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Factors associated with diabetic retinopathy screening and regular eye checkup practice among diabetic patients attending Felege Hiwot Specialized Hospital

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1829-1836页

作者： Sofonias Addis Fekadu Mohamed Abdu Seid Yonas Akalu Yibeltal Yismaw Gela Mengistie Diress Mihret Getnet Baye Dagnew Yitayeh Belsti department of Optometry College of Medicine and Health SciencesUniversity of GondarGondar P.O.BOX 196Ethiopia Unit of human Physiology Department of Biomedical ScienceCollege of Health SciencesDebre Tabor UniversityDebre Tabor P.O.BOX 272Ethiopia department of human Physiology School of MedicineCollege of Medicine and Health SciencesUniversity of GondarGondar P.O.BOX 196Ethiopia

AIM: To identify associated factors of diabetic retinopathy(DR) screening and ey e check-up practice among diabetes mellitus(DM) patients attending Felege Hiwot Specialized ***: An institution-based cross-sectional study was applied from October 4, 2019 to January 12, 2020 at Felege Hiwot Specialized Hospital. A systematic random sampling technique was used to recruit participants and an interviewer-administered questionnaire was employed to collect the data. The collected data were entered into Epi Info version 7 and transposed to SPSS version 24 for statistical analysis. Descriptive statistics were executed and associated factors were identified using binary logistic regression. The strength of association between the independent and the outcome variable was determined using an adjusted odds ratio(AOR) with 95% confidence interval(CI). RESULTS: Four hundred and six participants partake with a response rate of 95.7% and a mean age of 47±11.5y. The magnitude of DR screening was 308(75.9%, 95%CI: 71.5%, 79.8%). Higher educational level(AOR=3.25;95%CI: 1.40, 8.78), good knowledge of DR(AOR=2.50;95%CI: 1.55, 4.46), and family history of DM(AOR=2.15;95%CI: 1.41,3.85) were significantly associated with DR screening. On the other side, rural residence [AOR=3.11(1.89, 5.02)] and undesirable attitudes toward DR [AOR=5.65(3.14, 8.76)] were significantly associated with poor regular eye checkup ***: Most of the participants are screened for DR. Higher education, family history, and good knowledge are associated with DR screening. In addition, rural residence and undesirable attitudes toward DR are associated with regular eye checkup practice.

关键词： diabetic retinopathy eye checkup eye screening diabetes mellitus Ethiopia

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The compelling link between physical activity and the body's defense system

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Journal of Sport and health Science 2019年第3期8卷 201-217页

作者： David C.Nieman Laurel M.Wentz human Performance Laboratory Appalachian State University North Carolina Research Campus department of Nutrition and health Care Management Appalachian State University

This review summarizes research discoveries within 4 areas of exercise immunology that have received the most attention from investigators :(1) acute and chronic effects of exercise on the immune system,(2) clinical benefits of the exercise—immune relationship,(3) nutritional influen?ces on the immune response to exercise, and(4) the effect of exercise on immunosenescence. These scientific discoveries can be organized into distinctive time periods: 1900-1979, which focused on exercise-induced changes in basic immune cell counts and function; 1980-1989, during which seminal papers were published with evidence that heavy exertion was associated with transient immune dysfunction, elevated inflammatory biomarkers,and increased risk of upper respiratory tract infections; 1990-2009, when additional focus areas were added to the field of exercise immunology including the interactive effect of nutrition, effects on the aging immune system, and inflammatory cytokines; and 2010 to the present, when technological advances in mass spectrometry allowed system biology approaches(i.e., metabolomics, proteomics, lipidomics, and microbiome characterization) to be applied to exercise immunology studies. The future of exercise irmmunology will take advantage of these technologies to provide new insights on the interactions between exercise, nutrition, and immune function, with application down to the person?alized level. Additionally, these methodologies will improve mechanistic understanding of how exercise-induced immune perturbations reduce the risk of common chronic diseases.

关键词： Aging Exercise Immunology Infection Inflammation Mass Snectrometry Nutrition

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The effect of fitness level on cardiac autonomic regulation, IL-6,total antioxidant capacity, and muscle damage responses to a single bout of high-intensity interval training

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Journal of Sport and health Science 2018年第3期7卷 363-371页

作者： Lukas Cipryan human Motion Diagnostic Centre and department of human Movement Studies Ostrava University

Purpose:The aim of this study was to investigate the influence of the cardiorespiratory fitness level on the response to high-intensity interval training(HIIT)with an individually adjusted running speed of the same relative *** evaluation focused on acute cardiorespiratory response,postexercise cardiac autonomic modulation(heart rate variability(HRV))and biochemical markers of inflammation,oxidative stress,and muscle ***:Thirty participants were divided into 3 subgroups:well trained,moderately trained,and *** the participants performed30 min HIIT composed of 6×2 min interval exercise with work-to-relief ratio=1 and work intensity 100%of individual velocity at maximal oxygen consumption(VO2max).Acute cardiorespiratory variables,postexercise HRV,lactate,interleukin-6(IL-6),total antioxidant capacity(TAC),creatine kinase,and myoglobin up to 4h after HIIT were ***:The differences in relatively expressed cardiorespiratory variables(heart rate,VO2)during HIIT were at most moderate,with the most pronounced between-group differences in absolute VO2 *** disruption of the postexercise HRV was the most pronounced in untrained individuals,and this difference persisted 1 h after *** highest postexercise IL-6 and TAC concentrations and the lowest changes in creatine kinase and myoglobin were revealed in well-trained ***:The higher fitness level was associated with the less pronounced postexercise cardiac autonomic changes and their faster restoration,even when there were similar acute cardiorespiratory *** findings were simultaneously accompanied by the higher postexercise IL-6 and TAC concentrations and less significant changes in muscle damage biochemical markers in well-trained individuals.

关键词： Creatine kinase Heart rate variability Inflammation Myoglobin Total antioxidant capacity Training status

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Kinematic alterations after two high-intensity intermittent training protocols in endurance runners

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Journal of Sport and health Science 2019年第5期8卷 442-449页

作者： Felipe García-Pinillos Alejandro Molina-Molina Juan A.Párraga-Montilla Pedro A.Latorre-Román department of Corporal Expression University of JaenJaen 23071Spain human Lab Sport and Health University Institute(iMUDS)Granada 18007Spain

Purpose:This study aimed to evaluate running kinematic characteristics during the early and late stages of 2 high-intensity intermittent training(HIIT)protocols with similar external load but different average running pace,as well as to compare the fatigue-induced changes during both HIIT protocols at a kinematic ***:Eighteen endurance runners were tested on a track on 2 occasions:10 runs of 400 m with 90-120 s recovery between running bouts(10 × 400 m),and 40 runs of 100 m with 25-30 s recovery between running bouts(40 × 100 m).Heart rate was monitored during both protocols;blood lactate accumulation and rate of perceived exertion were recorded after both exercises.A high-speed camera was used to measure sagittalplane kinematics at the first and last runs during both HIIT *** dependent variables were spatial-temporal parameters(step length and contact and flight time),joint angles during support(relative angles of the hip,knee,and ankle),and foot strike ***:High levels of exhaustion were reached by the athletes during both workouts(blood lactate accumulation>12 mmol/L,rate of perceived exertion>15;peak heart rate(HRpeak)>176 bpm).A within-protocol paired t test(first *** run)revealed no significant changes(p≥0.05)in kinematic variables during any of the HIIT sessions.A between-protocol comparison with the first run of each protocol revealed the effect of running speed on kinematics:+2.44 km/h during the 40 × 100 m:shorter contact and flight time(p<0.01)and longer step length(p= 0.001);greater hip flexion(p = 0.031)and ankle extension(p = 0.001)at initial contact;smaller knee and ankle flexion(p<0.001)at midstance;and greater hip extension at toe-off(p<0.001).Conclusion:HIIT sessions including runs for 15-90 s and performed at intensity above the velocity associated with maximal oxygen uptake did not consistently perturb the running kinematics of trained endurance runners.

关键词： Biomechanics Fatigue-induced Runners Running Training Two-dimensional

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human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick Küry department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation human

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Modulation of the Nogo signaling pathway to overcome amyloid-β-mediated neurite inhibition in human pluripotent stem cell-derived neurites

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Neural Regeneration Research 2025年第9期20卷 2645-2654页

作者： Kirsty Goncalves Stefan Przyborski department of Biosciences Durham UniversityDurhamUK Reprocell Europe Ltd. GlasgowUK

Neuronal cell death and the loss of connectivity are two of the primary pathological mechanisms underlying Alzheimer's *** accumulation of amyloid-βpeptides,a key hallmark of Alzheimer's disease,is believed to induce neuritic abnormalities,including reduced growth,extension,and abnormal growth cone morphology,all of which contribute to decreased ***,the precise cellular and molecular mechanisms governing this response remain *** this study,we used an innovative approach to demonstrate the effect of amyloid-βon neurite dynamics in both two-dimensional and three-dimensional cultu re systems,in order to provide more physiologically relevant culture *** utilized various methodologies,including the addition of exogenous amyloid-βpeptides to the culture medium,growth substrate coating,and the utilization of human-induced pluripotent stem cell technology,to investigate the effect of endogenous amyloid-βsecretion on neurite outgrowth,thus paving the way for potential future applications in personalized ***,we also explore the involvement of the Nogo signaling cascade in amyloid-β-induced neurite *** demonstrate that inhibition of downstream ROCK and RhoA components of the Nogo signaling pathway,achieved through modulation with Y-27632(a ROCK inhibitor)and Ibuprofen(a Rho A inhibitor),respectively,can restore and even enhance neuronal connectivity in the presence of amyloid-β.In summary,this study not only presents a novel culture approach that offers insights into the biological process of neurite growth and inhibition,but also proposes a specific mechanism for reduced neural connectivity in the presence of amyloid-βpeptides,along with potential intervention points to restore neurite ***,we aim to establish a culture system that has the potential to serve as an assay for measuring preclinical,predictive outcomes of drugs and their ability to promote neurite outgrowth,both generally and in a patie

关键词： Alzheimer's disease induced pluripotent stem cell neurite outgrowth neuron Nogo Rho A ROCK stem cell three-dimensional culture

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Inflammatory pathways in the early steps of colorectal cancer development

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World Journal of Gastroenterology 2014年第29期20卷 9716-9731页

作者： Francesco Mariani Paola Sena Luca Roncucci department of Diagnostic Clinical and Public Health MedicineUniversity of Modena and Reggio Emilia department of Biomedical Metabolic and Neural SciencesSection of Human MorphologyUniversity of Modena and Reggio Emilia

Colorectal cancer is a major cause of cancer-related death in many *** carcinogenesis is a stepwise process which,from normal mucosa leads to *** factors have been shown to influence this process,however,at present,several points remain *** recent years some hypotheses have been considered on the mechanisms involved in cancer development,expecially in its early *** injury resulting from infectious,mechanical,or chemical agents may elicit a chronic immune response resulting in cellular proliferation and *** inflammation of the large bowel(as in inflammatory bowel diseases),has been associated with the subsequent development of colorectal *** this review we examine the inflammatory pathways involved in the early steps of carcinogenesis,with particular emphasis on ***,we describe cells and proteins recently suggested as central in the mechanism leading to tumor *** and neutrophils are among the cells mostly involved in these processes and proteins,as cyclooxygenases and resolvins,are crucial in these inflammatory ***,the activation of these pathways establishes an oxidative and anaerobic microenvironment with DNA damage to epithelial cells,and shifting from an aerobic to an anaerobic *** cellular mechanisms,such as proliferation,apoptosis,and autophagy are altered causing failure to control normal mucosa repair and renewal.

关键词： Myeloperoxidase Colorectal carcinogenesis Inflammation Aberrant crypt foci Autophagy Hypoxia Apoptosis

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh department of Neurosurgery Emory University School of MedicineAtlantaGAUSA department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis

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Neural Regeneration Research 2019年第2期14卷 217-221页

作者： Aejin Lee Ouliana Ziouzenkova department of human Sciences The Ohio State University

White adipose tissue(WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocular adipocytes express thermogenic genes and have phenotypic similarity with thermogenic brown adipose tissue. According to a current paradigm, multilocular adipocytes have a thermogenic function in WAT. In this mini review, we discuss data revealing heterogeneity among multilocular cell subsets in WAT and their functions beyond thermogenesis. We propose a hypothetical neuroendocrine role for multilocular adipocytes subsets in the formation of adaptive sensory-sympathetic circuits between the central nervous system and adipose tissue, which activate lipolysis and thermogenesis in WAT in high energy demand situations.

关键词： obesity thermogenesis innervation vitamin A aldehyde dehydrogenase paracrine efferent afferent brown adipose tissue

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