检索结果-南通市图书馆

VPS35 Protects Against TMEM230-mutation-induced Progressive Locomotor Deficits in Drosophila

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第6期38卷 652-656页

作者： Chao Ma Xiaobo Wang Wanli W.Smith Zhaohui Liu department of human Anatomy and Cytoneurobiology School of Biology and Basic Medical SciencesSoochow UniversitySuzhou 215123China department of psychiatry and behavioral sciences Johns Hopkins University School of MedicineBaltimore 21287USA

The discovery of genes related to Parkinson's disease(PD)provides an imporant basis for the progress of research into PD,helps to clarify is mechanism,and provides many new opportunities to find therapeutic targelts[1.2].The article by Deng and colleagues in 2016 found a new autosomal dominant PD(ADPD)gene,transmembrane protein 230(TMEM230).Four PD-linked mutations were identifed in PD patients:Y92C,RI4IL.184Wexr*5(replacing the stop codon with six ***,in the C-terminus in North American patients),and 184PGext*5(replacing the stop codon with proline and glycine,thus adding seven amino acids,PGHPPHS,to the C-lerminus in Chinese families with PD)[3].Subsequenly,studies have suggested thal TMEM230 variants are related to PD pathogenesis in viro[4-6].

关键词： adding replacing families

Endogenous retinal neural stem cell reprogramming for neuronal regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第11期12卷 1765-1767页

作者： Romain Madelaine Philippe Mourrain Stanford Center for Sleep sciences and Medicine Department of Psychiatry and Behavioral SciencesStanford University INSERM 1024 Ecole Normale SupérieureParisFrance

In humans, optic nerve injuries and associated neurodegenerative diseases are often followed by perma- nent vision loss. Consequently, an important challenge is to develop safe and effective methods to replace retinal neurons and thereby restore neuronal functions and vision. Identifying cellular and molecular mechanisms allowing to replace damaged neurons is a major goal for basic and translational research in regenerative medicine. Contrary to mammals, the zebrafish has the capacity to fully regenerate entire parts of the nervous system, including retina. This regenerative process depends on endogenous retinal neural stem cells, the Miiller glial cells. Following injury, zebrafish Miiller cells go back into cell cycle to proliferate and generate new neurons, while mammalian Mtiller cells undergo reactive gliosis. Recently, transcription factors and microRNAs have been identified to control the formation of new neurons derived from ze- brafish and mammalian Mtiller cells, indicating that cellular reprogramming can be an efficient strategy to regenerate human retinal neurons. Here we discuss recent insights into the use of endogenous neural stem cell reprogramming for neuronal regeneration, differences between zebrafish and mammalian Mtiller cells, and the need to pursue the identification and characterization of new molecular factors with an instructive and potent function in order to develop theurapeutic strategies for eye diseases.

关键词： neuronal regeneration retina Muller glial cells neural stem cell reprogramming achaete-scute homolog 1 microRNA-9 Tlx Onecut

Resilience by design:How nature,nurture,environment,and microbiome mitigate stress and allostatic load

在线全文

学校读者我要写书评

暂无评论

World Journal of psychiatry 2023年第5期13卷 144-159页

作者： Souhad Chbeir Victor Carrión department of psychiatry and behavioral sciences School of MedicineStanford UniversityStanfordCA 94305United States

Resilience to psychological stress is defined as adaption to challenging life experiences and not the absence of adverse life *** of resilience include personality traits,genetic/epigenetic modifications of genes involved in the stress response,cognitive and behavioral flexibility,secure attachment with a caregiver,social and community support systems,nutrition and exercise,and alignment of circadian rhythm to the natural light/dark ***,resilience is a dynamic and flexible process that continually evolves by the intersection of different domains in human’s life;biological,social,and *** objective of this minireview is to summarize the existing knowledge about the multitude factors and molecular alterations that result from resilience to stress *** the multiple contributing factors in building resilience,we set out a goal to identify which factors were most supportive of a causal role by the current *** focused on resilience-related molecular alterations resulting from mind-body homeostasis in connection with psychosocial and environmental *** conclude that there is no one causal factor that differentiates a resilient person from a vulnerable ***,building resilience requires an intricate network of positive experiences and a healthy lifestyle that contribute to a balanced mind-body ***,a holistic approach must be adopted in future research on stress response to address the multiple elements that promote resilience and prevent illnesses and psychopathology related to stress allostatic load.

关键词： stress load alignment

Optical neuroimaging:advancing transcranial magnetic stimulation treatments of psychiatric disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 268-278页

作者： Shixie Jiang Linda L.Carpenter Huabei Jiang department of psychiatry and behavioral sciences Stanford University School of MedicinePalo Alto CA 94305USA department of psychiatry and human Behavior Butler HospitalAlpert Medical School of Brown UniversityProvidence RI 02903USA department of Medical Engineering University of South FloridaTampa FL 33613USA

Transcranial magnetic stimulation(TMS)has been established as an important and effective treatment for various psychiatric ***,its effectiveness has likely been limited due to the dearth of neuronavigational tools for targeting purposes,unclear ideal stimulation parameters,and a lack of knowledge regarding the physiological response of the brain to TMS in each psychiatric *** optical imaging modalities,such as functional near-infrared spectroscopy and diffuse optical tomography,are promising tools for the study of TMS optimization and functional targeting in psychiatric *** possess a unique combination of high spatial and temporal resolutions,portability,real-time capability,and relatively low *** this mini-review,we discuss the advent of optical imaging techniques and their innovative use in several psychiatric conditions including depression,panic disorder,phobias,and eating *** further investment and research in the development of these optical imaging approaches,their potential will be paramount for the advancement of TMS treatment protocols in psychiatry.

关键词： Optical imaging Functional near-infrared spectroscopy Diffuse optical tomography Transcranial magnetic stimulation Major depressive disorder Panic disorder Phobia Bulimia nervosa Psychiatric disorders

The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime(HADES) framework

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第5期11卷 46-55页

作者： Jakub Vohryzek Joana Cabral Christopher Timmermann Selen Atasoy Leor Roseman David J.Nutt Robin L.Carhart-Harris Gustavo Deco Morten L.Kringelbach Centre for Eudaimonia and human Flourishing Linacre CollegeDepartment of Psychiatry University of Oxford department of psychiatry University of Oxford Center for Music in the Brain Aarhus University Center for Brain and Cognition Computational Neuroscience GroupDepartment of Information and Communication TechnologiesUniversitat Pompeu Fabra Life and Health sciences Research Institute School of MedicineUniversity of Minho ICVS/3B's-PT Government Associate Laboratory Centre for Psychedelic Research Department of Brain Sciences Imperial College London departments of Neurology and psychiatry University of California San Francisco Institució Catalana de la Recerca i Estudis Avan?ats (ICREA) department of Neuropsychology Max Planck Institute for Human Cognitive and Brain Sciences School of Psychological sciences Monash University

The human brain is a complex system, whose activity exhibits flexible and continuous reorganization across space and time. The decomposition of whole-brain recordings into harmonic modes has revealed a repertoire of gradient-like activity patterns associated with distinct brain functions. However, the way these activity patterns are expressed over time with their changes in various brain states remains unclear. Here, we investigate healthy participants taking the serotonergic psychedelic N,N-dimethyltryptamine(DMT) with the Harmonic Decomposition of Spacetime(HADES) framework that can characterize how different harmonic modes defined in space are expressed over time. HADES demonstrates significant decreases in contributions across most low-frequency harmonic modes in the DMT-induced brain state. When normalizing the contributions by condition(DMT and non-DMT), we detect a decrease specifically in the second functional harmonic, which represents the uni-to transmodal functional hierarchy of the brain,supporting the leading hypothesis that functional hierarchy is changed in psychedelics. Moreover, HADES'dynamic spacetime measures of fractional occupancy, life time and latent space provide a precise description of the significant changes of the spacetime hierarchical organization of brain activity in the psychedelic state.

关键词： spatio-temporal brain dynamics DMT harmonic modes

17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2016年第5期6卷 504-509页

作者： Sung-joon Cho Miaoran Ning Yanyan Zhang Leah H.Rubin Hyunyoung Jeong department of Biopharmaceutical sciences College of PharmacyUniversity of Illinois at Chicago department of Pharmacy Practice College of PharmacyUniversity of Illinois at Chicago department of psychiatry University of Illinois at Chicago

UDP-glucuronosyltransferase 1A9(UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous *** data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users,but the role of estrogen in the regulation of UGT1A9 expression remains *** this study,we investigated the effect of 17β-estradiol(E2) on UGT1A9 expression and the role of ERα in the transcriptional regulation of UGT1A9.E2 significantly increased UGT1A9 promoter activity in Hep G2 cells in the presence of ERα.UGT1A9 induction by E2 was abrogated by antiestrogen ICI182,780 in Hep G2 cells that constitutively express ERα.Results from transient transfection of ERα mutants into Hep G2 cells demonstrated that mutation at DNA-binding domain of ERα abrogates increased UGT1A9 promoter activity by *** and mutation assays of UGT1A9 promoter revealed a putative ERE located within -2262/-1987 *** of healthy human liver tissues revealed significantly higher UGT1A9 expression in women as compared to ***,these findings provide a mechanistic basis for the previous clinical reports and may shed a light on identifying sources for inter-individual variability in UGT1A9-mediated drug metabolism.

关键词： UGT1A9 17β-Estradiol Estrogen receptor Drug metabolism Sex difference

Inattentiveness in attention-deficit/hyperactivity disorder

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2013年第1期29卷 103-110页

作者： Ariane Sroubek Mary Kelly Xiaobo Li Ferkauf Graduate School of Psychology at Yeshiva University department of Pediatrics and behavioral sciences at Albert Einstein College of Medicine Yeshiva University Gruss Magnetic Resonance Research Center and behavioral sciences at Albert Einstein College of Medicine Yeshiva University department of Radiology and behavioral sciences at Albert Einstein College of Medicine Yeshiva University department of Neuroscience and behavioral sciences at Albert Einstein College of Medicine Yeshiva University department of psychiatry and behavioral sciences at Albert Einstein College of Medicine Yeshiva University

Attention-deficit/hyperactivity disorder （ADHD） is a neurodevelopmental disorder with a long-term impact on functioning, productivity and quality of life of patients. This impact is largely due to the symptoms of inattentiveness. However, despite its impairing role in the lives of ADHD patients, inattentiveness has been studied relatively less frequently than have symptoms of impulsivity/hyperactivity and problems with executive function. This review therefore seeks to integrate the neuropsychological theories and current findings in the research fields of neuropsychology, neurophysiology, and neuroimaging, in an attempt to gain a more complete understanding of the role that inattentiveness plays in ADHD, as well as to suggest directions for future studies. The need for a more comprehensive understanding of inattentiveness and ADHD, which integrates findings from each of the three disciplines mentioned above, is emphasized.

关键词： attention-deficit/hyperactivity disorder inattentiveness brain pathways neuropathology

Future of mental health in the metaverse

在线全文

学校读者我要写书评

暂无评论

General psychiatry 2022年第4期35卷 224-229页

作者： Sadia Suhail Usmani Medha Sharath Meghana Mehendale department of psychiatry Dow University of Health SciencesKarachiPakistan department of Medicine Insight Hospital&Medical Center ChicagoChicagoIllinoisUSA department of psychiatry Bangalore Medical College and Research InstituteBangaloreKarnatakaIndia department of psychiatry Smolensk State Medical UniversitySmolenskRussian Federation

The metaverse and non-fungible tokens(NFTs)were some of the hottest tech terms in 2021,according to a Google Trends *** review aims to describe the metaverse and NFTs in the context of their potential application in the treatment of mental health *** in technology have been changing human lives at an ever-increasing ***,also known as the threedimensional(3D)internet,is the convergence of virtual reality(VR)and physical reality in a digital *** could potentially change the internet as we know it,with NFTs as the key building blocks in the new expansive virtual *** immersive 3D virtual world boasts the features of the real world with the added ability to change the surrounding environment according to individual needs and ***,augmented reality(AR)and mixed reality(MR)have been employed as tools in the treatment of various mental health disorders for the past *** have reported positive results on their effectiveness in the diagnosis and treatment of mental health ***/AR/MR have been hailed as a solution to the acute shortage of mental health professionals and the lack of access to mental ***,on the flip side,young adults tend to spend a significant amount of time playing 3D immersive games and using social media,which can lead to insecurity,anxiety,depression,and behavioural ***,endless scrolling through social media platforms negatively affects individuals'attention span as well as aggravating the symptoms of adolescents with attention deficit hyperactivity *** aimed to explore the ramifications of expanding applications of the metaverse on mental *** far,no other review has explored the future of mental health in the context of the metaverse.

关键词： token diagnosis reality

Traumatic brain injury induced by exposure to blast overpressure via ear canal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第1期17卷 115-121页

作者： Yang Ou Brad AClifton Jinghui Li David Sandlin Na Li Li Wu Chunming Zhang Tianwen Chen Jun Huang Yue Yu Jerome Allison Fan Fan Richard JRoman James Shaffery Wu Zhou Yi Pang Hong Zhu Departmant of Otolaryngology and Head Neck Surgery department of Neurobiology and Anatomical sciences MD Program School of Medicine Graduate Program in Neuroscience department of Pediatrics department of Pharmacology and Toxicology department of psychiatry and human Behavior University of Mississippi Medical CenterJacksonMSUSA Kunming Medical University KunmingYunnan ProvinceChina department of Otolaryngology First Affiliated HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina

Exposure to explosive shockwave often leads to blast-induced traumatic brain injury in military and civilian *** ears are most often damaged following exposure to *** there is an association between tympanic membrane perforation and TBI in blast exposure victims,little is known about how and to what extent blast energy is transmitted to the central nervous system via the external ear *** present study investigated whether exposure to blasts directed through the ear canal causes brain injury in LongEvans *** were exposed to a single blast(0–30 pounds per square inch(psi))through the ear canal,and brain injury was evaluated by histological and behavioral outcomes at multiple *** exposure not only caused tympanic membrane perforation but also produced substantial neuropathological changes in the brain,including increased expression of c-Fos,induction of a profound chronic neuroinflammatory response,and apoptosis of *** blast-induced injury was not limited only to the brainstem most proximal to the source of the blast,but also affected the forebrain including the hippocampus,amygdala and the habenula,which are all involved in cognitive ***,the animals exhibited long-term neurological deficits,including signs of anxiety in open field tests 2 months following blast exposure,and impaired learning and memory in an 8-arm maze 12 months following blast *** results suggest that the unprotected ear canal provides a locus for blast waves to cause *** study was approved by the Institutional Animal Care and Use Committee at the University of Mississippi Medical Center(Animal protocol#0932 E,approval date:September 30,2016 and 0932 F,approval date:September 27,2019).

关键词： anxiety blast ear ear protection learning memory microglia neuroinflammation neuron rat traumatic brain injury