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Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats

World Journal of Gastroenterology 2007年第12期13卷 1851-1856页

作者： Bao-Qiang Cao Ji-Zong Lin Yue-Si Zhong Shao-Bin Huang Nan Lin Zhao-Feng Tang Rui Chen Peng Xiang Rui-Yun Xu department of hepatobility surgery the Third Affiliated Hospital of Sun Yat-Sen University Guangzhou 510630 Guangdong Province China Center for Stem Cell Biology and Tissue Engineering Sun Yat-Sen University 74# Zhongshan Road Ⅱ Guangzhou 510080 Guangdong Province China

AIM： To study the inhibitory effect of mononuclear bone marrow cell （BNC） transplantation on carbon tetrachloride （CCl4） -induced liver fibrosis in rats. METHODS： Rat liver fibrosis models were induced by CCl4 and alcohol administration. After 8 wk, twenty rats were randomly allocated into treatment group （n = 10） and control group （n = 10）. BMC were infused into the rats in treatment group via the portal vein, while heparinized saline was infused in control group. CCl4 was hypodermically injected into the rats twice a week for 4 wk. At the end of wk 12, all rats were humanely sacrificed. Uver samples were taken and stained with HE or Masson trichrome. The general conditions, liver fibrosis （hydroxyproline and collagen fibre） and liver pathological grades in rats were evaluated. RESULTS： The general conditions of the rats in treatment group improved markedly, but not in control group. Hydroxyproline was 504.6± 128.8 μg/g in treatment group, and 596.0 ± 341.8 μg/g in control group. The percentage of collagen fibre was 3.75% ± 0.98% in treatment group and 5.02% ± 0.44% in control group. There was a significant difference between the two groups （P 〈 0.05）. Liver pathological grade decreased from grade N to grade 11 partially in treatment group （P 〈 0.05） with no obvious improvement in control group （P 〉 0.05）. There was a significant difference between treatment group and control group （P 〈 0.05）.CONCLUSION： Transplantation of BMC can improve liver fibrosis due to chronic liver injury in rats.

关键词： Bone marrow cell Transplantation Liver cirrhosis Rat model

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