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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu Wen-Chang Jia Jing Wen Xue-Lin Cheng Yan Han Ming-Hui Peng Jing Zhou Yao Liu Sun-Fang Jiang Xiao-Pan Li department of health management Centre Zhongshan HospitalFudan UniversityShanghai 200030China department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China school of Public health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

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Controversies in fecal incontinence

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World Journal of Gastroenterology 2025年第3期31卷 113-119页

作者： Andreia Albuquerque Satish S C Rao school of Medicine and Biomedical Sciences Fernando Pessoa UniversityGondomar 4420-096PortoPortugal Precancerous Lesions and Early Cancer management Research Group RISE@CI-IPO(health Research Network) Portuguese Oncology Institute of PortoPorto 4200-072Portugal Division of Gastroenterology and Hepatology Department of Internal MedicineAugusta UniversityAugustaGA 30912United States

Fecal incontinence is a common condition that can significantly impact patients’quality of *** anal sphincter injury and anorectal surgeries are common *** ultrasound and anorectal manometry are important diagnostic tools for evaluating *** are various treatment options,including diet,lifestyle modifications,drugs,biofeedback therapy,tibial and sacral nerve neuromodulation therapy,and *** this editorial,we will discuss current controversies and novel approaches to fecal *** for asymptomatic anal sphincter defects after obstetric anal sphincter injury and in patients with inflammatory bowel disease is not generally recommended,but may be helpful in selected *** Garg incontinence score is a new score that includes the assessment of solid,liquid,flatus,mucous,stress and urge fecal *** tests such as translumbosacral anorectal magnetic stimulation and novel therapies such as translumbosacral neuromodulation therapy are promising diagnostic and treatment options,for both fecal incontinence and *** biofeedback therapy can overcome some limitations of the office-based *** muscle-derived cell implantation of the external anal sphincter has been further studied as a possible treatment *** neuromodulation may be useful in scleroderma,congenital fecal incontinence and inflammatory bowel disease but merits further study.

关键词： Fecal incontinence Endoanal ultrasound Anal sphincter defects Biofeedback Neuropathy Sacral neuromodulation

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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahul Mittal Keelin McKenna Grant Keith Evan McKenna Joana R.N.Lemos Jeenu Mittal Khemraj Hirani Diabetes Research Institute University of Miami Miller School of MedicineMiamiFLUSA department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA school of Medicine and Public health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly department of Engineering management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Quasi-variable Discount Rates and Market Volatility: An Empirical Study

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Journal of Systems Science and Systems Engineering 2023年第5期32卷 515-530页

作者： Pengju Zhao Wei Zhang Xi Wu Peter C.Coyte economics and management school Zhongyuan University of TechnologyZhengzhou450007China economics and management school Tianjin UniversityTianjin300072China economics and management school System and Industrial Engineering Research CentreZhongyuan University of TechnologyZhengzhou450007China Institute of health Policy Management and Evaluation(HPME)School of Public HealthUniversity of TorontoTorontoM5R 0A3Canada

This paper proposes an assumption of quasi-variable discount rates to explain the excess volatility puzzle of stock market. Under the assumption, the ARMAX model is derived based on the CCAPM model and CRRA utility function to describe the linear relationship between the discount rate and the consumption growth rate. We conducted empirical research on this model using historical data of the US stock market. The results confirm a significantly negative relationship between consumption growth rate and discount rate. Subsequently, the results of Monte Carlo simulation show that given the risk preference coefficient and dividend sequence, the rational expectations price fluctuation obtained under the assumption of quasivariable discount rate is the largest.

关键词： Stochastic discount factor market volatility dividend discount model ARMAX

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Insights from an academic endeavor into central nervous system drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An M.Voets Tim Vanmierlo Rudy Schreiber BIOMED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University MS Center(UMSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013).

关键词： academic approval consequences

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Resource Planning and Allocation Problem Under Uncertain Environment

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Journal of Systems Science & Complexity 2015年第5期28卷 1115-1127页

作者： ZHANG Juliang department of Logistics management School of Economics and Management Beijing Jiaotong University

This paper generalizes the classic resource allocation problem to the resource planning and allocation problem, in which the resource itself is a decision variable and the cost of each activity is uncertain when the resource is determined. The authors formulate this problem as a two-stage stochastic programming. The authors first propose an efficient algorithm for the case with finite ***, a sudgradient method is proposed for the general case and it is shown that the simple algorithm for the unique state case can be used to compute the subgradient of the objective function. Numerical experiments are conducted to show the effectiveness of the model.

关键词： Convex programming resource allocation problem resource planning and allocation problem stochastic programming.

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Evaluation matrix with the speed feature based on double inspiriting control lines

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Journal of Systems Engineering and Electronics 2013年第6期24卷 962-970页

作者： Weiwei Liu Chunsheng Shi Jing Li school of economics and management Harbin Engineering University school of economics and management Harbin Institute of Technology

Methods of the comprehensive evaluation have been studied for many years. However, the change speed of evaluated objects was rarely considered by the existing evaluation methods. An evaluation matrix is proposed to remedy this deficiency. Firstly, the change speed state （CSS） of the evaluated objects is analyzed based on double inspiriting control lines （DICLs）, and a matrix of the CSS is constructed. Then, 72 elements in the matrix are analyzed, and formulas describing each CSS are given. The efficiency of the proposed evaluation matrix is proved when the CSS merges with the change speed trend （CST） in the dynamic comprehensive evaluation. Finally, a computing example shows that the proposed evaluation matrix is feasible in the dynamic comprehensive evaluation with the speed feature.

关键词： double inspiriting control lines (DICLs) change speed state (CSS) change speed trend (CST) evaluation matrix

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THE EFFECTS OF MARKET DEPTH ON THE ARRIVAL RATE OF ORDERS

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Journal of Systems Science & Complexity 2014年第6期27卷 1192-1203页

作者： ZHANG Qiang LIU Shancun QIU Wanhua school of economics and management Beijing University of Chemical Technology school of economics and management Beihang University

This paper presents a model to describe the dynamic trading process in limit order *** studying the dynamic pattern of execution probabilities of limit orders with both time and the depth of limit order book,the authors conclude with the following properties:Arrival rates of market buy orders increase as the depth of buy queue in the book increases and decrease as the depth of sell queue increases,and vice versa;similar regularities for the arrival rate of market sell orders;both the arrival rate of market buy order and market sell orders increase as the depth of both sides in the book increases by the same ***,the authors describe more detailed temporary and permanent effects of the market depth on the arrival rates of orders.

关键词： Arrival rate limit order market market depth private value.

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Promote COVID-19 Vaccination for Older Adults in China

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China CDC weekly 2022年第37期4卷 832-834页

作者： Shujie Zang Xu Zhang Zhiqiang Qu Xi Chen Zhiyuan Hou school of Public health NHC Key Laboratory of Health Technology AssessmentFudan UniversityShanghai MunicipalityChina department of health Policy and management School of Public HealthYale UniversityNew HavenCTUSA department of economics Yale UniversityNew HavenCTUSA

The coronavirus disease 2019(COVID-19)vaccine effectively reduces the possibility of severe illness and mortality in older adults and is essential for controlling the *** with developed countries,the coverage of full vaccination and booster vaccination for older adults aged 60 or above in China is poor,making it urgent to accelerate their vaccination in *** discussed potential reasons for low vaccination coverage for older adults aged 60 or above and presented strategies to promote their COVID-19 vaccination in China.

关键词： vaccination China. vaccine

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