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Design and aligner-assisted fast fabrication of a microfluidic platform for quasi-3D cell studies on an elastic polymer

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Bioactive Materials 2022年第9期7卷 288-304页

作者： Yingning He Yue Yu Yuqian Yang Yexin Gu Tianjiao Mao Yang Shen Qiong Liu Ruili Liu Jiandong Ding State Key Laboratory of Molecular engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai200434China

While most studies of mechanical stimulation of cells are focused on two-dimensional(2D)and three-dimensional(3D)systems,it is rare to study the effects of cyclic stretching on cells under a quasi-3D microenvironment as a linkage between 2D and ***,we report a new method to prepare an elastic membrane with topographic microstructures and integrate the membrane into a microfluidic *** fabrication difficulty lay not only in the preparation of microstructures but also in the alignment and bonding of the patterned membrane to other *** resolve the problem,we designed and assembled a fast aligner that is cost-effective and convenient to *** enable quasi-3D microenvironment of cells,we fabricated polydimethylsiloxane(PDMS)microwell arrays(formed by micropillars of a few microns in diameter)with the microwell diameters close to the cell *** appropriate plasma treatment was found to afford a coating-free approach to enable cell adhesion on *** examined three types of cells in 2D,quasi-3D,and 3D microenvironments;the cell adhesion results showed that quasi-3D cells behaved between 2D and 3D *** also constructed transgenic human mesenchymal stem cells(hMSCs);under cyclic stretching,the visualizable live hMSCs in microwells were found to orientate differently from in a 3D Matrigel matrix and migrate differently from on a 2D flat *** study not only provides valuable tools for microfabrication of a microfluidic device for cell studies,but also inspires further studies of the topological effects of biomaterials on cells.

关键词： Microfluidic chip Biomaterials Cell-material interaction Polymer Cell stretching

Ultra-high speed holographic shape and displacement measurements in the hearing sciences

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Light(Advanced Manufacturing) 2022年第2期3卷 1-14页

作者： Haimi Tang Pavel Psota John J.Rosowski Cosme Furlong Jeffrey Tao Cheng Center for Holographic Studies and Laser micro-mechaTronics Worcester Polytechnic InstituteWorcesterMA USA01609 mechanical engineering department Worcester Polytechnic InstituteWorcesterMA USA01609 Faculty of Mechatronics Informatics and Interdisciplinary StudiesTechnical University of LiberecLiberecCzech Republic46117 Eaton-Peabody Laboratory Massachusetts Eye and EarBostonMA USA02114 department of Otolaryngology-Head and Neck Surgery Harvard Medical SchoolBostonMAUSA02115

The auditory system of mammals enables the perception of sound from our surrounding *** some of the smallest bones in the body,the ear transduces complex acoustic signals with high-temporal sensitivity to complex mechanical vibrations with magnitudes as small as tens of *** of the shape and acoustically induced motions of different components of the ear are essential if we are to expand our understanding of hearing mechanisms,and also provide quantitative information for the development of numerical ear models that can be used to improve hearing protection,clinical diagnosis,and repair of damaged or diseased *** are developing digital holographic methods and instrumentation using an ultra-high speed camera to measure shape and acoustically-induced motions in the middle *** we study the eardrum,the first structure of the middle ear which initializes the acoustic-mechanical transduction of sound for *** measurement system is capable of performing holographic measurement at rates up to 2.1 M frames per *** shape measurement modalities had previously been implemented into our holographic systems:(1)a multi-wavelength method with a wavelength tunable laser;and(2)a multi-angle illumination method with a single wavelength *** this paper,we present a third method using a miniaturized fringe projection system with a microelectromechanical system(MEMS)***,we optimize the processing of large data sets of holographic displacement measurements using a vectorized Pearson's correlation *** validate and compare the shape and displacement measurements of our methodologies using a National Institute of Standards and Technology(NIST)traceable gauge and sound-activated latex membranes and human eardrums.

关键词： Ultra-high speed digital holography Microelectromechanical systems(MEMS) Miniaturized Fringe Projection Middle-ear mechanics Shape and displacement measurements.

Printed elastic membranes for multimodal pacing and recording of human stem-cell-derived cardiomyocytes

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npj Flexible Electronics 2020年第1期4卷 109-116页

作者： Markos Athanasiadis Dzmitry Afanasenkau Wouter Derks Christoph Tondera Francesca Murganti Volker Busskamp Olaf Bergmann Ivan R.Minev Biotechnology Center(BIOTEC) Center for Molecular and Cellular Bioengineering(CMCB)Technische Universität Dresden01307 DresdenGermany Center for Regenerative Therapies Dresden(CRTD) Center for Molecular and Cellular Bioengineering(CMCB)Technische Universität Dresden01307 DresdenGermany department of Cell and Molecular Biology Karolinska InstitutetSE-17177 StockholmSweden Present address:Universitätsklinikum Bonn University of BonnBonnGermany Present address:department of Automatic Control and systems engineering University of SheffieldMappin StreetSheffield S13JDUK These authors contributed equally:Markos Athanasiadis Dzmitry AfanasenkauWouter Derks

Bioelectronic interfaces employing arrays of sensors and bioactuators are promising tools for the study,repair and engineering of cardiac *** are typically constructed from rigid and brittle materials processed in a cleanroom *** outstanding technological challenge is the integration of soft materials enabling a closer match to the mechanical properties of biological cells and *** we present an algorithm for direct writing of elastic membranes with embedded electrodes,optical waveguides and microfluidics using a commercial 3D printing system and a palette of silicone *** proof of principle,we demonstrate interfacing of cardiomyocytes derived from human induced pluripotent stem cells(hiPSCs),which are engineered to express *** demonstrate electrical recording of cardiomyocyte field potentials and their concomitant modulation by optical and pharmacological stimulation delivered via the *** work contributes a simple prototyping strategy with potential applications in organ-on-chip or implantable systems that are multi-modal and mechanically soft.

关键词： recording modal closer

Preface:Security and safety in unmanned systems

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Security and Safety 2023年第4期2卷 4-5页

作者： Jian Sun Youmin Zhang Hong Chen Mou Chen Qinglei Hu School of Automation Beijing Institute of TechnologyBeijing 100081China department of mechanical Industrial and Aerospace engineering Concordia UniversityQuebec H3G 1M8Canada College of Electronic and Information engineering Shanghai 201804China College of Automation engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Automation Science and Electrical engineering Beihang UniversityBeijing 100191China

An unmanned system is defined as an electro-mechanical system capable of exerting its power to perform designated missions with no human operator *** to the development of digital design(artificial intelligence,control,etc.)and robotics in recent years,unmanned systems are making a revolution as an emerging technology with many different applications in the military,civilian,and commercial fields such as autonomous driving,medicine and healthcare,deep space exploration,and national security and defense.

关键词： system driving autonomous

HEMODYNAMIC SIMULATION FOR THE EVALUATION OF VASCULAR SURGICAL TREATMENT USING WASEDA mechanical CIRCULATORY SIMULATOR

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HEMODYNAMIC SIMULATION FOR THE EVALUATION OF VASCULAR SURGIC...

新型杂化金属硫氰化物压电体用于能量收集和动作传感

亚州仿真会议暨第五届系统仿真和科学计算国际会议

作者： Yasuyuki Shiraishi Toshiaki Watanabe Yuji Saito Hidetaka Aoki Tetsuo Fujimoto Mitsuo Umezu Health Sciences and engineering Institute Waseda University Tokyo 169-8555 JAPAN Integrative Bioscience and Biomedical engineering Graduate School of Science and Engineering Waseda University Tokyo 169-8555 JAPAN Integrative Bioscience and Biomedical engineering Graduate School of Science and Engineering Waseda University Tokyo 169-8555 JAPAN Integrative Bioscience and Biomedical engineering Graduate School of Science and Engineering Waseda University department of mechanical engineering Shibaura Institute of Technology Tokyo 108-8548 JAPAN Integrative Bioscience and Biomedical engineering Graduate School of Science and Engineering Waseda University Tokyo 169-8555 JAPAN

Aging becomes a serious problem worldwide because of the progress of medical technology as well as social welfare. In human cardiovascular systems, histological changes in the structure of the bloo

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Science China Materials 2023年第5期66卷 1854-1860页

作者：赵盈安连财李凯龚勇吉郭甜梦高飞飞雷阳李泉文李伟卜显和 School of Materials Science and engineering Smart Sensing Interdisciplinary Science CenterNankai University&TKL of Metal and Molecule Based Material ChemistryTianjin 300350China department of Chemistry and Chemical engineering Jinzhong UniversityJinzhong 030619China College of Materials and Metallurgy Guizhou UniversityGuiyang 550025China

杂化有机-无机压电材料因其电光性能优异、合成简单以及机械柔性等优点而受到广泛关注,在能源和传感领域显示出巨大的应用潜力.本文合成了一例新的零维杂化压电材料[Me-V]_(3)Mn(SCN)_(5),并与聚己二酸丁二酯对苯二甲酸丁二酯复合成膜... 详细信息

杂化有机-无机压电材料因其电光性能优异、合成简单以及机械柔性等优点而受到广泛关注,在能源和传感领域显示出巨大的应用潜力.本文合成了一例新的零维杂化压电材料[Me-V]_(3)Mn(SCN)_(5),并与聚己二酸丁二酯对苯二甲酸丁二酯复合成膜制备了用于机械能收集的压电器件.实验结果表明,15 wt%组分的压电器件具有优异的能量收集性能,在仅0.03 MPa作用力下,可产生18.49 V的最大输出电压和7.88μW cm^(-2)的功率密度.同时,该器件在循环5500圈及60天内仍保持优异的压电性能.此外,该器件在包括手指敲击、手腕/肘部弯曲和踩踏等动作传感方面表现出良好的敏感性.这项工作证明了无铅无卤的杂化压电材料在柔性传感和能量收集方面具有巨大的应用潜力.

关键词： hybrid organic-inorganic piezoelectrics energy harvesting human motion sensing

Robust and Flexible Multimaterial Aerogel Fabric Toward Outdoor Passive Heating

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Advanced Fiber Materials 2022年第6期4卷 1545-1555页

作者： Jiawei Wu Manni Zhang Minyu Su Yuqi Zhang Jun Liang Shaoning Zeng Baishun Chen Li Cui Chong Hou Guangming Tao Wuhan National Laboratory for Optoelectronics and State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China School of Optics and Electronic Information Huazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China department of Textile Garment and DesignChangshu Institute of TechnologySuzhou 215500JiangsuPeople’s Republic of China College of Materials and Textile engineering Jiaxing UniversityJiaxing 314001ZhejiangPeople’s Republic of China

Outdoor passive heating to maintain a constant human body temperature is critical for human ***,most traditional energy-exhausted heating systems and inefficient passive heating technologies are incapable of dealing with the cold outdoor *** fabrics with low thermal radiation and conduction to passively heat the human body is a viable way to overcome the constraints of existing passive heating ***,a multimaterial aerogel fabric was developed to realize passive personal heating without any energy *** multimaterial aerogel fabric was fabricated by coating an Ag layer on an aerogel composite *** lightweight aerogel composite fabric,woven from aerogel composite fibers with multi-scale porous structure,exhibits excellent thermal insulation,self-cleaning,mechanical and thermal ***,by coating with an Ag layer,the multimaterial aerogel fabric exhibits both low thermal conductivity and low infrared emissivity at 7–14μm,demonstrating superior thermal insulating *** a result,the proposed multimaterial aerogel fabric with a thickness of only 1.29 mm is capable of improving the human body temperarure of 5.7℃ in a cold environment without energy *** strategy offers a potential energy-saving alternative for future outdoor passive heating.

关键词： Outdoor passive heating Aerogel fabric Thermal insulation Porous structure

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南方地板辐射供暖的舒适性地板温度范围

科学通报 2021年第19期66卷 2476-2485页

作者：吴语欣刘红李百战卢星宇陈露 Kosonen Risto 浙江理工大学建筑工程学院杭州310018 重庆大学绿色建筑与人居环境营造国际合作联合实验室(教育部)重庆400045 department of mechanical engineering Aalto UniversityEspoo 02150Finland

地板辐射供暖系统应用数量在我国南方地区日益增长,但人们对如何设定适宜的地板温度范围存在一定的疑惑.本文通过标准解读、文献调研和实地人体实验,对舒适性地板温度范围进行了研究.文献总结表明,东亚地区人群偏好的地板温度普遍高于... 详细信息

地板辐射供暖系统应用数量在我国南方地区日益增长,但人们对如何设定适宜的地板温度范围存在一定的疑惑.本文通过标准解读、文献调研和实地人体实验,对舒适性地板温度范围进行了研究.文献总结表明,东亚地区人群偏好的地板温度普遍高于现有标准推荐值(约25~29℃).在重庆某住宅中,招募了45名当地受试者,对25~35℃的6个不同地板温度进行了问卷投票人体实验研究.结果表明,夏热冬冷地区人们偏好较高的地板温度.长期停留时,中性地板温度约为28℃,但热舒适性地板温度约为29~32℃,期望的地板温度在32℃左右;而短暂停留时,期望的地板温度在33~35℃.因此,针对夏热冬冷地区的分散式地板辐射供暖系统,建议将经常停留和短暂停留区域的地板设计温度上限值分别提高到32和34℃.

关键词：地板辐射供暖冬季地板温度热舒适夏热冬冷地区

Dynamic Analysis of Steel Platforms When Subjected to mechanical Equipment-Induced Vibrations

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Journal of Civil engineering and Architecture 2016年第10期10卷 1103-1113页

作者： Jose Guilherme S. da Silva Ana Cristina C. F. Sieir~ Luis A. P. Simoes da Silva Bruno D. Rimola Structural engineering department (ESTR) State University of Rio de Janeiro (UERJ) Rio de Janeiro 20550-900 Brazil Civil engineering Post-graduate Programme (PGECIV) State University of Rio de Janeiro (UERJ) Rio de Janeiro 20550-900Brazil Civil engineering department University of Coimbra Coimbra 3030-788 Portugal

The competitive trends of the world market have long been forcing structural engineers to develop minimum weight and labour cost solutions. A direct consequence of this new design trend has been a considerable increase in problems related to undesired floor vibrations. For this reason, structural floor systems can become vulnerable to excessive vibrations that are produced by, for example, impacts due to mechanical equipment （e.g., rotating machinery）. This study investigates the dynamic behaviour of a production platform constructed of steel and located in the Santos Basin （Merluza field）, Sao Paulo/SP, Brazil, when subjected to impacts produced by mechanical equipment （rotating machinery）. The structural model consists of two steel decks with a total area of 1,915 m^2 （upper deck： 445 m^2, lower deck： 1,470 m^2） and supported by piles. A numerical analysis is performed to assess the dynamic impacts on the deck structure originating from the electrical generators and compressors. Based on the peak acceleration values obtained for the structure steady-state response, it is possible to evaluate the structural model performance in terms of human comfort, the maximum tolerances of the mechanical equipment and the vibration serviceability limit states of the structure.

关键词： Dynamic analysis steel structures production platforms human comfort structural behaviour computational modelling