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Histopathological impact of SARS-CoV-2 on the liver:Cellular damage and long-term complications

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World Journal of Gastroenterology 2024年第22期30卷 2866-2880页

作者： Alfonso Rodriguez-Espada moises Salgado-de la mora Briana mariette Rodriguez-Paniagua nathaly Limonde la Rosa monica Itzel martinez-Gutierrez Santiago Pastrana-Brandes nalu navarro-Alvarez department of molecular Biology Universidad Panamericana School of MedicineCampus MéxicoMexico 03920Mexico department of Internal medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico department of Surgery University of Colorado Anschutz Medical CampusDenverCO 80045United States PECEm Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico 04360Mexico department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico

Coronavirus disease 2019(COVID-19),caused by the highly pathogenic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),primarily impacts the respiratory tract and can lead to severe outcomes such as acute respiratory distress syndrome,multiple organ failure,and *** extensive studies on the pathogenicity of SARS-CoV-2,its impact on the hepatobiliary system remains *** liver injury is commonly indicated by reduced albumin and elevated bilirubin and transaminase levels,the exact source of this damage is not fully *** mechanisms for injury include direct cytotoxicity,collateral damage from inflammation,drug-induced liver injury,and ischemia/***,evidence often relies on blood tests with liver enzyme *** this comprehensive review,we focused solely on the different histopathological manifestations of liver injury in COVID-19 patients,drawing from liver biopsies,complete autopsies,and in vitro liver *** present evidence of the direct impact of SARS-CoV-2 on the liver,substantiated by in vitro observations of viral entry mechanisms and the actual presence of viral particles in liver samples resulting in a variety of cellular changes,including mitochondrial swelling,endoplasmic reticulum dilatation,and hepatocyte *** ly,we describe the diverse liver pathology observed during COVID-19 infection,encompassing necrosis,steatosis,cholestasis,and lobular *** also discuss the emergence of long-term complications,notably COVID-19-related secondary sclerosing *** the histopathological liver changes occurring during COVID-19 infection is pivotal for improving patient recovery and guiding decision.making.

关键词： Liver SARS-CoV-2 COVID-19 Angiotensin-converting enzyme 2 Histopathology Liver biopsies Liver autopsy In vitro

Unilateral rnurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia michael J.Bannon Irma Alicia martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo minerva maldonado-Berny mE Gutierrez-Castillo Armando J.Espadas-Alvarez manuel A.Fernandez-Parrilla Juan U.mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel martinez-Fong departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de medicina para la Educación y desarrollo y la Investigación Científica de Iztacala(Red mEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico nanoparticle Therapy institute AguascalientesMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela nacional de medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Biología molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rnurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rnurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton.markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rnurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

Optimizing nutrition in hepatic cirrhosis:A comprehensive assessment and care approach

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World Journal of Gastroenterology 2024年第10期30卷 1313-1328页

作者： Osvely mendez-Guerrero Anaisa Carranza-Carrasco Luis Alberto Chi-Cervera Aldo Torre nalu navarro-Alvarez department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Clínica de Especialidades Gastrointestinales y Hepáticas Hospital Star MedicaMerida 97133YucatanMexico molecular Biology Universidad Panamericana School of MedicineCampus MéxicoMexico City 03920Mexico department of Surgery University of Colorado Anschutz Medical CampusDenverCO 80045United States

Cirrhosis is considered a growing cause of morbidity and mortality,which represents a significant public health ***,there is no effective treatment to reverse *** primarily centers on addressing the underlying liver condition.monitoring,and managing portal hypertension-related complications,and evaluating the potential for liver transplantation in cases of decompensated cirrhosis,marked by rapid progression and the emer-gence of complications like variceal bleeding,hepatic encephalopathy,ascites,malnutrition,and ***,a prevalent complication across all disease stages,is often underdiagnosed in cirrhosis due to the complexities of nutritional assessment in patients with fluid retention and/or obesity,despite its crucial impact on *** emphasis has been placed on the collaboration of nutritionists within hepatology and Liver transplant teams to deliver compre-hensive care,a practice that has shown to improve *** review covers appropriate screening and assessment methods for evaluating the nutritional status of this population,diagnostic approaches for malnutrition,and context-specific nutrition *** also discusses evidence-based recommendations for supplementation and physical exercise,both essential elements of the standard care provided to cirrhotic patients.

关键词： Cirrhosis nutritional diagnosis Treatment Diet Guidelines

Sound waves and solutions:Point-of-care ultrasonography for acute kidney injury in cirrhosis

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World Journal of Critical Care medicine 2024年第2期13卷 83-92页

作者： David Aguirre-Villarreal mario Andrés de Jesús Leal-Villarreal Ignacio García-Juárez Eduardo R Argaiz Abhilash Koratala departamento de Gastroenterología Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Cardiología Instituto Nacional de Cardiología Ignacio ChávezMexico City 14080Mexico Unidad de Hepatología y Trasplante Departamento de GastroenterologíaInstituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranMexico City 14080Mexico departamento de nefrología y metabolismo mineral Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Tecnológico de monterrey Escuela de Medicina y Ciencias de la SaludMexico City 64710Mexico department of nephrology Medical College of WisconsinMilwaukeeWI 53226United States

This article delves into the intricate challenges of acute kidney injury(AKI)in cirrhosis,a condition fraught with high morbidity and *** complexities arise from distinguishing between various causes of AKI,particularly hemodyn.mic AKI,in cirrhotic patients,who experience hemodyn.mic changes due to portal *** term"hepatocardiorenal syndrome"is introduced to encapsulate the intricate interplay among the liver,heart,and *** narrative emphasizes the often-overlooked aspect of cardiac function in AKI assessments in cirrhosis,unveiling the prevalence of cirrhotic cardiomyopathy marked by impaired diastolic *** conventional empiric approach involving volume expansion and vasopressors for hepatorenal syndrome is critically analyzed,highlighting potential risks and variable patient *** advocate for a nuanced algorithm for AKI evaluation in cirrhosis,prominently featuring point-of-care ultrasonography(POCUS).POCUS applications encompass assessing fluid tolerance,detecting venous congestion,and evaluating cardiac function.

关键词： Point-of-care ultrasonography Bedside ultrasound Cirrhosis Congestion Acute kidney injury Congestive nephropathy

A novel heterozygous SF1/nR5A1 gene variant causes 46,Xy DSD-gonadal dysgenesis with hypergonadotropic hypogonadism without adrenal insufficiency

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Genes & Diseases 2024年第4期11卷 128-130页

作者： Luis Ramos department of Reproductive Biology Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubirdnTlalpanMexico City 14080Mexico

Steroidogenic factor 1(SF1/nR5A1;nuclear receptor subfamily 5 group A member 1)is an essential orphan protein involved in gonadal embryogenesis,sex determination,and reproductive endocrinology.

关键词： insufficiency determination gonadal

Association of the HLA-DRB1*0701 allele with perinuclear anti-neutrophil cytoplasmatic antibodies in.mexican patients with severe ulcerative colitis

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World Journal of Gastroenterology 2006年第10期12卷 1617-1620页

作者： Jesus K yamamoto-Furusho Luis Uscanga-Domínguez Alondra Lopez-martinez Julio Granados department of Gastroenterology institute nacional de ciencias médicas y nutrición salvador zubirán.méxico D FMéxico department of immunology institute nacional de ciencias médicas y nutrición salvador zubirán.méxico D FMéxico

AIm： To determine the association between the HLADRB1 alleles and perinuclear anti-neutrophil cytoplasmatic antibodies （p-AnCA） positive in.mexican patients with ulcerative colitis （UC）. mETHODS： ninety mexican.mestizo patients （45 females） with UC, confirmed by biopsy, were studied. High resolution HLA typing was performed by PCR-SSO reverse dot blot and PCR-SSP. molecular typing techniques were applied to define HLA-DRB1 alleles. Enzyme-linked immunosorbent assay and immunofluorescence techniques were used to detect p-AnCA. RESULTS： Forty-eight （53%） UC patients were positive for p-AnCA by ELISA and IF. We found that p-AnCA- positive UC patients had a significantly increased frequency of HLA-DR7 compared with p-AnCA-negative controls （22% vs 5.1%; pC=0.02, OR=5.2, CI 95%： 1.06-37.82）. Disease activity was scored as severe in 20 patients, moderate in 8, mild in 14 and no activity in the remaining 38 patients according to the Truelove and Witts criteria. Subgroup analysis showed a significantly increased frequency of the HLA-DRB1＊07 allele in 15 of 20 UC patients with severe activity of UC and p-AnCA positivity [100% vs 0%; pC=0.0000001; OR=35]. no significant differences were found between p-AnCA positive patients, HLA-DR alleles and other clinical features such as extraintestinal manifestations, proctocolectomy and ***： The HLA-DRB1＊07 is associated with p-AnCA positive UC mexican patients.

关键词： HLA-DR p-AnCA Ulcerative colitis mexicans

Extreme drought triggers parallel shifts in wood anatomical and physiological traits in upper treeline of the mediterranean Andes

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Ecological Processes 2024年第01期13卷 132-143页

作者： Luiz Santini Jr. Dylan Craven Daigard Ricardo Ortega Rodriguez manolo Trindade Quintilhan Stephanie Gibson-Carpintero Cristina Aravena Torres Fidel A.Roig Ariel A.mu?oz Alejandro Venegas-Gonzalez Hémera Centro de Observación de la Tierra Universidad Mayor GEmA Center for Gen.mics Ecology and Environment Universidad Mayor Data Observatory Foundation ANID Technology Center depart-ment of Forest Sciences ESALQ-University of Sao Paulo department of Plant Biology Institute of Biology University of Campinas Instituto de Geografía Universidad Nacional Autónoma de México (UNAM) Argentine institute of nivology Glaciology and Environmental Sciences(IANIGLA CONICET ) institute of Geography Pontificia Universidad Católica de Valparaíso Instituto de ciencias Agroalimentarias Animales y Ambientales (ICA3) Universidad de O'Higgins

Background Treeline ecotones of mediterranean ecoregions have been affected by the increasing intensity and severity of droughts. Even though the effect of droughts on forest dyn.mics has been widely documented, knowledge is relatively scarce of how extreme climate episodes affect the hydraulic structure and, therefore, the phys-iology of woody plants. The mediterranean Andes have experienced an uninterrupted period of drought since 2010, including an extremely dry year in 2019 with approximately 80% rainfall deficit. Here, we investigated shifts in wood anatomical and physiological traits of Kageneckia angustifolia, an endemic treeline species, in response to this drought *** We evaluated the xylem plasticity of three K. angustifolia populations across their natural distribution(31–35° SL) based on anatomical(vessel structure and distribution) and physiological(intrinsic water-use efficiency) variables in the tree rings. We focused on the period 2000–2020 that corresponds to before the megadrought(2000–2007),(ii) megadrought(2008–2018) and(iii) hyperdrought(2019–2020). The variables were annualized and analyzed by linear mixed-effects *** Our results provide insights to the anatomical and physiological mechanisms underlying the resilience of treeline forests to persistent droughts in central Chile. We found that the extreme drought in 2019–2020 triggered shifts in vessel size and frequency that increased hydraulic safety. These significant shifts in vessel traits occurred in parallel with a decrease in pit aperture area and an increase in water-use efficiency, further increasing the resilience of K. angustifolia to extreme drought *** Our results revealed coordinated shifts in vessel size and frequency and water-use efficiency in response to the megadrought, thereby reducing vulnerability to hydraulic failure. The apparent resilience of K. angustifolia to extreme droughts suggests that this adaptation to drought stress may incre

关键词： dendro-anatomy Kageneckia angustifolia Xylem vulnerability Drought Climate change

Geochemistry and mineralogy of beach sediments in the northern Gulf of mexico,Tamaulipas state,mexico:implication for provenance

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Journal of Palaeogeography 2024年第3期13卷 375-400页

作者： mayank Shukla Sanjeet K.Verma mayla A.Ramos-Vázquez John S.Armstrong-Altrin Karla R.Hernández-martínez Sumit mishra Vivek P.malviya Héctor Hernández-mendoza Posgrado de la Division de Geociencias Aplicadas Instituto Potosino de Investigacion Científica y Tecnologica(IPICYT)Camino a la Presa San José2055San Luis Potosí78216Mexico Division de Geociencias Aplicadas Instituto Potosino de Investigación Científica y Tecnologica(IPICYT)Camino a la Presa San Jose 2055San Luis Potosí78216Mexico Universidad nacional Auton.ma de méxico Instituto de Ciencias del Mar y LimnologíaUnidad de ProcesosOceanicos y CosterosCiudad UniversitariaCiudad de México 04510Mexico department of marine Sciences Bharathidasan UniversityTiruchirappalli620024Tamil NaduIndia Instituto de Geociencias Universidad Nacional Autonoma de MéxicoBoulevard Juriquilla 300176230JuriquillaQueretaroMexico department of Applied Geology Dr.Harisingh Gour Central UniversitySagar470002Madhya PradeshIndia Instituto de Investigacion de Zonas desérticas Universidad Autònoma de San Luis PotosíAltair 200CP 78377San LuisS.L.P.Mexico Universidad del Centro de mexico Capitán Caldera 75CP 78250San LuisS.L.P.Mexico

Geochemical and mineralogical studies were performed in the La Pesca(LP)and Tesoro Altamira(TA)beach sediments,located in the Tamaulipas state,northern Gulf of *** main aim of this study is to infer the weathering history and provenance and to discriminate the tectonic environment of the beach *** sediments are composed of quartz with small amounts of accessory minerals such as plagioclase,calcite,orthoclase,microcline,and *** beach sediments are classified as fine-grained and very well sorted,however LP has coarse skewed and leptokurtic sediments,whereas TA has fine-skewed and very leptokurtic *** chemical index of weathering(CIW’)indicates intense weathering in the source *** quartz grain.microtextures in the LP and TA are classified into mechanical,chemical,and mechanical/chemical *** features such as fractures,pits,percussion.marks,abrasion fatigue,and V-shaped marks favor high-energy littoral,fluvial,subaqueous-marine,and aeolian *** chemical features indicate solution pits and crystalline overgrowth,which suggests a silica saturated marine *** mechanical/chemical features display adhering particles and elongated depressions suggest formation in a sub-aqueous nearshore marine *** and trace elements-based provenance discrimination diagrams indicate a felsic source derived from the mesa Central(mC),Sierra madre Oriental(SmOr)and Oaxaquia *** major and trace element concentrations imply a passive margin setting for the northern Gulf of mexico,which is consistent with the general geology.

关键词： Beach sediments Geochemistry mineralogy Provenance Tamaulipas Tectonic setting

Environmental drivers of long-term variations in the abundance of the red hocicudo mouse (Oxymycterus rufus) in Pampas agroecosystems

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Integrative Zoology 2024年第1期19卷 37-51页

作者： Laura mariel CALFAyAn Regino CAVIA Jimena FRASCHInA Juan Santiago GUIDOBOnO Irene Laura GOROSITO maría BUSCH Laboratorio de Ecología de Poblaciones Departamento de EcologíaGenética y EvoluciónFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires and Instituto de EcologíaGenética y Evolución de Buenos Aires(IEGEBA)Buenos AiresArgentina

During the 20th century,there has been an ongoing agricultural expansion and global warming,two of the main determinants influencing biodiversity changes in *** red hocicudo mouse(Oxymycterus rufus)inhabits subtropical grasslands and riparian habitats and has increased its abundance in recent years in central Argentina *** paper describes the long-term temporal changes in *** abundance in Exaltación de la Cruz department,Buenos Aires province,Argentina,in relation to weatherfluctuations and landscape features,as well as analyzes the spatio-temporal structure of captures of *** used generalized liner models,semi-variograms,the mantel test,and autocorrelation functions for the analysis of rodent data obtained from trappings conducted between 1984 and *** showed an increase in abundance across the years of study,with its distribution depending on landscape features,such as habitat types and the distance *** rates showed a spatio-temporal aggregation,suggesting expansion from previously occupied *** was more abundant at lower min.mum temperatures in summer,higher precipitation in spring and summer,and lower precip-itations in *** conditions affected *** abundance,but there was local variation that differed from global patterns of climate change.

关键词： agroecosystems climate change linear habitats Oxymycterus rufus rodent