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Oxidative modification of the molecular chaperone family in a PC12 cell model of Parkinson's disease induced by Z-Ile-Glu(OtBu)-Ala-Leucinal

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Neural Regeneration Research 2011年第2期6卷 85-90页

作者： Ying Zhang Yimin Yang Jing Bai Ming Chang Linsen Hu department of Neurology First Hospital of Jilin University Changchun 130021 Jilin Province China department of icu First Hospital of Jilin University Changchun 130021 Jilin Province China

Previous studies have demonstrated that ubiquitin-proteasome system function is significantly decreased in the substantia nigra of Parkinson＇s disease patients. In the present study, proteasome inhibitor Z-Ile-Glu（OtBu）-Ala-Leucinal （PSI） was used to inhibit the function of the ubiquitin-proteasome system in PC12 cells to simulate Parkinson＇s disease. Oxidatively modified proteins were identified to determine pathogenesis of Parkinson＇s disease. Results demonstrated that 24 hours of 10 IJmol/L PSI-treatment in PC12 cells simulated pathological characteristics of Parkinson＇s disease： neuronal degeneration and eosinophilic inclusion formation in neurons. In PSI-treated PC12 cells, three oxidative proteins and a molecular chaperone family member were detected： chaperonin containing t-complex polypeptide 1 subunit 3, glucose-regulated protein 58, and heat shock protein 70. This is the first study to demonstrate oxidative modification of a molecule family in a cell model of Parkinson＇s disease induced with PSI.

关键词： molecular chaperones pathogenesis proteomics protein arbonylation Parkinson's disease ubiquitin-proteasome system

基于超声评估的膈肌指标在重症肺炎机械通气患者脱机中的应用

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医学影像学杂志 2024年第3期34卷 35-38页

作者：钟林汪敏张洁杭州医学院附属平湖医院平湖市第一人民医院ICU浙江嘉兴314200

目的评价基于超声评估的膈肌及其衍生指标在重症肺炎机械通气患者脱机拔管中的预测价值。方法选取收治的重症肺炎接受有创机械通气治疗的72例患者。所有患者均达到脱机标准,在通过自主呼吸试验(SBT)后给予脱机拔管,观察脱机48 h内患者... 详细信息

目的评价基于超声评估的膈肌及其衍生指标在重症肺炎机械通气患者脱机拔管中的预测价值。方法选取收治的重症肺炎接受有创机械通气治疗的72例患者。所有患者均达到脱机标准,在通过自主呼吸试验(SBT)后给予脱机拔管,观察脱机48 h内患者的呼吸、氧合等状态,并根据脱机结局分为脱机成功组和脱机失败组。比较两组患者的基本资料和脱机前的监测指标;与RSBI作对比,利用受试者工作特征曲线(ROC曲线)评价DD、DTF、D-RSBI三个指标对患者脱机成功的预测价值。结果脱机成功组机械通气时间(210.40±92.28)h、RR(15.62±3.34)次/min、DD(16.41±3.23)mm、DTF(32.98±7.03)%、D-RSBI(1.19±0.26)次/min·mm,脱机失败组机械通气时间(339.90±126.13)h、RR(18.43±4.86)次/min、DD(14.14±3.10)mm、DTF(24.00±5.53)%、D-RSBI(1.69±0.34)次/min·mm,差异有统计学意义(P<0.05)。利用ROC曲线,将尤登指数最大者作为最佳临界值,RSBI最佳临界值为60.69次(/min·L),AUCROC为0.79;DD最佳临界值为12.60 mm,AUCROC为0.70;DTF最佳临界值为30.00%,AUCROC为0.84;D-RSBI最佳临界值为1.36次/min·mm,AUCROC为0.87。其中D-RSB预测脱机成功ROC曲线下面积最大,预测价值最优。结论DD、DTF、DRSBI对重症肺炎机械通气脱机均有较好的预测价值,其中D-RSBI预测效果最佳。

关键词：超声检查膈肌重症肺炎机械通气脱机

三维干预模式在肝癌术后慢加急性肝衰竭患者中的应用效果

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癌症进展 2024年第7期22卷 775-778页

作者：王路卢瑞杰苏冰刘婉门翔南阳市中心医院感染icu 河南南阳4730000 南阳市中心医院呼吸内科河南南阳4730000

目的探讨三维干预模式在肝癌术后慢加急性肝衰竭(ACLF)患者中的应用效果。方法将106例肝癌术后ACLF患者按照干预模式的不同分为观察组(三维干预模式)57例和对照组(常规干预)49例。比较两组患者焦虑自评量表(SAS)、抑郁自评量表(SDS)、... 详细信息

目的探讨三维干预模式在肝癌术后慢加急性肝衰竭(ACLF)患者中的应用效果。方法将106例肝癌术后ACLF患者按照干预模式的不同分为观察组(三维干预模式)57例和对照组(常规干预)49例。比较两组患者焦虑自评量表(SAS)、抑郁自评量表(SDS)、生活质量综合评定问卷-74(GQOLI-74)、匹兹堡睡眠质量指数(PSQI)评分,并记录并发症发生情况。结果干预后,两组患者SAS、SDS评分均较干预前降低,且观察组患者SAS、SDS评分均低于对照组,差异均有统计学意义(P﹤0.05)。干预后,两组患者躯体功能、生理功能、社会功能、物质生活评分均较干预前升高,且观察组患者躯体功能、生理功能、社会功能、物质生活评分均高于对照组,差异均有统计学意义(P﹤0.05)。干预后,两组患者PSQI量表各维度评分均较干预前降低,且观察组患者PSQI量表各维度评分均低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者并发症总发生率低于对照组,差异有统计学意义(P﹤0.05)。结论将三维干预模式应用于肝癌术后ACLF患者中,可有效改善患者心理状况,提高睡眠质量与生活质量,且能有效降低相关并发症发生率,值得临床推广。

关键词：三维干预模式肝癌慢加急性肝衰竭

凝血功能紊乱在脓毒症心肌损伤发病机制中作用研究进展

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疑难病杂志 2024年第8期23卷 1002-1005,1010页

作者：廖夕茗(综述) 杨国辉(审校) 贵州医科大学贵阳550001 贵州医科大学附属医院内科icu

脓毒症是各种感染引起的宿主反应失调进而导致危及生命的器官功能障碍,全球发病率和病死率居高不下。脓毒症引起的心肌损伤(SIMI)是其最严重的并发症之一,其复杂的病理生理机制涉及过度炎性反应、氧化应激、线粒体损伤、细胞凋亡、细胞... 详细信息

脓毒症是各种感染引起的宿主反应失调进而导致危及生命的器官功能障碍,全球发病率和病死率居高不下。脓毒症引起的心肌损伤(SIMI)是其最严重的并发症之一,其复杂的病理生理机制涉及过度炎性反应、氧化应激、线粒体损伤、细胞凋亡、细胞自噬及凝血功能紊乱等。其中凝血功能紊乱在发病机制中具有重要作用,早期识别和治疗凝血功能紊乱,对改善患者心脏功能和预后至关重要。文章就凝血功能紊乱在SIMI中的角色作一综述,探讨其作为治疗新靶点的可能性,为临床提供参考。

关键词：脓毒症心肌损伤凝血功能紊乱发病机制

Change of MicroRNA-134,CREB and p-CREB expression in epileptic rat

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Asian Pacific Journal of Tropical Medicine 2015年第4期8卷 292-298页

作者： Yan Zhu Cheng-Shan Li Yuan-Ye Wang Sheng-Nian Zhou department of icu(Jining medical college affiliated hospital) department of Neurology Qilu Hospital of Shandong University Brain Science Research Institute Shandong University

Objective:To To investigate the changes of MicroRNA-134,CREB and p-CREB expression in epileptic rat brains in order to elucidate the molecular mechanisms of epilepsy,providing new ideas for clinical ***:Sixty-four Spraque-Dawley(SD)rats were divided into groups randomly,including control group,six hours after seizure group,24-hour group,threeday group,one-week group,two-week group,four-week group,and eight-week *** groups were placed under a pilocarpine-induced epilepsy model except the control group,and all rats were decapitated in different points of *** specimens were taken for quantitative PCR experiments,immunohistochemistry and Western blot *** results of the epilepsy model groups and the control group were ***:There were no significant differences between the six hours after seizure group,the 24-hour group and the control group about the MicroRNA-134 ***-134 in the hippocampus tissue of the three-day group significantly reduced compared with the control group;same result was observed with the one-week,two-week,four-week and eight-week *** CREB and p-CREB levels in the three-day group's rat hippocampus significantly increased compared with the control group;and the high levels of CREB and p-CREB were constantly maintained in the one-week,two-week,four-week and eight-week ***:The MicroRNA-134 level of the epileptic rat hippocampus is significantly lower than normal after three days,and continues to maintain a low level:while CREB and p-CREB levels are rsignificantly increased after three days,and continue to remain at a high ***-134 plays a role in inhibiting synaptic plasticity by inhibiting CREB and p-CREB expressions.

关键词： MicroRNA-134 CREB p-CREB Quantitative PCR Western blot Immunohistochemistry

The effect of high-flow oxygen via tracheostomy on respiratory pattern and diaphragmatic function in patients with prolonged mechanical ventilation:A randomized,physiological,crossover study

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Journal of Intensive Medicine 2024年第2期4卷 202-208页

作者： Elena Lytra Stelios Kokkoris Ioannis Poularas Dimitrios Filippiadis Demosthenes Cokkinos Dimitrios Exarhos Spyros Zakynthinos Christina Routsi 1st department of Intensive Care Medical SchoolNational and Kapodistrian University of AthensEvangelismos HospitalAthensGreece Radiology department Evangelismos HospitalAthensGreece 2nd Radiology department Medical SchoolNational and Kapodistrian University of AthensAttikon HospitalAthensGreece

Background Compared to conventional oxygen devices,high-flow oxygen treatment(HFOT)through the nasal cannulae has demonstrated clinical *** data exist on whether such effects are also present in HFOT through ***,we aimed to examine the short-term effects of HFOT through tracheostomy on diaphragmatic function and respiratory parameters in tracheostomized patients on prolonged mechanical *** A randomized,crossover,physiological study was conducted in our icu between December 2020 and April 2021,in patients with tracheostomy and prolonged mechanical *** patients underwent a 30-min spontaneous breathing trial(SBT)and received oxygen either via T-piece or by HFOT through tracheostomy,followed by a washout period of 15-min breathing through the T-piece and receipt of 30-min oxygen with the other modality in a randomized crossover *** the start and end of each session,blood gasses,breathing frequency(f),and tidal volume(VT)via a Wright's spirometer were measured,along with diaphragm ultrasonography including diaphragm excursion and diaphragmatic thickening fraction,which expressed the inspiratory muscle *** Eleven patients were enrolled in whom 19 sessions were uneventfully completed;eight patients were studied twice on two different days with alternate sessions;and three patients were studied *** were randomly assigned to start the SBT with a T-piece(n=10 sessions)or with HFOT(n=9 sessions).With HFOT,VT and minute ventilation(VE)significantly increased during SBT(from[465±119]mL to[549±134]mL,P<0.001 and from[12.4±4.3]L/min to[13.1±4.2]L/min,P<0.05,respectively),but they did not change significantly during SBT with T-piece(from[495±132]mL to[461±123]mL and from[12.8±4.4]mL to[12.0±4.4]mL,respectively);f/VT decreased during HFOT(from[64±31]breaths/(min∙L)to[49±24]breaths/(min∙L),P<0.001),but it did not change significantly during SBT with T-piece(from[59±28]breaths/(min∙L)to[64±33]breaths/(m

关键词： Diaphragm Diaphragm ultrasonography High-flow oxygen Prolonged mechanical ventilation Tracheostomy

Clinical practice guidelines for nutritional assessment and monitoring of adult icu patients in China

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Journal of Intensive Medicine 2024年第2期4卷 137-159页

作者： Xiangdong Guan Dechang Chen Yuan Xu Chinese Society of Critical Care Medicine department of Critical Care Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina department of Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Critical Care Medicine Beijing Tsinghua Changgung HospitalBeijingChina 不详

The Chinese Society of Critical Care Medicine(CSCCM)has developed clinical practice guidelines for nutrition assessment and monitoring for patients in adult intensive care units(icus)in *** guideline focuses on nutrition evaluation and metabolic monitoring to achieve optimal and personalized nutrition therapy for critically ill *** guideline was developed by experts in critical care medicine and evidence-based medicine methodology and was developed after a thorough review of the system and a summary of relevant trials or studies published from 2000 to July 2023.A total of 18 recommendations were formed and consensus was reached through discussions and reviews by expert groups in critical care medicine,parenteral and enteral nutrition,and *** recommendations are based on currently available evidence and cover several key fields,including screening and assessment,evaluation and assessment of enteral feeding intolerance,metabolic and nutritional measurement and monitoring during nutrition therapy,and organ function evaluation related to nutrition *** question was analyzed according to the Population,Intervention,Comparison,and Outcome(PICO)*** addition,interpretations were provided for four questions that did not reach a consensus but may have potential clinical and research *** plan is to update this nutrition assessment and monitoring guideline using the international guideline update method within 3–5 years.

关键词： Adults Critical illness Intensive care unit Nutriti on Nutriti on assessment and monitoring Guideline Recommendations Chinese Society of Critical Care Medicine-Chinese Medical Association(CSCCM-CMA)

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护士成长型思维能力现状及其影响因素研究

中国实用护理杂志 2024年第11期40卷 863-869页

作者：杨玉娇张艳艳彭鲁峰孙静娴高丽李丹杨欣欣薛友儒山东大学齐鲁医院东院区综合icu病区济南250101 山东大学齐鲁医院护理部济南250012

目的探究护士成长型思维能力现状并研究其相关影响因素,作为提高护士成长型思维能力的参考依据。方法使用便利抽样法于2022年4—6月选取山东省、上海市、广东省5家三级甲等医院的310名护士作为调查对象进行横断面调查。使用一般资料调... 详细信息

目的探究护士成长型思维能力现状并研究其相关影响因素,作为提高护士成长型思维能力的参考依据。方法使用便利抽样法于2022年4—6月选取山东省、上海市、广东省5家三级甲等医院的310名护士作为调查对象进行横断面调查。使用一般资料调查表、护士成长型思维评估量表、心理适应能力自测问卷、中国大五人格简版和团队心理安全气氛量表对护士成长型思维能力及其影响因素展开调查。结果回收有效问卷307份。男46名,女261名;年龄20~50岁。护士成长型思维评估量表得分(108.89±29.32)分,心理适应能力自测问卷得分为10.0(0.0,20.0)分,中国大五人格简版得分为(162.37±43.82)分,团队心理安全气氛量表得分为(55.84±15.12)分。最高学历(B=0.028,P=0.040)、职称(B=0.033,P=0.032)、家庭经济支持(B=0.025,P=0.048)、中国大五人格(B=0.039,P=0.037)、团队心理安全气氛(B=0.600,P<0.001)以及心理适应能力(B=0.313,P<0.001)对护士成长型思维能力有显著影响。结论护士成长型思维能力处于中等偏上水平,护士的学历、职称、家庭经济支持、人格特征、团队心理安全气氛和心理适应能力是其显著影响因素。医院、社会及卫生教育系统等可结合影响因素,为护士提供和谐的工作氛围,重点关注护士学历水平的提高和职称的晋升,培养护士的心理适应能力,提高护士成长型思维能力,提升护理服务团队的整体素质。

关键词：护士成长型思维影响因素

A retrospective analysis of carbapenem-resistant Acinetobacter baumannii infections in critically ill patients:Experience at a tertiary-care teaching hospital icu

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Journal of Intensive Medicine 2024年第2期4卷 181-186页

作者： Leyla Ferlicolak Neriman Defne Altintas Fugen Yoruk department of Internal Medicine Division of Intensive Care Unit Ankara University Faculty of MedicineAnkaraTurkey department of Infectious Diseases and Clinical Microbiology Ankara University Faculty of MedicineAnkaraTurkey

Background Acinetobacter baumannii is a clinically significant pathogen with a high incidence of multidrug resistance that is associated with life-threatening nosocomial ***,we aimed to provide an insight into the clinical characteristics and outcomes of a unique group of *** infections in which the isolates were resistant to carbapenems and most other antibiotic groups in a tertiary-care intensive care unit(icu).Methods We performed a retrospective observational study in which records of patients hospitalized in the icu between June 1,2021 and June 1,2023 were *** checked the clinical,laboratory,and microbiological records of all adult patients who had carbapenem-resistant ***(CRAB)*** antibiotic treatments and definitive antibiotic treatments after culture positivity and susceptibility test results were recorded.C-reactive protein(CRP)and procalcitonin levels and leukocyte counts were *** of icu stay and 30-day mortality were defined as the outcome *** During the study period,57 patients were diagnosed with CRAB *** respiratory tract was the leading infection site(80.7%).In non-survivors,bloodstream infections(21.9%vs.4.0%P=0.05)and colistin-resistant(col-R)CRAB infections(43.8%vs.24.0%,P=0.12)were more common than in survivors,but these parameters were not statistically *** length of icu stay was not different between survivors and ***,the rate of col-R among CRAB clinical isolates was 35.1%.The 30-day mortality in all patients with CRAB infection was 56.1%.Mortality in col-R CRAB and colistin-susceptible(col-S)CRAB infections was 70.0%and 48.6%,respectively(P=0.12).Prior carbapenem use was 56.1%.Prior colistin use before col-R and col-S CRAB infections was not significant(35.0%vs.27.0%,P=0.53).Conclusions Our study provides real-world data on highly resistant *** infections and shares the characteristics of infections with such resistant stra

关键词： Mortality Colistin-resi stant Gram-negative bacteria MDR Intensive care unit