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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen Xu Feng Yuan Shi Xin-Lin Li Zheng-Rong Shi Xiang Lan department of hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： Xing-Yu Chen Xiang Lan department of hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on liver cancer and the underlying *** inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of CB for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 62-72页

作者： Zhi-Da Long Xiao Yu Zhi-Xiang Xing Rui Wang department of hepatobiliary and Pancreaticosplenic Surgery Jingzhou Hospital Affiliated to Yangtze UniversityJingzhou 434100Hubei ProvinceChina

BACKGROUND The liver,as the main target organ for hematogenous metastasis of colorectal cancer,early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of ***,this study aims to investigate the application value of a combined machine learning(ML)based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis(MLM).AIM To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal *** We retrospectively analyzed 301 patients with rectal cancer confirmed by surgical pathology at Jingzhou Central Hospital from January 2017 to December *** participants were randomly assigned to the training or validation queue in a 7:3 *** first apply generalized linear regression model(GLRM)and random forest model(RFM)algorithm to construct an MLM prediction model in the training queue,and evaluate the discriminative power of the MLM prediction model using area under curve(AUC)and decision curve analysis(DCA).Then,the robustness and generalizability of the MLM prediction model were evaluated based on the internal validation set between the validation queue *** Among the 301 patients included in the study,16.28%were ultimately diagnosed with MLM through pathological *** analysis showed that carcinoembryonic antigen,and magnetic resonance imaging radiomics were independent predictors of ***,the GLRM prediction model was developed with a comprehensive nomogram to achieve satisfactory *** prediction performance of GLRM in the training and validation queue was 0.765[95%confidence interval(CI):0.710-0.820]and 0.767(95%CI:0.712-0.822),*** with GLRM,RFM achieved superior performance with AUC of 0.919(95%CI:0.868-0.970)and 0.901(95%CI:0.850-0.952)in the training and validation queue,respect

关键词： Rectal cancer Metachronous liver metastases Magnetic resonance imaging Radiomics Machine learning

The effect of the 18R-LPSO phase on the fatigue behavior of extruded Mg/LPSO two-phase alloy through a comparative experimental-numerical study

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Journal of Magnesium and Alloys 2021年第1期9卷 130-143页

作者： Fabien Briffod Takayuki Shiraiwa Manabu Enoki department of Materials Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

The fatigue behavior of four extruded Mg-Y-Zn alloys containing different volume fractions of long-period stacking ordered(LPSO)grains was investigated through a comparative study combining experiments and crystal plasticity finite element *** controlled low-cycle fatigue experiments were conducted at different strain amplitudes and revealed a limited cyclic hardening in Mg_(89)Zn_(4)Y_(7)alloy or softening in Mg_(99.2)Zn_(0.2)Y_(0.6)and Mg_(97)Zn_(1)Y_(2)alloys.A decrease in the fatigue life against the plastic strain with the increase in LPSO phase volume fraction was observed and was related the limited ductility of extruded LPSO ***-strain hysteresis curves were used to calibrate and validate a crystal plasticity model taking into account twinning and *** interaction of the different phases on the distribution of local micro-mechanical fields at the grain scale was then analyzed on synthetic microstructures under strain-controlled *** twinning activity was predicted in coarse unrecrystallized grains and tended to disappear with the increase in the LPSO phase volume ***-like facets observed in LPSO grains were related to high tensile stress,especially at the Mg/LPSO interface,due to the limited number of deformation mechanisms in LPSO crystal to accommodate out-of-basal plane *** increase of the fatigue limit with the increase in LPSO phase volume fraction was finally associated with the decreasing presence of coarse unrecrystallizedα-Mg grains due to a higher dynamic recrystallization activity during the extrusion process.

关键词： Magnesium alloy Fatigue Long-period stacking ordered phase Crystal plasticity Finite element method

Mechanical properties and failure mechanisms of Mg-Zn-Y alloys with different extrusion ratio and LPSO volume fraction

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Journal of Magnesium and Alloys 2022年第8期10卷 2158-2172页

作者： Wujun Yin Fabien Briffod Takayuki Shiraiwa Manabu Enoki department of Materials Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo113–8656Japan

In long period stacking ordered(LPSO)phase containing Mg-Zn-Y alloys,high elastic modulus and deformation kinks of LPSO phase considerably enhance the tensile yield strength,with slight detriment of or benefit to the ductility depending on its volume *** present work,uniaxial tensile tests and fracture toughness tests are carried out using Mg99.2Zn0.2Y0.6,Mg97Zn1Y2,Mg89Zn4Y7 and Mg85Zn6Y9(at%)materials with different extrusion *** processing enhances both strength and ductility due to the recrystallization of Mg *** plastic deformation mechanisms are activated depending on volume fraction of Mg and LPSO phase as well as their relative size during bending.{1012¯}101¯1¯>tensile twins in Mg grains and deformation kinks in LPSO phase are observed,which dissipate large amount of deformation energy favoring for ***,inherently brittle LPSO phase is detrimental to ***-motivated empirical models for yield strength and fracture toughness prediction based on rule of mixtures are calibrated by experimental *** release rates of individual mechanisms are estimated,which quantitatively indicate strong Mg/LPSO interaction.

关键词： Mg-Zn-Y alloys LPSO Phase Fracture toughness Rule of mixtures

Static recovery of A5083 aluminum alloy after a small deformation through various measuring approaches

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Journal of Materials Science & Technology 2022年第9期104卷 202-213页

作者： Sheng Ding Jingwei Zhang Sabrina Alam Khan Jun Yanagimoto department of Mechanical Engineering The University of TokyoHongo 7-3-1Bunkyo CityTokyo 113-8656Japan

Static recovery was confirmed to be the dominant softening mechanism during annealing for the studied A5083 aluminum *** kinetics of static recovery,described based on the activation parameters(activation energy and volume of static recovery)and the static softening fraction,were mainly studied through two thermomechanical tests,namely,double-pass compression and stress relaxation tests.A new approach was proposed to measure the static softening fraction in the stress relaxation *** general,a higher temperature or strain rate accelerates static recovery,while interestingly,the effect of pre-strain on static recovery is opposite in cases with and without external stress,owing to the enhanced static recovery by external stress during *** addition,microhardness tests and electron backscatter diffraction(EBSD)characterization were also conducted to verify the accuracy of the *** grain average misorientation approach based on EBSD characterization was confirmed to be effective in distinguishing and quantifying static *** is noteworthy that the special stress hardening phenomenon occurring at 400℃and 0.1/s is caused by strain aging,showing the complexity of the material behaviors after deformation of the studied aluminum alloy.

关键词： Aluminum alloy Static recovery Double-pass compression test Stress relaxation test Electron backscatter diffraction(EBSD) Grain average misorientation

Multiple liver metastases of unknown origin:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 233-238页

作者： Ying-Jin Wang Ze-Chuan Liu Jian Wang Yin-Mo Yang department of hepatobiliary Pancreatic Surgery Peking University First HospitalBeijing 100034China department of Interventional and Vascular Surgery Peking University First HospitalBeijing 100034China

BACKGROUND The liver is the most common site of digestive system tumor metastasis,but not all liver metastases can be traced back to the primary *** it is unusual,syphilis can impact the liver,manifesting as syphilitic hepatitis with inflammatory nodules,which might be misdiagnosed as *** SUMMARY This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three *** definitive diagnosis of a tumor had been made in the past decades,but signs of multiple liver metastases were recognized after a computed tomo-graphy scan without evidence of primary *** positive serological tests for syphilis and a biopsy of the liver nodules,a diagnosis of hepatic syphilis was made and confirmed with follow-up nodule reduction after anti-syphilis *** Clinicians must be aware of the possibility that syphilis can cause hepatic inflam-matory masses,especially when liver metastasis is suspected without evidence of primary lesions.A definitive diagnosis should be established in conjunction with a review of the patient’s medical history for accurate therapeutic intervention.

关键词： Syphilitic hepatitis Liver nodules Liver metastasis Treponema pallidum Case report

Bone Milling:On Monitoring Cutting State and Force Using Sound Signals

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Chinese Journal of Mechanical Engineering 2022年第3期35卷 123-134页

作者： Zhenzhi Ying Liming Shu Naohiko Sugita department of Mechanical Engineering School of EngineeringThe University of Tokyo7‑3‑1 HongoBunkyo‑kuTokyo 1138656Japan Research into Artifacts Center for Engineering School of EngineeringThe University of Tokyo7‑3‑1 HongoBunkyo‑kuTokyo 1138656Japan

Efficient monitoring of bone milling conditions in orthopedic and neurosurgical surgery can prevent tissue,bone,and tool damage,and reduce surgery *** researches are mainly focused on recognizing the cutting state using force ***,the force signal during the milling process is difficult and expensive to *** this study,a neural network-based method is proposed to recognize the cutting state and force during the bone milling process using sound *** modeling of the cutting force is performed to capture the relationship between the cutting force and the depth of cut in the bone milling *** force model is used to calibrate the training data to improve the recognition *** package transform is used for signal processing to understand bone-cutting phenomena using sound *** proposed system succeeds to monitor the bone milling process to reduce the surgical *** on standard bone specimens and vertebrae also indicate that the proposed approach has considerable potential for use in computer-assisted and robot-assisted bone-cutting systems used in various types of surgery.

关键词： Cutting state Force Milling Artificial neural network

Insights into the efficiency and stability of Cu-based nanowires for electrocatalytic oxygen evolution

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Nano Research 2018年第8期11卷 4323-4332页

作者： Jun Yu Qi Cao Bin Feng Changli Li Jingyuan Liu J. Kenji Clark Jean-Jacques Delaunay department of Mechanical Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Institute of Engineering Innovation The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan School of Materials Science and Engineering Tsinghua University Beijing 100084 China department of Chemical System Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan

Copper oxide nanowires with varying oxidation states are prepared and their activity for water oxidation is studied. The nanowires with a CuO phase are found to be the most active, and their degree of crystallinity is important in achieving efficient water oxidation. For the crystalline CuO nanowires in a weakly basic Na2CO3 electrolyte, a Tafel slope of 41 mV/decade, an overpotential of approximately 500 mV at - 10 mA/crn2 （without compensation for the solution resistance）, and a faradaic efficiency of nearly 100% are obtained. This electrode maintains a stable current for over 15 lx The low overpotential of 500 mV at 10 mA/cm2, small Tafel slope, long-term stability, and low cost make CuO one of the most promising catalysts for water oxidation. Moreover, the evolution of the CuO nanowire morphology over time is studied by electron microscop）-revealing that the diffusion of Cu ions from the interior of the nanowires to their surface causes the aggregation of individual nanowires over time. However, despite this aggregation, the current density remains nearly constant, because the total electrochemically active surface area of CuO does not change.

关键词： oxygen evolution reaction crystalline CuO active phase copper ion diffusion

DESIGN AND PHOTOFUNCTIONS OF DENDRIMER-ENCAPSULATED POLY(PHENYLENEETHYNYLENE)S

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Chinese Journal of Polymer Science 2001年第2期19卷 161-166页

作者： Takafumi Sato Takuzo Aida department of Chemistry and Biotechnology Graduate School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 JapanDepartment of Chemistry and Biotechnology Graduate School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan

A series of dendrimer-encapsulated poly(phenyleneethynylene)s 4～6 were Synthesize d. The light-harvesting antenna functions of dendrimer frameworks together with the blue-light emitting activities of 4～6 were highli... 详细信息

关键词： Dendrimer Poly(phenyleneethynylene) Molecular wire Light-harvesting antenna Energy transfer