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Mitigating fire risks in hospitals:Are we primed and geared up?

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 141-142页

作者： Raman Sharma Sruti Sharma department of Hospital Administration PGIMERChandigarhIndia department of Hospital Administration Satellite CentreSangrurPGIMERChandigarhIndia

The recent incidents have confirmed that fires in COVID-19 hospitals have become a gruelling and nerve-testing challenge[1-3].The increased volumes of oxygen flow,abundance of inflammable alcohol sanitizers,wearing of inflammable kits,and abundance of equipment make it more acquiescent for such incidents and even difficult to *** density of equipment(especially ventilators)“enriches”air with oxygen,thereby increasing the“combustion risk”.

关键词： nit thereby control

Hindi translation and validation of the English version of the gastrointestinal symptom rating scale questionnaire:An observational study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 33-39页

作者： Neha Jindal Anuraag Jena Krishan Kumar Bijaya K Padhi Rajni Sharma Vaneet Jearth Usha Dutta Vishal Sharma department of Gastroenterology Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India department of Psychiatry Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India department of Community Medicine and School of Public Health Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India Advanced Pediatric Centre Postgraduate Institute of Medical Education and Research(PGIMER)Chandigarh 160012India

BACKGROUND The gastrointestinal symptom rating scale(GSRS)is a questionnaire in English language which is designed to assess the clinical symptoms in patients with irritable bowel syndrome(IBS)and peptic ulcer *** validated scale has questions on around 15 items and has been validated in patients with dyspepsia and *** To translate and validate the English version of the GSRS questionnaire to the Hindi *** The purpose of the present work was to create a Hindi version of this questionnaire for use in the Indian *** process involved various steps as per the World Health Organization methodology including initial forward translation,backward translation,and assessment by an expert *** pilot testing was followed by testing in healthy and diseased *** The Hindi translation was pilot tested in 20 individuals and further validated in healthy controls(n=30,15 females)and diseased individuals(n=72,27 females).The diseased group included patients with functional dyspepsia and ***'s alpha for internal consistency on the final translated GSRS questionnaire was 0.715 which is considered *** questions significantly differentiated the diseased population from the healthy population(P value<0.05)in the translated Hindi version of the *** The translated Hindi GSRS can be used to evaluate gastrointestinal function in clinical trials and community surveys in Hindi speaking populations.

关键词： Irritable bowel syndrome Gut health Dyspepsia Symptoms Pain Constipation Diarrhoea

Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease

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World Journal of Gastroenterology 2006年第22期12卷 3602-3608页

作者： Kim Vaiphei Neeraj Kumari Saroj Kant Sinha Usha Dutta Birinder Nagi Kusum Joshi Kartar Singh department of histopathology pgimer ChandigarhIndia department of Gastroenterology pgimer ChandigarhIndia

AIM： To evaluate roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease （IPSID） and to study profiles of kappa （κ） and lambda （λ） light chains and IgA heavy chain. METHODS： The study consisted of 11 cases of IPSID and similar number of controls which included 11 of normal intestinal mucosa and 11 of high grade B cell lymphoma of ileum. The parameters analyzed included clinical profiles, biochemical and other laboratory investigations, radiologic and histological findings including immunohistochemistry. RESULTS： All IPSID cases had demonstrable serum IgA heavy chain and heavy mucosal plasma cell infiltration. According to Galian＇s histological staging, there were 4 patients with stage A and 7 with stage B. κ and ;λ light chains were over-expressed in 7 patients; 1 stage A patient had H pylori-positive active gastritis and eradication of H pylori led to disease remission. Stage A biopsies had higher expression for syndecan-1, while stage B had higher expression for bcl6 and p53. Syndecan-1,κ and λ light chains and IgA heavy chain showed inverse relationship with bcl6 and p53. All patients were treated with doxycycline. CHOP regime was added in 5 patients who developed frank lymphoma. Three died of the disease due to extensive organ infiltration. CONCLUSION： Certain immunomarkers like syndecan-1,κ and λ light chains and IgA heavy chain could be of much help in identifying early stage IPSID. Stage B IPSID showed higher expression for bcl6 and p53 than stage A IPSID. bcl6 and p53 expressions correlated with a more advanced disease stage and aggressive tumour behavior.

关键词： IPSID Syndecan-1 bcl6 p53 protein κ and λ light chains Alpha heavy chain H pylori

Tubularized incised plateurethroplasty and grafted tubularized incised plate urethroplasty: systematic review, metaanalysis and trial sequential analysis

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World Journal of Pediatric Surgery 2024年第1期7卷 10-19页

作者： Nitinkumar Borkar Charu Tiwari Abhijit Nair Debajyoti Mohanty C K Sinha Jai Kumar Mahajan Paediatric Surgery All India Institute of Medical Sciences-RaipurRaipurChhattisgardhIndia department of Anaesthesiology Ibra HospitalbraOman General Surgery All India Institute of Medical Sciences-RaipurRaipurChhattisgardhIndia Paediatric Surgery St George's University Hospitals NHS Foundation TrustLondonUK Pediatric Surgery PGIMERChandigarhIndia

Background Hypospadias is one of the most common genital birth *** are around 300 various techniques available for the repair of *** study aims to compare the reported outcomes of Tubularized incised plate urethroplasty(TIP)and Grafted TIP(GTIP)repair in children undergoing primary *** This meta-analysisadhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,and we framed our research question using the population,intervention,control and outcomes *** conducted comprehensive electronic searches across various databases,employing a Boolean search strategy with predefined search *** randomized controlled trials(RCTs)were included for quantitative *** Totally,10 RCTs met our inclusion criteria for quantitative *** results indicated that urethrocutaneous fistula,glans dehiscence,and stricture rates were comparable between the two *** incidence of meatal stenosis was found to be significantly lower in the GTIP group with a relative risk(RR)of 0.32(95%confidence interval(Cl)0.15 to 0.67).Conclusion The coucomes UCF,glans dehiscence,and stricture rates were comparable between the two ***,the incidence of meatal stenosis was found to be significantly lower in the grafted TIP *** terms of operative time,our quantitative synthesis demonstrated that the TIP group had a shorter operative time than the GTIP group with significant heterogeneity.

关键词： plate grafted analysis

Anti-HBc screening in Indian blood donors:Still an unresolved issue

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World Journal of Gastroenterology 2008年第34期14卷 5327-5330页

作者： Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain department of Transfusion Medicine pgimer department of Hepatology pgimer

AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed.

关键词： Hepatitis B core antigen Hepatitis B surface antigen Hepatitis B virus Transfusion-associated hepatitis B virus Blood donors

A phase II study of neoadjuvant chemotherapy followed by organ preservation in patients with muscle-invasive bladder cancer

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Asian Journal of Urology 2022年第3期9卷 318-328页

作者： Chinna Babu Dracham Narendra Kumar Santosh Kumar Arun Elangovan Budhi Singh Yadav Ravimohan S.Mavuduru Anupam Lal Pramod K.Gupta Rakesh Kapoor department of Radiotherapy&Oncology PGIMERChandigarhIndia department of Urology PGIMERChandigarhIndia department of Radiodiagnosis PGIMERChandigarhIndia department of Biostatistics PGIMERChandigarhIndia

Objective:Conservative approaches in muscle-invasive bladder cancer(MIBC)have been evolved to avoid aggressive surgery,but are limited to elderly,frail,and patients medically unfit for *** study aimed to assess the response rate of neoadjuvant chemotherapy(NACT)before radiotherapy(RT)in MIBC ***:Forty patients with urothelial carcinoma of stage T2-T4a,N0,M0 were enrolled between November 2013 and November 2015,and treated with three cycles of NACT with ***-NACT response was assessed using Response Evaluation Criteria in Solid Tumors(RECIST)*** who achieved complete response(CR)and partial response(PR)>50%were treated with radical RT,and those who had PR50%or CR,and were treated with ***(12.5%)patients who had PR<50%,SD,or PD underwent *** patients who received radiation showed CR after 6 *** follow-up was 43 months(range:10-66 months)and median overall survival(OS)was not ***-year OS,local control,and disease-free survival were 70.1%,60.9%,50.6%,respectively,and 50%of patients preserved their functioning ***-year OS rate was 88.9%in patients who achieved CR to NACT,73.1%in patients with PR≥50%and 40%in patients with PR<50%.Conclusion:NACT followed by RT provides a high probability of local response with bladder preservation in CR *** use of this treatment regimen in carefully selected patients may omit the need for morbid surgery.

关键词： Bladder preservation Neoadjuvant chemotherapy Radiotherapy Muscle-invasive bladder cancer

Perceived effectiveness of infection control practices in Laundry of a tertiary healthcare centre

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World Journal of Emergency Medicine 2019年第2期10卷 114-115页

作者： Raman Sharma Ashok Kumar Vipin Koushal department of Hospital Administration PGIMER

Hospital management in modern milieu has become patient oriented and good patient outcome is a result of effective and effi cient medical care along with provisions of hygienic food,clean linen,safe environment,congenial atmosphere and good interpersonal relationship.^[1]Laundry is one such important support service which ensures prevention as well as containment of hospital infections and is also a determining factor for maintenance of good image of a hospital[2].

关键词： Hospital management modern milieu oriented

Effect of face masks on speech understanding: A clinical perspective during speech audiometry

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Journal of Otology 2022年第3期17卷 140-145页

作者： Rawish Kumar Sanjay Kumar Munjal Anuradha Sharma Md Noorain Alam Naresh K.Panda department of Otolaryngology PGIMERChandigarhIndia

The objective was to measure the effect of various face masks on speech recognition threshold and the word recognition score in the presence of varying background noise levels.20 normal-hearing adult subjects(a total of 40 ears)*** tone audiometry followed by speech recognition threshold and word recognition score at the most comfortable level in varying signal-to-noise ratios(SNR0,SNR10,and SNR15)using surgical,pleated cloth,and N95 *** surgical,cloth,and N95 masks,speech recognition thresholds increased by 1.8 dB,4.4 dB,and 5.05 dB,*** recognition scores decreased by 32%without a mask,43.7%in a surgical mask,46.3%in a cloth mask,and 46.7%in N95 mask conditions,between SNR15 and *** speech recognition threshold was negatively affected with cloth and N95 *** masks do not affect the word recognition scores at lower background noise ***,as the signal-to-noise ratio decreased,even the surgical,cloth,and N95 masks significantly impacted the word recognition score even in normal-hearing individuals.

关键词： Face masks Speech recognition threshold Word recognition score Signal-to-noise ratio Communication

Correlation between soluble receptor for advanced glycation end products levels and coronary artery disease in postmenopausal nondiabetic women

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World Journal of Cardiology 2021年第5期13卷 130-143页

作者： Soumitra Ghosh Divya Kapoor Rajesh Vijayvergiya Sonal Sangwan Sujata Wangkheimayum Sakshi Mehta Veena Dhawan department ofCardiology PGIMERChandigarh 160012India department of Experimental Medicine and Biotechnology PGIMERChandigarh 160012India department of Biochemistry PGIMERChandigarh 160012India

BACKGROUND The established cardiovascular risk factors cannot explain the overall risk of coronary artery disease(CAD),especially in ***,there is a growing need for the assessment of novel biomarkers to identify women at *** receptor for advanced glycation end products(RAGE)and its interaction with the advanced glycation end product(AGE)ligand have been associated with *** soluble fraction of RAGE(sRAGE)antagonizes RAGE signaling and exerts an antiatherogenic *** The study aim was to explore the association between plasma levels of sRAGE and CAD in nondiabetic postmenopausal *** This case-control study included 110 nondiabetic postmenopausal women who were enrolled in two *** I included 55 angiographically proven CAD subjects with>50%stenosis in at least one of the major coronary arteries and Group II included 55 healthy control women who did not have CAD or had<50%stenosis of the coronary *** was confirmed by invasive *** sRAGE was determined by an enzyme-linked immunosorbent *** We observed significantly lower plasma sRAGE concentrations in subjects with CAD vs healthy controls(P<0.05).Univariate and multivariate logistic regression analysis also revealed a significant correlation between plasma sRAGE levels and CAD(P=0.01).Multivariate odds ratios for CAD revealed that subjects with sRAGE concentrations below 225 pg/mL(lowest quartile)had a 6-fold increase in CAD prevalence independent of other risk *** Our findings indicated that low sRAGE levels were independently associated with CAD in nondiabetic postmenopausal *** assessment of CAD in postmenopausal women can be improved by including sRAGE along with other risk factors.

关键词： Coronary artery disease Soluble receptor for advanced glycation end products Postmenopausal status Nondiabetic females Correlation Regression