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Performance of the walking trail making test in older adults with white matter hyperintensities

World Journal of Psychiatry 2024年第1期14卷 102-110页

作者： Hong-Yi Zhao Zhi-Qiang Zhang Yong-Hua Huang Hong Li Fang-Yuan Wei department of Neurology No.984 Hospital of PLABeijing 100094China department of Neurology The Seventh Medical Center of PLA General HospitalBeijing 100700China Mental Health Institute of Inner Mongolia Autonomous Region The Third Hospital of Inner Mongolia Autonomous RegionHohhot 010010Inner Mongolia Autonomous RegionChina department of Neurosurgery No.984 Hospital of PLABeijing 100094China department of hand and foot Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Engineering Research Center of Chinese Orthopaedic and Sports Rehabilitation Artificial Intelligent Ministry of EducationBeijing 100029China

BACKGROUND Several studies have reported that the walking trail making test(WTMT)completion time is significantly higher in patients with developmental coordination disorders and mild cognitive impairments.We hypothesized that WTMT performance would be altered in older adults with white matter hyperintensities(WMH).AIM To explore the performance in the WTMT in older people with WMH.METHODS In this single-center,observational study,25 elderly WMH patients admitted to our hospital from June 2019 to June 2020 served as the WMH group and 20 participants matched for age,gender,and educational level who were undergoing physical examination in our hospital during the same period served as the control group.The participants completed the WTMT-A and WTMT-B to obtain their gait parameters,including WTMT-A completion time,WTMT-B completion time,speed,step length,cadence,and stance phase percent.White matter lesions were scored according to the Fazekas scale.Multiple neuropsychological assessments were carried out to assess cognitive function.The relationships between WTMT performance and cognition and motion in elderly patients with WMH were analyzed by partial Pearson correlation analysis.RESULTS Patients with WMH performed significantly worse on the choice reaction test(CRT)(0.51±0.09 s vs 0.44±0.06 s,P=0.007),verbal fluency test(VFT,14.2±2.75 vs 16.65±3.54,P=0.012),and digit symbol substitution test(16.00±2.75 vs 18.40±3.27,P=0.010)than participants in the control group.The WMH group also required significantly more time to complete the WTMT-A(93.00±10.76 s vs 70.55±11.28 s,P<0.001)and WTMT-B(109.72±12.26 s vs 82.85±7.90 s,P<0.001).WTMT-A completion time was positively correlated with CRT time(r=0.460,P=0.001),while WTMT-B completion time was negatively correlated with VFT(r=-0.391,P=0.008).On the WTMT-A,only speed was found to statistically differ between the WMH and control groups(0.803±0.096 vs 0.975±0.050 m/s,P<0.001),whereas on the WTMT-B,the WMH group exhibited a significantly lower speed(0.778±0.111 vs 0.970±0.053

关键词： White matter hyperintensities Cognitive dysfunction Motor deficits Gait analysis Trail making test Small vessel disease

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A bibliometric analysis and visualization of osteochondral lesions of talus (2004-2021)

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Medical Data Mining 2024年第3期7卷 17-25页

作者： Xiao-Jie Sun Shu-Long Wang Zi-Dong Wang Zhao-Jun Chen The Third Affiliated Hospital of Beijing University of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China department of hand and foot Surgery The Third Affiliated Hospital of Beijing University of Chinese MedicineBeijing 100029China School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China

Background:Osteochondral lesions of the talus(OLTs)are a significant challenge for foot and ankle specialists,which could cause pain and decrease patient function.Researchers can use the findings of this study to shape future directions for research by exploring global trends and hotspots in OLT.Methods:Web of Science Core Collection was used to retrieve literature related to OLT between 2004 and 2021.This report covers the current state of OLTs,such as publications,journals,trends,hotspots,and the performances of relevant countries,institutions and authors.The co-citation analysis,the coauthorship analysis,the cooccurrence analysis,and the bibliographic coupling analysis were conducted with the Bibliometrix R package,VOSviewer v1.***.10.0,and CiteSpace 5.8.R3.Results:During an 18-year review,717 articles and 76 review articles on OLT published from 2004 to 2021 were reviewed.The USA has made the largest contribution to the OLT-related literature,and a significant contribution has been made by Kennedy JG(48/6.05%)and van Dijk CN(30/3.78%).In terms of total link strength,foot&Ankle International was the leading journal.Analysis showed that the global research hotspots of OLTs focused on the pathogenesis,diagnosis,clinical research,and surgical treatment of OLT.It would be significant to pay close attention to future research on osteochondral autograft transplantation and management,surgery,multidisciplinary integration and mechanisms of OLT,and its related diseases.Conclusions:The study provides information about the current status and hotspots of research in the domain of OLT over the past 18 years that will assist researchers in identifying potential perspectives on hot topics and research frontiers.

关键词： bibliometric analysis hotspots osteochondral lesions of the talus trends visualised analysis

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Bilateral carpal tunnel syndrome and motor dysfunction caused by gout and type 2 diabetes:A case report

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World Journal of Clinical Cases 2023年第11期11卷 2535-2540页

作者： Gao-Feng Zhang Cun-Min Rong Wei Li Ben-Lei Wei Ming-Tong Han Qing-Luan Han department of hand and foot Surgery Affiliated Hospital of Jining Medical UniversityJining 272029Shandong ProvinceChina

BACKGROUND Carpal tunnel syndrome(CTS)has been associated with gout and type 2 diabetes mellitus(T2DM).However,due to insufficient clinical understanding of goutrelated CTS and reliance on the diagnostic importance of elevated serum uric acid levels,such cases are prone to missed diagnosis,misdiagnosis,and delayed treatment.In addition,the effect of T2DM on gout-induced carpal tunnel syndrome has not been reported.CASE SUMMARY Herein,we present an unusual case of CTS and motor dysfunction caused by miliary tophaceous gout and T2DM.The patient presented to the hand and foot clinic with paresthesia of the fingers of both hands,especially at night.The patient was diagnosed with type 2 diabetes a month ago.Ultrasonography revealed bilateral transverse carpal ligament thickening with median nerve compression during hospitalization.The patient was successfully treated with carpal tunnel decompression and tendon release.The postoperative pathological examination revealed typical gout nodules.This case suggests that the presence of T2DM could accelerate tophi formation and worsen CTS symptoms,although no definitive proof in this regard has been described previously.CONCLUSION Tophi formation may most likely cause the co-occurrence of CTS and flexor dysfunction in gout and incipient diabetes patients.

关键词： Carpal tunnel syndrome Motor dysfunction Tophaceous gout Type 2 diabetes mellitus Operate Case report

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Total ankle replacement with INBONE-II prosthesis: A short-to-medium-term follow-up study in China

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Chinese Medical Journal 2022年第12期135卷 1459-1465页

作者： Yong Wu Hanyuan Yang Xiangbin Guo Hui Du Xiaofeng Gong department of foot and Ankle Surgery Beijing Jishuitan HospitalBeijing 100035China department of foot and Ankle Surgery Beijng Chaoyang Emergency Medical CenterBeijing 100021China

Background:Total ankle replacement(TAR)is a viable option for the treatment of end-stage ankle arthritis.In China,the INBONE-II implant is the only total ankle prosthesis approved since 2016.The purpose of this study is to report a large sample of findings for the TAR with INBONE-II prosthesis.Methods:A total of 64 patients with end-stage ankle arthritis,who underwent primary TAR using INBONE-II by the same surgeon from 2016 to 2019,at a single institution were included in this retrospective,single-center study.Clinical data,radiographic findings,survival rate,and complications were recorded and assessed pre-operatively and at the most recent follow-up.Results:A total of 64 patients were available for follow-up at least 2 years after surgery;the mean follow-up duration for clinical outcomes was 37.9 months(24–59 months),and for radiographic findings was 22.8 months(12–59 months).There were significant improvements(Pfoot and Ankle Society hindfoot scale,the visual analog scale for pain,and the Short Form-36.There were statistically significant differences between pre-operative and post-operative comparisons of the talar tilt angle(TT)and the tibial lateral surface angle(TLS)in the radiographic findings(TT from 4.7±4.3°to 1.3±1.3°,TLS from 80.4±7.7°to 87.4±2.3°,P<0.01).There was no statistically significant difference in improvement of the tibial anterior surface angle(P=0.14).Ten complications(all low grade)were recorded according to the Glazebrook classification system.The survivorship of the prosthesis was 100%(64/64).Conclusion:Patients who underwent TAR with INBONE-II prosthesis demonstrated significant improvements in all measures of pain and function as well as in radiographic findings.High survival and a low incidence of complications were observed in this study.

关键词： Total ankle replacement Total ankle arthroplasty Outcomes Complications INBONE-II

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Repair of sciatic nerve defects using tissue engineered nerves

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Neural Regeneration Research 2013年第21期8卷 1985-1994页

作者： Caishun Zhang Gang Lv department of hand and foot Surgery First Affiliated Hospital of Liaoning Medical University

In this study, we constructed tissue-engineered nerves with acellular nerve allografts in Sprague-Dawley rats, which were prepared using chemical detergents-enzymatic digestion and mechanical methods, in combination with bone marrow mesenchymal stem cells of Wistar rats cultured in vitro, to repair 15 mm sciatic bone defects in Wistar rats. At postoperative 12 weeks, electrophysiological detection results showed that the conduction velocity of regenerated nerve after repair with tissue-engineered nerves was similar to that after autologous nerve grafting, and was higher than that after repair with acellular nerve allografts. Immunohistochemical staining revealed that motor endplates with acetylcholinesterase-positive nerve fibers were orderly arranged in the middle and superior parts of the gastrocnemius muscle; regenerated nerve tracts and sprouted branches were connected with motor endplates, as shown by acetylcholinesterase histochemistry combined with silver staining. The wet weight ratio of the tibialis anterior muscle at the affected contralateral hind limb was similar to the sciatic nerve after repair with autologous nerve grafts, and higher than that after repair with acellular nerve allografts. The hind limb motor function at the affected side was significantly improved, indicating that acellular nerve allografts combined with bone marrow mesenchymal stem cell bridging could promote functional recovery of rats with sciatic nerve defects.

关键词： neural regeneration peripheral nerve injury tissue engineering artificial nerve sciatic nerve defects bone marrow mesenchymal stem cells nerve scaffold grants-supported paper neuroregeneration

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Rare pattern of Maisonneuve fracture:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4684-4690页

作者： Bin Zhao Nan Li Hong-Bin Cao Gui-Xin Wang Jin-Quan He department of foot and Ankle SurgeryⅠ Tianjin HospitalTianjin 300211China

BACKGROUND Maisonneuve fracture is a special type of ankle fracture that consists of proximal fibular fracture,a lesion of the inferior tibiofibular syndesmotic complex(interosseous ligament,anterior inferior tibiofibular ligament and posterior inferior tibiofibular ligament),and injury of the medial structure of the ankle(deltoid ligament tear or medial malleolar fracture).The accepted mechanism of Maisonneuve fracture is pronation external rotation according to the Lauge-Hansen classification.In this paper,we report a rare pattern of Maisonneuve fracture,which has the characteristics of both pronation external rotation ankle fracture and supination adduction ankle fracture.CASE SUMMARY A 31-year-old female patient accidentally sprained her right ankle while walking 5 d before hospitalization in our hospital.The patient was initially missed in other hospitals and later rediagnosed in our outpatient department.Full-length radiographs of the lower leg revealed proximal fibula fracture,inferior tibiofibular joint separation,and medial malleolar fracture involving the posterior malleolus,which was also revealed on computed tomography scans.Magnetic resonance imaging revealed rupture of the anterior inferior tibiofibular ligament and anterior talofibular ligament.We diagnosed a rare pattern of Maisonneuve fracture with proximal fibular fracture,inferior tibiofibular joint separation,medial malleolar fracture and ruptures of the anterior inferior tibiofibular ligament and anterior talofibular ligament.The patient underwent open reduction and internal fixation in our hospital.A 6-mo postoperative follow-up confirmed a good clinical outcome.CONCLUSION To our knowledge,this rare pattern of Maisonneuve fracture has not been previously described.The possible mechanism of injury is supination adduction combined with pronation external rotation.Careful analysis of the injury mechanism of Maisonneuve fracture is of great clinical significance and can better guide clinical treatment.

关键词： Ankle fracture Maisonneuve fracture Mechanism analysis Pronation external rotation Supination adduction Case report

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Corrigendum to“3Cpro of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation”[Virol Sin 38(2023)387–397]

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Virologica Sinica 2024年第2期39卷 351-354页

作者： Xiangju Wu Lei Chen Chao Sui Yue Hu Dandan Jiang Fan Yang Laura C.Miller Juntong Li Xiaoyan Cong Nataliia Hrabchenko Changhee Lee Yijun Du Jing Qi Shandong Key Laboratory of Animal Disease Control and Breeding Key Laboratory of Livestock and Poultry Multi-omics of MARAInstitute of Animal Science and Veterinary MedicineInstitute of Crop Germplasm ResourcesShandong Academy of Agricultural SciencesJinan250100China College of Life Science Shandong Normal UniversityJinan250358China State Key Laboratory of Veterinary Etiological Biology National Foot and Mouth Disease Reference LaboratoryKey Laboratory of Animal Virology of Ministry of AgricultureLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou730050China department of Diagnostic Medicine and Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKS66506USA College of Veterinary Medicine and Virus Vaccine Research Center Gyeongsang National UniversityJinju52828Republic of Korea

Due to our negligence,the original version of this article,published online on Mar 14,2023,contained some mistakes in several Figs.In Fig.2D,the positions of the bands for protein 3A and 3B were incorrectly shifted.Th... 详细信息

关键词： STAT1 FMDV bands

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Lower limb suspension induces threshold-specific alterations of motor units properties that are reversed by active recovery

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Journal of Sport and Health Science 2024年第2期13卷 264-276页

作者： Giacomo Valli Fabio Sarto Andrea Casolo Alessandro Del Vecchio Martino V.Franchi Marco V.Narici Giuseppe De Vito department of Biomedical Sciences University of PadovaPadova 35131Italy department Artificial Intelligence in Biomedical Engineering Friedrich-Alexander UniversityErlangen-Nurnberg 91052Germany

Purpose:This study aimed to non-invasively test the hypothesis that(a) short-term lower limb unloading would induce changes in the neural control of force production(based on motor units(MUs) properties) in the vastus lateralis muscle and(b) possible changes are reversed by active recovery(AR).Methods:Ten young males underwent 10 days of unilateral lower limb suspension(ULLS) followed by 21 days of AR.During ULLS,participants walked exclusively on crutches with the dominant leg suspended in a slightly flexed position(15°-20°) and with the contralateral foot raised by an elevated shoe.The AR was based on resistance exercise(leg press and leg extension) and executed at 70% of each participant’s 1repetition maximum,3 times/week.Maximal voluntary isometric contraction(MVC) of knee extensors and MUs properties of the vastus lateralis muscle were measured at baseline,after ULLS,and after AR.MUs were identified using high-density electromyography during trapezoidal isometric contractions at 10%,25%,and 50% of the current MVC,and individual MUs were tracked across the 3 data collection points.Results:We identified 1428 unique MUs,and 270 of them(18.9%) were accurately tracked.After ULLS,MVC decreased by 29.77%,MUs absolute recruitment/derecruitment thresholds were reduced at all contraction intensities(with changes between the 2 variables strongly correlated),while discharge rate was reduced at 10% and 25% but not at 50% MVC.Impaired MVC and MUs properties fully recovered to baseline levels after AR.Similar changes were observed in the pool of total as well as tracked MUs.Conclusion:Our novel results demonstrate,non-invasively,that 10 days of ULLS affected neural control predominantly by altering the discharge rate of lower-threshold but not of higher-threshold MUs,suggesting a preferential impact of disuse on motoneurons with a lower depolarization threshold.However,after 21 days of AR,the impaired MUs properties were fully restored to baseline levels,highlighting the plasticity of the components involved in neural cont

关键词： Disuse High-density EMG Muscle disuse Neural impairment Neuromuscular degeneration

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Brain injury in combination with tacrolimus promotes the regeneration of injured peripheral nerves

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Neural Regeneration Research 2017年第6期12卷 987-994页

作者： Xin-ze He Jian-jun Ma Hao-qi Wang Tie-min Hu Bo Sun Yun-feng Gao Shi-bo Liu Wei Wang Pei Wang department of hand and foot Surgery Affiliated Hospital of Chengde Medical College Binzhou Central Hospital Postgraduate School Chengde Medical College department of Neurosurgery Affiliated Hospital of Chengde Medical College department of hand and foot Surgery the First Hospital of Qinhuangdao

Both brain injury and tacrolimus have been reported to promote the regeneration of injured peripheral nerves. In this study, before transection of rat sciatic nerve, moderate brain contusion was（or was not） induced. After sciatic nerve injury, tacrolimus, an immunosuppressant, was（or was not） intraperitoneally administered. At 4, 8 and 12 weeks after surgery, Masson＇s trichrome, hematoxylin-eosin, and toluidine blue staining results revealed that brain injury or tacrolimus alone or their combination alleviated gastrocnemius muscle atrophy and sciatic nerve fiber impairment on the experimental side, simultaneously improved sciatic nerve function, and increased gastrocnemius muscle wet weight on the experimental side. At 8 and 12 weeks after surgery, brain injury induction and/or tacrolimus treatment increased action potential amplitude in the sciatic nerve trunk. Horseradish peroxidase retrograde tracing revealed that the number of horseradish peroxidase-positive neurons in the anterior horn of the spinal cord was greatly increased. Brain injury in combination with tacrolimus exhibited better effects on repair of injured peripheral nerves than brain injury or tacrolimus alone. This result suggests that brain injury in combination with tacrolimus promotes repair of peripheral nerve injury.

关键词： tacrolimus injured nerves regeneration alone axonal hematoxylin peroxidase tracing Schwann

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Transfer of the extensor indicis proprius branch of posterior interosseous nerve to reconstruct ulnar nerve and median nerve injured proximally:an anatomical study

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Neural Regeneration Research 2017年第1期12卷 143-148页

作者： Pei-ji Wang Yong Zhang Jia-ju Zhao Ju-pu Zhou Zhi-cheng Zuo Bing-bing Wu department of hand and foot Surgery Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina

Proximal or middle lesions of the ulnar or median nerves are responsible for extensive loss of hand motor function.This occurs even when the most meticulous microsurgical techniques or nerve grafts are used.Previous studies had proposed that nerve transfer was more effective than nerve grafting for nerve repair.Our hypothesis is that transfer of the posterior interosseous nerve,which contains mainly motor fibers,to the ulnar or median nerve can innervate the intrinsic muscles of hands.The present study sought to investigate the feasibility of reconstruction of the deep branch of the ulnar nerve and the thenar branch of median nerve by transferring the extensor indicis proprius branch of the posterior interosseous nerve obtained from adult cadavers.The results suggested that the extensor indicis proprius branch of the posterior interosseous nerve had approximately similar diameters and number of fascicles and myelinated nerve fibers to those of the deep branch of ulnar nerve and the thenar branch of the median nerve.These confirm the feasibility of extensor indicis proprius branch of posterior interosseous nerve transfer for reconstruction of the deep branch of the ulnar nerve and the thenar branch of median nerve.This procedure could be a novel and effective method for the functional recovery of the intrinsic muscles of hands after ulnar nerve or median nerve injury.

关键词： nerve regeneration posterior interosseous nerve ulnar nerve median nerve extensor indicis proprius thenar branch nerve transfer neural regeneration

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