检索结果-南通市图书馆

Hepatitis B virus-related liver cirrhosis complicated with dermatomyositis: A case report

World Journal of Clinical Cases 2019年第10期7卷 1206-1212页

作者： Juan Zhang Xiao-Yu Wen Run-Ping Gao Department of Hepatic-Biliary-Pancreatic Medicine the First Hospital of Jilin University

BACKGROUND Twenty percent of patients infected with hepatitis B virus(HBV)develop extrahepatic manifestations with HBV detected in the lymph nodes,spleen,bone marrow,kidneys,and skin.HBV infection has been associated with some autoimmune disorders.Dermatomyositis(DM)is an idiopathic inflammatory myopathy,which involves a viral infection,and DM has been identified in patients infected with HBV,but there is no direct histological evidence for an association between HBV and DM.CASE SUMMARY We describe a familial HBV-infected patient admitted with liver function abnormality,rashes,a movement disorder,and an elevated level of creatine kinase(CK).A computed tomography scan of the lung showed pulmonary fibrosis,and a liver biopsy identified nodular cirrhosis.An electromyogram revealed myogenic damage,and a muscle biopsy showed nuclear migration in local sarcolemma and infiltration of chronic inflammatory cells.Immunohistochemical staining showed negative results for HBsAg and HBcAg.Fluorescence in situ hybridization showed a negative result for HBV DNA.The patient was diagnosed with HBV-related liver cirrhosis complicated with DM and was treated with methylprednisolone,mycophenolate mofetil,and lamivudine.Eight months later,the patient was readmitted for anorexia and fatigue.The blood examination showed elevated levels of aminotransferases and HBV DNA,however,the CK level was within the normal range.The patient developed a virological breakthrough and lamivudine was replaced with tenofovir.CONCLUSION DM in chronic HBV-infected patients does not always associate with HBV.Antiviral and immunosuppressive drugs should be taken into consideration.

关键词： Chronic hepatitis B Dermatomyositis Extrahepatic manifestations Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An immortalized rat pancreatic stellate cell line RP-2 as a new cell model for evaluating pancreatic fibrosis,inflammation and immunity

引用

Hepatobiliary & pancreatic Diseases International 2015年第6期14卷 651-659页

作者： Rong-Li Piao Ming Xiu David R Brigstock Run-Ping Gao Department of Hepatic-Biliary-Pancreatic Medicine the First Hospital of Jilin University The Research Institute at Nationwide Children's Hospital Division of Pediatric Surgery Department of Surgerythe Ohio State University

BACKGROUND： pancreatic stellate cells （PSCs） play a critical role in the pathogenesis of pancreatic fibrosis and have emerging functions as progenitor cells, immune cells or intermediaries in pancreatic exocrine secretion. Increasing evidence has shown that desmin as an exclusive cytoskeleton marker of PSC is only expressed in part of these cells. This study was to establish a desmin-positive PSC cell line and evaluate its actions on pancreatic fibrosis, inflammation and immunity.

关键词： pancreatic stellate cell pancreatic fibrosis Toll-like receptor 4 inflammation immunity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Connective tissue growth factor is overexpressed in human hepatocellular carcinoma and promotes cell invasion and growth

引用

World Journal of Gastroenterology 2012年第47期18卷 7070-7078页

作者： Ming Xiu Ya-Hui Liu David R Brigstock Fang-Hui He Rui-Juan Zhang Run-Ping Gao Department of Hepatic-Biliary-Pancreatic Medicine First HospitalJilin University department of hepatic-biliary-pancreatic Surgery First HospitalJilin University the Research Institute at Nationwide Children's Hospital ColumbusOH 43205United States Division of Pediatric Surgery Department of Surgerythe Ohio State UniversityColumbusOH 43205United States

AIM:To determine the expression characteristics of connective tissue growth factor(CTGF/CCN2) in human hepatocellular carcinoma(HCC) in histology and to elucidate the roles of CCN2 on hepatoma cell cycle progression and metastasis in vitro.METHODS:Liver samples from 36 patients(who underwent hepatic resection for the first HCC between 2006 and 2011) and 6 normal individuals were examined for transforming growth factor β1(TGF-β1) or CCN2 mRNA by in situ hybridization.Computer image analysis was performed to measure integrated optimal density of CCN2 mRNA-positive cells in carcinoma foci and the surrounding stroma.Fibroblast-specific protein-1(FSP-1) and E-cadherin were examined to evaluate the process of epithelial to mesenchymal transition,α-smooth muscle actin and FSP-1 were detected to identify hepatic stellate cells,and CD34 was measured to evaluate the extent of vascularization in liver tissues by immunohistochemical ***2 was assessed for its stimulation of HepG2 cell migration and invasion using commercial kits while flow cytometry was used to determine CCN2 effects on HepG2 cell-cycle.RESULTS:In situ hybridization analysis showed that TGF-β1 mRNA was mainly detected in connective tissues and vasculature around carcinoma foci.In comparison to normal controls,CCN2 mRNA was enhanced 1.9-fold in carcinoma foci(12.36 ± 6.08 vs 6.42 ± 2.35) or 9.4-fold in the surrounding stroma(60.27 ± 28.71 vs 6.42 ± 2.35),with concomitant expression of CCN2 and TGF-β1 mRNA in those areas.Epithelial-mesenchymal transition phenotype related with CCN2 was detected in 12/36(33.3%) of HCC liver samples at the edges between carcinoma foci and vasculature.Incubation of HepG2 cells with CCN2(100 ng/mL) resulted in more of the cells transitioning into S phase(23.85 ± 2.35 vs 10.94 ± 0.23),and induced a significant migratory(4.0-fold) and invasive(5.7-fold) effect.TGF-β1-induced cell invasion was abrogated by a neutralizing CCN2 antibody showing that CCN2 is a downstream mediator of TGF-β1-induced hepatoma cell invasion.CONCLUSION:These

关键词：结缔组织生长因子肝细胞肝癌 HepG2细胞转化生长因子 mRNA表达计算机图像分析高表浸润

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

引用

Hepatobiliary & pancreatic Diseases International 2017年第4期16卷 443-445页

作者： Li Sun Hong-Yan Li David R Brigstock Run-Ping Gao Department of Hepatic-Biliary-Pancreatic Medicine First Hospital of Jilin University The Research Institute at Nationwide Children’s Hospital and Division of Pediatric Surgery Department of SurgeryThe Ohio State University

To the Editor:IgG4-related sclerosing cholangitis（IgG4-SC）has re cently been recognized as a biliary manifestation of IgG4-related disease（IgG4-RD）.Type 3 IgG4-SC pre sented biliary strictures in both the porta hepatis and the distal common bile duct（CBD）.;Its manifestation especially in the absence of autoimmune pancreatitis,is extremely rare and very similar to that of cholangiocarci noma（CC）.

关键词： IgG4-related sclerosing cholangitis and chronic sclerosing sialadenitis mimicking cholangiocarcinoma and neck malignancy is it been of CBD in

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rare case of Helicobacter pylori-positive multiorgan Ig G4-related disease and gastric cancer

引用

World Journal of Gastroenterology 2015年第11期21卷 3429-3434页

作者： Min Li Qiang Zhou Kun Yang David R Brigstock Lu Zhang Ming Xiu Li Sun Run-Ping Gao Department of Hepatic-Biliary-Pancreatic Medicine The First Hospital of Jilin University The Research Institute at Nationwide Children’s Hospital Division of Pediatric Surgery Department of SurgeryThe Ohio State University

A 61-year-old male from Northeast China presented with a 2-mo history of abdominal distension,pruritus and jaundice.Laboratory testing revealed an elevated serum Ig G4 level.A computed tomography scan showed a typical feature of autoimmune pancreatitis(AIP) and cholecystocholangitis.Early gastric cancer was incidentally discovered when endoscopic untrasound-guided fine needle aspiration(EUSFNA) of the pancreas was carried out.The patient underwent radical subtotal gastrectomy for gastric cancer combined with cholecystectomy.Helicobacter pylori(H.pylori) and Ig G4-positive plasmacytes were detected in gastric cancer tissue,pancreatic EUSFNA sample and resected gallbladder specimen by immunohistochemistry.The patient was diagnosed with H.pylori-positive Ig G4-related AIP and sclerosing cholecystocholangitis as well as H.pylori-positive gastric cancer.He responded well to steroid therapy and remains healthy with no signs of recurrence at one year follow-up.We speculate that H.pylori might act as a trigger via direct or indirect action in the initiation of onset of gastric cancer and multiorgan Ig G4-related disease.

关键词： Ig G4-related disease Helicobacter pylori Type 1 a

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroprotective effects of SMAds in a rat model of cerebral ischemia/reperfusion

引用

Neural Regeneration Research 2015年第3期10卷 438-444页

作者： Fang-fang Liu Chao-ying Liu Xiao-ping Li Sheng-zhe Zheng Qing-quan Li Qun Liu Lei Song department of Neurology First Hospital of Jilin University department of Respiratory medicine First Hospital of Jilin University department of Pediatrics First Hospital of Jilin University department of Neurology Affiliated Hospital of Yanbian University Department of Hepatic-Biliary-Pancreatic Medicine First Hospital of Jilin University

Previous studies have shown that up-regulation of transforming growth factor β1 results in neuroprotective effects. However, the role of the transforming growth factor β1 downstream molecule, SMAD2/3, following ischemia/reperfusion remains unclear. Here, we investigated the neuroprotective effects of SMAD2/3 by analyzing the relationships between SMAD2/3 expression and cell apoptosis and inflammation in the brain of a rat model of cerebral ischemia/reperfusion. Levels of SMAD2/3 mRNA were up-regulated in the ischemic penumbra 6 hours after cerebral ischemia/reperfusion, reached a peak after 72 hours and were then decreased at 7 days. Phos- phorylated SMAD2/3 protein levels at the aforementioned time points were consistent with the mRNA levels. Over-expression of SMAD3 in the brains of the ischemia/reperfusion model rats via delivery of an adeno-associated virus containing the SMAD3 gene could reduce tumor ne- crosis factor-a and interleukin-lβ mRNA levels, down-regulate expression of the pro-apoptotic gene, capase-3, and up-regulate expression of the anti-apoptotic protein, Bcl-2. The SMAD3 protein level was negatively correlated with cell apoptosis. These findings indicate that SMAD3 exhibits neuroprotective effects on the brain after ischemia/reperfusion through anti-inflamma- tory and anti-apoptotic pathways.

关键词： nerve regeneration brain injury neuroprotection inflammation apoptosis cerebralischemia SMAD3 transforming growth factor ~81 NSFC granl neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Added value of indocyanine green fluorescence imaging in liver surgery

引用

Hepatobiliary & pancreatic Diseases International 2022年第4期21卷 310-317页

作者： Nobuyuki Takemura Kyoji Ito Fuyuki Inagaki Fuminori Mihara Norihiro Kokudo department of Surgery Hepato-Biliary Pancreatic Surgery DivisionNational Center for Global Health and Medicine1-21-1 ToyamaShinjyuku-kuTokyo162-8655Japan

Recently,indocyanine green(ICG)fluorescence imaging has been widely used as a substitute for cholangiography in hepatobiliary surgery,to detect hepatic tumors,for accurate anatomical hepatectomy,and to increase the safety and accuracy of minimally invasive(laparoscopic and robotic)hepatectomy.The clinical relevance of this method has been increasing gradually,as new procedures develop in this field.Various important roles and the latest added value of ICG fluorescence imaging in liver surgery are discussed in this report.

关键词： Florescence imaging Indocyanine green Hepatocellular carcinoma Colorectal metastasis Hepatectomy Minimally invasive surgery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

mi R-1181 inhibits invasion and proliferation via STAT3 in pancreatic cancer

引用

World Journal of Gastroenterology 2017年第9期23卷 1594-1601页

作者： Jie Wang Xing-Jun Guo You-Ming Ding Jian-Xin Jiang department of hepatic-biliary-pancreatic Surgery The Affiliated Hospital of Guizhou Medical University department of biliary-pancreatic Surgery Affiliated Tongji Hospital Tongji Medical College Huazhong University of Science and Technology department of hepatic-biliary-pancreatic Surgery Renmin Hospital of Wuhan University

AIM To examine the role of micro RNA 1181(miR-1181) ininvasionandproliferationinpancreaticcancer.METHODS We analyzed the expression of mi R-1181 in severalpancreatic cancer cell lines and generated stableMIA-Pa Ca-2 and PANC-1 cell lines with up-regulatedmi R-1181 expression using an adenovirus deliverysystem. We then investigated mi R-1181's effect oninvasion and proliferation of pancreatic cancer cells bytranswell assay, wound healing assay, cell countingkit-8 assay and colony-forming assay, and exploredany underlying mechanisms by western bolt. Beyondthat, we observed the change of the PANC-1 cell'scytoskeletonbyimmunofluorescencestaining.RESULTS Our data showed that mi R-1181 was relatively downregulatedinpancreaticcancercelllinescomparedwithnormalpancreaticductalepithelialcells.AndmiR-1181inhibited the migration, invasion and proliferationactivities of MIA-Pa Ca-2 and PANC-1 cells. Notably,after over-expressing of mi R-1181 in PANC-1 cells,F-actin depolymerized. Immunofluorescence stainingshows decreased F-actin and β-tubulin expression inPANC-1 cells over-expressing mi R-1181 comparedwith the control cells. Furthermore, we found thatover-expressing mi R-1181 inhibited the expressionof signal transducer and activator of transcription 3(STAT3) while knocking-down mi R-1181 up-regulatedthe expression of STAT3. Knocking-down mi R-1181promoted the invasion and proliferation of pancreaticcancer cells. And inhibition of STAT3 blocked thepromotion effects of knocking-down mi R-1181 onproliferationandinvasioninpancreaticcancer.CONCLUSION Together our findings suggest that mi R-1181 maybe involved in pancreatic cancer cell invasion andproliferation by targeting STAT3 and indicate thatmi R-1181 may be a potential therapeutic agent forpancreaticcancer.

关键词：胰腺的癌症 miR-1181 增长侵略 STAT3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status and future directions

引用

Frontiers of medicine 2020年第3期14卷 251-261页

作者： Li Jiang Deng Ning Xiao-ping Chen department of biliary and pancreatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Postoperative pancreatic fistula (POPF) is the most common and critical complication after pancreatic body and tail resection.How to effectively reduce the occurrence of pancreatic fistula and conduct timely treatment thereafter is an urgent clinical issue to be solved.Recent research standardized the definition of pancreatic fistula and stressed the correlation between POPF classification and patient prognosis.According to the literature,identification of the risk factors for pancreatic fistula contributed to lowering the rate of the complication.Appropriate management of the pancreatic stump and perioperative treatment are of great significance to reduce the rate of POPF in clinical practice.After the occurrence of POPF,the treatment of choice should be determined according to the classification of the pancreatic fistula.However,despite the progress and promising treatment approaches,POPF remains to be a clinical issue that warrants further studies in the future.

关键词： pancreatic fistula pancreatic body and tail resection distal pancreatectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

pancreaticoduodenectomy: how to handle a replaced right hepatic artery

引用

Hepatobiliary Surgery and Nutrition 2023年第2期12卷 280-283页

作者： Junichi Kaneko Akihiko Ichida Yoshikuni Kawaguchi Kiyoshi Hasegawa Hepato-biliary-pancreatic Surgery Division Department of SurgeryGraduate School of MedicineThe University of TokyoTokyoJapan

Hepatobiliary pancreatic surgeons sometimes encounter an aberrant(or replaced)right hepatic artery(a-RHA,Hiatt types III-VI)during pancreaticoduodenectomy(PD).Arterial flow cutoff to the a-RHA may be associated with a biliary leak or stenosis at the choledocho-jejunostomy and liver ischemia,resulting in ischemic cholangitis,liver abscess,and sepsis(1).

关键词： pancreaticoduodenectomy(PD) replaced right hepatic artery pancreatic ductal adenocarcinoma(PDAC)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：