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Laparoscopic management of remnant gall bladder with stones: Lessons from a tertiary care centre's experience

Laparoscopic, Endoscopic and Robotic surgery 2024年第1期7卷 27-33页

作者： Gilbert Samuel Jebakumar Jeevanandham Muthiah Loganathan Jayapal R.Santhosh Kumar Siddhesh Tasgaonkar K.S.Santhosh Anand J.K.A.Jameel Sudeepta Kumar Swain K.J.Raghunath Prasanna Kumar Reddy Tirupporur Govindaswamy Balachandar department of Surgical Gastroenterology Apollo HospitalsChennai 600006India department of General surgery Apollo HospitalsChennai 600006India department of Minimal access surgery Apollo HospitalsChennai 600006India

Objective:Laparoscopic cholecystectomy is currently the gold standard for treating symptomatic gallstone *** its success,approximately 10%of patients may experience persistent biliary symptoms,leading to the post-cholecystectomy syndrome.A remnant gallbladder with cystic duct or bile duct stones is one of the causes of this *** objective of this study was to shed light on the clinical manifestations,evaluation,therapeutic strategies,and outcomes associated with laparoscopic management of symptomatic remnant ***:This was a retrospective study,conducted over a five-year period(January 2017 to December 2022)at Apollo Hospitals in South *** patients who underwent laparoscopic completion cholecystectomy for a remnant gall bladder were *** following data were collected:patient demographics,symptoms,preoperative investigations,intraoperative details and post operative ***:In total,36 patients were included and *** majority of patients were male(25,69.4%),with a mean age of 50.7±12.1 *** most common presentation was pain in the upper abdomen or right upper quadrant region(24,66.7%).The laparoscopic approach was attempted in all patients,with a success rate of 94.4%.Two patients required conversion to open *** fistula to the colon was observed in one *** was observed in 7 patients(19.4%),and stone clearance was successfully achieved using endoscopic retrograde cholangiopancreatography in all patients ***:Incomplete gall bladder removal either intentionally or unintentionally leaves a remnant gall bladder that is at risk for stone formation and *** who have this clinical entity with symptoms require a redo or complete cholecystectomy,a complex procedure associated with certain *** study highlights the feasibility and safety of laparoscopic completion cholecystectomy for the management of remnant gallbladder

关键词： Remnant gall bladder Stump cholecystitis Subtotal cholecystectomy Laparoscopic completion cholecystectomy

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Editorial:Transcriptome analysis in tumor microenvironment and tumor heterogeneity

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Oncology Research 2024年第1期32卷 99-100页

作者： JINHUI LIU JIAHENG XIE PEIXIN DONG department of gynecology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210029China department of Plastic and Cosmetic surgery Xiangya HospitalCentral South UniversityChangsha410008China department of Obstetrics and gynecology Hokkaido University School of MedicineHokkaido UniversitySapporo060-8638Japan

Cancer,a disease as intricate as it is devastating,continues to challenge the medical and scientific community[1].Its complex nature is epitomized by the tumor microenvironment and tumor *** we delve deeper into the realms of cancer research,the advent of transcriptome analysis has emerged as a powerful torchbearer,illuminating our understanding of these enigmatic facets of cancer biology[2].

关键词： heterogeneity. tumor Cancer

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Traction force with extracellular matrix mediated by cytoskeleton influences metastasis through SLC8A1 induced Wnt-b-catenin pathway in endometrial cancer

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Genes & Diseases 2024年第5期11卷 98-101页

作者： Xingchen Li Xin Xu Jianliu Wang department of Obstetrics and gynecology Peking University People’s HospitalBeijing 100044China department of Obstetrics and gynecology Beijing ChaoYang HospitalCapital Medical UniversityBeijing 100020China

Endometrial cancer(EC)is one of the most prominent malignancies in ***,despite these advancements in understanding EC pathogenesis,mortality rates have not *** force(TF)refers to endogenous mechanical forces exerted by cells.1 These forces act on the extracellular matrix and the extracellular tumor microenvironment through focal adhesions,thereby regulating cell proliferation and ***,the TF characteristics of endometrial cancer cells and their heterogeneity remain unclear.

关键词： endometrial metastasis endogenous

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TGF-β-regulated different iron metabolism processes in the development and cisplatin resistance of ovarian cancer

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Oncology Research 2024年第2期32卷 373-391页

作者： JIANFA WU QIANYI LIAO LI ZHANG SUQIN WU ZHOU LIU department of gynecology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina department of gynecology Shanghai University of Medicine&Health SciencesShanghaiChina department of gynecology Gongshan People’s HospitalNujiang Lisu Autonomous PrefectureChina

The impact of different iron metabolism processes(DIMP)on ovarian cancer remains *** this study,we employed various gene chips and databases to investigate the role of DIMP in the initiation and development of ovarian *** was used to determine mutations in DIMP-associated genes in ovarian ***-Meier plotter was used to examine the influence of DIMP on the prognosis of ovarian *** analyzing 1669 serous ovarian cancer cases,we identified a range of mutations in iron metabolism genes,notably in those coding for the transferrin receptor(19%),melanotransferrin(19%),and ceruloplasmin(10%)in the iron import process,and glucose-6-phosphate isomerase(9%),hepcidin antimicrobial peptide(9%),metal regulatory transcription factor 1(8%),and bone morphogenetic protein 6(8%)in the iron regulation *** to the unaltered group,the group with gene alterations exhibited a higher tumor mutation burden count(43 vs.54)and more advanced histologic grade(78.19%vs.87.90%).Compared to the normal ovarian counterparts,a reduction in expression was observed in 9 out of the 14 genes involved in iron utilization and 4 out of the 5 genes involved in iron export in ovarian cancer;in contrast,an increase in expression was observed in 2 out of the 3 genes involved in iron storage in ovarian ***,in cisplatin-resistant cells compared to cisplatin-sensitive ones,the expression of all genes in iron storage and 13 out of 14 genes in iron import was decreased,while that of 8 out of the 10 genes in iron utilization was *** addition,survival curve analysis indicated that a higher expression in the majority of genes in the iron import process(12/21),or a reduced expression in most genes in the iron export process(4/5)correlated with poor progression-free ***,TGF-βcould regulate the expression of most iron metabolism-associated genes;particularly,expression of genes involved in the iron storage process(2/2)was inhibited aft

关键词： Chemoresistance Cisplatin Iron Ovarian neoplasms TGF-β

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Knockdown of circular RNA (CircRNA)_001896 inhibits cervical cancer proliferation and stemness in vivo and in vitro

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BIOCELL 2024年第4期48卷 571-580页

作者： JIA SHAO CAN ZHANG YAONAN TANG AIQIN HE WEIPEI ZHU department of Obstetrics and gynecology The Second Affiliated Hospital of Soochow UniversitySuzhou215004China department of gynecology Oncology Affiliated Tumor Hospital of Nantong UniversityNantong226361China

Objective:Previous studies indicated that aberrant circular RNA(circRNA)expression affects gene expression regulatory networks,leading to the aberrant activation of tumor pathways and promoting tumor cell ***,the expression,clinical signiﬁcance,and effects on cell propagation,invasion,and dissemination of circRNA_001896 in cervical cancer(CC)tissues remain ***:The Gene Expression Omnibus(GEO)datasets(GSE113696 and GSE102686)were used to examine differential circRNA expression in CC and adjacent *** expression of circRNA_001896 was detected in 72 CC patients usingﬂuorescence quantitative *** analysis with clinical pathological features was performed through COX multivariate and univariate *** effect of circRNA_001896 downregulation on CC cell propagation was examined using the cell counting kit-8(CCK-8)test,clonogenic,3D sphere formation,and in vivo tumorigenesis ***:Intersection of the GSE113696 and GSE102686 datasets revealed an increased expression of four circRNAs,including circRNA_001896,in CC *** quantitative PCR conﬁrmed circRNA_001896 as a circular *** expression of circRNA_001896 was considerably associated with lymph node metastasis,International Federation of Gynecologists and Obstetricians(FIGO)stage,tumor diameter,and survival period in CC *** hazards model(COX)univariate and multivariate analyses revealed that circRNA_001896 expressions are a distinct risk factor affecting CC patients’*** functional experiments showed that downregulating circRNA_001896 substantially suppressed CC cell growth,colony formation,and 3D sphere-forming *** vivo,tumorigenesis analysis in nude mice demonstrated that downregulating circRNA_001896 remarkably reduced the in vivo proliferation capacity of CC ***:CircRNA_001896 is highly expressed in CC tissues and is substantially related to lymph node metastasis,FIGO stage,tumor size,and surviva

关键词： Uterine cervical neoplasms RNA Circular Cell proliferation Cancer stem cells

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LncRNA PCGEM1 facilitates cervical cancer progression via miR-642a-5p/KIF5B axis

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Oncology Research 2024年第7期32卷 1221-1229页

作者： YUANLIN LIU YAN LIU YAN WANG QIANG WANG YAN YAN DANDAN ZHANG HUIQIN LIU department of Obstetrics and gynecology Shanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghai200092China department of Obstetrics and gynecology The Second People’s Hospital of Nantong CityNantong226002China department of Obstetrics and gynecology Affiliated Hospital of Nantong UniversityNantong226002China

At present,the role of many long non-coding RNAs(lncRNAs)as tumor suppressors in the formation and development of cervical cancer(CC)has been ***,lncRNA prostate cancer gene expression marker 1(PCGEM1),whose high expression not only aggravates ovarian cancer but also can induce tumorigenesis and endometrial cancer progression,has not been studied in *** objective of this study was to investigate the expression and the underlying role of PCGEM1 in *** relative expression of PCGEM1 in CC cells was detected by real-time *** the suppression of PCGEM1 expression by shRNA,the changes in the proliferation,migration,and invasion capacities were detected via CCK-8 assay,EdU assay,and colony formation assay wound healing *** assay and the changes in expressions of epithelial-to-mesenchymal transition(EMT)markers were determined by western blot and immunoﬂ*** interplay among PCGEM1,miR-642a-5p,and kinesin family member 5B(KIF5B)was conﬁrmed by bioinformatics analyses and luciferase reporter *** showed that PCGEM1 expressions were up-regulated within CC *** viabilities,migration,and invasion were remarkably reduced after the suppression of PCGEM1 expression by shRNA in Hela and SiHa cells.N-cadherin was silenced,but E-cadherin expression was elevated by ***,by sponging miR-642a-5p in CC,PCGEM1 was veriﬁed as a competitive endogenous RNA(ceRNA)that modulates KIF5B ***-642a-5p down-regulation partially rescued sh-PCGEM1’s inhibitory effects on cell proliferation,migration,invasion,and EMT *** conclusion,the PCGEM1/miR-642a-5p/KIF5B signaling axis might be a novel therapeutic target in *** study provides a research basis and new direction for targeted therapy of CC.

关键词： Cervical cancer PCGEM1 KIF5B MiR-642a-5p tumorigenesis

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Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse

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World Journal of Stem Cells 2024年第6期16卷 708-727页

作者： Lei-Mei Xu Xin-Xin Yu Ning Zhang Yi-Song Chen department of gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China department of gynecology Shanghai Key Laboratory of Female Reproductive Endocrine-related DiseasesShanghai 200011China

BACKGROUND Pelvic organ prolapse(POP)involves pelvic organ herniation into the vagina due to pelvic floor tissue laxity,and vaginal structure is an essential *** POP,the vaginal walls exhibit abnormal collagen distribution and decreased fibroblast levels and *** intricate etiology of POP and the prohibition of trans-vaginal meshes in pelvic reconstruction surgery present challenges in targeted therapy *** umbilical cord mesenchymal stromal cells(hucMSCs)present limitations,but their exosomes(hucMSC-Exo)are promising therapeutic tools for promoting fibroblast proliferation and extracellular matrix *** inflammation in POP group fibroblasts,stimulated primary fibroblast growth,and elevated collagen I(Col1)production in ***-throughput RNA-seq of fibroblasts treated with hucMSC-Exo and miRNA sequencing of hucMSC-Exo revealed that abundant exosomal miRNAs downregulated matrix metalloproteinase 11(MMP11)*** HucMSC-Exo normalized the growth and function of primary fibroblasts from patients with POP by promoting cell growth and Col1 expression in *** miRNAs in hucMSC-Exo targeted and downregulated MMP11 ***-Exo-based therapy may be ideal for safely and effectively treating POP.

关键词： Pelvic organ prolapse Exosomes Fibroblasts Human umbilical cord mesenchymal stromal cells Extracellular matrix Collagen I

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Inpatient disease spectrum and clinical characteristics of surgical disorders in pediatric and adolescent gynecology:A single-institute study of 12 years data from China

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Chinese Medical Journal 2024年第10期137卷 1240-1242页

作者： He Huang Siyun Wang Ruixi Zhan Ling Yin Yongchun Hu Donglai Yang Yangyang Shi department of Obstetrics and gynecology Peking University First HospitalXicheng DistrictBeijing 100034China department of Obstetrics and gynecology Inner Mongolia Ulanqab Second HospitalUlanqabInner Mongolia 012000China department of Obstetrics and gynecology Jiujiang University Affiliated HospitalJiujiangJiangxi 332000China

To the Editor:Pediatric and adolescent gynecology(PAG)is a specialized branch of gynecology that focuses on reproductive health issues of women from infancy to adolescence.[1]In 1939,the Hungarian Dobszayrst established the new *** then,the PAG subject has begun to develop and gradually matured in the past 80 *** PAG has witnessed signicant development in western countries,a substantial unmet need persists in addressing specic health concerns among children and adolescents with gynecological disorders.

关键词： adolescent disorders branch

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Exploring the molecular mechanisms and potential therapeutic strategies of ferroptosis in ovarian cancer

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BIOCELL 2024年第3期48卷 379-386页

作者： LISHA MA WANQI SHAO WEILI ZHU department of gynecology Jiaxing University Master Degree Cultivation BaseZhejiang Chinese Medical UniversityJiaxingChina department of gynecology Jiaxing University Affiliated Women and Children’s HospitalJiaxingChina

The morbidity rate of ovarian cancer,a malignant tumour in gynaecological tumours,is rising,and it is considered to be the most lethal *** majority of patients are typically diagnosed during the advanced stages of the illness due to the elusive characteristics of ovarian cancer and an absence of highly sensitive and speciﬁc diagnostic *** excision of the lesions,along with chemotherapy,is the conventional treatment for ovarian cancer;however,resistance to platinum-based chemotherapeutic drugs and molecular targeted therapies frequently *** the survival rate and prognosis of patients with end-stage or recurring ovarian cancer requires the identiﬁcation of new therapeutic targets due to the absence of efﬁcient medications,and this has emerged as a highly demanding *** have demonstrated that ferroptosis effectively hinders the proliferation of ovarian cancer and induces the demise of malignant *** is composed of the cystine/glutamate antiporter system(the system Xc-)and glutathione peroxidase 4(GPX4).Solute carrier family 7 member 11(SLC7A11)and solute carrier family 3 member 2(SLC3A2)play crucial roles in the regulation of ferroptosis by facilitating the uptake of cystine into cells and the efﬂux of glutamate out of cells,*** cells,GPX4 is the exclusive enzyme employed for reducing liposomal peroxide through glutathione peroxidase *** occurrence of ferroptosis in ovarian cancer is strongly associated with three main pathways,namely,the GPX4-glutathione(GSH)protective pathway,the ferroptosis suppressor protein 1(FSP1)-coenzyme Q10(CoQ10)protective pathway,and the guanosine 5'-triphosphate cyclohydrolase I(GCH1)protective *** ovarian cancer cells,the postsynaptic density-95,discs-large,zona occludens 1(PDZ)-binding motif-angiopoietin-like 4-nicotinamide adenine dinucleotide phosphate oxidases 2(TAZ-ANGPTL4-NOX2)pathway can be regulated by Yes-associated protein(YAP)/TAZ,a downstream

关键词： Ovarian cancer Ferroptosis Therapy

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Curcumin modulates oxidative stress to inhibit pyroptosis and improve the inflammatory microenvironment to treat endometriosis

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Genes & Diseases 2024年第3期11卷 102-105页

作者： Jie Ding Shanshan Mei Kaili Wang Wen Cheng Shuai Sun Zhexin Ni Xiaoqiu Wang Chaoqin Yu department of gynecology of Traditional Chinese Medicine Changhai Hospital Affiliated to Naval Medical UniversityShanghai 200433China Obstetrics and gynecology department The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhouZhejiang 310006China department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Obstetrics and gynecology Hospital of Fudan University Shanghai 200433China

Endometriosis(EM)is a common disease that affects approximately 10%-15%of women of childbearing *** pathogenesis of EM is unclear,but studies have shown a strong association between EM and inflammation,as well as oxidative stress.^(1) Pyroptosis is also called inflammatory cell *** pyroptosis occurs,it activates a strong inflammatory *** is associated with oxidative stress,and Ros act as intermediate triggers to activate pyroptosi.

关键词： inflammatory death oxidative

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