopmental disorders including autism spectrum disorder,attention deficit hyperactivity disorder,and Rett *** researchers have examined the physiological and pathophysiological mechanisms influenced by the gut microbiota in neurodevelopmental disorders(NDDs).This review aims to provide a comprehensive overview of advancements in research pertaining to the microbiota-gut-brain axis in ***,we analyzed both the current state of research progress and discuss future perspectives in this field.

关键词： neurodevelopmental disorders gut microbiome microbiota gut brain axis

Genome-wide identification of endogenous retrovirus elements and their active transcription in mink genome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

微生物(英文) 2023年第2期2卷 201-208页

作者： Zheng Li Qing Wang Na Lv Guojin Xu Xuemei Yang Baoli Zhu CAS Key Laboratory of pathogen Microbiology and immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Jiangxi Science and Technology Normal University NanchangChina Jinan Microecological Biomedicine Shandong Laboratory JinanChina Beijing Pediatric Research Institute BeijingChina department of pathogenic biology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouChina

Mammalian endogenous retroviruses(ERVs)are ancient retroviruses that have been integrated into *** were believed to be inactive until the discovery of ERV transcription in the mouse ***,the transcription level and function of ERV elements in mammalian genomes are not well *** this study,we performed the first genome‐wide scanning of ERV loci in the American mink(Neogale vison)genome(NeoERV)followed by transcriptomic analysis to detect actively transcribed NeoERV elements.A total of 365,791 NeoERV loci were identified,and161,205(44%)of these loci were found to be actively transcribed based on transcriptomic data from three types of tissues(amygdala,trachea and lung).More than one third of the actively transcribed NeoERV loci were tissue‐***,some of the active loci were associated with host gene transcription,and the level of NeoERV transcription was positively correlated with that of host genes,specifically when active loci were located in overlapped gene *** in‐depth analysis of the envelope protein coding env gene showed that,in general,its transcription level was higher than that of NeoERVs,which is believed to be associated with host immunity.

关键词： endogenous retrovirus mink tissue-specific transcriptome

Evolution and host-specific adaptation of Pseudomonas aeruginosa

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四川生理科学杂志 2024年第7期46卷 1579-1579页

作者： Aaron Weimann Victor Phillip Dahdaleh Heart & Lung Research Institute University of Cambridge Cambridge UK University of Cambridge Molecular Immunity Unit MRC Laboratory of Molecular Biology Cambridge UK Cambridge Centre for AI in Medicine University of Cambridge Cambridge UK department of Veterinary Medicine University of Cambridge Cambridge UK Victor Phillip Dahdaleh Heart & Lung Research Institute University of Cambridge Cambridge UK University of Cambridge Molecular Immunity Unit MRC Laboratory of Molecular Biology Cambridge UK Cambridge Centre for AI in Medicine University of Cambridge Cambridge UK Laboratory of pathogens and Host Immunity (LPHI) UMR5235 CNRS/Université de Montpellier Montpellier France Victor Phillip Dahdaleh Heart & Lung Research Institute University of Cambridge Cambridge UK University of Cambridge Molecular Immunity Unit MRC Laboratory of Molecular Biology Cambridge UK Cambridge Centre for Lung Infection Royal Papworth Hospital Cambridge UK Victor Phillip Dahdaleh Heart & Lung Research Institute University of Cambridge Cambridge UK University of Cambridge Molecular Immunity Unit MRC Laboratory of Molecular Biology Cambridge UK department of Physiology Bioscience Institute University College Cork Cork Ireland University of Cambridge Molecular Immunity Unit MRC Laboratory of Molecular Biology Cambridge UK University of Cambridge Molecular Immunity Unit MRC Laboratory of Molecular Biology Cambridge UK Cambridge Centre for Lung Infection Royal Papworth Hospital Cambridge UK Victor Phillip Dahdaleh Heart & Lung Research Institute University of Cambridge Cambridge UK department of Biochemistry University of Cambridge Cambridge UK department of Medicine University of Cambridge Cambridge UK department of Biochemistry University of Cambridge Cambridge UK department of Medicine University of Cambridge Cambridge UK Wellcome Sanger Institute Hinxton UK department of Medicine University of Cambridge Cambridge UK Cambridge Unive

The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis(CF).We show that a few environmental isolates,driven by horizontal gene acquisition,have become dominant epidemic clones that have sequentially emerged and spread through global transmission networks over the past 200 years.

关键词： lung diseases sequentially

Assessing the risk of spread of Zika virus under current and future climate scenarios

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biosafety and Health 2022年第3期4卷 193-204页

作者： Ye Xu Jingni Zhou Tong Liu Peiwen Liu Yang Wu Zetian Lai Jinbao Gu Xiaoguang Chen department of pathogen biology Key Laboratory of Tropical Disease Research of Guangdong ProvinceSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China Institute of Tropical Medicine School of Public HealthSouthern Medical UniversityGuangzhou 510515China

Zika virus(ZIKV)may cause severe microcephaly in newborn babies and Guillain‐Barrésyndrome in some *** recent decades,its range has expanded in 86 *** are two ecologically and evolutionarily district cycles:urban cycle and sylvatic *** work aimed to estimate the urban and sylvatic cycle areas of ZIKV throughout the *** occurrence records of vectors,non‐human primate hosts,and ZIKV were *** chose historical climate data,predicted vectors distribution,human population density,and elevation data as the variables to fit the maximum entropy model(MaxEnt).Current risk area and future prediction were performed with global climate models(GCMs)and shared socioeconomic pathways(SSPs).Predicting the ZIKV risk area would help tailor related control *** results indicated that 16.6%of the world’s landmass(except Antarctica)is a risk area in the urban *** 6.22 billion people(78.69%of the global population)live in the risk area,with the vast majority in South Asia,tropical Africa,South America,North America,and countries around the Mediterranean *** climate change decreases the risk area of *** study also suggested that the sylvatic cycle happened between the Tropic of Cancer and the Tropic of *** overlap region of the urban and sylvatic cycles could be hotpots that ZIKV spill from the sylvatic to the urban *** is indicated that long‐term passenger screening,mosquito surveillance,and control are necessary.

关键词： Zika virus Aedes aegypti Aedes albopictus Species distribution modeling MaxEnt Urban cycle Sylvatic cycle

Thermal-annealing-regulated plasmonic enhanced fluorescence platform enables accurate detection of antigen/antibody against infectious diseases

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第2期16卷 3215-3223页

作者： Ying Yue Jingjie Nan Yuanyuan Che Hongqin Xu Weihong Sun Feiran Zhang Lei Wang Wei Xu Junqi Niu Shoujun Zhu Junhu Zhang Bai Yang State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry The First Hospital of Jilin UniversityChangchun 130021China department of Laboratory Medicine The First Hospital of Jilin UniversityChangchun 130021China department of Hepatology Center of Infectious Diseases and Pathogen BiologyThe First Hospital of Jilin UniversityChangchun 130021China

Plasmonic enhanced fluorescence(PEF)technology is a powerful strategy to improve the sensitivity of immunofluorescence microarrays(IFMA),however,current approaches to constructing PEF platforms are either expensive/time-consuming or reliant on specialized ***,we develop a completely alternative approach relying on a two-step protocol that includes the self-assembly of gold nanoparticles(GNPs)at the water–oil interface and subsequent annealing-assisted regulation of gold *** optimized thermal-annealing GNPs(TA-GNP)platform generates adequate hot spots,and thus produces high-density electromagnetic coupling,eventually enabling 240-fold fluorescence enhancement of probed dyes in the near-infrared *** clinical detection of human samples,TA-GNP provides super-high sensitivity and low detection limits for both hepatitis B surface antigen and SARS-CoV-2 binding antibody,coupled with a much-improved detection dynamic range up to six orders of *** fast detection,high sensitivity,and low detection limit,TA-GNP could not only substantially improve the outcomes of IFMA-based precision medicine but also find applications in fields of proteomic research and clinical pathology.

关键词： plasmonic enhanced fluorescence electromagnetic coupling SARS-CoV-2 antibodies hepatitis B surface antigen immunofluorescence microarrays

Host pathogen interactions in Helicobacter pylori related gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第9期23卷 1521-1540页

作者： Magdalena Chmiela Zuzanna Karwowska Weronika Gonciarz Bujana Allushi Pawel Staczek department of immunology and Infectious biology Institute of MicrobiologyBiotechnology and ImmunologyFaculty of Biology and Environmental ProtectionUniversity of Lodz department of Genetics of Bacteria Institute of MicrobiologyBiotechnology and ImmunologyFaculty of Biology and Environmental ProtectionUniversity of Lodz

Helicobacter pylori (H. pylori), discovered in 1982, is a microaerophilic, spiral-shaped gram-negative bacterium that is able to colonize the human stomach. Nearly half of the world's population is infected by this pathogen. Its ability to induce gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma has been confirmed. The susceptibility of an individual to these clinical outcomes is multifactorial and depends on H. pylori virulence, environmental factors, the genetic susceptibility of the host and the reactivity of the host immune system. Despite the host immune response, H. pylori infection can be difficult to eradicate. H. pylori is categorized as a group?Ⅰ?carcinogen since this bacterium is responsible for the highest rate of cancerrelated deaths worldwide. Early detection of cancer can be lifesaving. The 5-year survival rate for gastric cancer patients diagnosed in the early stages is nearly 90%. Gastric cancer is asymptomatic in the early stages but always progresses over time and begins to cause symptoms when untreated. In 97% of stomach cancer cases, cancer cells metastasize to other organs. H. pylori infection is responsible for nearly 60% of the intestinaltype gastric cancer cases but also influences the development of diffuse gastric cancer. The host genetic susceptibility depends on polymorphisms of genes involved in H. pylori-related inflammation and the cytokine response of gastric epithelial and immune cells. H. pylori strains differ in their ability to induce a deleterious inflammatory response. H. pylori-driven cytokines accelerate the inflammatory response and promote malignancy. Chronic H. pylori infection induces genetic instability in gastric epithelial cells and affects the DNA damage repair systems. Therefore, H. pylori infection should always be considered a pro-cancerous factor.

关键词： Helicobacter pylori 招待危险性 Carcinogenesis 细菌的差异