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Retinal microvasculature is a potential biomarker for acute mountain sickness

Science China(Life Sciences) 2023年第6期66卷 1290-1302页

作者： Yuan Xie Diya Yang Alex S.Huang Yiquan Yang Ying Han Yunxiao Sun Kai Cao Huaizhou Wang Shizheng Wu Qiang Zhu Guozhong Wang Tianyi Wu Ningli Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing100730China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing100005China The Viterbi Family department of Ophthalmology Shiley Eye InstituteUniversity of CaliforniaSan DiegoCA92121USA department of Ophthalmology University of CaliforniaSan FranciscoCA94143USA Institution of Geriatric Qinghai Provincial Hospital Xining810007China department of Ultrasound Beijing Tongren HospitalCapital Medical UniversityBeijing100730China department of hyperbaric and hypobaric chamber Civil Aviation General HospitalBeijing100025China National Key Laboratory of High Altitude Medicine China High Altitude Medical Research InstituteXining810012China

Increased cerebral blood flow resulting from altered capillary level autoregulation at high altitudes leads to capillary overperfusion and then vasogenic cerebral edema,which is the leading hypothesis of acute mountain sickness(AMS).However,studies on cerebral blood flow in AMS have been mostly restricted to gross cerebrovascular endpoints as opposed to the *** study aimed to investigate ocular microcirculation alterations,the only visualized capillaries in the central neural system(CNS),during early-stage AMS using a hypobaric *** study found that after high altitude simulation,the optic nerve showed retinal nerve fiber layer thickening(P=0.004–0.018)in some locations,and the area of the optic nerve subarachnoid space(P=0.004)*** coherence tomography angiography(OCTA)showed increased retinal radial peripapillary capillary(RPC)flow density(P=0.003–0.046),particularly on the nasal side of the *** AMSpositive group had the largest increases in RPC flow density in the nasal sector(AMS-positive,?3.21±2.37;AMS-negative,?0.01±2.16,P=0.004).Among multiple ocular changes,OCTA increase in RPC flow density was associated with simulated early-stage AMS symptoms(beta=0.222,95%CI,0.009–0.435,P=0.042).The area under the receiver operating characteristics curve(AUC)for the changes in RPC flow density to predict early-stage AMS outcomes was 0.882(95%CI,0.746–0.998).The results further confirmed that overperfusion of microvascular beds is the key pathophysiologic change in early-stage *** OCTA endpoints may serve as a rapid,noninvasive potential biomarker for CNS microvascular changes and AMS development during risk assessment of individuals at high altitudes.

关键词： optical coherence tomography angiography retinal microvasculature acute mountain sickness

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Oral Epidemic Diseases of Exposure Personnel in Long-term Low Dose Radiation

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Chinese Medical Sciences Journal 2012年第3期27卷 188-189页

作者： Guang-wen Li Jun Wang Zong-ke Gao Zeng-qiang Zhao Yan Zhang Hui Li Yu-xing Wang Dong-ping Wang Jing Guo Gang Li department of Stomatology 537 Hospital of the People's Liberation ArmyBaoJiShaanxi 721006China department of Epidemiology Huaxi Public Health SchoolSichuan UniversityChengdu 610000China department of hyperbaric Oxygen chamber 451 Hospital of the People's Liberation ArmyXi'an 710000China department of Preventive Dentistry School of StomatologyFourth Military Medical UniversityXi'an 710032China

ORAL epidemic diseases of exposure personnel in long-term low-dose radiation yet have rarely been *** to WHO oral health survey method and symptom grading standard,data of 341 exposure persons in long-term low-dose radiation including o particle,β particle,and y rays,etc.,were collected from one camp in China in 2011 with cluster sampling and analyzed with Foxpro 6.0 and SPSS 16.0software.

关键词：低剂量辐射口腔流行病传染疾病评分标准 WHO

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Influence of hyperbaric oxygen on the differentiation of hypoxic/ischemic brainderived neural stem cells

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Neural Regeneration Research 2009年第7期4卷 492-496页

作者： Zhengrong Peng Sue Wang Pingtian Xiao department of hyperbaric Oxygen Xiangya Hospital Central South University Changsha 410008 Hunan Province China

BACKGROUND： It has been previously shown that hyperbaric oxygen may promote proliferation of neural stem cells and reduce death of endogenous neural stem cells （NSCs）. OBJECTIVE： To explore the effects of hyperbaric oxygen on the differentiation of hypoxic/ischemic brain-derived NSCs into neuron-like cells and compare with high-concentration oxygen and high pressure. DESIGN, TIME AND SETTING： An in vitro contrast study, performed at Laboratory of Neurology, Central South University between January and May 2006. MATERIALS： A hyperbaric oxygen chamber （YLC 0.5/1A） was provided by Wuhan Shipping Design Research Institute; mouse anti-rat microtubule-associated protein 2 monoclonal antibody by Jingmei Company, Beijing; mouse anti-rat glial fibrillary acidic protein monoclonal antibody by Neo Markers, USA; mouse anti-rat galactocerebroside monoclonal antibody by Santa Cruz Biotechnology Inc., USA; and goat anti-mouse fluorescein isothiocyanate-labeled secondary antibody by Wuhan Boster Bioengineering Co., Ltd., China. METHODS： Brain-derived NSCs isolated from brain tissues of neonatal Sprague Dawley rats were cloned and passaged, and assigned into five groups： normal control, model, high-concentration oxygen, high pressure, and hyperbaric oxygen groups. Cells in the four groups, excluding the normal control group, were incubated in serum-containing DMEM/F12 culture medium. Hypoxic/ischemic models of NSCs were established in an incubator comprising 93% N2, 5% 002, and 2% 02. Thereafter, cells were continuously cultured as follows： compressed air （0.2 MPa, 1 hour, once a day） in the high pressure group, compressed air ＋ a minimum of 80% 02 in the hyperbaric oxygen group, and a minimum of 80% Q2 in the high-concentration oxygen group. Cells in the normal control and model groups were cultured as normal. MAIN OUTCOME MEASURES： At day 7 after culture, glial fibrillary acidic protein, microtubule-associated protein 2, and galactocerebroside immunofluorescence staining

关键词： hyperbaric oxygen brain-derived neural stem cells differentiation hypoxic/ischemicmodel

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Inhibition of retinal angiogenesis by gold nanoparticles via inducing autophagy

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1269-1276页

作者： Ni Shen Rui Zhang Hao-Rui Zhang Hao-Yang Luo Wei Shen Xin Gao Da-Zhi Guo Jie Shen department of Ophthalmology Shanghai Renji HospitalShanghai Jiao Tong University School of Medicine department of Ophthalmology Changhai Hospitalthe Second Military Medical Univerisity Company 6 of Basic Medical School the Second Military Medical University School of Life Science Fudan University department of hyperbaric Oxygen Navy General Hospital

AIM： To investigate the effect of gold nanoparticles on retinal angiogenesis in vitro and in vivo, and to reveal the possible ***： Seed growth method was used to synthesize gold nanoparticles（GNPs）. The size, zeta potential, absorption spectrum and morphology of GNPs were identified using Malvern Nano-ZS, multimode reader（Bio Tek synergy2） and transmission electron microscope. Cell viability was analyzed using cell counting kit-8 method and cell growth was assessed with EdU kit. Transwell chamber was used to investigate cell migration. Tube formation method was used to assess the angiogenic property in vitro. Oxygen induced retinopathy（OIR） model was used to investigate the effect of GNPs on retinal angiogenesis. Confocal microscope and Western blot were used to study the possible mechanism of GNPs inhibited ***： The GNPs synthesized were uniform and well dispersed. GNPs of 10 μg/mL and 20 μg/mL were able to inhibit human umbilical vein endothelial cells proliferation（50% and 72% separately, P〈0.001）, migration（54% and 83% separately, P〈0.001） and tube formation（52% and 90% separately, P〈0.001）. Further data showed that GNPs were able to improve the retinopathy in an OIR model. The possible mechanism might be that GNPs were able to induce autophagy significantly（P〈0.05）.CONCLUSION： The present study suggests that GNPs are able to inhibit retinal neovascularization in vitro and in vivo. GNPs might be a potential nanomedicine for the treatment of retinal angiogenesis.

关键词： gold nanoparticles retinal angiogenesis oxygen induced retinopathy autophagy nanomedicine

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hyperbaric oxygen treatment for experimental intraocular hypertension in rats: An electroretinogram detection

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Neural Regeneration Research 2007年第1期2卷 62-64页

作者： Junhui Yi Zhengrong Peng Qiuli Liu Zhongqi Wu department of Ophthalmology Third Xiangya Hospital Central South University Changsha 410013 Hunan Province China department of hyperbaric Oxygen Xiangya Hospital Central South University Changsha 410000 Hunan Province China department of Anatomy Xiangya Hospital Central South University Changsha 410013 Hunan Province China

BACKGROUND： hyperbaric oxygen （HBO） is used for treating glaucoma, and affirmative curative effect has been obtained. HBO can sensitively reflect the obviously heightened b wave of electroretinogram （ERG） of injured tissue. OBJECTIVE： To observe the effect of HBO treatment on retinal function of rats with acute experimental intraocular hypertension with ERG. DESIGN： Randomized controlled experiment. SETTING： department of Ophthalmology, Third Xiangya Hospital, Central South University; department of hyperbaric Oxygen, Xiangya Hospital, Central South University; department of Anatomy, Xiangya Hospital, Central South University. MATERIALS： Eighteen adult healthy Wistar rats, of either gender, weighing from 150 to 250 g, were provided by the Animal Room of Central South University. Type YLCO. 5/I A baby hyperbaric oxygen chamber, type LMS-2A two-channel physiological recorder, type BG-1 retina exposure system, Jiangwan type Ⅰ stereotaxis instrument. METHODS： This experiment was carried out in the Central South University between March and September 2006. Eighteen healthy Wistar rats were made into models of acute experimental intraocular hypertension. Then, they were divided into two groups： model group and HBO treatment group, with 9 in each group. Following 7 days of HBO treatment, the rats in HBO treatment group were placed in Type YLCO. 5/I A baby hyperbaric oxygen chamber, which was pressurized with pure oxygen（ volume fraction 0.825 ± 0.025）.The treatment pressure was 0.2 MPa. The rats in HBO treatment group daily inhaled HBO for 80 minutes within 7 days; Rats in the model group were untouched. The performance of eyes was observed under the status of intraocular hypertension. ERG was recorded before, during and 7 days after modeling, meanwhile, the recovery rate of b wave from ERG was calculated. Recovery rate of b wave from ERG=（amplitude orb wave 7 days after modeling/amplitude orb wave before modeling）× 100%. MAIN OUTCOME MEASURES： ①Performance of eyes under t

关键词： hyperbaric oxygenation ocular hypertension electroretinography

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Changes of plasma C-reactive protein in patients with craniocerebral injury before and after hyperbaric oxygenation: A randomly controlled study

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Neural Regeneration Research 2007年第5期2卷 314-317页

作者： Zeyu Xie Minghua Zhuang Lan Lin Hongwu Xu Linxing Chen Lina Hu department of Neurosurgery Second Affiliated Hospital Medical College of Shantou University Shantou 515041 Guangdong ProvinceChina department of Laboratory Second Affiliated Hospital Medical College of Shantou University Shantou 515041 Guangdong ProvinceChina department of hyperbaric Oxygen Second Affifiated Hospital Medical College of Shantou University Shantou 515041 Guangdong Province China

Changes of plasma C-reactive protein in patients with craniocerebral injury before and after hyperbaric oxygenation： A randomly controlled study BACKGROUND： Plasma inflammatory factor, such as C-reactive protein, whose content is regarded as a sensitively pathological marked protein and quantitative indexes of central nervous system injury, has been paid more and more attention in clinic. OBJECTIVE： To observe the effects and clinical significance of C-reactive protein in patients with craniocerebral injury after hyperbaric oxygenation. DESIGN： Randomized controlled study. SETTING： departments of Neurosurgery, Laboratory and hyperbaric Oxygen, the Second Affiliated Hospital, Medical College of Shantou University. PARTICIPANTS： A total of 60 patients with craniocerebral injury were selected from department of Neurosurgery, the Second Affiliated Hospital, Medical College of Shantou University from October 2006 to April 2007. There were 37 males and 23 females and the mean age was 26 years. All subjects were certainly diagnosed as history of craniocerebral injury. Patients hospitalized at 24 hours after injury, Glasgow Coma Score ranged from 3 to 12 points, and all patients were certainly diagnosed with CT or MR scanning. Patients and their relatives provided confirmed consent. All the subjects were randomly divided into hyperbaric oxygenation group and control group with 30 in each group. METHODS： Patients in the control group were treated with routinely neurosurgical therapy after hospitalization; however, based the same basic treatment in the control group, patients in the hyperbaric oxygenation group received hyperbaric oxygenation by using iced-wheel four-door 2-cabin air-compression chamber （made in Yantai） from 24 hours to 10 days after operation or injury. After entering the cabin, patients who had a clear consciousness breathed the oxygen by using face mask; contrarily, patients directly breathed the oxygen. Therapeutic project： Expression was increas

关键词： craniocerebral trauma hyperbaric oxygenation C-reactive protein Glasgow Coma Scale

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hypobaric hypoxia preconditioning attenuates acute lung injury during high-altitude exposure in rats via up-regulating heat-shock protein 70

Hypobaric hypoxia preconditioning attenuates acute lung inju...

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第八届海峡两岸心血管科学研讨会

作者：林宏荣王嘉地牛柯琪林茂村黄戊田许淑芬张菁萍 department of Emergency Medicine Chi Mei Medical Center department of Biotechnology Southern Taiwan University department of hyperbaric Oxygen Chi Mei Medical Center department of Medical Research Chi Mei medical Center department of Recreation and Health-Care Management Chia-Nan University of Pharmacy and Science department of Physical Therapy Shu-Zen College of Medicine and Management

＜正＞Objective HHP（hypobaric hypoxia preconditioning） induces the overexpression of HSP70（heat -shock protein 70）,as well as tolerance to cerebral *** the present study,we hypothesized that HHP would protect against HAE（high - altitude exposure） - induced acute lung injury and edema via promoting the expression of HSP70 in lungs prior to the onset of *** At 2 weeks after the start of HHP, animals were exposed to a simulated HAE of 6000 m in a hypobaric chamber for 24 *** after being returned to ambient pressure,the non - HHP animals had higher scores of alveolar edema,neutrophil infiltration and hemorrhage,acute pleurisy（*** exudate volume,increased numbers of polymorphonuclear cells and increased lung myeloperoxidase activity）,increased pro - inflammatory cytokines[*** -α（tumor necrosis factor -α）,IL（interleukin） - 1 β and IL - 6],and increased cellular ischemia（*** and lactate/ pyruvate ratio） and oxidative damage[glycerol,NOx（combined nitrate + nitrite） and 2,3 - dihydroxybenzoic acid]markers in the BALF（bronchoalveolar fluid）.Results HHP,in addition to inducing overexpression of HSP70 in the lungs,significantly attenuated HAE - induced pulmonary edema,inflammation, and ischemic and oxidative damage in the *** beneficial effects of HHP in preventing the occurrence of HAE - induced pulmonary edema,inflammation,and ischemic and oxidative damage was reduced significantly by pretreatment with a neutralizing anti - HSP70 *** In conclusion,HHP may attenuate the occurrence of pulmonary edema,inflammation,and ischemic and oxidative damage caused by HAE in part via up - regulating HSP70 in the lungs.

关键词： hypobaric hypoxia preconditioning heat-shock protein 70 acute lung injury

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Impairment of Autophagic Flux After hypobaric Hypoxia Potentiates Oxidative Stress and Cognitive Function Disturbances in Mice

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Neuroscience Bulletin 2024年第1期40卷 35-49页

作者： Shuhui Dai Yuan Feng Chuanhao Lu Hongchen Zhang Wenke Ma Wenyu Xie Xiuquan Wu Peng Luo Lei Zhang Fei Fei Zhou Fei Xia Li department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi'an 710000China National Translational Science Center for Molecular Medicine and department of Cell Biology Fourth Military Medical UniversityXi'an 710000China department of Neurosurgery The Central Hospital of BaojiBaoji 721000China department of Ophthalmology Xijing HospitalFourth Military Medical UniversityXi'an 710000China

Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude *** plays a critical role in ischemic brain injury,but its role in hypo-baric hypoxia(HH)remains *** we used an HH chamber to demonstrate that acute HH exposure impairs autophagic activity in both the early and late stages of the mouse brain,and is partially responsible for HH-induced oxidative stress,neuronal loss,and brain *** autophagic agonist rapamycin only promotes the initiation of *** proteome analysis,a screen showed that protein dynamin2(DNM2)potentially regulates autophagic *** of DNM2 significantly increased the formation of autolysosomes,thus maintaining autophagic flux in combination with ***,the enhancement of autophagic activity attenuated oxidative stress and neurological deficits after HH *** results contribute to evidence supporting the conclusion that DNM2-mediated autophagic flux represents a new therapeutic target in HH-induced brain damage.

关键词： Autophagy-Proteomics Oxidative stress hypobaric hypoxia-Brain injury

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Antioxidant activity and potential ameliorating effective ingredients for high altitude-induced fatigue from Gansu Maxianhao(Pedicularis Kansuensis Maxim.)

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Journal of Traditional Chinese Medicine 2020年第1期40卷 83-93页

作者： Yu Lijun Cao Xinyuan Tao Wendi Li Maoxing Li Xiaolin Chen Liping department of Pharmacy Gansu People Hospital of PLALanzhou 730000China department of Pharmacy The 940th Hospital of Joint Logistic Support Force of PLA&Key Laboratory of the Prevention and Cure for the Plateau Environment Damage of PLALanzhou 730050China department of Pharmacy Lanzhou UniversityLanzhou 730000China department of Pharmacy Gansu University of Chinese MedicineLanzhou 730000China Gansu University of Chinese Medicine Lanzhou 730000China

OBJECTIVE:To investigate the antioxidant property and potential ameliorating effective ingredients for high altitude-induced fatigue from Gansu Maxianhao(Pedicularis Kansuensis Maxim.).METHODS:Macroporous adsorptive resin combined with polyamide chromatographic column was used to obtain water extract(P1),high polar part(P2),iridoid glycosides part(P3)and phenylethanoid glycosides part(P4)of Gansu Maxianhao(Pedicularis Kansuensis Maxim.).Antioxidant activity of each part was investigated employing a series of in vitro ***-eosin staining,analysis of blood biochemical parameters,along with molecular analyses examining oxidative stress makers,metabolite,metabolic enzyme and energy substance in liver,skeletal muscle and/or serum were further ***:The results showed phenylethanoid glycosides(Ph Gs)exhibited more effective with 1,1-diphenyl-2-picrylhydrazyl radical scavenging ability,2-2-Azinbis(3-ehtylbenzothiazolin-6-sulfnic Acid)Diammonium Salt+scavenging activity,hydroxyl radical scavenging activity,reducing ability and antioxidant activity to varying *** a hypobaric hypoxia attack in a hypobaric chamber(8000 m,7 consecutive days),Ph Gs was administered to BALB/C mice at doses of 50,200,400 mg/kg and antifatigue property was evaluated using a swimming test at an altitude of 4000 *** results showed that Ph Gs of Gansu Maxianhao(Pedicularis Kansuensis Maxim.)could significantly prolong the burden swimming time of mice,reduce the hypoxia-induced oxidative stress,remove the accumulated products of metabolism,improve the energy metabolism as well as improve preservation of endogenous glycogen ***:The ameliorating effect against altitude-induced fatigue of Ph Gs from Gansu Maxianhao(Pedicularis Kansuensis Maxim.)might come from the alleviation of oxidative stress,reduction of the adverse metabolic products,normalizing energy metabolism and increasing energy substances *** Gs is a potential antioxidant and novel rem

关键词： Pedicularis Glycosides Antioxidants Fatigue Hypoxia

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Observation on promoting resuscitation in the patients with coma of acute carbon monoxide poisoning by acupuncture combined with hyperbaric oxygen

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World Journal of Acupuncture-Moxibustion 2019年第2期29卷 103-107页

作者： Mao-li LUO Hui-jie LI Liang-ce MA Yuan JIANG Emergency department Dazhou Central Hospital Dazhou 635000 Sichuan Povince China department of Rehabilitation Medicine The First Affiliated Hospital of Chengdu Medical College Chengdu 610500 Sichuan Povince China

Objective:To evaluate the effect of promoting resuscitation and the effect differences between acupuncture combined with hyperbaric oxygen therapy(HBOT)and simple HBOT in the patients with coma of acute carbon monoxide poisoning(ACMP).Methods:A total of 36 patients with ACMP coma were randomized into a simple HBOT group and acupuncture combined with HBOT group,18 cases in each *** the simple HBOT group,HBOT was provided once a day for 2 *** the acupuncture combined with HBOT group,acupuncture was provided during *** acupuncture was given before the patients were sent to the hyperbaric oxygen chamber and the needles were retained until the hyperbaric oxygen treatment was *** acupoints included B?ihuì(百会 GV 20),Shuǐgōu(水沟 GV 26),Sìshéncōng(四神聪 EX-HN1),Fēngchí(风池 GB20),Hégǔ(合谷 LI 4),Tàichōng(太冲 LR 3)and Yǒngquán(涌泉 KI 1).The needles were retained through the entire process of *** combined treatment was given once a day for 2 *** the treatment,the score of Glasgow Coma Scale(GCS)was recorded,the levels of serum interleukin-6(IL-6),interleukin-8(IL-8)and brain-derived growth factor(BDNF)were tested and the time from unconsciousness to resuscitation was recorded of the two *** treatment,the levels of serum IL-6,IL-8 and BDNF were tested again and the clinical therapeutic effects were ***:At last,there were 16 cases in the simple HBOT group and 17 cases in acupuncture combined with HBOT group got *** time from unconsciousness to resuscitation was(5.17±1.10)h in the acupuncture combined with HBOT group,which was less than(6.83±2.73)h in the simple HBOT group,indicating the significant difference in statistic(P<0.05).After treatment,the total effective rate was 94.4% in the acupuncture combined with HBOT group,which was higher than 88.9% in the simple HBOT group,indicating the significant difference in statistic(P<0.05).After treatment,the levels of serum IL-6 and IL-8 were(29.72±3.49)and(67.17±7.61)p

关键词： Acupuncture hyperbaric oxygen Acute carbon monoxide coma Cytokines Serum brain-derived growth factor

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